Human papillomavirus KC5

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Gammapapillomavirus; unclassified Gammapapillomavirus

Average proteome isoelectric point is 6.15

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|K4MNJ7|K4MNJ7_9PAPI Protein E7 OS=Human papillomavirus KC5 OX=1647924 GN=E7 PE=3 SV=1
MM1 pKa = 7.4SKK3 pKa = 9.74IRR5 pKa = 11.84RR6 pKa = 11.84KK7 pKa = 9.71RR8 pKa = 11.84ASPEE12 pKa = 3.71DD13 pKa = 4.09LYY15 pKa = 11.12KK16 pKa = 10.67QCVLGADD23 pKa = 4.1CMPDD27 pKa = 3.06VKK29 pKa = 10.84NKK31 pKa = 10.45YY32 pKa = 7.38EE33 pKa = 4.06QNTLADD39 pKa = 3.34ILLKK43 pKa = 11.05VFGSLVYY50 pKa = 10.32FGGLGIGSGRR60 pKa = 11.84GTGGRR65 pKa = 11.84LGYY68 pKa = 10.2RR69 pKa = 11.84PLGEE73 pKa = 4.64AGGSRR78 pKa = 11.84SGRR81 pKa = 11.84PITSTPVRR89 pKa = 11.84PSVTVDD95 pKa = 2.94VLGPSDD101 pKa = 4.04IVPVDD106 pKa = 3.47AEE108 pKa = 4.4TPAIVPLAEE117 pKa = 4.31GTPDD121 pKa = 3.9LDD123 pKa = 4.73FVAPDD128 pKa = 3.82AGPGVGVEE136 pKa = 4.06EE137 pKa = 4.78LEE139 pKa = 4.95LYY141 pKa = 9.93TITDD145 pKa = 3.51STATTGGVTQSTTVTTNEE163 pKa = 3.65TSFAVLDD170 pKa = 3.83VNTIGEE176 pKa = 4.15KK177 pKa = 10.07PIQVFYY183 pKa = 11.34DD184 pKa = 3.98PAAPDD189 pKa = 3.72TQILNVFTASPANTSDD205 pKa = 2.8INIFVDD211 pKa = 4.49SSITGQTIGEE221 pKa = 4.33YY222 pKa = 10.58EE223 pKa = 4.57SIPLEE228 pKa = 3.95RR229 pKa = 11.84LDD231 pKa = 3.6YY232 pKa = 11.38SEE234 pKa = 5.87FEE236 pKa = 4.08IEE238 pKa = 4.31EE239 pKa = 4.7PPTTSTPSQRR249 pKa = 11.84LDD251 pKa = 3.24RR252 pKa = 11.84TINRR256 pKa = 11.84ARR258 pKa = 11.84QLYY261 pKa = 9.36NRR263 pKa = 11.84FVRR266 pKa = 11.84QVPVSSAEE274 pKa = 4.0FVTQPSRR281 pKa = 11.84LVQFEE286 pKa = 4.51FEE288 pKa = 4.04NAAYY292 pKa = 10.13DD293 pKa = 3.65ADD295 pKa = 3.7VSIEE299 pKa = 3.91FEE301 pKa = 3.85RR302 pKa = 11.84DD303 pKa = 3.08LAEE306 pKa = 4.29VAAAPDD312 pKa = 3.35NAFRR316 pKa = 11.84DD317 pKa = 4.01VTRR320 pKa = 11.84LHH322 pKa = 6.8RR323 pKa = 11.84PILTEE328 pKa = 3.61TSEE331 pKa = 4.62GIVRR335 pKa = 11.84VSRR338 pKa = 11.84LAEE341 pKa = 4.02TGTITTRR348 pKa = 11.84SGTTIGQPIHH358 pKa = 6.76FYY360 pKa = 11.15YY361 pKa = 10.51DD362 pKa = 2.96ISEE365 pKa = 4.26IPPIEE370 pKa = 5.14DD371 pKa = 4.3IEE373 pKa = 4.37LQTIAGQSNTATATIVDD390 pKa = 5.38DD391 pKa = 3.98ILATTVIDD399 pKa = 5.0PINATDD405 pKa = 4.09VIHH408 pKa = 7.03NDD410 pKa = 4.23DD411 pKa = 3.86ILEE414 pKa = 4.34DD415 pKa = 3.98EE416 pKa = 4.51YY417 pKa = 11.96AEE419 pKa = 4.42SFNNAQLVIQSTIEE433 pKa = 4.06EE434 pKa = 4.48GDD436 pKa = 3.93SLIMPTFAPEE446 pKa = 3.54ASIKK450 pKa = 10.8VFVNDD455 pKa = 3.9LGGGLFVTYY464 pKa = 9.52PSGSDD469 pKa = 3.05SSNIIILPNDD479 pKa = 3.4IPIGPPVIIDD489 pKa = 3.76AFDD492 pKa = 4.68DD493 pKa = 4.76YY494 pKa = 11.11ILHH497 pKa = 6.98PAVIPKK503 pKa = 9.21KK504 pKa = 9.79RR505 pKa = 11.84RR506 pKa = 11.84RR507 pKa = 11.84IEE509 pKa = 3.88LFF511 pKa = 3.27

Molecular weight: 55.36 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|K4MKX9|K4MKX9_9PAPI Major capsid protein L1 OS=Human papillomavirus KC5 OX=1647924 GN=L1 PE=3 SV=1
MM1 pKa = 7.42EE2 pKa = 5.25SKK4 pKa = 10.28PRR6 pKa = 11.84NLEE9 pKa = 4.2EE10 pKa = 4.05YY11 pKa = 8.89CKK13 pKa = 10.46HH14 pKa = 5.88YY15 pKa = 10.77GISFFNLQLRR25 pKa = 11.84CVFCHH30 pKa = 5.83HH31 pKa = 7.4WIDD34 pKa = 4.44SIQLASFHH42 pKa = 6.62CKK44 pKa = 9.18QLALIWKK51 pKa = 9.59NNVCFAACTQCLKK64 pKa = 10.9LSAAHH69 pKa = 5.42EE70 pKa = 4.12RR71 pKa = 11.84EE72 pKa = 3.79RR73 pKa = 11.84FYY75 pKa = 11.27QCNVRR80 pKa = 11.84SDD82 pKa = 3.89LLADD86 pKa = 4.8FLHH89 pKa = 6.82KK90 pKa = 10.27PLNDD94 pKa = 3.26VVIRR98 pKa = 11.84CLYY101 pKa = 10.12CLRR104 pKa = 11.84KK105 pKa = 9.76LDD107 pKa = 4.62FIEE110 pKa = 5.05KK111 pKa = 10.54LEE113 pKa = 4.01HH114 pKa = 7.14CYY116 pKa = 11.14NKK118 pKa = 10.66DD119 pKa = 3.17CFHH122 pKa = 7.46LVRR125 pKa = 11.84CYY127 pKa = 9.8WRR129 pKa = 11.84GKK131 pKa = 9.78CRR133 pKa = 11.84NCKK136 pKa = 9.87YY137 pKa = 11.0NEE139 pKa = 4.04GG140 pKa = 3.74

Molecular weight: 16.87 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2364

93

600

337.7

38.3

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.795 ± 0.372

2.411 ± 0.945

5.964 ± 0.487

7.064 ± 0.515

5.161 ± 0.442

5.203 ± 0.766

2.2 ± 0.428

5.668 ± 0.865

5.626 ± 0.827

8.756 ± 0.736

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.481 ± 0.429

4.822 ± 0.541

6.303 ± 1.025

3.723 ± 0.263

5.541 ± 0.602

7.149 ± 0.828

6.514 ± 0.966

5.922 ± 0.492

1.311 ± 0.289

3.384 ± 0.328
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski