Amino acid dipepetide frequency for Croceicoccus naphthovorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.701AlaAla: 16.701 ± 0.198	1.101AlaCys: 1.101 ± 0.037	7.748AlaAsp: 7.748 ± 0.11	8.328AlaGlu: 8.328 ± 0.112	4.33AlaPhe: 4.33 ± 0.061	10.71AlaGly: 10.71 ± 0.112	2.218AlaHis: 2.218 ± 0.054	6.888AlaIle: 6.888 ± 0.083	4.448AlaLys: 4.448 ± 0.094	13.199AlaLeu: 13.199 ± 0.156	4.077AlaMet: 4.077 ± 0.071	3.261AlaAsn: 3.261 ± 0.077	5.582AlaPro: 5.582 ± 0.085	4.223AlaGln: 4.223 ± 0.069	8.883AlaArg: 8.883 ± 0.114	6.429AlaSer: 6.429 ± 0.122	6.173AlaThr: 6.173 ± 0.092	8.346AlaVal: 8.346 ± 0.1	1.6AlaTrp: 1.6 ± 0.048	2.518AlaTyr: 2.518 ± 0.074	0.0AlaXaa: 0.0 ± 0.0
Cys	1.066CysAla: 1.066 ± 0.037	0.112CysCys: 0.112 ± 0.01	0.611CysAsp: 0.611 ± 0.024	0.539CysGlu: 0.539 ± 0.025	0.306CysPhe: 0.306 ± 0.017	0.888CysGly: 0.888 ± 0.031	0.246CysHis: 0.246 ± 0.02	0.361CysIle: 0.361 ± 0.021	0.204CysLys: 0.204 ± 0.015	0.697CysLeu: 0.697 ± 0.021	0.153CysMet: 0.153 ± 0.014	0.225CysAsn: 0.225 ± 0.016	0.462CysPro: 0.462 ± 0.021	0.223CysGln: 0.223 ± 0.017	0.597CysArg: 0.597 ± 0.025	0.424CysSer: 0.424 ± 0.022	0.387CysThr: 0.387 ± 0.021	0.61CysVal: 0.61 ± 0.025	0.139CysTrp: 0.139 ± 0.012	0.195CysTyr: 0.195 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.977AspAla: 7.977 ± 0.116	0.569AspCys: 0.569 ± 0.024	3.952AspAsp: 3.952 ± 0.092	3.876AspGlu: 3.876 ± 0.069	2.346AspPhe: 2.346 ± 0.051	6.079AspGly: 6.079 ± 0.116	1.321AspHis: 1.321 ± 0.039	3.04AspIle: 3.04 ± 0.056	1.88AspLys: 1.88 ± 0.048	6.093AspLeu: 6.093 ± 0.069	1.522AspMet: 1.522 ± 0.041	1.524AspAsn: 1.524 ± 0.043	3.867AspPro: 3.867 ± 0.067	1.795AspGln: 1.795 ± 0.041	4.996AspArg: 4.996 ± 0.075	2.566AspSer: 2.566 ± 0.059	2.961AspThr: 2.961 ± 0.068	4.307AspVal: 4.307 ± 0.08	1.187AspTrp: 1.187 ± 0.031	1.657AspTyr: 1.657 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	8.128GluAla: 8.128 ± 0.107	0.433GluCys: 0.433 ± 0.021	3.356GluAsp: 3.356 ± 0.071	3.589GluGlu: 3.589 ± 0.078	1.759GluPhe: 1.759 ± 0.037	5.018GluGly: 5.018 ± 0.067	1.239GluHis: 1.239 ± 0.035	3.295GluIle: 3.295 ± 0.06	2.262GluLys: 2.262 ± 0.061	5.399GluLeu: 5.399 ± 0.081	1.605GluMet: 1.605 ± 0.043	1.637GluAsn: 1.637 ± 0.039	2.777GluPro: 2.777 ± 0.06	2.206GluGln: 2.206 ± 0.052	5.073GluArg: 5.073 ± 0.094	2.53GluSer: 2.53 ± 0.049	3.512GluThr: 3.512 ± 0.066	3.922GluVal: 3.922 ± 0.069	0.912GluTrp: 0.912 ± 0.026	1.186GluTyr: 1.186 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.894PheAla: 4.894 ± 0.075	0.338PheCys: 0.338 ± 0.018	2.742PheAsp: 2.742 ± 0.048	2.249PheGlu: 2.249 ± 0.046	1.258PhePhe: 1.258 ± 0.046	3.566PheGly: 3.566 ± 0.07	0.703PheHis: 0.703 ± 0.028	1.462PheIle: 1.462 ± 0.038	0.877PheLys: 0.877 ± 0.035	3.091PheLeu: 3.091 ± 0.056	0.774PheMet: 0.774 ± 0.033	0.945PheAsn: 0.945 ± 0.036	1.59PhePro: 1.59 ± 0.036	0.894PheGln: 0.894 ± 0.031	2.168PheArg: 2.168 ± 0.044	2.038PheSer: 2.038 ± 0.047	1.981PheThr: 1.981 ± 0.054	2.737PheVal: 2.737 ± 0.053	0.583PheTrp: 0.583 ± 0.026	0.886PheTyr: 0.886 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.408GlyAla: 9.408 ± 0.125	0.79GlyCys: 0.79 ± 0.031	5.172GlyAsp: 5.172 ± 0.095	5.412GlyGlu: 5.412 ± 0.08	3.544GlyPhe: 3.544 ± 0.064	8.023GlyGly: 8.023 ± 0.154	1.76GlyHis: 1.76 ± 0.042	4.488GlyIle: 4.488 ± 0.081	3.496GlyLys: 3.496 ± 0.065	8.424GlyLeu: 8.424 ± 0.094	2.518GlyMet: 2.518 ± 0.048	2.401GlyAsn: 2.401 ± 0.063	3.59GlyPro: 3.59 ± 0.061	2.964GlyGln: 2.964 ± 0.047	5.976GlyArg: 5.976 ± 0.086	5.046GlySer: 5.046 ± 0.097	4.923GlyThr: 4.923 ± 0.096	6.004GlyVal: 6.004 ± 0.088	1.528GlyTrp: 1.528 ± 0.044	2.267GlyTyr: 2.267 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.361HisAla: 2.361 ± 0.052	0.23HisCys: 0.23 ± 0.014	1.324HisAsp: 1.324 ± 0.036	1.043HisGlu: 1.043 ± 0.028	0.783HisPhe: 0.783 ± 0.03	1.873HisGly: 1.873 ± 0.046	0.542HisHis: 0.542 ± 0.028	0.933HisIle: 0.933 ± 0.029	0.514HisLys: 0.514 ± 0.023	1.89HisLeu: 1.89 ± 0.051	0.449HisMet: 0.449 ± 0.021	0.444HisAsn: 0.444 ± 0.023	1.239HisPro: 1.239 ± 0.036	0.533HisGln: 0.533 ± 0.025	1.457HisArg: 1.457 ± 0.037	0.938HisSer: 0.938 ± 0.032	0.774HisThr: 0.774 ± 0.025	1.478HisVal: 1.478 ± 0.041	0.355HisTrp: 0.355 ± 0.02	0.592HisTyr: 0.592 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.8IleAla: 7.8 ± 0.096	0.436IleCys: 0.436 ± 0.022	4.219IleAsp: 4.219 ± 0.072	3.884IleGlu: 3.884 ± 0.067	1.581IlePhe: 1.581 ± 0.039	5.065IleGly: 5.065 ± 0.076	0.877IleHis: 0.877 ± 0.027	1.98IleIle: 1.98 ± 0.052	1.304IleLys: 1.304 ± 0.039	3.887IleLeu: 3.887 ± 0.064	0.962IleMet: 0.962 ± 0.031	1.305IleAsn: 1.305 ± 0.043	2.16IlePro: 2.16 ± 0.047	1.114IleGln: 1.114 ± 0.034	3.1IleArg: 3.1 ± 0.058	2.677IleSer: 2.677 ± 0.056	2.609IleThr: 2.609 ± 0.062	4.169IleVal: 4.169 ± 0.069	0.644IleTrp: 0.644 ± 0.023	1.095IleTyr: 1.095 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.244LysAla: 4.244 ± 0.079	0.193LysCys: 0.193 ± 0.013	1.734LysAsp: 1.734 ± 0.046	1.498LysGlu: 1.498 ± 0.047	0.903LysPhe: 0.903 ± 0.033	2.796LysGly: 2.796 ± 0.054	0.63LysHis: 0.63 ± 0.028	1.58LysIle: 1.58 ± 0.037	1.245LysLys: 1.245 ± 0.047	3.232LysLeu: 3.232 ± 0.059	0.8LysMet: 0.8 ± 0.031	0.809LysAsn: 0.809 ± 0.032	1.954LysPro: 1.954 ± 0.049	0.987LysGln: 0.987 ± 0.032	2.45LysArg: 2.45 ± 0.055	1.749LysSer: 1.749 ± 0.041	1.805LysThr: 1.805 ± 0.047	2.327LysVal: 2.327 ± 0.051	0.41LysTrp: 0.41 ± 0.022	0.617LysTyr: 0.617 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.607LeuAla: 13.607 ± 0.132	0.772LeuCys: 0.772 ± 0.032	6.247LeuAsp: 6.247 ± 0.075	5.083LeuGlu: 5.083 ± 0.08	3.505LeuPhe: 3.505 ± 0.066	7.967LeuGly: 7.967 ± 0.094	1.791LeuHis: 1.791 ± 0.047	4.868LeuIle: 4.868 ± 0.075	3.048LeuLys: 3.048 ± 0.064	8.777LeuLeu: 8.777 ± 0.113	2.159LeuMet: 2.159 ± 0.046	2.498LeuAsn: 2.498 ± 0.052	5.348LeuPro: 5.348 ± 0.086	2.546LeuGln: 2.546 ± 0.049	6.559LeuArg: 6.559 ± 0.095	6.165LeuSer: 6.165 ± 0.084	5.602LeuThr: 5.602 ± 0.071	6.902LeuVal: 6.902 ± 0.085	1.102LeuTrp: 1.102 ± 0.035	1.872LeuTyr: 1.872 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.548MetAla: 3.548 ± 0.065	0.154MetCys: 0.154 ± 0.011	1.304MetAsp: 1.304 ± 0.032	1.232MetGlu: 1.232 ± 0.035	0.708MetPhe: 0.708 ± 0.027	2.021MetGly: 2.021 ± 0.051	0.484MetHis: 0.484 ± 0.021	1.388MetIle: 1.388 ± 0.035	0.965MetLys: 0.965 ± 0.029	2.632MetLeu: 2.632 ± 0.058	0.667MetMet: 0.667 ± 0.027	0.73MetAsn: 0.73 ± 0.027	1.524MetPro: 1.524 ± 0.039	0.854MetGln: 0.854 ± 0.03	1.884MetArg: 1.884 ± 0.042	1.474MetSer: 1.474 ± 0.038	1.794MetThr: 1.794 ± 0.043	1.726MetVal: 1.726 ± 0.042	0.237MetTrp: 0.237 ± 0.013	0.275MetTyr: 0.275 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.373AsnAla: 3.373 ± 0.069	0.292AsnCys: 0.292 ± 0.017	1.554AsnAsp: 1.554 ± 0.043	1.312AsnGlu: 1.312 ± 0.036	0.994AsnPhe: 0.994 ± 0.035	2.534AsnGly: 2.534 ± 0.068	0.501AsnHis: 0.501 ± 0.023	1.28AsnIle: 1.28 ± 0.037	0.623AsnLys: 0.623 ± 0.027	2.49AsnLeu: 2.49 ± 0.046	0.576AsnMet: 0.576 ± 0.024	0.659AsnAsn: 0.659 ± 0.031	1.829AsnPro: 1.829 ± 0.049	0.733AsnGln: 0.733 ± 0.026	1.96AsnArg: 1.96 ± 0.049	1.275AsnSer: 1.275 ± 0.041	1.201AsnThr: 1.201 ± 0.042	1.995AsnVal: 1.995 ± 0.055	0.433AsnTrp: 0.433 ± 0.021	0.697AsnTyr: 0.697 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	6.222ProAla: 6.222 ± 0.09	0.358ProCys: 0.358 ± 0.019	4.054ProAsp: 4.054 ± 0.068	3.768ProGlu: 3.768 ± 0.058	1.803ProPhe: 1.803 ± 0.05	4.328ProGly: 4.328 ± 0.071	1.079ProHis: 1.079 ± 0.03	2.388ProIle: 2.388 ± 0.055	1.562ProLys: 1.562 ± 0.041	4.474ProLeu: 4.474 ± 0.078	1.269ProMet: 1.269 ± 0.032	1.29ProAsn: 1.29 ± 0.038	2.548ProPro: 2.548 ± 0.076	1.657ProGln: 1.657 ± 0.034	2.846ProArg: 2.846 ± 0.061	2.699ProSer: 2.699 ± 0.053	2.545ProThr: 2.545 ± 0.051	4.215ProVal: 4.215 ± 0.06	0.678ProTrp: 0.678 ± 0.026	1.05ProTyr: 1.05 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.987GlnAla: 3.987 ± 0.075	0.254GlnCys: 0.254 ± 0.016	1.599GlnAsp: 1.599 ± 0.04	1.397GlnGlu: 1.397 ± 0.039	1.057GlnPhe: 1.057 ± 0.035	2.376GlnGly: 2.376 ± 0.048	0.587GlnHis: 0.587 ± 0.026	1.75GlnIle: 1.75 ± 0.041	0.932GlnLys: 0.932 ± 0.027	2.863GlnLeu: 2.863 ± 0.058	0.93GlnMet: 0.93 ± 0.028	0.835GlnAsn: 0.835 ± 0.029	1.705GlnPro: 1.705 ± 0.043	1.167GlnGln: 1.167 ± 0.041	2.404GlnArg: 2.404 ± 0.055	1.783GlnSer: 1.783 ± 0.047	1.628GlnThr: 1.628 ± 0.042	2.439GlnVal: 2.439 ± 0.055	0.428GlnTrp: 0.428 ± 0.022	0.66GlnTyr: 0.66 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	7.972ArgAla: 7.972 ± 0.129	0.515ArgCys: 0.515 ± 0.025	4.399ArgAsp: 4.399 ± 0.073	4.476ArgGlu: 4.476 ± 0.079	3.034ArgPhe: 3.034 ± 0.057	4.962ArgGly: 4.962 ± 0.076	1.694ArgHis: 1.694 ± 0.042	4.129ArgIle: 4.129 ± 0.067	2.544ArgLys: 2.544 ± 0.047	7.617ArgLeu: 7.617 ± 0.108	1.991ArgMet: 1.991 ± 0.044	1.83ArgAsn: 1.83 ± 0.034	3.347ArgPro: 3.347 ± 0.067	2.528ArgGln: 2.528 ± 0.051	5.594ArgArg: 5.594 ± 0.09	3.673ArgSer: 3.673 ± 0.07	3.467ArgThr: 3.467 ± 0.06	4.636ArgVal: 4.636 ± 0.089	1.144ArgTrp: 1.144 ± 0.031	1.786ArgTyr: 1.786 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.279SerAla: 6.279 ± 0.119	0.445SerCys: 0.445 ± 0.024	3.532SerAsp: 3.532 ± 0.071	3.055SerGlu: 3.055 ± 0.059	2.104SerPhe: 2.104 ± 0.049	5.604SerGly: 5.604 ± 0.101	0.988SerHis: 0.988 ± 0.035	2.58SerIle: 2.58 ± 0.054	1.496SerLys: 1.496 ± 0.041	5.209SerLeu: 5.209 ± 0.087	1.266SerMet: 1.266 ± 0.036	1.447SerAsn: 1.447 ± 0.043	2.591SerPro: 2.591 ± 0.052	1.636SerGln: 1.636 ± 0.038	3.691SerArg: 3.691 ± 0.065	2.784SerSer: 2.784 ± 0.059	2.577SerThr: 2.577 ± 0.056	3.84SerVal: 3.84 ± 0.076	0.723SerTrp: 0.723 ± 0.028	1.304SerTyr: 1.304 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	6.126ThrAla: 6.126 ± 0.108	0.444ThrCys: 0.444 ± 0.023	3.19ThrAsp: 3.19 ± 0.083	2.616ThrGlu: 2.616 ± 0.049	1.871ThrPhe: 1.871 ± 0.045	5.398ThrGly: 5.398 ± 0.101	0.927ThrHis: 0.927 ± 0.028	3.032ThrIle: 3.032 ± 0.063	1.433ThrLys: 1.433 ± 0.043	5.55ThrLeu: 5.55 ± 0.079	1.294ThrMet: 1.294 ± 0.038	1.429ThrAsn: 1.429 ± 0.052	3.099ThrPro: 3.099 ± 0.06	1.407ThrGln: 1.407 ± 0.037	3.546ThrArg: 3.546 ± 0.054	2.647ThrSer: 2.647 ± 0.059	2.619ThrThr: 2.619 ± 0.057	4.338ThrVal: 4.338 ± 0.07	0.617ThrTrp: 0.617 ± 0.026	1.22ThrTyr: 1.22 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	9.059ValAla: 9.059 ± 0.11	0.628ValCys: 0.628 ± 0.026	4.413ValAsp: 4.413 ± 0.073	4.634ValGlu: 4.634 ± 0.073	2.392ValPhe: 2.392 ± 0.054	5.524ValGly: 5.524 ± 0.077	1.309ValHis: 1.309 ± 0.037	3.847ValIle: 3.847 ± 0.07	2.067ValLys: 2.067 ± 0.056	6.918ValLeu: 6.918 ± 0.077	1.754ValMet: 1.754 ± 0.04	1.931ValAsn: 1.931 ± 0.059	3.928ValPro: 3.928 ± 0.068	1.988ValGln: 1.988 ± 0.045	5.009ValArg: 5.009 ± 0.083	4.194ValSer: 4.194 ± 0.063	4.441ValThr: 4.441 ± 0.071	5.334ValVal: 5.334 ± 0.079	0.958ValTrp: 0.958 ± 0.036	1.38ValTyr: 1.38 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.323TrpAla: 1.323 ± 0.042	0.135TrpCys: 0.135 ± 0.012	0.752TrpAsp: 0.752 ± 0.03	0.629TrpGlu: 0.629 ± 0.025	0.626TrpPhe: 0.626 ± 0.029	0.91TrpGly: 0.91 ± 0.031	0.38TrpHis: 0.38 ± 0.02	0.711TrpIle: 0.711 ± 0.026	0.491TrpLys: 0.491 ± 0.019	1.841TrpLeu: 1.841 ± 0.052	0.394TrpMet: 0.394 ± 0.02	0.46TrpAsn: 0.46 ± 0.02	0.69TrpPro: 0.69 ± 0.028	0.664TrpGln: 0.664 ± 0.027	1.287TrpArg: 1.287 ± 0.042	0.864TrpSer: 0.864 ± 0.029	0.779TrpThr: 0.779 ± 0.026	0.812TrpVal: 0.812 ± 0.031	0.249TrpTrp: 0.249 ± 0.017	0.275TrpTyr: 0.275 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.691TyrAla: 2.691 ± 0.069	0.245TyrCys: 0.245 ± 0.015	1.614TyrAsp: 1.614 ± 0.044	1.22TyrGlu: 1.22 ± 0.039	0.871TyrPhe: 0.871 ± 0.031	2.09TyrGly: 2.09 ± 0.049	0.476TyrHis: 0.476 ± 0.021	0.869TyrIle: 0.869 ± 0.029	0.572TyrLys: 0.572 ± 0.027	2.135TyrLeu: 2.135 ± 0.045	0.44TyrMet: 0.44 ± 0.021	0.649TyrAsn: 0.649 ± 0.028	1.003TyrPro: 1.003 ± 0.033	0.662TyrGln: 0.662 ± 0.028	1.859TyrArg: 1.859 ± 0.044	1.195TyrSer: 1.195 ± 0.038	1.026TyrThr: 1.026 ± 0.035	1.568TyrVal: 1.568 ± 0.039	0.345TyrTrp: 0.345 ± 0.018	0.591TyrTyr: 0.591 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3411 proteins (1042385 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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