Amino acid dipepetide frequency for Human papillomavirus type 50

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.681AlaAla: 6.681 ± 2.119
1.253AlaCys: 1.253 ± 0.807
3.758AlaAsp: 3.758 ± 0.947
2.923AlaGlu: 2.923 ± 1.277
2.923AlaPhe: 2.923 ± 1.085
2.505AlaGly: 2.505 ± 0.994
1.253AlaHis: 1.253 ± 0.709
2.505AlaIle: 2.505 ± 1.094
3.758AlaLys: 3.758 ± 1.542
4.175AlaLeu: 4.175 ± 1.224
0.418AlaMet: 0.418 ± 0.332
2.088AlaAsn: 2.088 ± 1.119
4.175AlaPro: 4.175 ± 2.115
2.088AlaGln: 2.088 ± 0.521
2.923AlaArg: 2.923 ± 1.129
3.34AlaSer: 3.34 ± 0.879
4.593AlaThr: 4.593 ± 0.782
3.34AlaVal: 3.34 ± 0.768
0.418AlaTrp: 0.418 ± 0.376
1.67AlaTyr: 1.67 ± 0.748
0.0AlaXaa: 0.0 ± 0.0
Cys
1.253CysAla: 1.253 ± 0.807
2.088CysCys: 2.088 ± 0.99
1.67CysAsp: 1.67 ± 0.924
0.835CysGlu: 0.835 ± 0.556
1.67CysPhe: 1.67 ± 0.995
0.0CysGly: 0.0 ± 0.0
0.835CysHis: 0.835 ± 0.782
1.253CysIle: 1.253 ± 0.552
2.923CysLys: 2.923 ± 1.609
2.923CysLeu: 2.923 ± 1.86
0.418CysMet: 0.418 ± 0.476
0.0CysAsn: 0.0 ± 0.0
0.835CysPro: 0.835 ± 0.706
0.418CysGln: 0.418 ± 0.49
1.253CysArg: 1.253 ± 0.832
1.67CysSer: 1.67 ± 1.031
0.835CysThr: 0.835 ± 0.664
0.418CysVal: 0.418 ± 0.547
1.67CysTrp: 1.67 ± 0.605
2.505CysTyr: 2.505 ± 1.367
0.0CysXaa: 0.0 ± 0.0
Asp
4.593AspAla: 4.593 ± 0.892
0.835AspCys: 0.835 ± 0.529
6.263AspAsp: 6.263 ± 1.815
4.593AspGlu: 4.593 ± 1.159
2.505AspPhe: 2.505 ± 0.416
2.088AspGly: 2.088 ± 0.846
1.253AspHis: 1.253 ± 0.744
6.263AspIle: 6.263 ± 2.676
2.088AspLys: 2.088 ± 0.804
7.098AspLeu: 7.098 ± 1.704
1.67AspMet: 1.67 ± 0.866
2.923AspAsn: 2.923 ± 1.18
6.263AspPro: 6.263 ± 1.454
0.418AspGln: 0.418 ± 0.353
0.835AspArg: 0.835 ± 0.444
6.263AspSer: 6.263 ± 1.517
5.01AspThr: 5.01 ± 0.926
5.01AspVal: 5.01 ± 2.237
1.253AspTrp: 1.253 ± 0.587
4.175AspTyr: 4.175 ± 1.786
0.0AspXaa: 0.0 ± 0.0
Glu
2.505GluAla: 2.505 ± 1.317
1.67GluCys: 1.67 ± 0.904
3.34GluAsp: 3.34 ± 1.086
4.175GluGlu: 4.175 ± 0.809
2.088GluPhe: 2.088 ± 0.683
2.505GluGly: 2.505 ± 1.417
1.253GluHis: 1.253 ± 0.575
1.67GluIle: 1.67 ± 0.684
2.923GluLys: 2.923 ± 0.814
6.263GluLeu: 6.263 ± 1.163
0.835GluMet: 0.835 ± 0.451
5.01GluAsn: 5.01 ± 1.407
3.758GluPro: 3.758 ± 0.606
3.34GluGln: 3.34 ± 1.283
4.593GluArg: 4.593 ± 0.597
3.758GluSer: 3.758 ± 1.327
2.505GluThr: 2.505 ± 0.676
2.505GluVal: 2.505 ± 1.066
0.418GluTrp: 0.418 ± 0.332
2.923GluTyr: 2.923 ± 1.143
0.0GluXaa: 0.0 ± 0.0
Phe
2.505PheAla: 2.505 ± 0.891
0.835PheCys: 0.835 ± 0.573
3.758PheAsp: 3.758 ± 0.762
3.34PheGlu: 3.34 ± 1.942
1.253PhePhe: 1.253 ± 0.569
2.923PheGly: 2.923 ± 1.46
1.253PheHis: 1.253 ± 0.973
1.67PheIle: 1.67 ± 0.501
4.593PheLys: 4.593 ± 2.274
3.758PheLeu: 3.758 ± 1.033
1.253PheMet: 1.253 ± 0.913
3.34PheAsn: 3.34 ± 1.17
1.253PhePro: 1.253 ± 0.624
1.67PheGln: 1.67 ± 0.623
0.835PheArg: 0.835 ± 0.383
2.923PheSer: 2.923 ± 1.241
2.923PheThr: 2.923 ± 0.492
2.088PheVal: 2.088 ± 1.065
1.253PheTrp: 1.253 ± 0.624
2.505PheTyr: 2.505 ± 0.611
0.0PheXaa: 0.0 ± 0.0
Gly
2.088GlyAla: 2.088 ± 0.972
0.835GlyCys: 0.835 ± 0.556
6.263GlyAsp: 6.263 ± 1.581
1.253GlyGlu: 1.253 ± 0.657
1.253GlyPhe: 1.253 ± 0.332
3.758GlyGly: 3.758 ± 2.112
1.253GlyHis: 1.253 ± 0.709
3.34GlyIle: 3.34 ± 0.885
2.088GlyLys: 2.088 ± 0.704
5.846GlyLeu: 5.846 ± 2.09
0.835GlyMet: 0.835 ± 0.43
4.175GlyAsn: 4.175 ± 0.949
4.593GlyPro: 4.593 ± 1.381
1.253GlyGln: 1.253 ± 1.128
3.758GlyArg: 3.758 ± 1.121
2.505GlySer: 2.505 ± 1.066
3.34GlyThr: 3.34 ± 2.029
1.67GlyVal: 1.67 ± 1.104
0.0GlyTrp: 0.0 ± 0.0
1.253GlyTyr: 1.253 ± 0.575
0.0GlyXaa: 0.0 ± 0.0
His
1.253HisAla: 1.253 ± 0.657
1.253HisCys: 1.253 ± 1.263
0.0HisAsp: 0.0 ± 0.0
0.418HisGlu: 0.418 ± 0.476
0.835HisPhe: 0.835 ± 0.363
0.835HisGly: 0.835 ± 0.575
0.418HisHis: 0.418 ± 0.376
0.835HisIle: 0.835 ± 0.451
0.835HisLys: 0.835 ± 0.451
2.505HisLeu: 2.505 ± 0.503
0.418HisMet: 0.418 ± 0.332
1.253HisAsn: 1.253 ± 0.594
1.67HisPro: 1.67 ± 0.805
1.253HisGln: 1.253 ± 1.004
0.835HisArg: 0.835 ± 0.537
1.67HisSer: 1.67 ± 0.902
1.67HisThr: 1.67 ± 0.286
0.835HisVal: 0.835 ± 0.383
0.418HisTrp: 0.418 ± 0.353
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
4.593IleAla: 4.593 ± 1.371
1.67IleCys: 1.67 ± 0.558
3.34IleAsp: 3.34 ± 0.872
4.175IleGlu: 4.175 ± 0.555
1.67IlePhe: 1.67 ± 0.536
2.923IleGly: 2.923 ± 1.228
0.835IleHis: 0.835 ± 0.537
2.088IleIle: 2.088 ± 0.848
1.67IleLys: 1.67 ± 0.748
2.088IleLeu: 2.088 ± 1.187
0.0IleMet: 0.0 ± 0.0
4.175IleAsn: 4.175 ± 1.539
4.593IlePro: 4.593 ± 1.752
2.923IleGln: 2.923 ± 0.577
2.088IleArg: 2.088 ± 0.732
2.505IleSer: 2.505 ± 0.697
2.923IleThr: 2.923 ± 1.181
5.01IleVal: 5.01 ± 1.136
0.0IleTrp: 0.0 ± 0.0
0.835IleTyr: 0.835 ± 0.451
0.0IleXaa: 0.0 ± 0.0
Lys
1.67LysAla: 1.67 ± 0.85
2.088LysCys: 2.088 ± 0.912
4.175LysAsp: 4.175 ± 1.605
4.175LysGlu: 4.175 ± 1.133
4.593LysPhe: 4.593 ± 1.653
1.253LysGly: 1.253 ± 0.697
1.253LysHis: 1.253 ± 0.835
1.67LysIle: 1.67 ± 0.744
3.34LysLys: 3.34 ± 1.038
5.01LysLeu: 5.01 ± 1.35
0.835LysMet: 0.835 ± 0.383
4.175LysAsn: 4.175 ± 1.814
1.67LysPro: 1.67 ± 0.944
2.505LysGln: 2.505 ± 0.503
3.34LysArg: 3.34 ± 0.875
5.428LysSer: 5.428 ± 2.1
1.253LysThr: 1.253 ± 0.564
3.758LysVal: 3.758 ± 1.287
1.253LysTrp: 1.253 ± 0.786
2.505LysTyr: 2.505 ± 1.367
0.0LysXaa: 0.0 ± 0.0
Leu
5.01LeuAla: 5.01 ± 0.975
2.088LeuCys: 2.088 ± 1.166
6.681LeuAsp: 6.681 ± 1.049
4.175LeuGlu: 4.175 ± 0.906
5.01LeuPhe: 5.01 ± 0.817
5.428LeuGly: 5.428 ± 1.874
1.253LeuHis: 1.253 ± 0.657
5.01LeuIle: 5.01 ± 1.054
5.846LeuLys: 5.846 ± 1.232
11.273LeuLeu: 11.273 ± 2.222
0.835LeuMet: 0.835 ± 0.529
4.593LeuAsn: 4.593 ± 1.044
5.01LeuPro: 5.01 ± 0.535
5.428LeuGln: 5.428 ± 1.159
3.758LeuArg: 3.758 ± 1.169
7.516LeuSer: 7.516 ± 1.364
2.923LeuThr: 2.923 ± 1.246
6.681LeuVal: 6.681 ± 1.58
0.418LeuTrp: 0.418 ± 0.353
7.933LeuTyr: 7.933 ± 0.888
0.0LeuXaa: 0.0 ± 0.0
Met
1.67MetAla: 1.67 ± 0.721
0.835MetCys: 0.835 ± 0.573
0.835MetAsp: 0.835 ± 0.454
0.835MetGlu: 0.835 ± 0.575
0.0MetPhe: 0.0 ± 0.0
0.835MetGly: 0.835 ± 0.444
0.0MetHis: 0.0 ± 0.0
0.418MetIle: 0.418 ± 0.332
0.0MetLys: 0.0 ± 0.0
1.67MetLeu: 1.67 ± 0.579
0.0MetMet: 0.0 ± 0.0
0.835MetAsn: 0.835 ± 0.363
1.253MetPro: 1.253 ± 0.787
0.418MetGln: 0.418 ± 0.332
2.088MetArg: 2.088 ± 1.097
0.418MetSer: 0.418 ± 0.376
1.253MetThr: 1.253 ± 0.414
1.253MetVal: 1.253 ± 0.787
0.0MetTrp: 0.0 ± 0.0
1.253MetTyr: 1.253 ± 0.624
0.0MetXaa: 0.0 ± 0.0
Asn
2.505AsnAla: 2.505 ± 1.191
2.505AsnCys: 2.505 ± 1.04
1.253AsnAsp: 1.253 ± 0.414
3.34AsnGlu: 3.34 ± 1.007
2.088AsnPhe: 2.088 ± 0.612
2.505AsnGly: 2.505 ± 0.811
1.253AsnHis: 1.253 ± 0.787
2.923AsnIle: 2.923 ± 1.161
3.758AsnLys: 3.758 ± 1.006
5.428AsnLeu: 5.428 ± 0.969
0.835AsnMet: 0.835 ± 0.451
2.923AsnAsn: 2.923 ± 0.662
2.923AsnPro: 2.923 ± 1.279
2.088AsnGln: 2.088 ± 1.341
2.088AsnArg: 2.088 ± 0.657
6.681AsnSer: 6.681 ± 2.004
2.923AsnThr: 2.923 ± 0.577
5.428AsnVal: 5.428 ± 1.395
1.67AsnTrp: 1.67 ± 0.757
1.253AsnTyr: 1.253 ± 0.624
0.0AsnXaa: 0.0 ± 0.0
Pro
4.175ProAla: 4.175 ± 1.836
0.418ProCys: 0.418 ± 0.353
5.846ProAsp: 5.846 ± 1.466
3.34ProGlu: 3.34 ± 1.039
2.088ProPhe: 2.088 ± 0.764
1.67ProGly: 1.67 ± 0.835
0.418ProHis: 0.418 ± 0.49
2.923ProIle: 2.923 ± 1.632
5.01ProLys: 5.01 ± 1.121
7.098ProLeu: 7.098 ± 1.866
0.418ProMet: 0.418 ± 0.332
2.923ProAsn: 2.923 ± 1.241
5.428ProPro: 5.428 ± 0.919
2.088ProGln: 2.088 ± 0.905
2.088ProArg: 2.088 ± 0.359
3.34ProSer: 3.34 ± 1.505
4.593ProThr: 4.593 ± 1.855
1.67ProVal: 1.67 ± 0.623
0.418ProTrp: 0.418 ± 0.376
2.505ProTyr: 2.505 ± 0.977
0.0ProXaa: 0.0 ± 0.0
Gln
0.0GlnAla: 0.0 ± 0.0
0.835GlnCys: 0.835 ± 0.573
2.923GlnAsp: 2.923 ± 0.991
3.758GlnGlu: 3.758 ± 0.832
2.088GlnPhe: 2.088 ± 0.681
1.67GlnGly: 1.67 ± 0.501
0.0GlnHis: 0.0 ± 0.0
1.253GlnIle: 1.253 ± 0.513
1.253GlnLys: 1.253 ± 0.786
6.263GlnLeu: 6.263 ± 1.427
0.835GlnMet: 0.835 ± 0.451
3.34GlnAsn: 3.34 ± 0.612
4.175GlnPro: 4.175 ± 2.063
3.758GlnGln: 3.758 ± 1.148
1.253GlnArg: 1.253 ± 0.751
2.088GlnSer: 2.088 ± 0.963
2.088GlnThr: 2.088 ± 0.723
1.67GlnVal: 1.67 ± 0.579
0.835GlnTrp: 0.835 ± 0.451
2.088GlnTyr: 2.088 ± 1.341
0.0GlnXaa: 0.0 ± 0.0
Arg
3.758ArgAla: 3.758 ± 1.281
0.835ArgCys: 0.835 ± 0.556
2.923ArgAsp: 2.923 ± 0.805
1.253ArgGlu: 1.253 ± 0.761
1.67ArgPhe: 1.67 ± 0.954
3.34ArgGly: 3.34 ± 1.055
2.088ArgHis: 2.088 ± 0.64
1.253ArgIle: 1.253 ± 0.476
3.34ArgLys: 3.34 ± 0.848
7.098ArgLeu: 7.098 ± 1.144
0.835ArgMet: 0.835 ± 0.501
3.34ArgAsn: 3.34 ± 0.588
2.505ArgPro: 2.505 ± 1.403
1.253ArgGln: 1.253 ± 0.556
5.428ArgArg: 5.428 ± 1.353
3.34ArgSer: 3.34 ± 1.005
3.34ArgThr: 3.34 ± 1.345
2.923ArgVal: 2.923 ± 1.385
0.0ArgTrp: 0.0 ± 0.0
1.67ArgTyr: 1.67 ± 0.558
0.0ArgXaa: 0.0 ± 0.0
Ser
4.175SerAla: 4.175 ± 1.175
1.67SerCys: 1.67 ± 0.882
5.428SerAsp: 5.428 ± 0.946
7.098SerGlu: 7.098 ± 1.494
4.593SerPhe: 4.593 ± 1.396
4.593SerGly: 4.593 ± 1.337
2.088SerHis: 2.088 ± 0.631
3.34SerIle: 3.34 ± 0.709
3.34SerLys: 3.34 ± 1.192
5.01SerLeu: 5.01 ± 0.829
1.67SerMet: 1.67 ± 0.734
2.923SerAsn: 2.923 ± 1.46
1.67SerPro: 1.67 ± 0.8
2.505SerGln: 2.505 ± 0.934
4.175SerArg: 4.175 ± 1.258
5.01SerSer: 5.01 ± 1.988
6.681SerThr: 6.681 ± 1.67
2.088SerVal: 2.088 ± 0.579
0.0SerTrp: 0.0 ± 0.0
2.923SerTyr: 2.923 ± 0.998
0.0SerXaa: 0.0 ± 0.0
Thr
0.835ThrAla: 0.835 ± 0.363
1.67ThrCys: 1.67 ± 0.997
5.846ThrAsp: 5.846 ± 1.558
3.34ThrGlu: 3.34 ± 1.329
3.34ThrPhe: 3.34 ± 1.198
3.34ThrGly: 3.34 ± 0.571
1.253ThrHis: 1.253 ± 0.624
3.758ThrIle: 3.758 ± 1.721
1.67ThrLys: 1.67 ± 0.74
3.34ThrLeu: 3.34 ± 1.241
1.253ThrMet: 1.253 ± 0.796
2.923ThrAsn: 2.923 ± 0.814
3.34ThrPro: 3.34 ± 0.436
4.175ThrGln: 4.175 ± 1.055
2.923ThrArg: 2.923 ± 0.694
4.593ThrSer: 4.593 ± 1.214
5.01ThrThr: 5.01 ± 1.243
6.681ThrVal: 6.681 ± 2.085
0.0ThrTrp: 0.0 ± 0.0
0.835ThrTyr: 0.835 ± 0.444
0.0ThrXaa: 0.0 ± 0.0
Val
3.34ValAla: 3.34 ± 0.822
1.253ValCys: 1.253 ± 0.787
3.34ValAsp: 3.34 ± 0.79
1.253ValGlu: 1.253 ± 0.657
2.505ValPhe: 2.505 ± 1.32
6.681ValGly: 6.681 ± 3.01
0.835ValHis: 0.835 ± 0.363
4.175ValIle: 4.175 ± 1.154
3.34ValLys: 3.34 ± 0.931
4.175ValLeu: 4.175 ± 1.136
0.418ValMet: 0.418 ± 0.353
2.923ValAsn: 2.923 ± 1.411
2.088ValPro: 2.088 ± 1.154
2.923ValGln: 2.923 ± 1.103
2.923ValArg: 2.923 ± 0.981
5.01ValSer: 5.01 ± 1.302
2.923ValThr: 2.923 ± 0.977
2.923ValVal: 2.923 ± 1.016
0.418ValTrp: 0.418 ± 0.353
3.758ValTyr: 3.758 ± 1.22
0.0ValXaa: 0.0 ± 0.0
Trp
0.418TrpAla: 0.418 ± 0.332
0.0TrpCys: 0.0 ± 0.0
0.418TrpAsp: 0.418 ± 0.353
1.253TrpGlu: 1.253 ± 0.957
0.0TrpPhe: 0.0 ± 0.0
0.418TrpGly: 0.418 ± 0.353
0.418TrpHis: 0.418 ± 0.376
1.67TrpIle: 1.67 ± 0.924
1.67TrpLys: 1.67 ± 0.605
1.253TrpLeu: 1.253 ± 0.414
0.418TrpMet: 0.418 ± 0.332
0.418TrpAsn: 0.418 ± 0.353
0.418TrpPro: 0.418 ± 0.353
0.418TrpGln: 0.418 ± 0.353
0.835TrpArg: 0.835 ± 0.575
0.418TrpSer: 0.418 ± 0.353
1.253TrpThr: 1.253 ± 0.761
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.758TyrAla: 3.758 ± 1.287
0.835TyrCys: 0.835 ± 0.573
3.34TyrAsp: 3.34 ± 0.52
2.505TyrGlu: 2.505 ± 0.593
4.175TyrPhe: 4.175 ± 1.103
2.088TyrGly: 2.088 ± 0.884
0.0TyrHis: 0.0 ± 0.0
2.088TyrIle: 2.088 ± 0.762
2.505TyrLys: 2.505 ± 0.887
4.593TyrLeu: 4.593 ± 1.311
1.253TyrMet: 1.253 ± 0.615
2.088TyrAsn: 2.088 ± 0.612
0.835TyrPro: 0.835 ± 0.477
1.253TyrGln: 1.253 ± 0.697
4.175TyrArg: 4.175 ± 1.206
2.505TyrSer: 2.505 ± 0.611
2.088TyrThr: 2.088 ± 0.89
1.253TyrVal: 1.253 ± 0.657
1.253TyrTrp: 1.253 ± 0.709
1.253TyrTyr: 1.253 ± 0.587
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2396 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski