Amino acid dipepetide frequency for Anaerococcus prevotii ACS-065-V-Col13

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.548AlaAla: 3.548 ± 0.115	0.627AlaCys: 0.627 ± 0.04	3.478AlaAsp: 3.478 ± 0.088	3.324AlaGlu: 3.324 ± 0.092	2.716AlaPhe: 2.716 ± 0.082	4.138AlaGly: 4.138 ± 0.104	0.793AlaHis: 0.793 ± 0.047	6.098AlaIle: 6.098 ± 0.126	5.129AlaLys: 5.129 ± 0.103	5.803AlaLeu: 5.803 ± 0.127	1.87AlaMet: 1.87 ± 0.075	3.335AlaAsn: 3.335 ± 0.075	1.336AlaPro: 1.336 ± 0.05	1.333AlaGln: 1.333 ± 0.053	2.349AlaArg: 2.349 ± 0.065	3.968AlaSer: 3.968 ± 0.1	2.808AlaThr: 2.808 ± 0.073	3.593AlaVal: 3.593 ± 0.086	0.313AlaTrp: 0.313 ± 0.023	2.476AlaTyr: 2.476 ± 0.072	0.0AlaXaa: 0.0 ± 0.0
Cys	0.406CysAla: 0.406 ± 0.031	0.088CysCys: 0.088 ± 0.014	0.584CysAsp: 0.584 ± 0.03	0.535CysGlu: 0.535 ± 0.036	0.258CysPhe: 0.258 ± 0.024	0.832CysGly: 0.832 ± 0.043	0.19CysHis: 0.19 ± 0.02	0.465CysIle: 0.465 ± 0.034	0.612CysLys: 0.612 ± 0.034	0.68CysLeu: 0.68 ± 0.038	0.141CysMet: 0.141 ± 0.015	0.32CysAsn: 0.32 ± 0.028	0.363CysPro: 0.363 ± 0.028	0.164CysGln: 0.164 ± 0.017	0.199CysArg: 0.199 ± 0.02	0.42CysSer: 0.42 ± 0.026	0.295CysThr: 0.295 ± 0.022	0.44CysVal: 0.44 ± 0.032	0.035CysTrp: 0.035 ± 0.008	0.307CysTyr: 0.307 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	3.128AspAla: 3.128 ± 0.081	0.512AspCys: 0.512 ± 0.035	4.486AspAsp: 4.486 ± 0.092	6.026AspGlu: 6.026 ± 0.118	3.961AspPhe: 3.961 ± 0.105	4.201AspGly: 4.201 ± 0.098	0.92AspHis: 0.92 ± 0.05	6.692AspIle: 6.692 ± 0.126	7.02AspLys: 7.02 ± 0.133	6.997AspLeu: 6.997 ± 0.128	1.884AspMet: 1.884 ± 0.066	3.607AspAsn: 3.607 ± 0.088	1.989AspPro: 1.989 ± 0.071	1.669AspGln: 1.669 ± 0.059	2.728AspArg: 2.728 ± 0.079	3.873AspSer: 3.873 ± 0.086	2.88AspThr: 2.88 ± 0.078	3.978AspVal: 3.978 ± 0.093	0.41AspTrp: 0.41 ± 0.031	3.568AspTyr: 3.568 ± 0.087	0.0AspXaa: 0.0 ± 0.0
Glu	4.336GluAla: 4.336 ± 0.106	0.358GluCys: 0.358 ± 0.029	6.01GluAsp: 6.01 ± 0.122	7.72GluGlu: 7.72 ± 0.168	3.167GluPhe: 3.167 ± 0.072	4.263GluGly: 4.263 ± 0.093	0.666GluHis: 0.666 ± 0.036	7.65GluIle: 7.65 ± 0.146	8.062GluLys: 8.062 ± 0.154	5.766GluLeu: 5.766 ± 0.11	1.891GluMet: 1.891 ± 0.064	6.245GluAsn: 6.245 ± 0.12	1.239GluPro: 1.239 ± 0.051	1.221GluGln: 1.221 ± 0.052	2.55GluArg: 2.55 ± 0.076	4.088GluSer: 4.088 ± 0.09	3.044GluThr: 3.044 ± 0.093	4.928GluVal: 4.928 ± 0.097	0.338GluTrp: 0.338 ± 0.026	2.886GluTyr: 2.886 ± 0.091	0.0GluXaa: 0.0 ± 0.0
Phe	2.825PheAla: 2.825 ± 0.079	0.307PheCys: 0.307 ± 0.023	3.681PheAsp: 3.681 ± 0.09	2.902PheGlu: 2.902 ± 0.075	2.048PhePhe: 2.048 ± 0.079	2.952PheGly: 2.952 ± 0.096	0.565PheHis: 0.565 ± 0.036	4.228PheIle: 4.228 ± 0.118	3.394PheLys: 3.394 ± 0.076	4.062PheLeu: 4.062 ± 0.132	1.182PheMet: 1.182 ± 0.054	2.265PheAsn: 2.265 ± 0.065	1.219PhePro: 1.219 ± 0.059	0.836PheGln: 0.836 ± 0.042	1.612PheArg: 1.612 ± 0.059	3.496PheSer: 3.496 ± 0.083	2.462PheThr: 2.462 ± 0.071	3.152PheVal: 3.152 ± 0.091	0.309PheTrp: 0.309 ± 0.024	2.013PheTyr: 2.013 ± 0.057	0.0PheXaa: 0.0 ± 0.0
Gly	3.966GlyAla: 3.966 ± 0.099	0.539GlyCys: 0.539 ± 0.038	3.701GlyAsp: 3.701 ± 0.081	4.365GlyGlu: 4.365 ± 0.115	3.193GlyPhe: 3.193 ± 0.089	4.045GlyGly: 4.045 ± 0.113	0.932GlyHis: 0.932 ± 0.047	5.926GlyIle: 5.926 ± 0.137	5.729GlyLys: 5.729 ± 0.112	6.268GlyLeu: 6.268 ± 0.12	1.63GlyMet: 1.63 ± 0.062	2.925GlyAsn: 2.925 ± 0.084	1.208GlyPro: 1.208 ± 0.05	1.493GlyGln: 1.493 ± 0.054	2.313GlyArg: 2.313 ± 0.078	3.914GlySer: 3.914 ± 0.097	2.823GlyThr: 2.823 ± 0.073	4.322GlyVal: 4.322 ± 0.108	0.369GlyTrp: 0.369 ± 0.027	2.894GlyTyr: 2.894 ± 0.083	0.0GlyXaa: 0.0 ± 0.0
His	0.721HisAla: 0.721 ± 0.037	0.102HisCys: 0.102 ± 0.015	0.809HisAsp: 0.809 ± 0.039	0.809HisGlu: 0.809 ± 0.04	0.631HisPhe: 0.631 ± 0.037	0.899HisGly: 0.899 ± 0.043	0.313HisHis: 0.313 ± 0.044	1.147HisIle: 1.147 ± 0.054	0.969HisLys: 0.969 ± 0.042	1.106HisLeu: 1.106 ± 0.051	0.34HisMet: 0.34 ± 0.024	0.615HisAsn: 0.615 ± 0.034	0.574HisPro: 0.574 ± 0.031	0.33HisGln: 0.33 ± 0.027	0.565HisArg: 0.565 ± 0.031	0.739HisSer: 0.739 ± 0.04	0.662HisThr: 0.662 ± 0.039	0.705HisVal: 0.705 ± 0.041	0.082HisTrp: 0.082 ± 0.014	0.522HisTyr: 0.522 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.83IleAla: 5.83 ± 0.128	0.774IleCys: 0.774 ± 0.034	7.013IleAsp: 7.013 ± 0.136	7.059IleGlu: 7.059 ± 0.132	4.387IlePhe: 4.387 ± 0.129	5.719IleGly: 5.719 ± 0.124	1.09IleHis: 1.09 ± 0.053	8.177IleIle: 8.177 ± 0.177	8.033IleLys: 8.033 ± 0.13	8.671IleLeu: 8.671 ± 0.18	2.14IleMet: 2.14 ± 0.072	5.666IleAsn: 5.666 ± 0.102	2.831IlePro: 2.831 ± 0.082	1.719IleGln: 1.719 ± 0.057	3.296IleArg: 3.296 ± 0.089	6.983IleSer: 6.983 ± 0.128	4.351IleThr: 4.351 ± 0.099	5.477IleVal: 5.477 ± 0.112	0.43IleTrp: 0.43 ± 0.033	3.873IleTyr: 3.873 ± 0.088	0.0IleXaa: 0.0 ± 0.0
Lys	5.43LysAla: 5.43 ± 0.107	0.43LysCys: 0.43 ± 0.034	7.437LysAsp: 7.437 ± 0.146	8.599LysGlu: 8.599 ± 0.159	3.062LysPhe: 3.062 ± 0.079	4.359LysGly: 4.359 ± 0.093	0.942LysHis: 0.942 ± 0.038	8.062LysIle: 8.062 ± 0.126	8.797LysLys: 8.797 ± 0.158	7.759LysLeu: 7.759 ± 0.127	2.253LysMet: 2.253 ± 0.067	6.315LysAsn: 6.315 ± 0.145	1.876LysPro: 1.876 ± 0.065	1.796LysGln: 1.796 ± 0.054	3.218LysArg: 3.218 ± 0.1	5.492LysSer: 5.492 ± 0.109	4.523LysThr: 4.523 ± 0.101	5.151LysVal: 5.151 ± 0.101	0.477LysTrp: 0.477 ± 0.033	3.845LysTyr: 3.845 ± 0.085	0.0LysXaa: 0.0 ± 0.0
Leu	6.432LeuAla: 6.432 ± 0.125	0.594LeuCys: 0.594 ± 0.04	6.972LeuAsp: 6.972 ± 0.125	6.579LeuGlu: 6.579 ± 0.133	3.732LeuPhe: 3.732 ± 0.108	6.071LeuGly: 6.071 ± 0.137	0.899LeuHis: 0.899 ± 0.048	8.343LeuIle: 8.343 ± 0.142	7.39LeuLys: 7.39 ± 0.107	7.634LeuLeu: 7.634 ± 0.145	2.353LeuMet: 2.353 ± 0.071	5.217LeuAsn: 5.217 ± 0.104	2.665LeuPro: 2.665 ± 0.085	1.723LeuGln: 1.723 ± 0.055	3.363LeuArg: 3.363 ± 0.089	7.114LeuSer: 7.114 ± 0.141	4.439LeuThr: 4.439 ± 0.094	6.17LeuVal: 6.17 ± 0.133	0.492LeuTrp: 0.492 ± 0.033	3.06LeuTyr: 3.06 ± 0.08	0.0LeuXaa: 0.0 ± 0.0
Met	2.073MetAla: 2.073 ± 0.064	0.162MetCys: 0.162 ± 0.02	1.891MetAsp: 1.891 ± 0.057	1.69MetGlu: 1.69 ± 0.052	0.967MetPhe: 0.967 ± 0.041	1.844MetGly: 1.844 ± 0.062	0.283MetHis: 0.283 ± 0.022	2.304MetIle: 2.304 ± 0.072	2.394MetLys: 2.394 ± 0.064	2.081MetLeu: 2.081 ± 0.066	0.655MetMet: 0.655 ± 0.037	1.469MetAsn: 1.469 ± 0.061	0.825MetPro: 0.825 ± 0.04	0.615MetGln: 0.615 ± 0.033	0.926MetArg: 0.926 ± 0.043	1.44MetSer: 1.44 ± 0.056	1.475MetThr: 1.475 ± 0.062	1.575MetVal: 1.575 ± 0.062	0.127MetTrp: 0.127 ± 0.016	0.856MetTyr: 0.856 ± 0.041	0.0MetXaa: 0.0 ± 0.0
Asn	2.849AsnAla: 2.849 ± 0.086	0.389AsnCys: 0.389 ± 0.03	3.507AsnAsp: 3.507 ± 0.078	4.203AsnGlu: 4.203 ± 0.099	2.708AsnPhe: 2.708 ± 0.08	3.322AsnGly: 3.322 ± 0.093	0.846AsnHis: 0.846 ± 0.04	6.36AsnIle: 6.36 ± 0.109	5.741AsnLys: 5.741 ± 0.121	6.053AsnLeu: 6.053 ± 0.124	1.559AsnMet: 1.559 ± 0.057	3.47AsnAsn: 3.47 ± 0.099	2.437AsnPro: 2.437 ± 0.071	1.583AsnGln: 1.583 ± 0.069	2.079AsnArg: 2.079 ± 0.069	3.238AsnSer: 3.238 ± 0.085	2.753AsnThr: 2.753 ± 0.08	3.038AsnVal: 3.038 ± 0.084	0.356AsnTrp: 0.356 ± 0.027	2.534AsnTyr: 2.534 ± 0.071	0.0AsnXaa: 0.0 ± 0.0
Pro	1.465ProAla: 1.465 ± 0.058	0.215ProCys: 0.215 ± 0.019	1.61ProAsp: 1.61 ± 0.062	2.226ProGlu: 2.226 ± 0.069	1.268ProPhe: 1.268 ± 0.054	1.501ProGly: 1.501 ± 0.066	0.451ProHis: 0.451 ± 0.031	2.564ProIle: 2.564 ± 0.072	2.085ProLys: 2.085 ± 0.061	2.286ProLeu: 2.286 ± 0.068	0.694ProMet: 0.694 ± 0.035	1.463ProAsn: 1.463 ± 0.06	0.471ProPro: 0.471 ± 0.035	0.758ProGln: 0.758 ± 0.039	0.868ProArg: 0.868 ± 0.04	1.778ProSer: 1.778 ± 0.061	1.52ProThr: 1.52 ± 0.063	2.001ProVal: 2.001 ± 0.067	0.225ProTrp: 0.225 ± 0.022	1.194ProTyr: 1.194 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	1.786GlnAla: 1.786 ± 0.06	0.106GlnCys: 0.106 ± 0.017	1.227GlnAsp: 1.227 ± 0.046	1.712GlnGlu: 1.712 ± 0.071	0.85GlnPhe: 0.85 ± 0.047	1.417GlnGly: 1.417 ± 0.058	0.203GlnHis: 0.203 ± 0.021	2.167GlnIle: 2.167 ± 0.072	1.966GlnLys: 1.966 ± 0.072	1.598GlnLeu: 1.598 ± 0.063	0.717GlnMet: 0.717 ± 0.037	1.323GlnAsn: 1.323 ± 0.057	0.389GlnPro: 0.389 ± 0.027	0.514GlnGln: 0.514 ± 0.037	1.112GlnArg: 1.112 ± 0.051	1.213GlnSer: 1.213 ± 0.056	1.176GlnThr: 1.176 ± 0.051	1.557GlnVal: 1.557 ± 0.057	0.184GlnTrp: 0.184 ± 0.018	0.815GlnTyr: 0.815 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.093ArgAla: 2.093 ± 0.059	0.293ArgCys: 0.293 ± 0.025	2.575ArgAsp: 2.575 ± 0.075	3.077ArgGlu: 3.077 ± 0.091	1.63ArgPhe: 1.63 ± 0.059	2.028ArgGly: 2.028 ± 0.06	0.432ArgHis: 0.432 ± 0.025	3.208ArgIle: 3.208 ± 0.086	3.623ArgLys: 3.623 ± 0.093	3.447ArgLeu: 3.447 ± 0.088	0.932ArgMet: 0.932 ± 0.042	2.247ArgAsn: 2.247 ± 0.062	1.041ArgPro: 1.041 ± 0.05	1.055ArgGln: 1.055 ± 0.047	1.676ArgArg: 1.676 ± 0.054	2.14ArgSer: 2.14 ± 0.071	1.54ArgThr: 1.54 ± 0.056	2.21ArgVal: 2.21 ± 0.06	0.223ArgTrp: 0.223 ± 0.021	1.465ArgTyr: 1.465 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	3.122SerAla: 3.122 ± 0.083	0.506SerCys: 0.506 ± 0.035	4.097SerAsp: 4.097 ± 0.093	4.385SerGlu: 4.385 ± 0.092	3.55SerPhe: 3.55 ± 0.085	4.213SerGly: 4.213 ± 0.104	1.022SerHis: 1.022 ± 0.046	5.95SerIle: 5.95 ± 0.137	5.743SerLys: 5.743 ± 0.107	6.78SerLeu: 6.78 ± 0.135	1.671SerMet: 1.671 ± 0.064	3.568SerAsn: 3.568 ± 0.092	1.622SerPro: 1.622 ± 0.056	1.798SerGln: 1.798 ± 0.072	2.2SerArg: 2.2 ± 0.075	4.316SerSer: 4.316 ± 0.107	2.966SerThr: 2.966 ± 0.082	3.552SerVal: 3.552 ± 0.085	0.381SerTrp: 0.381 ± 0.029	3.335SerTyr: 3.335 ± 0.088	0.0SerXaa: 0.0 ± 0.0
Thr	2.843ThrAla: 2.843 ± 0.075	0.399ThrCys: 0.399 ± 0.029	3.202ThrAsp: 3.202 ± 0.094	2.935ThrGlu: 2.935 ± 0.081	2.065ThrPhe: 2.065 ± 0.071	3.496ThrGly: 3.496 ± 0.096	0.717ThrHis: 0.717 ± 0.033	4.621ThrIle: 4.621 ± 0.104	3.652ThrLys: 3.652 ± 0.093	4.179ThrLeu: 4.179 ± 0.083	1.166ThrMet: 1.166 ± 0.041	2.845ThrAsn: 2.845 ± 0.087	1.54ThrPro: 1.54 ± 0.064	0.942ThrGln: 0.942 ± 0.038	1.776ThrArg: 1.776 ± 0.058	3.349ThrSer: 3.349 ± 0.082	2.394ThrThr: 2.394 ± 0.072	2.886ThrVal: 2.886 ± 0.086	0.289ThrTrp: 0.289 ± 0.023	2.046ThrTyr: 2.046 ± 0.068	0.0ThrXaa: 0.0 ± 0.0
Val	3.72ValAla: 3.72 ± 0.101	0.602ValCys: 0.602 ± 0.035	4.641ValAsp: 4.641 ± 0.117	4.492ValGlu: 4.492 ± 0.097	2.945ValPhe: 2.945 ± 0.087	4.412ValGly: 4.412 ± 0.109	0.723ValHis: 0.723 ± 0.038	5.381ValIle: 5.381 ± 0.111	4.906ValLys: 4.906 ± 0.098	5.541ValLeu: 5.541 ± 0.119	1.446ValMet: 1.446 ± 0.061	3.54ValAsn: 3.54 ± 0.077	1.544ValPro: 1.544 ± 0.058	0.985ValGln: 0.985 ± 0.046	2.29ValArg: 2.29 ± 0.075	4.406ValSer: 4.406 ± 0.1	2.991ValThr: 2.991 ± 0.081	3.955ValVal: 3.955 ± 0.099	0.354ValTrp: 0.354 ± 0.029	2.306ValTyr: 2.306 ± 0.065	0.0ValXaa: 0.0 ± 0.0
Trp	0.33TrpAla: 0.33 ± 0.032	0.031TrpCys: 0.031 ± 0.007	0.426TrpAsp: 0.426 ± 0.031	0.387TrpGlu: 0.387 ± 0.029	0.199TrpPhe: 0.199 ± 0.02	0.42TrpGly: 0.42 ± 0.035	0.106TrpHis: 0.106 ± 0.014	0.543TrpIle: 0.543 ± 0.035	0.445TrpLys: 0.445 ± 0.029	0.512TrpLeu: 0.512 ± 0.03	0.174TrpMet: 0.174 ± 0.021	0.277TrpAsn: 0.277 ± 0.026	0.178TrpPro: 0.178 ± 0.02	0.256TrpGln: 0.256 ± 0.024	0.207TrpArg: 0.207 ± 0.022	0.303TrpSer: 0.303 ± 0.026	0.322TrpThr: 0.322 ± 0.027	0.322TrpVal: 0.322 ± 0.028	0.051TrpTrp: 0.051 ± 0.01	0.227TrpTyr: 0.227 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.13TyrAla: 2.13 ± 0.064	0.303TyrCys: 0.303 ± 0.025	3.181TyrAsp: 3.181 ± 0.091	3.404TyrGlu: 3.404 ± 0.092	2.173TyrPhe: 2.173 ± 0.072	2.423TyrGly: 2.423 ± 0.077	0.547TyrHis: 0.547 ± 0.036	3.634TyrIle: 3.634 ± 0.093	4.134TyrLys: 4.134 ± 0.106	4.017TyrLeu: 4.017 ± 0.092	0.955TyrMet: 0.955 ± 0.045	2.31TyrAsn: 2.31 ± 0.069	1.295TyrPro: 1.295 ± 0.056	1.241TyrGln: 1.241 ± 0.052	1.608TyrArg: 1.608 ± 0.052	2.507TyrSer: 2.507 ± 0.072	1.915TyrThr: 1.915 ± 0.063	2.169TyrVal: 2.169 ± 0.081	0.274TyrTrp: 0.274 ± 0.025	1.87TyrTyr: 1.87 ± 0.066	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1634 proteins (511794 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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