Amino acid dipepetide frequency for Enterovibrio sp. CAIM 600

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.257AlaAla: 7.257 ± 0.113	0.891AlaCys: 0.891 ± 0.03	4.708AlaAsp: 4.708 ± 0.072	5.455AlaGlu: 5.455 ± 0.089	3.557AlaPhe: 3.557 ± 0.062	5.879AlaGly: 5.879 ± 0.068	1.49AlaHis: 1.49 ± 0.039	5.385AlaIle: 5.385 ± 0.077	4.459AlaLys: 4.459 ± 0.084	9.17AlaLeu: 9.17 ± 0.115	2.583AlaMet: 2.583 ± 0.053	3.244AlaAsn: 3.244 ± 0.062	2.682AlaPro: 2.682 ± 0.057	2.967AlaGln: 2.967 ± 0.058	3.555AlaArg: 3.555 ± 0.066	5.858AlaSer: 5.858 ± 0.077	4.315AlaThr: 4.315 ± 0.068	5.775AlaVal: 5.775 ± 0.074	0.942AlaTrp: 0.942 ± 0.032	2.184AlaTyr: 2.184 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.726CysAla: 0.726 ± 0.026	0.161CysCys: 0.161 ± 0.013	0.641CysAsp: 0.641 ± 0.026	0.67CysGlu: 0.67 ± 0.026	0.481CysPhe: 0.481 ± 0.025	0.882CysGly: 0.882 ± 0.033	0.371CysHis: 0.371 ± 0.017	0.575CysIle: 0.575 ± 0.026	0.478CysLys: 0.478 ± 0.018	1.123CysLeu: 1.123 ± 0.033	0.253CysMet: 0.253 ± 0.015	0.367CysAsn: 0.367 ± 0.019	0.458CysPro: 0.458 ± 0.023	0.511CysGln: 0.511 ± 0.023	0.572CysArg: 0.572 ± 0.025	0.78CysSer: 0.78 ± 0.028	0.441CysThr: 0.441 ± 0.02	0.663CysVal: 0.663 ± 0.026	0.158CysTrp: 0.158 ± 0.011	0.333CysTyr: 0.333 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.865AspAla: 4.865 ± 0.073	0.576AspCys: 0.576 ± 0.02	3.693AspAsp: 3.693 ± 0.071	3.998AspGlu: 3.998 ± 0.07	2.575AspPhe: 2.575 ± 0.053	4.431AspGly: 4.431 ± 0.089	1.091AspHis: 1.091 ± 0.035	4.493AspIle: 4.493 ± 0.063	3.409AspLys: 3.409 ± 0.059	5.153AspLeu: 5.153 ± 0.065	1.493AspMet: 1.493 ± 0.037	2.756AspAsn: 2.756 ± 0.058	2.09AspPro: 2.09 ± 0.054	1.829AspGln: 1.829 ± 0.042	2.403AspArg: 2.403 ± 0.052	3.581AspSer: 3.581 ± 0.066	3.267AspThr: 3.267 ± 0.073	4.295AspVal: 4.295 ± 0.067	0.882AspTrp: 0.882 ± 0.026	1.983AspTyr: 1.983 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.141GluAla: 5.141 ± 0.072	0.556GluCys: 0.556 ± 0.025	3.059GluAsp: 3.059 ± 0.064	3.847GluGlu: 3.847 ± 0.077	2.449GluPhe: 2.449 ± 0.054	3.836GluGly: 3.836 ± 0.062	1.6GluHis: 1.6 ± 0.043	3.885GluIle: 3.885 ± 0.06	4.294GluLys: 4.294 ± 0.058	6.609GluLeu: 6.609 ± 0.091	1.711GluMet: 1.711 ± 0.042	3.062GluAsn: 3.062 ± 0.057	2.061GluPro: 2.061 ± 0.052	3.44GluGln: 3.44 ± 0.069	3.317GluArg: 3.317 ± 0.072	4.124GluSer: 4.124 ± 0.068	3.438GluThr: 3.438 ± 0.052	4.277GluVal: 4.277 ± 0.068	0.784GluTrp: 0.784 ± 0.027	1.753GluTyr: 1.753 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.4PheAla: 3.4 ± 0.056	0.553PheCys: 0.553 ± 0.023	3.037PheAsp: 3.037 ± 0.059	2.63PheGlu: 2.63 ± 0.053	1.87PhePhe: 1.87 ± 0.046	3.233PheGly: 3.233 ± 0.055	0.931PheHis: 0.931 ± 0.027	2.711PheIle: 2.711 ± 0.048	1.874PheLys: 1.874 ± 0.045	3.625PheLeu: 3.625 ± 0.064	0.928PheMet: 0.928 ± 0.026	2.123PheAsn: 2.123 ± 0.043	1.455PhePro: 1.455 ± 0.04	1.286PheGln: 1.286 ± 0.039	1.802PheArg: 1.802 ± 0.04	3.979PheSer: 3.979 ± 0.071	2.588PheThr: 2.588 ± 0.049	2.872PheVal: 2.872 ± 0.056	0.641PheTrp: 0.641 ± 0.024	1.327PheTyr: 1.327 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	4.869GlyAla: 4.869 ± 0.069	0.933GlyCys: 0.933 ± 0.032	3.971GlyAsp: 3.971 ± 0.072	4.528GlyGlu: 4.528 ± 0.071	3.364GlyPhe: 3.364 ± 0.048	4.733GlyGly: 4.733 ± 0.087	1.612GlyHis: 1.612 ± 0.041	4.539GlyIle: 4.539 ± 0.07	4.154GlyLys: 4.154 ± 0.062	6.621GlyLeu: 6.621 ± 0.086	1.91GlyMet: 1.91 ± 0.044	3.002GlyAsn: 3.002 ± 0.087	1.743GlyPro: 1.743 ± 0.043	2.895GlyGln: 2.895 ± 0.052	2.991GlyArg: 2.991 ± 0.054	4.299GlySer: 4.299 ± 0.074	3.623GlyThr: 3.623 ± 0.084	5.037GlyVal: 5.037 ± 0.076	1.029GlyTrp: 1.029 ± 0.034	2.491GlyTyr: 2.491 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.685HisAla: 1.685 ± 0.036	0.358HisCys: 0.358 ± 0.02	1.178HisAsp: 1.178 ± 0.032	1.16HisGlu: 1.16 ± 0.036	1.206HisPhe: 1.206 ± 0.034	1.574HisGly: 1.574 ± 0.035	0.728HisHis: 0.728 ± 0.03	1.415HisIle: 1.415 ± 0.035	0.982HisLys: 0.982 ± 0.032	2.225HisLeu: 2.225 ± 0.047	0.512HisMet: 0.512 ± 0.021	0.829HisAsn: 0.829 ± 0.028	1.118HisPro: 1.118 ± 0.032	1.117HisGln: 1.117 ± 0.034	1.124HisArg: 1.124 ± 0.03	1.475HisSer: 1.475 ± 0.045	1.147HisThr: 1.147 ± 0.032	1.349HisVal: 1.349 ± 0.038	0.359HisTrp: 0.359 ± 0.018	0.86HisTyr: 0.86 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.75IleAla: 5.75 ± 0.08	0.705IleCys: 0.705 ± 0.024	4.33IleAsp: 4.33 ± 0.062	4.408IleGlu: 4.408 ± 0.059	2.291IlePhe: 2.291 ± 0.058	4.393IleGly: 4.393 ± 0.059	1.292IleHis: 1.292 ± 0.033	3.327IleIle: 3.327 ± 0.061	3.125IleLys: 3.125 ± 0.047	4.947IleLeu: 4.947 ± 0.073	1.169IleMet: 1.169 ± 0.035	3.083IleAsn: 3.083 ± 0.059	2.544IlePro: 2.544 ± 0.051	2.016IleGln: 2.016 ± 0.043	2.836IleArg: 2.836 ± 0.058	4.853IleSer: 4.853 ± 0.073	3.746IleThr: 3.746 ± 0.061	3.955IleVal: 3.955 ± 0.059	0.67IleTrp: 0.67 ± 0.023	1.687IleTyr: 1.687 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.714LysAla: 4.714 ± 0.076	0.381LysCys: 0.381 ± 0.019	2.939LysAsp: 2.939 ± 0.049	3.368LysGlu: 3.368 ± 0.061	1.65LysPhe: 1.65 ± 0.035	3.498LysGly: 3.498 ± 0.062	1.259LysHis: 1.259 ± 0.032	2.919LysIle: 2.919 ± 0.047	3.171LysLys: 3.171 ± 0.063	5.221LysLeu: 5.221 ± 0.075	1.403LysMet: 1.403 ± 0.034	2.387LysAsn: 2.387 ± 0.049	2.403LysPro: 2.403 ± 0.048	2.478LysGln: 2.478 ± 0.049	2.895LysArg: 2.895 ± 0.05	3.524LysSer: 3.524 ± 0.056	3.131LysThr: 3.131 ± 0.058	3.867LysVal: 3.867 ± 0.064	0.6LysTrp: 0.6 ± 0.023	1.442LysTyr: 1.442 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	9.025LeuAla: 9.025 ± 0.105	1.088LeuCys: 1.088 ± 0.036	5.805LeuAsp: 5.805 ± 0.076	5.875LeuGlu: 5.875 ± 0.073	4.266LeuPhe: 4.266 ± 0.06	6.474LeuGly: 6.474 ± 0.083	1.951LeuHis: 1.951 ± 0.04	5.852LeuIle: 5.852 ± 0.08	5.326LeuLys: 5.326 ± 0.07	9.999LeuLeu: 9.999 ± 0.139	2.703LeuMet: 2.703 ± 0.052	4.681LeuAsn: 4.681 ± 0.068	4.707LeuPro: 4.707 ± 0.07	3.21LeuGln: 3.21 ± 0.057	4.484LeuArg: 4.484 ± 0.078	8.792LeuSer: 8.792 ± 0.103	6.243LeuThr: 6.243 ± 0.079	6.737LeuVal: 6.737 ± 0.086	1.039LeuTrp: 1.039 ± 0.034	2.537LeuTyr: 2.537 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.496MetAla: 2.496 ± 0.056	0.216MetCys: 0.216 ± 0.013	1.24MetAsp: 1.24 ± 0.038	1.337MetGlu: 1.337 ± 0.036	0.955MetPhe: 0.955 ± 0.03	1.614MetGly: 1.614 ± 0.036	0.462MetHis: 0.462 ± 0.023	1.418MetIle: 1.418 ± 0.035	1.561MetLys: 1.561 ± 0.037	2.73MetLeu: 2.73 ± 0.051	0.798MetMet: 0.798 ± 0.028	1.1MetAsn: 1.1 ± 0.031	1.259MetPro: 1.259 ± 0.039	1.014MetGln: 1.014 ± 0.034	1.216MetArg: 1.216 ± 0.034	2.001MetSer: 2.001 ± 0.042	1.804MetThr: 1.804 ± 0.039	1.783MetVal: 1.783 ± 0.04	0.2MetTrp: 0.2 ± 0.013	0.539MetTyr: 0.539 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.483AsnAla: 3.483 ± 0.061	0.42AsnCys: 0.42 ± 0.019	2.606AsnAsp: 2.606 ± 0.059	2.522AsnGlu: 2.522 ± 0.046	1.603AsnPhe: 1.603 ± 0.045	3.261AsnGly: 3.261 ± 0.068	1.024AsnHis: 1.024 ± 0.029	2.873AsnIle: 2.873 ± 0.054	2.358AsnLys: 2.358 ± 0.047	3.927AsnLeu: 3.927 ± 0.056	1.018AsnMet: 1.018 ± 0.03	2.056AsnAsn: 2.056 ± 0.06	2.086AsnPro: 2.086 ± 0.045	1.881AsnGln: 1.881 ± 0.043	2.095AsnArg: 2.095 ± 0.037	2.668AsnSer: 2.668 ± 0.05	2.613AsnThr: 2.613 ± 0.063	2.954AsnVal: 2.954 ± 0.061	0.671AsnTrp: 0.671 ± 0.026	1.299AsnTyr: 1.299 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	3.165ProAla: 3.165 ± 0.054	0.36ProCys: 0.36 ± 0.017	2.724ProAsp: 2.724 ± 0.049	3.358ProGlu: 3.358 ± 0.065	1.739ProPhe: 1.739 ± 0.039	2.361ProGly: 2.361 ± 0.049	0.853ProHis: 0.853 ± 0.024	2.251ProIle: 2.251 ± 0.044	1.872ProLys: 1.872 ± 0.048	3.942ProLeu: 3.942 ± 0.067	1.037ProMet: 1.037 ± 0.032	1.578ProAsn: 1.578 ± 0.039	1.279ProPro: 1.279 ± 0.031	1.426ProGln: 1.426 ± 0.038	1.368ProArg: 1.368 ± 0.037	2.798ProSer: 2.798 ± 0.049	2.149ProThr: 2.149 ± 0.044	3.05ProVal: 3.05 ± 0.055	0.5ProTrp: 0.5 ± 0.02	1.183ProTyr: 1.183 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.446GlnAla: 3.446 ± 0.057	0.401GlnCys: 0.401 ± 0.02	1.856GlnAsp: 1.856 ± 0.043	2.068GlnGlu: 2.068 ± 0.049	1.684GlnPhe: 1.684 ± 0.04	2.593GlnGly: 2.593 ± 0.048	1.111GlnHis: 1.111 ± 0.033	2.343GlnIle: 2.343 ± 0.051	2.105GlnLys: 2.105 ± 0.047	4.446GlnLeu: 4.446 ± 0.078	1.074GlnMet: 1.074 ± 0.031	1.606GlnAsn: 1.606 ± 0.044	1.572GlnPro: 1.572 ± 0.038	2.485GlnGln: 2.485 ± 0.072	2.258GlnArg: 2.258 ± 0.046	2.88GlnSer: 2.88 ± 0.06	2.265GlnThr: 2.265 ± 0.044	2.624GlnVal: 2.624 ± 0.048	0.582GlnTrp: 0.582 ± 0.026	1.274GlnTyr: 1.274 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	3.405ArgAla: 3.405 ± 0.061	0.495ArgCys: 0.495 ± 0.021	2.705ArgAsp: 2.705 ± 0.054	3.246ArgGlu: 3.246 ± 0.061	2.326ArgPhe: 2.326 ± 0.053	2.592ArgGly: 2.592 ± 0.051	1.25ArgHis: 1.25 ± 0.033	2.743ArgIle: 2.743 ± 0.054	2.579ArgLys: 2.579 ± 0.048	5.014ArgLeu: 5.014 ± 0.081	1.19ArgMet: 1.19 ± 0.034	1.864ArgAsn: 1.864 ± 0.039	1.619ArgPro: 1.619 ± 0.036	2.357ArgGln: 2.357 ± 0.052	2.553ArgArg: 2.553 ± 0.062	2.689ArgSer: 2.689 ± 0.055	2.144ArgThr: 2.144 ± 0.043	3.345ArgVal: 3.345 ± 0.057	0.674ArgTrp: 0.674 ± 0.029	1.682ArgTyr: 1.682 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.665SerAla: 5.665 ± 0.073	0.585SerCys: 0.585 ± 0.025	4.598SerAsp: 4.598 ± 0.087	4.667SerGlu: 4.667 ± 0.081	3.184SerPhe: 3.184 ± 0.053	5.663SerGly: 5.663 ± 0.072	1.694SerHis: 1.694 ± 0.041	4.194SerIle: 4.194 ± 0.071	3.371SerLys: 3.371 ± 0.054	7.727SerLeu: 7.727 ± 0.092	1.79SerMet: 1.79 ± 0.041	2.828SerAsn: 2.828 ± 0.058	2.813SerPro: 2.813 ± 0.044	2.996SerGln: 2.996 ± 0.053	3.188SerArg: 3.188 ± 0.055	5.131SerSer: 5.131 ± 0.074	3.545SerThr: 3.545 ± 0.058	5.355SerVal: 5.355 ± 0.072	0.935SerTrp: 0.935 ± 0.03	2.037SerTyr: 2.037 ± 0.049	0.001SerXaa: 0.001 ± 0.001
Thr	4.45ThrAla: 4.45 ± 0.062	0.564ThrCys: 0.564 ± 0.022	3.336ThrAsp: 3.336 ± 0.071	3.541ThrGlu: 3.541 ± 0.059	2.456ThrPhe: 2.456 ± 0.052	4.071ThrGly: 4.071 ± 0.08	1.283ThrHis: 1.283 ± 0.038	3.37ThrIle: 3.37 ± 0.056	2.397ThrLys: 2.397 ± 0.048	6.815ThrLeu: 6.815 ± 0.095	1.238ThrMet: 1.238 ± 0.039	2.062ThrAsn: 2.062 ± 0.044	2.638ThrPro: 2.638 ± 0.047	2.192ThrGln: 2.192 ± 0.048	2.314ThrArg: 2.314 ± 0.053	3.754ThrSer: 3.754 ± 0.07	3.034ThrThr: 3.034 ± 0.079	4.435ThrVal: 4.435 ± 0.087	0.648ThrTrp: 0.648 ± 0.031	1.643ThrTyr: 1.643 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	6.021ValAla: 6.021 ± 0.082	0.835ValCys: 0.835 ± 0.026	4.254ValAsp: 4.254 ± 0.064	4.364ValGlu: 4.364 ± 0.066	3.089ValPhe: 3.089 ± 0.051	4.475ValGly: 4.475 ± 0.068	1.28ValHis: 1.28 ± 0.031	4.562ValIle: 4.562 ± 0.065	3.731ValLys: 3.731 ± 0.056	6.522ValLeu: 6.522 ± 0.08	1.959ValMet: 1.959 ± 0.043	3.179ValAsn: 3.179 ± 0.06	2.632ValPro: 2.632 ± 0.043	2.031ValGln: 2.031 ± 0.046	3.04ValArg: 3.04 ± 0.053	5.802ValSer: 5.802 ± 0.083	4.639ValThr: 4.639 ± 0.099	5.253ValVal: 5.253 ± 0.079	0.835ValTrp: 0.835 ± 0.033	1.89ValTyr: 1.89 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.761TrpAla: 0.761 ± 0.026	0.155TrpCys: 0.155 ± 0.01	0.582TrpAsp: 0.582 ± 0.026	0.616TrpGlu: 0.616 ± 0.024	0.615TrpPhe: 0.615 ± 0.024	0.767TrpGly: 0.767 ± 0.029	0.362TrpHis: 0.362 ± 0.018	0.67TrpIle: 0.67 ± 0.024	0.589TrpLys: 0.589 ± 0.024	1.766TrpLeu: 1.766 ± 0.048	0.377TrpMet: 0.377 ± 0.018	0.514TrpAsn: 0.514 ± 0.022	0.479TrpPro: 0.479 ± 0.021	0.9TrpGln: 0.9 ± 0.031	0.696TrpArg: 0.696 ± 0.026	0.835TrpSer: 0.835 ± 0.033	0.583TrpThr: 0.583 ± 0.027	0.945TrpVal: 0.945 ± 0.034	0.208TrpTrp: 0.208 ± 0.014	0.384TrpTyr: 0.384 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.031TyrAla: 2.031 ± 0.048	0.412TyrCys: 0.412 ± 0.019	1.601TyrAsp: 1.601 ± 0.038	1.585TyrGlu: 1.585 ± 0.037	1.504TyrPhe: 1.504 ± 0.044	2.013TyrGly: 2.013 ± 0.043	0.758TyrHis: 0.758 ± 0.025	1.6TyrIle: 1.6 ± 0.041	1.413TyrLys: 1.413 ± 0.037	3.212TyrLeu: 3.212 ± 0.051	0.592TyrMet: 0.592 ± 0.024	1.101TyrAsn: 1.101 ± 0.036	1.356TyrPro: 1.356 ± 0.034	1.639TyrGln: 1.639 ± 0.042	1.766TyrArg: 1.766 ± 0.041	2.147TyrSer: 2.147 ± 0.052	1.526TyrThr: 1.526 ± 0.047	1.823TyrVal: 1.823 ± 0.046	0.449TyrTrp: 0.449 ± 0.02	0.882TyrTyr: 0.882 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4013 proteins (1136605 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---