Amino acid dipepetide frequency for Escherichia virus AAPEc6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.455AlaAla: 8.455 ± 1.202
0.51AlaCys: 0.51 ± 0.196
5.394AlaAsp: 5.394 ± 0.592
5.904AlaGlu: 5.904 ± 0.74
3.353AlaPhe: 3.353 ± 0.585
6.997AlaGly: 6.997 ± 0.942
1.385AlaHis: 1.385 ± 0.321
5.029AlaIle: 5.029 ± 0.395
5.539AlaLys: 5.539 ± 0.536
7.216AlaLeu: 7.216 ± 0.799
2.843AlaMet: 2.843 ± 0.445
3.571AlaAsn: 3.571 ± 0.368
3.353AlaPro: 3.353 ± 0.545
5.029AlaGln: 5.029 ± 0.946
5.175AlaArg: 5.175 ± 0.688
5.248AlaSer: 5.248 ± 0.593
4.956AlaThr: 4.956 ± 0.656
6.487AlaVal: 6.487 ± 0.869
1.093AlaTrp: 1.093 ± 0.296
2.77AlaTyr: 2.77 ± 0.455
0.0AlaXaa: 0.0 ± 0.0
Cys
0.656CysAla: 0.656 ± 0.233
0.219CysCys: 0.219 ± 0.135
0.656CysAsp: 0.656 ± 0.21
0.364CysGlu: 0.364 ± 0.194
0.729CysPhe: 0.729 ± 0.22
0.875CysGly: 0.875 ± 0.249
0.437CysHis: 0.437 ± 0.194
0.51CysIle: 0.51 ± 0.153
0.729CysLys: 0.729 ± 0.277
0.875CysLeu: 0.875 ± 0.28
0.437CysMet: 0.437 ± 0.195
0.51CysAsn: 0.51 ± 0.184
0.364CysPro: 0.364 ± 0.189
0.437CysGln: 0.437 ± 0.188
0.729CysArg: 0.729 ± 0.227
0.292CysSer: 0.292 ± 0.169
0.219CysThr: 0.219 ± 0.107
0.729CysVal: 0.729 ± 0.215
0.073CysTrp: 0.073 ± 0.073
0.729CysTyr: 0.729 ± 0.218
0.0CysXaa: 0.0 ± 0.0
Asp
6.633AspAla: 6.633 ± 0.77
0.656AspCys: 0.656 ± 0.183
3.571AspAsp: 3.571 ± 0.676
4.592AspGlu: 4.592 ± 0.704
2.114AspPhe: 2.114 ± 0.473
4.738AspGly: 4.738 ± 0.769
1.02AspHis: 1.02 ± 0.261
4.446AspIle: 4.446 ± 0.495
3.936AspLys: 3.936 ± 0.475
4.446AspLeu: 4.446 ± 0.659
2.259AspMet: 2.259 ± 0.396
2.988AspAsn: 2.988 ± 0.554
1.822AspPro: 1.822 ± 0.302
1.239AspGln: 1.239 ± 0.311
2.915AspArg: 2.915 ± 0.38
4.446AspSer: 4.446 ± 0.621
3.644AspThr: 3.644 ± 0.475
3.571AspVal: 3.571 ± 0.532
1.02AspTrp: 1.02 ± 0.322
2.041AspTyr: 2.041 ± 0.404
0.0AspXaa: 0.0 ± 0.0
Glu
7.58GluAla: 7.58 ± 0.789
0.875GluCys: 0.875 ± 0.329
4.81GluAsp: 4.81 ± 0.604
7.07GluGlu: 7.07 ± 0.813
2.405GluPhe: 2.405 ± 0.385
5.466GluGly: 5.466 ± 0.507
1.312GluHis: 1.312 ± 0.325
1.968GluIle: 1.968 ± 0.348
4.592GluLys: 4.592 ± 0.52
6.487GluLeu: 6.487 ± 0.917
1.822GluMet: 1.822 ± 0.411
1.603GluAsn: 1.603 ± 0.367
2.041GluPro: 2.041 ± 0.381
3.134GluGln: 3.134 ± 0.493
3.426GluArg: 3.426 ± 0.354
3.644GluSer: 3.644 ± 0.626
3.061GluThr: 3.061 ± 0.439
6.778GluVal: 6.778 ± 0.672
1.822GluTrp: 1.822 ± 0.352
2.187GluTyr: 2.187 ± 0.384
0.0GluXaa: 0.0 ± 0.0
Phe
2.697PheAla: 2.697 ± 0.367
0.146PheCys: 0.146 ± 0.12
3.207PheAsp: 3.207 ± 0.464
3.061PheGlu: 3.061 ± 0.391
1.239PhePhe: 1.239 ± 0.317
2.915PheGly: 2.915 ± 0.495
0.656PheHis: 0.656 ± 0.201
2.259PheIle: 2.259 ± 0.266
2.843PheLys: 2.843 ± 0.464
3.28PheLeu: 3.28 ± 0.511
1.676PheMet: 1.676 ± 0.274
1.676PheAsn: 1.676 ± 0.374
1.093PhePro: 1.093 ± 0.298
1.603PheGln: 1.603 ± 0.375
1.676PheArg: 1.676 ± 0.387
2.551PheSer: 2.551 ± 0.508
2.041PheThr: 2.041 ± 0.288
1.385PheVal: 1.385 ± 0.41
0.219PheTrp: 0.219 ± 0.126
0.948PheTyr: 0.948 ± 0.25
0.0PheXaa: 0.0 ± 0.0
Gly
6.778GlyAla: 6.778 ± 0.589
0.875GlyCys: 0.875 ± 0.257
5.394GlyAsp: 5.394 ± 0.671
4.883GlyGlu: 4.883 ± 0.612
3.061GlyPhe: 3.061 ± 0.548
5.466GlyGly: 5.466 ± 0.858
2.041GlyHis: 2.041 ± 0.435
4.956GlyIle: 4.956 ± 0.604
6.268GlyLys: 6.268 ± 0.679
5.394GlyLeu: 5.394 ± 0.863
2.041GlyMet: 2.041 ± 0.384
3.207GlyAsn: 3.207 ± 0.493
0.583GlyPro: 0.583 ± 0.198
3.644GlyGln: 3.644 ± 0.503
3.426GlyArg: 3.426 ± 0.45
5.248GlySer: 5.248 ± 0.899
4.592GlyThr: 4.592 ± 0.658
5.321GlyVal: 5.321 ± 0.596
1.312GlyTrp: 1.312 ± 0.272
2.478GlyTyr: 2.478 ± 0.422
0.073GlyXaa: 0.073 ± 0.063
His
1.239HisAla: 1.239 ± 0.304
0.292HisCys: 0.292 ± 0.167
1.385HisAsp: 1.385 ± 0.322
1.02HisGlu: 1.02 ± 0.298
1.093HisPhe: 1.093 ± 0.199
1.676HisGly: 1.676 ± 0.428
0.437HisHis: 0.437 ± 0.166
1.02HisIle: 1.02 ± 0.229
1.749HisLys: 1.749 ± 0.302
2.405HisLeu: 2.405 ± 0.38
0.51HisMet: 0.51 ± 0.301
0.802HisAsn: 0.802 ± 0.209
0.948HisPro: 0.948 ± 0.271
0.802HisGln: 0.802 ± 0.221
1.458HisArg: 1.458 ± 0.45
0.656HisSer: 0.656 ± 0.178
0.802HisThr: 0.802 ± 0.21
1.531HisVal: 1.531 ± 0.354
0.073HisTrp: 0.073 ± 0.073
1.093HisTyr: 1.093 ± 0.32
0.0HisXaa: 0.0 ± 0.0
Ile
4.956IleAla: 4.956 ± 0.639
0.219IleCys: 0.219 ± 0.124
4.373IleAsp: 4.373 ± 0.562
3.717IleGlu: 3.717 ± 0.542
1.895IlePhe: 1.895 ± 0.485
4.519IleGly: 4.519 ± 0.558
0.948IleHis: 0.948 ± 0.295
3.134IleIle: 3.134 ± 0.608
3.571IleLys: 3.571 ± 0.573
2.988IleLeu: 2.988 ± 0.447
1.385IleMet: 1.385 ± 0.323
1.968IleAsn: 1.968 ± 0.284
2.259IlePro: 2.259 ± 0.459
2.041IleGln: 2.041 ± 0.405
3.353IleArg: 3.353 ± 0.48
2.551IleSer: 2.551 ± 0.403
3.644IleThr: 3.644 ± 0.537
3.28IleVal: 3.28 ± 0.465
0.729IleTrp: 0.729 ± 0.152
1.676IleTyr: 1.676 ± 0.442
0.0IleXaa: 0.0 ± 0.0
Lys
7.726LysAla: 7.726 ± 0.825
0.802LysCys: 0.802 ± 0.224
3.426LysAsp: 3.426 ± 0.549
4.956LysGlu: 4.956 ± 0.575
1.458LysPhe: 1.458 ± 0.315
5.758LysGly: 5.758 ± 0.675
1.895LysHis: 1.895 ± 0.323
3.207LysIle: 3.207 ± 0.341
4.81LysLys: 4.81 ± 0.784
5.029LysLeu: 5.029 ± 0.703
1.603LysMet: 1.603 ± 0.298
2.187LysAsn: 2.187 ± 0.441
3.207LysPro: 3.207 ± 0.565
2.332LysGln: 2.332 ± 0.408
3.863LysArg: 3.863 ± 0.508
3.353LysSer: 3.353 ± 0.456
2.551LysThr: 2.551 ± 0.338
4.082LysVal: 4.082 ± 0.703
0.729LysTrp: 0.729 ± 0.226
2.843LysTyr: 2.843 ± 0.475
0.0LysXaa: 0.0 ± 0.0
Leu
6.122LeuAla: 6.122 ± 0.762
0.948LeuCys: 0.948 ± 0.251
5.758LeuAsp: 5.758 ± 0.501
5.102LeuGlu: 5.102 ± 0.601
2.988LeuPhe: 2.988 ± 0.518
5.831LeuGly: 5.831 ± 1.046
1.749LeuHis: 1.749 ± 0.488
4.155LeuIle: 4.155 ± 0.439
5.321LeuLys: 5.321 ± 0.541
4.956LeuLeu: 4.956 ± 0.766
2.624LeuMet: 2.624 ± 0.708
3.061LeuAsn: 3.061 ± 0.393
3.499LeuPro: 3.499 ± 0.406
3.426LeuGln: 3.426 ± 0.661
4.082LeuArg: 4.082 ± 0.656
3.863LeuSer: 3.863 ± 0.571
5.175LeuThr: 5.175 ± 0.551
5.175LeuVal: 5.175 ± 0.561
0.948LeuTrp: 0.948 ± 0.259
2.405LeuTyr: 2.405 ± 0.43
0.0LeuXaa: 0.0 ± 0.0
Met
3.571MetAla: 3.571 ± 0.438
0.146MetCys: 0.146 ± 0.099
1.385MetAsp: 1.385 ± 0.325
2.041MetGlu: 2.041 ± 0.333
0.802MetPhe: 0.802 ± 0.253
1.968MetGly: 1.968 ± 0.524
0.656MetHis: 0.656 ± 0.185
1.385MetIle: 1.385 ± 0.315
1.385MetLys: 1.385 ± 0.294
2.697MetLeu: 2.697 ± 0.479
0.802MetMet: 0.802 ± 0.249
1.166MetAsn: 1.166 ± 0.274
1.385MetPro: 1.385 ± 0.293
1.676MetGln: 1.676 ± 0.357
1.895MetArg: 1.895 ± 0.479
2.405MetSer: 2.405 ± 0.365
2.187MetThr: 2.187 ± 0.331
1.822MetVal: 1.822 ± 0.368
0.219MetTrp: 0.219 ± 0.109
0.802MetTyr: 0.802 ± 0.246
0.0MetXaa: 0.0 ± 0.0
Asn
3.353AsnAla: 3.353 ± 0.568
0.292AsnCys: 0.292 ± 0.133
1.895AsnAsp: 1.895 ± 0.331
2.478AsnGlu: 2.478 ± 0.423
1.749AsnPhe: 1.749 ± 0.29
3.426AsnGly: 3.426 ± 0.402
0.437AsnHis: 0.437 ± 0.15
2.041AsnIle: 2.041 ± 0.384
2.988AsnLys: 2.988 ± 0.368
3.426AsnLeu: 3.426 ± 0.399
0.948AsnMet: 0.948 ± 0.436
2.187AsnAsn: 2.187 ± 0.453
1.968AsnPro: 1.968 ± 0.337
1.749AsnGln: 1.749 ± 0.457
2.988AsnArg: 2.988 ± 0.52
2.332AsnSer: 2.332 ± 0.5
2.332AsnThr: 2.332 ± 0.43
3.061AsnVal: 3.061 ± 0.603
0.583AsnTrp: 0.583 ± 0.217
1.749AsnTyr: 1.749 ± 0.385
0.0AsnXaa: 0.0 ± 0.0
Pro
2.988ProAla: 2.988 ± 0.499
0.51ProCys: 0.51 ± 0.186
2.77ProAsp: 2.77 ± 0.664
3.134ProGlu: 3.134 ± 0.565
1.312ProPhe: 1.312 ± 0.22
0.948ProGly: 0.948 ± 0.297
0.802ProHis: 0.802 ± 0.312
0.948ProIle: 0.948 ± 0.243
2.114ProLys: 2.114 ± 0.297
2.77ProLeu: 2.77 ± 0.379
1.239ProMet: 1.239 ± 0.22
1.239ProAsn: 1.239 ± 0.294
0.802ProPro: 0.802 ± 0.188
1.822ProGln: 1.822 ± 0.354
1.093ProArg: 1.093 ± 0.272
2.697ProSer: 2.697 ± 0.385
2.405ProThr: 2.405 ± 0.378
3.28ProVal: 3.28 ± 0.432
0.802ProTrp: 0.802 ± 0.188
1.822ProTyr: 1.822 ± 0.311
0.0ProXaa: 0.0 ± 0.0
Gln
4.3GlnAla: 4.3 ± 0.495
0.51GlnCys: 0.51 ± 0.213
2.332GlnAsp: 2.332 ± 0.348
2.77GlnGlu: 2.77 ± 0.487
1.895GlnPhe: 1.895 ± 0.329
3.28GlnGly: 3.28 ± 0.396
1.02GlnHis: 1.02 ± 0.265
2.551GlnIle: 2.551 ± 0.4
1.822GlnLys: 1.822 ± 0.352
2.843GlnLeu: 2.843 ± 0.579
1.895GlnMet: 1.895 ± 0.384
1.822GlnAsn: 1.822 ± 0.387
1.02GlnPro: 1.02 ± 0.266
2.478GlnGln: 2.478 ± 0.413
2.697GlnArg: 2.697 ± 0.483
1.822GlnSer: 1.822 ± 0.448
1.749GlnThr: 1.749 ± 0.389
2.915GlnVal: 2.915 ± 0.485
0.875GlnTrp: 0.875 ± 0.267
1.968GlnTyr: 1.968 ± 0.383
0.0GlnXaa: 0.0 ± 0.0
Arg
5.029ArgAla: 5.029 ± 0.745
0.51ArgCys: 0.51 ± 0.262
2.843ArgAsp: 2.843 ± 0.41
4.446ArgGlu: 4.446 ± 0.525
2.405ArgPhe: 2.405 ± 0.355
4.81ArgGly: 4.81 ± 0.53
1.02ArgHis: 1.02 ± 0.24
3.353ArgIle: 3.353 ± 0.443
2.988ArgLys: 2.988 ± 0.408
4.446ArgLeu: 4.446 ± 0.627
2.041ArgMet: 2.041 ± 0.342
2.697ArgAsn: 2.697 ± 0.462
1.385ArgPro: 1.385 ± 0.339
2.405ArgGln: 2.405 ± 0.448
3.134ArgArg: 3.134 ± 0.512
1.822ArgSer: 1.822 ± 0.432
2.405ArgThr: 2.405 ± 0.48
3.353ArgVal: 3.353 ± 0.412
0.802ArgTrp: 0.802 ± 0.212
2.405ArgTyr: 2.405 ± 0.52
0.0ArgXaa: 0.0 ± 0.0
Ser
4.665SerAla: 4.665 ± 0.709
0.583SerCys: 0.583 ± 0.208
3.717SerAsp: 3.717 ± 0.579
3.936SerGlu: 3.936 ± 0.467
2.478SerPhe: 2.478 ± 0.422
5.685SerGly: 5.685 ± 0.515
1.02SerHis: 1.02 ± 0.229
2.697SerIle: 2.697 ± 0.584
3.426SerLys: 3.426 ± 0.631
5.248SerLeu: 5.248 ± 0.661
2.041SerMet: 2.041 ± 0.347
2.697SerAsn: 2.697 ± 0.645
1.749SerPro: 1.749 ± 0.316
2.114SerGln: 2.114 ± 0.382
3.426SerArg: 3.426 ± 0.449
3.571SerSer: 3.571 ± 0.767
2.988SerThr: 2.988 ± 0.58
3.936SerVal: 3.936 ± 0.499
0.948SerTrp: 0.948 ± 0.247
1.895SerTyr: 1.895 ± 0.499
0.0SerXaa: 0.0 ± 0.0
Thr
3.644ThrAla: 3.644 ± 0.659
0.729ThrCys: 0.729 ± 0.234
3.571ThrAsp: 3.571 ± 0.69
4.446ThrGlu: 4.446 ± 0.573
2.624ThrPhe: 2.624 ± 0.454
4.155ThrGly: 4.155 ± 0.505
1.166ThrHis: 1.166 ± 0.25
2.988ThrIle: 2.988 ± 0.416
3.936ThrLys: 3.936 ± 0.543
4.155ThrLeu: 4.155 ± 0.708
1.093ThrMet: 1.093 ± 0.265
2.624ThrAsn: 2.624 ± 0.471
2.551ThrPro: 2.551 ± 0.349
1.968ThrGln: 1.968 ± 0.54
2.551ThrArg: 2.551 ± 0.466
4.009ThrSer: 4.009 ± 0.774
2.915ThrThr: 2.915 ± 0.477
3.207ThrVal: 3.207 ± 0.533
0.729ThrTrp: 0.729 ± 0.206
1.531ThrTyr: 1.531 ± 0.346
0.0ThrXaa: 0.0 ± 0.0
Val
5.977ValAla: 5.977 ± 0.665
0.802ValCys: 0.802 ± 0.243
2.697ValAsp: 2.697 ± 0.48
4.665ValGlu: 4.665 ± 0.488
1.895ValPhe: 1.895 ± 0.306
4.665ValGly: 4.665 ± 0.687
1.531ValHis: 1.531 ± 0.362
3.863ValIle: 3.863 ± 0.547
4.81ValLys: 4.81 ± 0.533
4.592ValLeu: 4.592 ± 0.834
1.676ValMet: 1.676 ± 0.326
3.644ValAsn: 3.644 ± 0.468
3.207ValPro: 3.207 ± 0.394
2.915ValGln: 2.915 ± 0.498
3.499ValArg: 3.499 ± 0.484
5.029ValSer: 5.029 ± 0.591
4.883ValThr: 4.883 ± 0.574
3.644ValVal: 3.644 ± 0.592
0.656ValTrp: 0.656 ± 0.188
1.895ValTyr: 1.895 ± 0.397
0.0ValXaa: 0.0 ± 0.0
Trp
0.802TrpAla: 0.802 ± 0.23
0.364TrpCys: 0.364 ± 0.156
0.948TrpAsp: 0.948 ± 0.219
1.531TrpGlu: 1.531 ± 0.295
0.437TrpPhe: 0.437 ± 0.199
0.656TrpGly: 0.656 ± 0.211
0.437TrpHis: 0.437 ± 0.173
0.51TrpIle: 0.51 ± 0.169
1.166TrpLys: 1.166 ± 0.372
0.875TrpLeu: 0.875 ± 0.273
0.292TrpMet: 0.292 ± 0.135
0.364TrpAsn: 0.364 ± 0.142
1.093TrpPro: 1.093 ± 0.276
0.656TrpGln: 0.656 ± 0.191
0.802TrpArg: 0.802 ± 0.255
1.166TrpSer: 1.166 ± 0.376
0.364TrpThr: 0.364 ± 0.175
1.239TrpVal: 1.239 ± 0.278
0.073TrpTrp: 0.073 ± 0.077
0.292TrpTyr: 0.292 ± 0.122
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.134TyrAla: 3.134 ± 0.408
0.583TyrCys: 0.583 ± 0.185
1.968TyrAsp: 1.968 ± 0.485
1.968TyrGlu: 1.968 ± 0.296
1.239TyrPhe: 1.239 ± 0.3
3.207TyrGly: 3.207 ± 0.644
1.02TyrHis: 1.02 ± 0.301
2.187TyrIle: 2.187 ± 0.349
1.822TyrLys: 1.822 ± 0.343
3.061TyrLeu: 3.061 ± 0.536
1.02TyrMet: 1.02 ± 0.239
1.968TyrAsn: 1.968 ± 0.348
1.166TyrPro: 1.166 ± 0.35
1.093TyrGln: 1.093 ± 0.187
2.114TyrArg: 2.114 ± 0.367
2.114TyrSer: 2.114 ± 0.424
1.676TyrThr: 1.676 ± 0.347
1.822TyrVal: 1.822 ± 0.295
0.364TyrTrp: 0.364 ± 0.145
1.166TyrTyr: 1.166 ± 0.415
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.073XaaMet: 0.073 ± 0.063
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 52 proteins (13721 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski