Amino acid dipepetide frequency for Melittangium boletus DSM 14713

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.929AlaAla: 12.929 ± 0.098	1.271AlaCys: 1.271 ± 0.023	4.817AlaAsp: 4.817 ± 0.043	7.399AlaGlu: 7.399 ± 0.078	3.724AlaPhe: 3.724 ± 0.038	8.813AlaGly: 8.813 ± 0.071	2.543AlaHis: 2.543 ± 0.031	3.307AlaIle: 3.307 ± 0.038	2.873AlaLys: 2.873 ± 0.036	14.609AlaLeu: 14.609 ± 0.103	2.267AlaMet: 2.267 ± 0.03	2.264AlaAsn: 2.264 ± 0.038	7.005AlaPro: 7.005 ± 0.081	4.308AlaGln: 4.308 ± 0.041	10.578AlaArg: 10.578 ± 0.082	7.021AlaSer: 7.021 ± 0.057	5.659AlaThr: 5.659 ± 0.056	8.055AlaVal: 8.055 ± 0.066	1.779AlaTrp: 1.779 ± 0.031	2.328AlaTyr: 2.328 ± 0.028	0.0AlaXaa: 0.0 ± 0.0
Cys	1.152CysAla: 1.152 ± 0.024	0.111CysCys: 0.111 ± 0.008	0.532CysAsp: 0.532 ± 0.017	0.572CysGlu: 0.572 ± 0.015	0.334CysPhe: 0.334 ± 0.012	1.031CysGly: 1.031 ± 0.027	0.256CysHis: 0.256 ± 0.011	0.283CysIle: 0.283 ± 0.01	0.208CysLys: 0.208 ± 0.009	0.916CysLeu: 0.916 ± 0.019	0.177CysMet: 0.177 ± 0.008	0.243CysAsn: 0.243 ± 0.012	0.571CysPro: 0.571 ± 0.018	0.305CysGln: 0.305 ± 0.01	0.66CysArg: 0.66 ± 0.02	0.571CysSer: 0.571 ± 0.018	0.56CysThr: 0.56 ± 0.017	0.731CysVal: 0.731 ± 0.018	0.126CysTrp: 0.126 ± 0.007	0.2CysTyr: 0.2 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	6.421AspAla: 6.421 ± 0.057	0.499AspCys: 0.499 ± 0.017	2.298AspAsp: 2.298 ± 0.032	3.441AspGlu: 3.441 ± 0.04	2.131AspPhe: 2.131 ± 0.029	4.685AspGly: 4.685 ± 0.065	0.835AspHis: 0.835 ± 0.02	1.891AspIle: 1.891 ± 0.028	1.517AspLys: 1.517 ± 0.027	4.917AspLeu: 4.917 ± 0.047	0.921AspMet: 0.921 ± 0.019	1.092AspAsn: 1.092 ± 0.02	3.006AspPro: 3.006 ± 0.041	1.28AspGln: 1.28 ± 0.021	2.927AspArg: 2.927 ± 0.031	2.64AspSer: 2.64 ± 0.036	2.746AspThr: 2.746 ± 0.032	4.371AspVal: 4.371 ± 0.038	0.818AspTrp: 0.818 ± 0.016	1.21AspTyr: 1.21 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	8.304GluAla: 8.304 ± 0.079	0.459GluCys: 0.459 ± 0.012	3.302GluAsp: 3.302 ± 0.033	4.539GluGlu: 4.539 ± 0.05	1.66GluPhe: 1.66 ± 0.027	5.684GluGly: 5.684 ± 0.049	1.542GluHis: 1.542 ± 0.024	1.748GluIle: 1.748 ± 0.029	2.189GluLys: 2.189 ± 0.032	7.468GluLeu: 7.468 ± 0.068	1.213GluMet: 1.213 ± 0.025	1.249GluAsn: 1.249 ± 0.023	3.859GluPro: 3.859 ± 0.047	2.744GluGln: 2.744 ± 0.034	6.741GluArg: 6.741 ± 0.069	3.324GluSer: 3.324 ± 0.039	2.942GluThr: 2.942 ± 0.032	5.247GluVal: 5.247 ± 0.046	0.868GluTrp: 0.868 ± 0.026	1.142GluTyr: 1.142 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.396PheAla: 3.396 ± 0.034	0.344PheCys: 0.344 ± 0.01	2.085PheAsp: 2.085 ± 0.026	2.196PheGlu: 2.196 ± 0.026	1.403PhePhe: 1.403 ± 0.024	2.856PheGly: 2.856 ± 0.034	0.847PheHis: 0.847 ± 0.016	1.268PheIle: 1.268 ± 0.021	0.962PheLys: 0.962 ± 0.021	3.57PheLeu: 3.57 ± 0.04	0.621PheMet: 0.621 ± 0.015	0.987PheAsn: 0.987 ± 0.02	1.607PhePro: 1.607 ± 0.023	1.25PheGln: 1.25 ± 0.017	2.251PheArg: 2.251 ± 0.03	2.328PheSer: 2.328 ± 0.028	2.139PheThr: 2.139 ± 0.032	2.495PheVal: 2.495 ± 0.028	0.469PheTrp: 0.469 ± 0.014	0.793PheTyr: 0.793 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	9.054GlyAla: 9.054 ± 0.068	1.033GlyCys: 1.033 ± 0.023	4.088GlyAsp: 4.088 ± 0.042	5.471GlyGlu: 5.471 ± 0.047	3.108GlyPhe: 3.108 ± 0.038	7.859GlyGly: 7.859 ± 0.088	1.918GlyHis: 1.918 ± 0.028	2.969GlyIle: 2.969 ± 0.033	2.985GlyLys: 2.985 ± 0.042	9.221GlyLeu: 9.221 ± 0.07	2.001GlyMet: 2.001 ± 0.028	2.105GlyAsn: 2.105 ± 0.036	4.189GlyPro: 4.189 ± 0.043	3.327GlyGln: 3.327 ± 0.039	6.477GlyArg: 6.477 ± 0.055	5.057GlySer: 5.057 ± 0.052	5.437GlyThr: 5.437 ± 0.063	6.84GlyVal: 6.84 ± 0.058	1.389GlyTrp: 1.389 ± 0.025	2.083GlyTyr: 2.083 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.509HisAla: 2.509 ± 0.033	0.216HisCys: 0.216 ± 0.009	0.98HisAsp: 0.98 ± 0.016	1.38HisGlu: 1.38 ± 0.024	0.887HisPhe: 0.887 ± 0.017	1.954HisGly: 1.954 ± 0.027	0.658HisHis: 0.658 ± 0.017	0.655HisIle: 0.655 ± 0.014	0.471HisLys: 0.471 ± 0.014	2.514HisLeu: 2.514 ± 0.031	0.38HisMet: 0.38 ± 0.012	0.41HisAsn: 0.41 ± 0.012	1.651HisPro: 1.651 ± 0.029	0.737HisGln: 0.737 ± 0.017	1.678HisArg: 1.678 ± 0.023	1.084HisSer: 1.084 ± 0.022	1.058HisThr: 1.058 ± 0.022	1.712HisVal: 1.712 ± 0.028	0.341HisTrp: 0.341 ± 0.009	0.581HisTyr: 0.581 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.525IleAla: 3.525 ± 0.034	0.279IleCys: 0.279 ± 0.009	1.859IleAsp: 1.859 ± 0.029	2.064IleGlu: 2.064 ± 0.027	0.986IlePhe: 0.986 ± 0.02	2.412IleGly: 2.412 ± 0.033	0.871IleHis: 0.871 ± 0.017	1.194IleIle: 1.194 ± 0.025	0.841IleLys: 0.841 ± 0.019	2.811IleLeu: 2.811 ± 0.035	0.369IleMet: 0.369 ± 0.012	0.942IleAsn: 0.942 ± 0.022	1.982IlePro: 1.982 ± 0.026	1.227IleGln: 1.227 ± 0.021	2.237IleArg: 2.237 ± 0.031	1.883IleSer: 1.883 ± 0.029	1.805IleThr: 1.805 ± 0.029	2.237IleVal: 2.237 ± 0.03	0.322IleTrp: 0.322 ± 0.011	0.704IleTyr: 0.704 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	3.412LysAla: 3.412 ± 0.043	0.217LysCys: 0.217 ± 0.009	1.741LysAsp: 1.741 ± 0.028	1.777LysGlu: 1.777 ± 0.027	0.663LysPhe: 0.663 ± 0.016	2.584LysGly: 2.584 ± 0.035	0.555LysHis: 0.555 ± 0.014	0.822LysIle: 0.822 ± 0.019	1.379LysLys: 1.379 ± 0.03	3.069LysLeu: 3.069 ± 0.037	0.635LysMet: 0.635 ± 0.015	0.825LysAsn: 0.825 ± 0.016	1.965LysPro: 1.965 ± 0.031	1.041LysGln: 1.041 ± 0.02	2.164LysArg: 2.164 ± 0.031	1.543LysSer: 1.543 ± 0.026	1.638LysThr: 1.638 ± 0.024	2.438LysVal: 2.438 ± 0.038	0.347LysTrp: 0.347 ± 0.011	0.596LysTyr: 0.596 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	13.545LeuAla: 13.545 ± 0.086	1.028LeuCys: 1.028 ± 0.02	5.803LeuAsp: 5.803 ± 0.047	7.591LeuGlu: 7.591 ± 0.07	3.63LeuPhe: 3.63 ± 0.038	9.804LeuGly: 9.804 ± 0.064	2.376LeuHis: 2.376 ± 0.03	3.105LeuIle: 3.105 ± 0.037	3.367LeuLys: 3.367 ± 0.041	12.349LeuLeu: 12.349 ± 0.102	2.054LeuMet: 2.054 ± 0.026	2.316LeuAsn: 2.316 ± 0.035	6.656LeuPro: 6.656 ± 0.059	3.325LeuGln: 3.325 ± 0.037	9.107LeuArg: 9.107 ± 0.072	7.453LeuSer: 7.453 ± 0.061	6.03LeuThr: 6.03 ± 0.047	8.737LeuVal: 8.737 ± 0.06	1.405LeuTrp: 1.405 ± 0.026	2.378LeuTyr: 2.378 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.291MetAla: 2.291 ± 0.033	0.141MetCys: 0.141 ± 0.006	1.013MetAsp: 1.013 ± 0.019	1.183MetGlu: 1.183 ± 0.021	0.435MetPhe: 0.435 ± 0.012	1.766MetGly: 1.766 ± 0.03	0.392MetHis: 0.392 ± 0.013	0.499MetIle: 0.499 ± 0.013	0.907MetLys: 0.907 ± 0.019	2.043MetLeu: 2.043 ± 0.028	0.464MetMet: 0.464 ± 0.014	0.625MetAsn: 0.625 ± 0.015	1.219MetPro: 1.219 ± 0.021	0.566MetGln: 0.566 ± 0.014	1.701MetArg: 1.701 ± 0.026	1.486MetSer: 1.486 ± 0.023	1.163MetThr: 1.163 ± 0.021	1.324MetVal: 1.324 ± 0.022	0.202MetTrp: 0.202 ± 0.008	0.284MetTyr: 0.284 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.566AsnAla: 2.566 ± 0.034	0.232AsnCys: 0.232 ± 0.01	1.072AsnAsp: 1.072 ± 0.022	1.2AsnGlu: 1.2 ± 0.023	0.733AsnPhe: 0.733 ± 0.019	2.133AsnGly: 2.133 ± 0.04	0.511AsnHis: 0.511 ± 0.014	0.865AsnIle: 0.865 ± 0.019	0.642AsnLys: 0.642 ± 0.02	2.365AsnLeu: 2.365 ± 0.029	0.368AsnMet: 0.368 ± 0.011	0.714AsnAsn: 0.714 ± 0.02	1.747AsnPro: 1.747 ± 0.027	0.792AsnGln: 0.792 ± 0.016	1.455AsnArg: 1.455 ± 0.023	1.11AsnSer: 1.11 ± 0.024	1.338AsnThr: 1.338 ± 0.025	1.755AsnVal: 1.755 ± 0.027	0.348AsnTrp: 0.348 ± 0.01	0.591AsnTyr: 0.591 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	6.576ProAla: 6.576 ± 0.071	0.392ProCys: 0.392 ± 0.012	3.283ProAsp: 3.283 ± 0.041	5.261ProGlu: 5.261 ± 0.049	1.975ProPhe: 1.975 ± 0.025	5.706ProGly: 5.706 ± 0.051	1.228ProHis: 1.228 ± 0.021	1.559ProIle: 1.559 ± 0.026	1.478ProLys: 1.478 ± 0.025	6.064ProLeu: 6.064 ± 0.051	1.197ProMet: 1.197 ± 0.019	1.192ProAsn: 1.192 ± 0.023	4.818ProPro: 4.818 ± 0.066	1.782ProGln: 1.782 ± 0.031	4.425ProArg: 4.425 ± 0.042	4.121ProSer: 4.121 ± 0.044	3.176ProThr: 3.176 ± 0.038	4.823ProVal: 4.823 ± 0.053	0.853ProTrp: 0.853 ± 0.018	1.14ProTyr: 1.14 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	4.256GlnAla: 4.256 ± 0.041	0.297GlnCys: 0.297 ± 0.01	1.575GlnAsp: 1.575 ± 0.024	2.217GlnGlu: 2.217 ± 0.032	0.874GlnPhe: 0.874 ± 0.02	3.232GlnGly: 3.232 ± 0.034	0.696GlnHis: 0.696 ± 0.014	0.823GlnIle: 0.823 ± 0.016	1.116GlnLys: 1.116 ± 0.02	3.705GlnLeu: 3.705 ± 0.039	0.683GlnMet: 0.683 ± 0.017	0.679GlnAsn: 0.679 ± 0.017	1.983GlnPro: 1.983 ± 0.035	1.311GlnGln: 1.311 ± 0.026	3.043GlnArg: 3.043 ± 0.041	1.727GlnSer: 1.727 ± 0.025	1.567GlnThr: 1.567 ± 0.023	3.304GlnVal: 3.304 ± 0.04	0.516GlnTrp: 0.516 ± 0.015	0.653GlnTyr: 0.653 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.135ArgAla: 9.135 ± 0.078	0.738ArgCys: 0.738 ± 0.018	3.83ArgAsp: 3.83 ± 0.039	6.123ArgGlu: 6.123 ± 0.059	3.184ArgPhe: 3.184 ± 0.038	5.922ArgGly: 5.922 ± 0.047	1.774ArgHis: 1.774 ± 0.027	2.948ArgIle: 2.948 ± 0.034	2.182ArgLys: 2.182 ± 0.028	9.504ArgLeu: 9.504 ± 0.073	2.077ArgMet: 2.077 ± 0.029	1.503ArgAsn: 1.503 ± 0.025	4.264ArgPro: 4.264 ± 0.042	2.843ArgGln: 2.843 ± 0.033	6.333ArgArg: 6.333 ± 0.056	3.862ArgSer: 3.862 ± 0.042	3.995ArgThr: 3.995 ± 0.038	6.697ArgVal: 6.697 ± 0.058	1.316ArgTrp: 1.316 ± 0.023	2.062ArgTyr: 2.062 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.785SerAla: 6.785 ± 0.06	0.558SerCys: 0.558 ± 0.017	2.677SerAsp: 2.677 ± 0.034	3.385SerGlu: 3.385 ± 0.04	2.262SerPhe: 2.262 ± 0.032	5.806SerGly: 5.806 ± 0.059	1.208SerHis: 1.208 ± 0.019	1.888SerIle: 1.888 ± 0.026	1.445SerLys: 1.445 ± 0.023	6.88SerLeu: 6.88 ± 0.063	1.171SerMet: 1.171 ± 0.022	1.376SerAsn: 1.376 ± 0.024	3.922SerPro: 3.922 ± 0.041	1.871SerGln: 1.871 ± 0.028	4.565SerArg: 4.565 ± 0.045	3.872SerSer: 3.872 ± 0.053	3.344SerThr: 3.344 ± 0.042	4.464SerVal: 4.464 ± 0.046	0.902SerTrp: 0.902 ± 0.017	1.244SerTyr: 1.244 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.502ThrAla: 5.502 ± 0.054	0.572ThrCys: 0.572 ± 0.022	2.419ThrAsp: 2.419 ± 0.035	2.873ThrGlu: 2.873 ± 0.03	1.993ThrPhe: 1.993 ± 0.03	5.073ThrGly: 5.073 ± 0.051	1.253ThrHis: 1.253 ± 0.021	1.362ThrIle: 1.362 ± 0.024	1.198ThrLys: 1.198 ± 0.025	6.643ThrLeu: 6.643 ± 0.052	0.742ThrMet: 0.742 ± 0.016	1.18ThrAsn: 1.18 ± 0.023	4.25ThrPro: 4.25 ± 0.035	1.966ThrGln: 1.966 ± 0.03	4.174ThrArg: 4.174 ± 0.037	3.295ThrSer: 3.295 ± 0.046	2.896ThrThr: 2.896 ± 0.04	4.408ThrVal: 4.408 ± 0.051	0.888ThrTrp: 0.888 ± 0.018	1.321ThrTyr: 1.321 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	8.557ValAla: 8.557 ± 0.067	0.776ValCys: 0.776 ± 0.019	4.366ValAsp: 4.366 ± 0.042	5.419ValGlu: 5.419 ± 0.051	2.527ValPhe: 2.527 ± 0.031	6.309ValGly: 6.309 ± 0.05	1.624ValHis: 1.624 ± 0.025	2.385ValIle: 2.385 ± 0.028	2.563ValLys: 2.563 ± 0.033	9.327ValLeu: 9.327 ± 0.066	1.528ValMet: 1.528 ± 0.026	1.8ValAsn: 1.8 ± 0.028	4.522ValPro: 4.522 ± 0.045	2.356ValGln: 2.356 ± 0.031	6.592ValArg: 6.592 ± 0.052	4.918ValSer: 4.918 ± 0.05	4.367ValThr: 4.367 ± 0.054	6.39ValVal: 6.39 ± 0.057	0.998ValTrp: 0.998 ± 0.023	1.599ValTyr: 1.599 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.318TrpAla: 1.318 ± 0.026	0.162TrpCys: 0.162 ± 0.008	0.685TrpAsp: 0.685 ± 0.02	0.79TrpGlu: 0.79 ± 0.016	0.478TrpPhe: 0.478 ± 0.014	1.118TrpGly: 1.118 ± 0.025	0.314TrpHis: 0.314 ± 0.01	0.393TrpIle: 0.393 ± 0.011	0.536TrpLys: 0.536 ± 0.015	1.704TrpLeu: 1.704 ± 0.025	0.426TrpMet: 0.426 ± 0.012	0.478TrpAsn: 0.478 ± 0.014	0.708TrpPro: 0.708 ± 0.015	0.399TrpGln: 0.399 ± 0.012	1.384TrpArg: 1.384 ± 0.024	1.014TrpSer: 1.014 ± 0.023	0.907TrpThr: 0.907 ± 0.019	1.138TrpVal: 1.138 ± 0.023	0.245TrpTrp: 0.245 ± 0.01	0.293TrpTyr: 0.293 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.317TyrAla: 2.317 ± 0.029	0.215TyrCys: 0.215 ± 0.009	1.219TyrAsp: 1.219 ± 0.025	1.341TyrGlu: 1.341 ± 0.026	0.879TyrPhe: 0.879 ± 0.016	1.863TyrGly: 1.863 ± 0.032	0.455TyrHis: 0.455 ± 0.012	0.59TyrIle: 0.59 ± 0.015	0.551TyrLys: 0.551 ± 0.014	2.381TyrLeu: 2.381 ± 0.031	0.41TyrMet: 0.41 ± 0.012	0.559TyrAsn: 0.559 ± 0.016	1.125TyrPro: 1.125 ± 0.022	0.827TyrGln: 0.827 ± 0.019	1.801TyrArg: 1.801 ± 0.025	1.315TyrSer: 1.315 ± 0.026	1.241TyrThr: 1.241 ± 0.025	1.753TyrVal: 1.753 ± 0.027	0.358TyrTrp: 0.358 ± 0.012	0.601TyrTyr: 0.601 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7973 proteins (2961835 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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