Amino acid dipepetide frequency for Dragonfly-associated microphage 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.452AlaAla: 7.452 ± 3.163
0.0AlaCys: 0.0 ± 0.0
6.706AlaAsp: 6.706 ± 1.342
2.981AlaGlu: 2.981 ± 0.932
1.49AlaPhe: 1.49 ± 1.045
4.471AlaGly: 4.471 ± 3.507
0.0AlaHis: 0.0 ± 0.0
0.745AlaIle: 0.745 ± 0.523
1.49AlaLys: 1.49 ± 0.89
12.668AlaLeu: 12.668 ± 2.345
2.235AlaMet: 2.235 ± 1.276
4.471AlaAsn: 4.471 ± 1.671
5.216AlaPro: 5.216 ± 0.679
9.687AlaGln: 9.687 ± 2.383
12.668AlaArg: 12.668 ± 2.436
3.726AlaSer: 3.726 ± 1.056
2.981AlaThr: 2.981 ± 1.055
5.216AlaVal: 5.216 ± 2.548
3.726AlaTrp: 3.726 ± 0.673
2.981AlaTyr: 2.981 ± 0.988
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.745CysPhe: 0.745 ± 0.782
1.49CysGly: 1.49 ± 1.564
0.0CysHis: 0.0 ± 0.0
0.745CysIle: 0.745 ± 0.782
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.745CysGln: 0.745 ± 0.921
1.49CysArg: 1.49 ± 1.159
0.0CysSer: 0.0 ± 0.0
0.745CysThr: 0.745 ± 0.782
0.745CysVal: 0.745 ± 0.523
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
6.706AspAla: 6.706 ± 2.85
0.0AspCys: 0.0 ± 0.0
6.706AspAsp: 6.706 ± 4.775
3.726AspGlu: 3.726 ± 2.42
2.235AspPhe: 2.235 ± 1.107
2.235AspGly: 2.235 ± 1.711
0.745AspHis: 0.745 ± 0.863
0.745AspIle: 0.745 ± 0.707
0.745AspLys: 0.745 ± 0.707
3.726AspLeu: 3.726 ± 1.362
2.235AspMet: 2.235 ± 0.941
2.235AspAsn: 2.235 ± 0.879
6.706AspPro: 6.706 ± 1.974
2.981AspGln: 2.981 ± 0.753
3.726AspArg: 3.726 ± 1.333
4.471AspSer: 4.471 ± 1.52
1.49AspThr: 1.49 ± 0.754
5.961AspVal: 5.961 ± 1.339
1.49AspTrp: 1.49 ± 1.045
2.235AspTyr: 2.235 ± 1.568
0.0AspXaa: 0.0 ± 0.0
Glu
7.452GluAla: 7.452 ± 1.396
0.0GluCys: 0.0 ± 0.0
3.726GluAsp: 3.726 ± 1.15
2.235GluGlu: 2.235 ± 0.879
5.216GluPhe: 5.216 ± 1.02
2.981GluGly: 2.981 ± 0.801
0.745GluHis: 0.745 ± 0.523
0.745GluIle: 0.745 ± 0.863
2.981GluLys: 2.981 ± 1.603
5.961GluLeu: 5.961 ± 1.339
1.49GluMet: 1.49 ± 0.721
1.49GluAsn: 1.49 ± 0.754
0.745GluPro: 0.745 ± 0.707
2.235GluGln: 2.235 ± 1.625
2.235GluArg: 2.235 ± 1.107
5.216GluSer: 5.216 ± 1.552
2.235GluThr: 2.235 ± 1.461
6.706GluVal: 6.706 ± 3.285
2.235GluTrp: 2.235 ± 1.365
4.471GluTyr: 4.471 ± 0.882
0.0GluXaa: 0.0 ± 0.0
Phe
4.471PheAla: 4.471 ± 1.248
0.745PheCys: 0.745 ± 0.921
2.235PheAsp: 2.235 ± 1.625
2.981PheGlu: 2.981 ± 1.008
0.745PhePhe: 0.745 ± 0.523
5.216PheGly: 5.216 ± 1.77
1.49PheHis: 1.49 ± 0.89
0.745PheIle: 0.745 ± 0.523
0.0PheLys: 0.0 ± 0.0
1.49PheLeu: 1.49 ± 0.683
0.745PheMet: 0.745 ± 0.453
0.0PheAsn: 0.0 ± 0.0
0.745PhePro: 0.745 ± 0.707
0.745PheGln: 0.745 ± 0.921
5.216PheArg: 5.216 ± 1.02
2.235PheSer: 2.235 ± 1.089
2.235PheThr: 2.235 ± 1.178
3.726PheVal: 3.726 ± 1.15
0.745PheTrp: 0.745 ± 0.707
0.745PheTyr: 0.745 ± 0.523
0.0PheXaa: 0.0 ± 0.0
Gly
4.471GlyAla: 4.471 ± 1.671
0.745GlyCys: 0.745 ± 0.782
7.452GlyAsp: 7.452 ± 3.133
4.471GlyGlu: 4.471 ± 1.955
2.235GlyPhe: 2.235 ± 1.05
5.216GlyGly: 5.216 ± 2.303
1.49GlyHis: 1.49 ± 1.045
5.961GlyIle: 5.961 ± 2.384
3.726GlyLys: 3.726 ± 2.022
2.981GlyLeu: 2.981 ± 1.509
0.745GlyMet: 0.745 ± 0.523
2.981GlyAsn: 2.981 ± 1.192
5.961GlyPro: 5.961 ± 2.09
4.471GlyGln: 4.471 ± 0.9
8.942GlyArg: 8.942 ± 3.358
7.452GlySer: 7.452 ± 2.307
2.981GlyThr: 2.981 ± 1.512
5.961GlyVal: 5.961 ± 2.036
0.745GlyTrp: 0.745 ± 0.782
1.49GlyTyr: 1.49 ± 0.683
0.0GlyXaa: 0.0 ± 0.0
His
0.745HisAla: 0.745 ± 0.523
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.745HisGlu: 0.745 ± 0.863
2.235HisPhe: 2.235 ± 0.667
2.981HisGly: 2.981 ± 1.008
1.49HisHis: 1.49 ± 1.045
0.0HisIle: 0.0 ± 0.0
0.0HisLys: 0.0 ± 0.0
0.745HisLeu: 0.745 ± 0.523
0.745HisMet: 0.745 ± 0.782
0.0HisAsn: 0.0 ± 0.0
1.49HisPro: 1.49 ± 0.754
1.49HisGln: 1.49 ± 0.754
2.235HisArg: 2.235 ± 1.372
1.49HisSer: 1.49 ± 1.045
0.0HisThr: 0.0 ± 0.0
0.745HisVal: 0.745 ± 0.782
0.745HisTrp: 0.745 ± 0.523
0.745HisTyr: 0.745 ± 0.523
0.0HisXaa: 0.0 ± 0.0
Ile
2.235IleAla: 2.235 ± 0.667
0.0IleCys: 0.0 ± 0.0
0.0IleAsp: 0.0 ± 0.0
1.49IleGlu: 1.49 ± 0.97
1.49IlePhe: 1.49 ± 1.045
5.216IleGly: 5.216 ± 1.797
2.235IleHis: 2.235 ± 0.931
0.745IleIle: 0.745 ± 0.782
0.0IleLys: 0.0 ± 0.0
1.49IleLeu: 1.49 ± 0.89
0.0IleMet: 0.0 ± 0.0
0.745IleAsn: 0.745 ± 0.523
0.745IlePro: 0.745 ± 0.863
0.745IleGln: 0.745 ± 0.523
5.216IleArg: 5.216 ± 1.302
1.49IleSer: 1.49 ± 0.9
0.745IleThr: 0.745 ± 0.523
1.49IleVal: 1.49 ± 0.754
1.49IleTrp: 1.49 ± 1.045
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
3.726LysAla: 3.726 ± 1.786
0.0LysCys: 0.0 ± 0.0
2.235LysAsp: 2.235 ± 1.372
3.726LysGlu: 3.726 ± 1.056
0.745LysPhe: 0.745 ± 0.863
4.471LysGly: 4.471 ± 1.236
0.745LysHis: 0.745 ± 0.523
0.745LysIle: 0.745 ± 0.782
0.745LysLys: 0.745 ± 0.782
0.745LysLeu: 0.745 ± 0.782
0.745LysMet: 0.745 ± 0.782
0.0LysAsn: 0.0 ± 0.0
0.745LysPro: 0.745 ± 0.863
0.745LysGln: 0.745 ± 0.707
5.216LysArg: 5.216 ± 1.015
2.981LysSer: 2.981 ± 0.753
0.745LysThr: 0.745 ± 0.523
1.49LysVal: 1.49 ± 1.564
0.0LysTrp: 0.0 ± 0.0
1.49LysTyr: 1.49 ± 1.413
0.0LysXaa: 0.0 ± 0.0
Leu
7.452LeuAla: 7.452 ± 1.776
1.49LeuCys: 1.49 ± 1.564
1.49LeuAsp: 1.49 ± 0.683
6.706LeuGlu: 6.706 ± 1.824
0.745LeuPhe: 0.745 ± 0.782
5.961LeuGly: 5.961 ± 1.602
0.745LeuHis: 0.745 ± 0.707
1.49LeuIle: 1.49 ± 0.844
1.49LeuLys: 1.49 ± 1.564
5.961LeuLeu: 5.961 ± 1.39
2.235LeuMet: 2.235 ± 1.171
2.981LeuAsn: 2.981 ± 1.532
8.197LeuPro: 8.197 ± 1.326
4.471LeuGln: 4.471 ± 1.399
7.452LeuArg: 7.452 ± 2.415
5.961LeuSer: 5.961 ± 2.266
4.471LeuThr: 4.471 ± 2.567
1.49LeuVal: 1.49 ± 0.683
0.745LeuTrp: 0.745 ± 0.523
0.745LeuTyr: 0.745 ± 0.707
0.0LeuXaa: 0.0 ± 0.0
Met
4.471MetAla: 4.471 ± 1.202
0.0MetCys: 0.0 ± 0.0
0.745MetAsp: 0.745 ± 0.707
0.0MetGlu: 0.0 ± 0.0
1.49MetPhe: 1.49 ± 0.9
2.235MetGly: 2.235 ± 1.107
1.49MetHis: 1.49 ± 0.683
0.0MetIle: 0.0 ± 0.0
2.235MetLys: 2.235 ± 1.107
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.745MetPro: 0.745 ± 0.707
0.0MetGln: 0.0 ± 0.0
2.235MetArg: 2.235 ± 1.404
1.49MetSer: 1.49 ± 0.683
2.235MetThr: 2.235 ± 1.52
2.981MetVal: 2.981 ± 0.753
0.745MetTrp: 0.745 ± 0.707
2.235MetTyr: 2.235 ± 0.9
0.0MetXaa: 0.0 ± 0.0
Asn
2.235AsnAla: 2.235 ± 1.089
0.745AsnCys: 0.745 ± 0.782
3.726AsnAsp: 3.726 ± 1.898
2.981AsnGlu: 2.981 ± 2.039
2.235AsnPhe: 2.235 ± 1.107
2.235AsnGly: 2.235 ± 0.667
0.0AsnHis: 0.0 ± 0.0
1.49AsnIle: 1.49 ± 1.413
2.235AsnLys: 2.235 ± 1.5
2.981AsnLeu: 2.981 ± 1.733
0.0AsnMet: 0.0 ± 0.0
1.49AsnAsn: 1.49 ± 1.045
0.745AsnPro: 0.745 ± 0.863
0.745AsnGln: 0.745 ± 0.782
0.745AsnArg: 0.745 ± 0.707
1.49AsnSer: 1.49 ± 1.045
0.745AsnThr: 0.745 ± 0.523
2.981AsnVal: 2.981 ± 1.242
0.0AsnTrp: 0.0 ± 0.0
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
5.216ProAla: 5.216 ± 2.487
0.745ProCys: 0.745 ± 0.782
4.471ProAsp: 4.471 ± 2.652
5.216ProGlu: 5.216 ± 1.651
2.235ProPhe: 2.235 ± 0.667
5.961ProGly: 5.961 ± 0.653
0.745ProHis: 0.745 ± 0.782
0.745ProIle: 0.745 ± 0.863
0.0ProLys: 0.0 ± 0.0
5.216ProLeu: 5.216 ± 1.378
0.745ProMet: 0.745 ± 0.707
1.49ProAsn: 1.49 ± 1.315
2.235ProPro: 2.235 ± 1.089
2.235ProGln: 2.235 ± 0.667
4.471ProArg: 4.471 ± 2.722
5.216ProSer: 5.216 ± 0.679
5.961ProThr: 5.961 ± 1.888
8.197ProVal: 8.197 ± 1.441
1.49ProTrp: 1.49 ± 1.045
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
3.726GlnAla: 3.726 ± 1.19
0.745GlnCys: 0.745 ± 0.782
4.471GlnAsp: 4.471 ± 1.923
5.961GlnGlu: 5.961 ± 2.244
0.745GlnPhe: 0.745 ± 0.863
2.981GlnGly: 2.981 ± 1.008
1.49GlnHis: 1.49 ± 0.97
2.235GlnIle: 2.235 ± 0.84
1.49GlnLys: 1.49 ± 0.9
1.49GlnLeu: 1.49 ± 0.9
1.49GlnMet: 1.49 ± 0.97
0.745GlnAsn: 0.745 ± 0.707
2.981GlnPro: 2.981 ± 1.435
1.49GlnGln: 1.49 ± 1.045
5.961GlnArg: 5.961 ± 0.926
2.235GlnSer: 2.235 ± 0.941
2.235GlnThr: 2.235 ± 1.365
2.235GlnVal: 2.235 ± 0.9
0.745GlnTrp: 0.745 ± 0.782
2.981GlnTyr: 2.981 ± 1.478
0.0GlnXaa: 0.0 ± 0.0
Arg
6.706ArgAla: 6.706 ± 3.34
0.0ArgCys: 0.0 ± 0.0
5.216ArgAsp: 5.216 ± 1.302
9.687ArgGlu: 9.687 ± 3.507
2.235ArgPhe: 2.235 ± 0.667
7.452ArgGly: 7.452 ± 3.273
0.745ArgHis: 0.745 ± 0.523
5.216ArgIle: 5.216 ± 1.365
4.471ArgLys: 4.471 ± 0.964
6.706ArgLeu: 6.706 ± 2.174
3.726ArgMet: 3.726 ± 0.67
1.49ArgAsn: 1.49 ± 1.159
8.197ArgPro: 8.197 ± 3.607
2.981ArgGln: 2.981 ± 1.407
13.413ArgArg: 13.413 ± 7.767
8.197ArgSer: 8.197 ± 2.629
5.961ArgThr: 5.961 ± 2.026
4.471ArgVal: 4.471 ± 1.008
2.981ArgTrp: 2.981 ± 1.657
7.452ArgTyr: 7.452 ± 2.299
0.0ArgXaa: 0.0 ± 0.0
Ser
5.216SerAla: 5.216 ± 2.203
0.0SerCys: 0.0 ± 0.0
5.216SerAsp: 5.216 ± 1.78
2.235SerGlu: 2.235 ± 0.84
1.49SerPhe: 1.49 ± 0.97
5.216SerGly: 5.216 ± 1.288
1.49SerHis: 1.49 ± 1.045
2.981SerIle: 2.981 ± 1.347
2.981SerLys: 2.981 ± 0.669
5.961SerLeu: 5.961 ± 1.602
1.49SerMet: 1.49 ± 1.045
2.981SerAsn: 2.981 ± 2.05
2.981SerPro: 2.981 ± 0.753
2.981SerGln: 2.981 ± 1.657
7.452SerArg: 7.452 ± 5.067
5.216SerSer: 5.216 ± 2.09
4.471SerThr: 4.471 ± 1.671
2.981SerVal: 2.981 ± 1.94
0.745SerTrp: 0.745 ± 0.523
2.235SerTyr: 2.235 ± 0.9
0.0SerXaa: 0.0 ± 0.0
Thr
6.706ThrAla: 6.706 ± 2.277
1.49ThrCys: 1.49 ± 0.9
2.235ThrAsp: 2.235 ± 1.404
1.49ThrGlu: 1.49 ± 1.045
2.235ThrPhe: 2.235 ± 1.148
4.471ThrGly: 4.471 ± 1.399
0.745ThrHis: 0.745 ± 0.707
2.235ThrIle: 2.235 ± 1.568
5.216ThrLys: 5.216 ± 1.674
2.981ThrLeu: 2.981 ± 1.435
1.49ThrMet: 1.49 ± 1.029
2.235ThrAsn: 2.235 ± 0.667
7.452ThrPro: 7.452 ± 1.257
1.49ThrGln: 1.49 ± 0.844
2.981ThrArg: 2.981 ± 1.242
2.981ThrSer: 2.981 ± 1.055
2.235ThrThr: 2.235 ± 0.931
0.745ThrVal: 0.745 ± 0.523
0.745ThrTrp: 0.745 ± 0.523
0.745ThrTyr: 0.745 ± 0.782
0.0ThrXaa: 0.0 ± 0.0
Val
5.216ValAla: 5.216 ± 0.679
0.0ValCys: 0.0 ± 0.0
2.981ValAsp: 2.981 ± 1.261
1.49ValGlu: 1.49 ± 1.413
2.235ValPhe: 2.235 ± 0.941
6.706ValGly: 6.706 ± 1.104
0.745ValHis: 0.745 ± 0.782
0.0ValIle: 0.0 ± 0.0
1.49ValLys: 1.49 ± 1.106
5.961ValLeu: 5.961 ± 1.984
3.726ValMet: 3.726 ± 1.381
2.981ValAsn: 2.981 ± 1.242
4.471ValPro: 4.471 ± 1.283
2.235ValGln: 2.235 ± 1.148
7.452ValArg: 7.452 ± 2.032
1.49ValSer: 1.49 ± 0.683
8.197ValThr: 8.197 ± 0.793
2.981ValVal: 2.981 ± 1.801
0.745ValTrp: 0.745 ± 0.707
2.981ValTyr: 2.981 ± 1.055
0.0ValXaa: 0.0 ± 0.0
Trp
2.981TrpAla: 2.981 ± 2.039
0.0TrpCys: 0.0 ± 0.0
0.745TrpAsp: 0.745 ± 0.782
2.235TrpGlu: 2.235 ± 1.568
0.745TrpPhe: 0.745 ± 0.523
0.745TrpGly: 0.745 ± 0.921
1.49TrpHis: 1.49 ± 1.045
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.745TrpLeu: 0.745 ± 0.921
0.745TrpMet: 0.745 ± 0.523
0.745TrpAsn: 0.745 ± 0.523
1.49TrpPro: 1.49 ± 1.045
1.49TrpGln: 1.49 ± 0.754
2.235TrpArg: 2.235 ± 2.12
2.235TrpSer: 2.235 ± 0.941
1.49TrpThr: 1.49 ± 0.683
0.745TrpVal: 0.745 ± 0.523
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.726TyrAla: 3.726 ± 1.799
0.0TyrCys: 0.0 ± 0.0
0.745TyrAsp: 0.745 ± 0.863
0.745TyrGlu: 0.745 ± 0.523
3.726TyrPhe: 3.726 ± 1.19
2.235TyrGly: 2.235 ± 0.667
0.0TyrHis: 0.0 ± 0.0
0.0TyrIle: 0.0 ± 0.0
0.745TyrLys: 0.745 ± 0.782
5.216TyrLeu: 5.216 ± 2.203
0.0TyrMet: 0.0 ± 0.0
0.745TyrAsn: 0.745 ± 0.523
0.745TyrPro: 0.745 ± 0.782
4.471TyrGln: 4.471 ± 1.785
5.961TyrArg: 5.961 ± 2.231
0.745TyrSer: 0.745 ± 0.921
0.745TyrThr: 0.745 ± 0.523
2.235TyrVal: 2.235 ± 0.941
0.745TyrTrp: 0.745 ± 0.523
0.745TyrTyr: 0.745 ± 0.782
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1343 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski