Amino acid dipepetide frequency for Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.916AlaAla: 8.916 ± 0.332
1.212AlaCys: 1.212 ± 0.063
5.161AlaAsp: 5.161 ± 0.116
7.007AlaGlu: 7.007 ± 0.177
2.902AlaPhe: 2.902 ± 0.099
7.487AlaGly: 7.487 ± 0.15
1.294AlaHis: 1.294 ± 0.051
5.632AlaIle: 5.632 ± 0.133
5.128AlaLys: 5.128 ± 0.149
8.815AlaLeu: 8.815 ± 0.164
2.345AlaMet: 2.345 ± 0.076
2.813AlaAsn: 2.813 ± 0.079
2.818AlaPro: 2.818 ± 0.079
2.629AlaGln: 2.629 ± 0.084
4.419AlaArg: 4.419 ± 0.117
5.212AlaSer: 5.212 ± 0.125
3.639AlaThr: 3.639 ± 0.109
6.693AlaVal: 6.693 ± 0.173
0.78AlaTrp: 0.78 ± 0.047
2.331AlaTyr: 2.331 ± 0.083
0.0AlaXaa: 0.0 ± 0.0
Cys
0.871CysAla: 0.871 ± 0.045
0.254CysCys: 0.254 ± 0.028
0.564CysAsp: 0.564 ± 0.039
0.607CysGlu: 0.607 ± 0.036
0.499CysPhe: 0.499 ± 0.036
1.594CysGly: 1.594 ± 0.075
0.423CysHis: 0.423 ± 0.034
0.749CysIle: 0.749 ± 0.048
0.588CysLys: 0.588 ± 0.04
1.515CysLeu: 1.515 ± 0.07
0.259CysMet: 0.259 ± 0.029
0.48CysAsn: 0.48 ± 0.036
1.047CysPro: 1.047 ± 0.061
0.682CysGln: 0.682 ± 0.044
0.994CysArg: 0.994 ± 0.053
0.727CysSer: 0.727 ± 0.045
0.607CysThr: 0.607 ± 0.039
0.66CysVal: 0.66 ± 0.046
0.113CysTrp: 0.113 ± 0.017
0.437CysTyr: 0.437 ± 0.035
0.0CysXaa: 0.0 ± 0.0
Asp
4.028AspAla: 4.028 ± 0.104
0.667AspCys: 0.667 ± 0.043
2.177AspAsp: 2.177 ± 0.084
3.57AspGlu: 3.57 ± 0.11
2.393AspPhe: 2.393 ± 0.086
3.514AspGly: 3.514 ± 0.103
0.72AspHis: 0.72 ± 0.042
5.01AspIle: 5.01 ± 0.108
3.214AspLys: 3.214 ± 0.097
4.729AspLeu: 4.729 ± 0.105
1.661AspMet: 1.661 ± 0.064
2.18AspAsn: 2.18 ± 0.081
2.043AspPro: 2.043 ± 0.074
1.296AspGln: 1.296 ± 0.056
2.213AspArg: 2.213 ± 0.083
2.898AspSer: 2.898 ± 0.083
3.03AspThr: 3.03 ± 0.095
2.886AspVal: 2.886 ± 0.091
0.598AspTrp: 0.598 ± 0.038
2.004AspTyr: 2.004 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
5.896GluAla: 5.896 ± 0.186
0.699GluCys: 0.699 ± 0.046
3.14GluAsp: 3.14 ± 0.09
4.804GluGlu: 4.804 ± 0.138
2.081GluPhe: 2.081 ± 0.072
3.939GluGly: 3.939 ± 0.097
1.188GluHis: 1.188 ± 0.057
5.269GluIle: 5.269 ± 0.128
4.465GluLys: 4.465 ± 0.105
7.233GluLeu: 7.233 ± 0.148
2.038GluMet: 2.038 ± 0.072
3.032GluAsn: 3.032 ± 0.085
2.045GluPro: 2.045 ± 0.08
2.079GluGln: 2.079 ± 0.075
3.327GluArg: 3.327 ± 0.113
3.358GluSer: 3.358 ± 0.084
3.531GluThr: 3.531 ± 0.108
4.467GluVal: 4.467 ± 0.109
0.574GluTrp: 0.574 ± 0.038
2.333GluTyr: 2.333 ± 0.075
0.0GluXaa: 0.0 ± 0.0
Phe
2.922PheAla: 2.922 ± 0.084
0.607PheCys: 0.607 ± 0.039
2.125PheAsp: 2.125 ± 0.071
2.321PheGlu: 2.321 ± 0.067
1.556PhePhe: 1.556 ± 0.075
3.246PheGly: 3.246 ± 0.1
0.759PheHis: 0.759 ± 0.047
2.943PheIle: 2.943 ± 0.08
2.237PheLys: 2.237 ± 0.077
3.519PheLeu: 3.519 ± 0.116
1.071PheMet: 1.071 ± 0.056
1.628PheAsn: 1.628 ± 0.065
1.462PhePro: 1.462 ± 0.07
0.994PheGln: 0.994 ± 0.053
1.714PheArg: 1.714 ± 0.069
2.994PheSer: 2.994 ± 0.088
2.028PheThr: 2.028 ± 0.079
2.302PheVal: 2.302 ± 0.08
0.485PheTrp: 0.485 ± 0.033
1.27PheTyr: 1.27 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
5.641GlyAla: 5.641 ± 0.137
1.162GlyCys: 1.162 ± 0.064
3.464GlyAsp: 3.464 ± 0.101
4.446GlyGlu: 4.446 ± 0.111
3.526GlyPhe: 3.526 ± 0.102
5.596GlyGly: 5.596 ± 0.161
1.606GlyHis: 1.606 ± 0.058
6.28GlyIle: 6.28 ± 0.147
4.916GlyLys: 4.916 ± 0.136
8.409GlyLeu: 8.409 ± 0.164
2.185GlyMet: 2.185 ± 0.076
2.638GlyAsn: 2.638 ± 0.093
1.781GlyPro: 1.781 ± 0.072
2.888GlyGln: 2.888 ± 0.089
3.846GlyArg: 3.846 ± 0.093
4.371GlySer: 4.371 ± 0.119
3.74GlyThr: 3.74 ± 0.113
5.565GlyVal: 5.565 ± 0.136
0.931GlyTrp: 0.931 ± 0.044
3.104GlyTyr: 3.104 ± 0.096
0.0GlyXaa: 0.0 ± 0.0
His
1.2HisAla: 1.2 ± 0.051
0.288HisCys: 0.288 ± 0.028
0.835HisAsp: 0.835 ± 0.045
1.054HisGlu: 1.054 ± 0.055
0.795HisPhe: 0.795 ± 0.044
1.26HisGly: 1.26 ± 0.063
0.42HisHis: 0.42 ± 0.032
1.361HisIle: 1.361 ± 0.059
0.831HisLys: 0.831 ± 0.046
2.115HisLeu: 2.115 ± 0.071
0.406HisMet: 0.406 ± 0.029
0.79HisAsn: 0.79 ± 0.043
1.162HisPro: 1.162 ± 0.043
0.737HisGln: 0.737 ± 0.047
0.967HisArg: 0.967 ± 0.046
1.097HisSer: 1.097 ± 0.051
1.047HisThr: 1.047 ± 0.056
0.905HisVal: 0.905 ± 0.046
0.185HisTrp: 0.185 ± 0.021
0.679HisTyr: 0.679 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
6.052IleAla: 6.052 ± 0.126
1.073IleCys: 1.073 ± 0.055
3.795IleAsp: 3.795 ± 0.099
4.271IleGlu: 4.271 ± 0.109
2.689IlePhe: 2.689 ± 0.084
5.003IleGly: 5.003 ± 0.129
1.316IleHis: 1.316 ± 0.051
5.219IleIle: 5.219 ± 0.139
4.376IleLys: 4.376 ± 0.108
6.779IleLeu: 6.779 ± 0.156
1.762IleMet: 1.762 ± 0.065
3.094IleAsn: 3.094 ± 0.089
3.469IlePro: 3.469 ± 0.084
2.028IleGln: 2.028 ± 0.074
3.649IleArg: 3.649 ± 0.113
5.413IleSer: 5.413 ± 0.111
4.225IleThr: 4.225 ± 0.115
4.175IleVal: 4.175 ± 0.108
0.727IleTrp: 0.727 ± 0.047
2.254IleTyr: 2.254 ± 0.081
0.0IleXaa: 0.0 ± 0.0
Lys
5.572LysAla: 5.572 ± 0.154
0.766LysCys: 0.766 ± 0.054
3.001LysAsp: 3.001 ± 0.079
4.167LysGlu: 4.167 ± 0.116
1.431LysPhe: 1.431 ± 0.058
3.829LysGly: 3.829 ± 0.108
1.032LysHis: 1.032 ± 0.044
3.863LysIle: 3.863 ± 0.099
3.622LysLys: 3.622 ± 0.109
6.009LysLeu: 6.009 ± 0.118
1.762LysMet: 1.762 ± 0.069
2.547LysAsn: 2.547 ± 0.075
2.722LysPro: 2.722 ± 0.091
2.074LysGln: 2.074 ± 0.084
2.919LysArg: 2.919 ± 0.085
3.246LysSer: 3.246 ± 0.092
3.502LysThr: 3.502 ± 0.092
3.997LysVal: 3.997 ± 0.114
0.543LysTrp: 0.543 ± 0.04
1.976LysTyr: 1.976 ± 0.062
0.0LysXaa: 0.0 ± 0.0
Leu
9.905LeuAla: 9.905 ± 0.168
1.376LeuCys: 1.376 ± 0.064
5.493LeuAsp: 5.493 ± 0.135
6.774LeuGlu: 6.774 ± 0.137
3.598LeuPhe: 3.598 ± 0.116
8.347LeuGly: 8.347 ± 0.155
1.69LeuHis: 1.69 ± 0.07
6.566LeuIle: 6.566 ± 0.141
6.954LeuLys: 6.954 ± 0.132
9.677LeuLeu: 9.677 ± 0.189
2.365LeuMet: 2.365 ± 0.073
4.052LeuAsn: 4.052 ± 0.098
5.116LeuPro: 5.116 ± 0.107
2.372LeuGln: 2.372 ± 0.076
4.878LeuArg: 4.878 ± 0.115
8.179LeuSer: 8.179 ± 0.146
5.024LeuThr: 5.024 ± 0.118
7.096LeuVal: 7.096 ± 0.146
0.903LeuTrp: 0.903 ± 0.051
2.653LeuTyr: 2.653 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.828MetAla: 2.828 ± 0.079
0.262MetCys: 0.262 ± 0.026
1.488MetAsp: 1.488 ± 0.062
1.69MetGlu: 1.69 ± 0.066
0.802MetPhe: 0.802 ± 0.043
2.18MetGly: 2.18 ± 0.073
0.377MetHis: 0.377 ± 0.027
1.311MetIle: 1.311 ± 0.056
1.56MetLys: 1.56 ± 0.056
2.857MetLeu: 2.857 ± 0.079
0.567MetMet: 0.567 ± 0.039
0.958MetAsn: 0.958 ± 0.053
1.556MetPro: 1.556 ± 0.055
0.893MetGln: 0.893 ± 0.045
1.21MetArg: 1.21 ± 0.055
1.659MetSer: 1.659 ± 0.063
1.397MetThr: 1.397 ± 0.069
1.99MetVal: 1.99 ± 0.075
0.17MetTrp: 0.17 ± 0.021
0.583MetTyr: 0.583 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
2.9AsnAla: 2.9 ± 0.089
0.583AsnCys: 0.583 ± 0.041
1.467AsnAsp: 1.467 ± 0.058
1.949AsnGlu: 1.949 ± 0.071
1.464AsnPhe: 1.464 ± 0.053
2.984AsnGly: 2.984 ± 0.096
0.694AsnHis: 0.694 ± 0.041
3.274AsnIle: 3.274 ± 0.085
2.012AsnLys: 2.012 ± 0.064
4.292AsnLeu: 4.292 ± 0.11
1.157AsnMet: 1.157 ± 0.05
1.464AsnAsn: 1.464 ± 0.073
2.427AsnPro: 2.427 ± 0.084
1.371AsnGln: 1.371 ± 0.052
2.194AsnArg: 2.194 ± 0.071
2.069AsnSer: 2.069 ± 0.07
2.427AsnThr: 2.427 ± 0.077
2.18AsnVal: 2.18 ± 0.078
0.519AsnTrp: 0.519 ± 0.038
1.239AsnTyr: 1.239 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
3.973ProAla: 3.973 ± 0.089
0.54ProCys: 0.54 ± 0.039
2.799ProAsp: 2.799 ± 0.081
4.203ProGlu: 4.203 ± 0.109
1.844ProPhe: 1.844 ± 0.071
3.481ProGly: 3.481 ± 0.096
0.78ProHis: 0.78 ± 0.042
2.089ProIle: 2.089 ± 0.065
2.225ProLys: 2.225 ± 0.075
4.05ProLeu: 4.05 ± 0.091
0.936ProMet: 0.936 ± 0.049
1.4ProAsn: 1.4 ± 0.065
1.899ProPro: 1.899 ± 0.075
1.565ProGln: 1.565 ± 0.058
1.884ProArg: 1.884 ± 0.073
2.667ProSer: 2.667 ± 0.078
1.832ProThr: 1.832 ± 0.073
3.743ProVal: 3.743 ± 0.096
0.374ProTrp: 0.374 ± 0.032
1.296ProTyr: 1.296 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
3.447GlnAla: 3.447 ± 0.092
0.3GlnCys: 0.3 ± 0.026
1.508GlnAsp: 1.508 ± 0.065
1.889GlnGlu: 1.889 ± 0.068
0.814GlnPhe: 0.814 ± 0.05
2.3GlnGly: 2.3 ± 0.07
0.564GlnHis: 0.564 ± 0.034
2.557GlnIle: 2.557 ± 0.08
1.98GlnLys: 1.98 ± 0.062
3.006GlnLeu: 3.006 ± 0.091
1.049GlnMet: 1.049 ± 0.049
1.637GlnAsn: 1.637 ± 0.065
1.491GlnPro: 1.491 ± 0.07
1.234GlnGln: 1.234 ± 0.057
1.635GlnArg: 1.635 ± 0.075
2.288GlnSer: 2.288 ± 0.073
1.988GlnThr: 1.988 ± 0.08
2.209GlnVal: 2.209 ± 0.077
0.259GlnTrp: 0.259 ± 0.026
0.919GlnTyr: 0.919 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
3.33ArgAla: 3.33 ± 0.106
0.617ArgCys: 0.617 ± 0.042
2.365ArgAsp: 2.365 ± 0.079
3.426ArgGlu: 3.426 ± 0.118
2.254ArgPhe: 2.254 ± 0.073
3.111ArgGly: 3.111 ± 0.093
1.071ArgHis: 1.071 ± 0.056
3.764ArgIle: 3.764 ± 0.101
2.95ArgLys: 2.95 ± 0.1
6.033ArgLeu: 6.033 ± 0.139
1.308ArgMet: 1.308 ± 0.055
1.882ArgAsn: 1.882 ± 0.059
2.115ArgPro: 2.115 ± 0.071
2.355ArgGln: 2.355 ± 0.07
3.147ArgArg: 3.147 ± 0.101
2.667ArgSer: 2.667 ± 0.087
2.456ArgThr: 2.456 ± 0.075
3.409ArgVal: 3.409 ± 0.085
0.531ArgTrp: 0.531 ± 0.033
1.906ArgTyr: 1.906 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
5.632SerAla: 5.632 ± 0.126
0.869SerCys: 0.869 ± 0.048
2.876SerAsp: 2.876 ± 0.082
3.634SerGlu: 3.634 ± 0.098
2.669SerPhe: 2.669 ± 0.082
6.22SerGly: 6.22 ± 0.154
1.253SerHis: 1.253 ± 0.056
3.863SerIle: 3.863 ± 0.098
3.061SerLys: 3.061 ± 0.105
7.13SerLeu: 7.13 ± 0.146
1.496SerMet: 1.496 ± 0.063
2.007SerAsn: 2.007 ± 0.08
2.878SerPro: 2.878 ± 0.09
2.645SerGln: 2.645 ± 0.083
3.757SerArg: 3.757 ± 0.106
3.875SerSer: 3.875 ± 0.106
2.905SerThr: 2.905 ± 0.091
4.16SerVal: 4.16 ± 0.101
0.691SerTrp: 0.691 ± 0.045
1.913SerTyr: 1.913 ± 0.077
0.0SerXaa: 0.0 ± 0.0
Thr
5.202ThrAla: 5.202 ± 0.12
0.631ThrCys: 0.631 ± 0.035
3.018ThrAsp: 3.018 ± 0.081
3.378ThrGlu: 3.378 ± 0.085
1.916ThrPhe: 1.916 ± 0.064
4.578ThrGly: 4.578 ± 0.123
0.97ThrHis: 0.97 ± 0.055
3.202ThrIle: 3.202 ± 0.1
2.377ThrLys: 2.377 ± 0.085
5.255ThrLeu: 5.255 ± 0.108
1.073ThrMet: 1.073 ± 0.05
1.8ThrAsn: 1.8 ± 0.074
3.097ThrPro: 3.097 ± 0.102
1.553ThrGln: 1.553 ± 0.063
2.581ThrArg: 2.581 ± 0.08
3.018ThrSer: 3.018 ± 0.097
2.845ThrThr: 2.845 ± 0.11
3.574ThrVal: 3.574 ± 0.114
0.435ThrTrp: 0.435 ± 0.037
1.599ThrTyr: 1.599 ± 0.075
0.0ThrXaa: 0.0 ± 0.0
Val
5.737ValAla: 5.737 ± 0.151
1.123ValCys: 1.123 ± 0.056
3.346ValAsp: 3.346 ± 0.103
3.915ValGlu: 3.915 ± 0.106
3.138ValPhe: 3.138 ± 0.101
4.285ValGly: 4.285 ± 0.118
1.061ValHis: 1.061 ± 0.05
5.675ValIle: 5.675 ± 0.11
4.076ValLys: 4.076 ± 0.102
6.767ValLeu: 6.767 ± 0.136
1.959ValMet: 1.959 ± 0.073
2.6ValAsn: 2.6 ± 0.082
2.475ValPro: 2.475 ± 0.071
1.692ValGln: 1.692 ± 0.062
3.051ValArg: 3.051 ± 0.089
5.18ValSer: 5.18 ± 0.113
3.625ValThr: 3.625 ± 0.099
4.823ValVal: 4.823 ± 0.136
0.768ValTrp: 0.768 ± 0.041
1.947ValTyr: 1.947 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.816TrpAla: 0.816 ± 0.048
0.122TrpCys: 0.122 ± 0.018
0.643TrpAsp: 0.643 ± 0.044
0.588TrpGlu: 0.588 ± 0.043
0.377TrpPhe: 0.377 ± 0.033
0.787TrpGly: 0.787 ± 0.048
0.23TrpHis: 0.23 ± 0.022
0.528TrpIle: 0.528 ± 0.032
0.509TrpLys: 0.509 ± 0.036
1.251TrpLeu: 1.251 ± 0.06
0.218TrpMet: 0.218 ± 0.023
0.398TrpAsn: 0.398 ± 0.036
0.401TrpPro: 0.401 ± 0.035
0.6TrpGln: 0.6 ± 0.039
0.509TrpArg: 0.509 ± 0.035
0.509TrpSer: 0.509 ± 0.034
0.389TrpThr: 0.389 ± 0.032
0.711TrpVal: 0.711 ± 0.043
0.235TrpTrp: 0.235 ± 0.024
0.353TrpTyr: 0.353 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.367TyrAla: 2.367 ± 0.071
0.519TyrCys: 0.519 ± 0.038
1.568TyrAsp: 1.568 ± 0.079
1.805TyrGlu: 1.805 ± 0.066
1.433TyrPhe: 1.433 ± 0.056
2.355TyrGly: 2.355 ± 0.085
0.687TyrHis: 0.687 ± 0.043
2.216TyrIle: 2.216 ± 0.081
1.496TyrLys: 1.496 ± 0.064
3.577TyrLeu: 3.577 ± 0.103
0.718TyrMet: 0.718 ± 0.037
1.265TyrAsn: 1.265 ± 0.056
1.58TyrPro: 1.58 ± 0.071
1.385TyrGln: 1.385 ± 0.065
1.8TyrArg: 1.8 ± 0.059
2.108TyrSer: 2.108 ± 0.078
1.863TyrThr: 1.863 ± 0.069
1.702TyrVal: 1.702 ± 0.061
0.355TyrTrp: 0.355 ± 0.03
1.181TyrTyr: 1.181 ± 0.069
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1502 proteins (416566 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski