Amino acid dipepetide frequency for Hoeflea phototrophica (strain DSM 17068 / NCIMB 14078 / DFL-43)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.45AlaAla: 15.45 ± 0.146	1.007AlaCys: 1.007 ± 0.032	6.879AlaAsp: 6.879 ± 0.089	7.472AlaGlu: 7.472 ± 0.094	4.441AlaPhe: 4.441 ± 0.06	10.609AlaGly: 10.609 ± 0.119	2.253AlaHis: 2.253 ± 0.045	6.755AlaIle: 6.755 ± 0.075	4.144AlaLys: 4.144 ± 0.067	12.448AlaLeu: 12.448 ± 0.116	3.751AlaMet: 3.751 ± 0.056	3.144AlaAsn: 3.144 ± 0.046	4.955AlaPro: 4.955 ± 0.079	3.84AlaGln: 3.84 ± 0.064	7.963AlaArg: 7.963 ± 0.078	6.683AlaSer: 6.683 ± 0.092	5.636AlaThr: 5.636 ± 0.069	8.159AlaVal: 8.159 ± 0.08	1.417AlaTrp: 1.417 ± 0.035	2.491AlaTyr: 2.491 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.976CysAla: 0.976 ± 0.029	0.116CysCys: 0.116 ± 0.009	0.595CysAsp: 0.595 ± 0.02	0.498CysGlu: 0.498 ± 0.019	0.377CysPhe: 0.377 ± 0.018	0.948CysGly: 0.948 ± 0.03	0.242CysHis: 0.242 ± 0.014	0.403CysIle: 0.403 ± 0.02	0.235CysLys: 0.235 ± 0.015	0.848CysLeu: 0.848 ± 0.027	0.191CysMet: 0.191 ± 0.013	0.248CysAsn: 0.248 ± 0.015	0.449CysPro: 0.449 ± 0.019	0.236CysGln: 0.236 ± 0.013	0.576CysArg: 0.576 ± 0.018	0.475CysSer: 0.475 ± 0.019	0.385CysThr: 0.385 ± 0.019	0.614CysVal: 0.614 ± 0.02	0.113CysTrp: 0.113 ± 0.009	0.21CysTyr: 0.21 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.741AspAla: 6.741 ± 0.085	0.557AspCys: 0.557 ± 0.017	3.262AspAsp: 3.262 ± 0.063	3.589AspGlu: 3.589 ± 0.054	2.417AspPhe: 2.417 ± 0.047	5.308AspGly: 5.308 ± 0.063	1.367AspHis: 1.367 ± 0.034	3.434AspIle: 3.434 ± 0.061	1.884AspLys: 1.884 ± 0.046	5.943AspLeu: 5.943 ± 0.063	1.701AspMet: 1.701 ± 0.033	1.513AspAsn: 1.513 ± 0.03	3.485AspPro: 3.485 ± 0.058	2.024AspGln: 2.024 ± 0.04	4.118AspArg: 4.118 ± 0.065	2.407AspSer: 2.407 ± 0.048	2.788AspThr: 2.788 ± 0.058	4.196AspVal: 4.196 ± 0.069	1.017AspTrp: 1.017 ± 0.025	1.527AspTyr: 1.527 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	7.766GluAla: 7.766 ± 0.081	0.401GluCys: 0.401 ± 0.018	3.137GluAsp: 3.137 ± 0.053	3.288GluGlu: 3.288 ± 0.063	1.981GluPhe: 1.981 ± 0.038	4.322GluGly: 4.322 ± 0.059	1.206GluHis: 1.206 ± 0.033	4.032GluIle: 4.032 ± 0.054	2.33GluLys: 2.33 ± 0.045	5.531GluLeu: 5.531 ± 0.073	1.737GluMet: 1.737 ± 0.038	1.912GluAsn: 1.912 ± 0.043	2.748GluPro: 2.748 ± 0.055	2.029GluGln: 2.029 ± 0.041	4.515GluArg: 4.515 ± 0.077	2.673GluSer: 2.673 ± 0.043	4.048GluThr: 4.048 ± 0.058	3.792GluVal: 3.792 ± 0.059	0.692GluTrp: 0.692 ± 0.023	0.982GluTyr: 0.982 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.702PheAla: 4.702 ± 0.057	0.468PheCys: 0.468 ± 0.018	2.854PheAsp: 2.854 ± 0.05	2.429PheGlu: 2.429 ± 0.043	1.552PhePhe: 1.552 ± 0.038	3.827PheGly: 3.827 ± 0.061	0.764PheHis: 0.764 ± 0.025	1.904PheIle: 1.904 ± 0.041	1.18PheLys: 1.18 ± 0.036	3.473PheLeu: 3.473 ± 0.055	0.969PheMet: 0.969 ± 0.03	1.18PheAsn: 1.18 ± 0.031	1.577PhePro: 1.577 ± 0.035	1.006PheGln: 1.006 ± 0.029	2.128PheArg: 2.128 ± 0.041	2.477PheSer: 2.477 ± 0.04	1.955PheThr: 1.955 ± 0.043	2.824PheVal: 2.824 ± 0.048	0.566PheTrp: 0.566 ± 0.022	0.919PheTyr: 0.919 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	8.933GlyAla: 8.933 ± 0.097	0.887GlyCys: 0.887 ± 0.029	4.632GlyAsp: 4.632 ± 0.06	5.112GlyGlu: 5.112 ± 0.063	3.978GlyPhe: 3.978 ± 0.063	7.153GlyGly: 7.153 ± 0.101	1.984GlyHis: 1.984 ± 0.035	4.864GlyIle: 4.864 ± 0.071	3.57GlyLys: 3.57 ± 0.057	9.008GlyLeu: 9.008 ± 0.096	2.506GlyMet: 2.506 ± 0.042	2.307GlyAsn: 2.307 ± 0.042	3.333GlyPro: 3.333 ± 0.051	2.966GlyGln: 2.966 ± 0.053	5.403GlyArg: 5.403 ± 0.063	4.89GlySer: 4.89 ± 0.056	4.294GlyThr: 4.294 ± 0.064	6.321GlyVal: 6.321 ± 0.07	1.266GlyTrp: 1.266 ± 0.035	2.326GlyTyr: 2.326 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.282HisAla: 2.282 ± 0.042	0.243HisCys: 0.243 ± 0.015	1.226HisAsp: 1.226 ± 0.033	1.101HisGlu: 1.101 ± 0.029	0.879HisPhe: 0.879 ± 0.025	1.946HisGly: 1.946 ± 0.044	0.566HisHis: 0.566 ± 0.024	1.017HisIle: 1.017 ± 0.029	0.58HisLys: 0.58 ± 0.024	2.018HisLeu: 2.018 ± 0.041	0.531HisMet: 0.531 ± 0.019	0.495HisAsn: 0.495 ± 0.021	1.264HisPro: 1.264 ± 0.031	0.622HisGln: 0.622 ± 0.023	1.263HisArg: 1.263 ± 0.032	1.069HisSer: 1.069 ± 0.029	0.888HisThr: 0.888 ± 0.029	1.533HisVal: 1.533 ± 0.032	0.3HisTrp: 0.3 ± 0.014	0.585HisTyr: 0.585 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.685IleAla: 7.685 ± 0.087	0.594IleCys: 0.594 ± 0.022	3.988IleAsp: 3.988 ± 0.06	3.964IleGlu: 3.964 ± 0.052	1.815IlePhe: 1.815 ± 0.04	5.282IleGly: 5.282 ± 0.071	1.004IleHis: 1.004 ± 0.025	2.809IleIle: 2.809 ± 0.05	1.79IleLys: 1.79 ± 0.037	4.687IleLeu: 4.687 ± 0.071	1.247IleMet: 1.247 ± 0.034	1.734IleAsn: 1.734 ± 0.042	2.412IlePro: 2.412 ± 0.044	1.276IleGln: 1.276 ± 0.032	3.397IleArg: 3.397 ± 0.065	3.505IleSer: 3.505 ± 0.051	2.981IleThr: 2.981 ± 0.041	4.207IleVal: 4.207 ± 0.069	0.698IleTrp: 0.698 ± 0.024	1.203IleTyr: 1.203 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.471LysAla: 4.471 ± 0.061	0.175LysCys: 0.175 ± 0.011	1.87LysAsp: 1.87 ± 0.044	1.509LysGlu: 1.509 ± 0.035	0.929LysPhe: 0.929 ± 0.028	2.758LysGly: 2.758 ± 0.05	0.732LysHis: 0.732 ± 0.024	1.975LysIle: 1.975 ± 0.047	1.371LysLys: 1.371 ± 0.039	3.388LysLeu: 3.388 ± 0.056	0.912LysMet: 0.912 ± 0.03	0.913LysAsn: 0.913 ± 0.031	2.368LysPro: 2.368 ± 0.046	1.176LysGln: 1.176 ± 0.032	2.487LysArg: 2.487 ± 0.05	2.238LysSer: 2.238 ± 0.041	2.309LysThr: 2.309 ± 0.047	2.44LysVal: 2.44 ± 0.043	0.417LysTrp: 0.417 ± 0.019	0.635LysTyr: 0.635 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	12.485LeuAla: 12.485 ± 0.124	0.882LeuCys: 0.882 ± 0.024	5.87LeuAsp: 5.87 ± 0.066	5.8LeuGlu: 5.8 ± 0.08	3.614LeuPhe: 3.614 ± 0.057	7.986LeuGly: 7.986 ± 0.09	1.63LeuHis: 1.63 ± 0.034	5.567LeuIle: 5.567 ± 0.068	3.92LeuLys: 3.92 ± 0.066	8.44LeuLeu: 8.44 ± 0.103	2.573LeuMet: 2.573 ± 0.042	2.815LeuAsn: 2.815 ± 0.049	5.112LeuPro: 5.112 ± 0.07	2.434LeuGln: 2.434 ± 0.051	5.758LeuArg: 5.758 ± 0.072	6.883LeuSer: 6.883 ± 0.077	5.378LeuThr: 5.378 ± 0.065	7.257LeuVal: 7.257 ± 0.087	1.074LeuTrp: 1.074 ± 0.033	2.019LeuTyr: 2.019 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.541MetAla: 3.541 ± 0.052	0.184MetCys: 0.184 ± 0.012	1.372MetAsp: 1.372 ± 0.042	1.332MetGlu: 1.332 ± 0.033	0.866MetPhe: 0.866 ± 0.029	2.039MetGly: 2.039 ± 0.042	0.493MetHis: 0.493 ± 0.018	1.729MetIle: 1.729 ± 0.04	1.114MetLys: 1.114 ± 0.031	2.649MetLeu: 2.649 ± 0.043	0.826MetMet: 0.826 ± 0.028	0.951MetAsn: 0.951 ± 0.027	1.507MetPro: 1.507 ± 0.035	0.9MetGln: 0.9 ± 0.027	1.891MetArg: 1.891 ± 0.038	1.908MetSer: 1.908 ± 0.035	1.94MetThr: 1.94 ± 0.039	1.968MetVal: 1.968 ± 0.039	0.22MetTrp: 0.22 ± 0.013	0.345MetTyr: 0.345 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.364AsnAla: 3.364 ± 0.06	0.266AsnCys: 0.266 ± 0.013	1.525AsnAsp: 1.525 ± 0.04	1.435AsnGlu: 1.435 ± 0.037	0.983AsnPhe: 0.983 ± 0.033	2.668AsnGly: 2.668 ± 0.052	0.59AsnHis: 0.59 ± 0.022	1.489AsnIle: 1.489 ± 0.036	0.81AsnLys: 0.81 ± 0.03	2.621AsnLeu: 2.621 ± 0.043	0.741AsnMet: 0.741 ± 0.022	0.785AsnAsn: 0.785 ± 0.024	1.989AsnPro: 1.989 ± 0.045	0.951AsnGln: 0.951 ± 0.027	2.051AsnArg: 2.051 ± 0.041	1.516AsnSer: 1.516 ± 0.031	1.347AsnThr: 1.347 ± 0.032	2.019AsnVal: 2.019 ± 0.044	0.458AsnTrp: 0.458 ± 0.019	0.696AsnTyr: 0.696 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.626ProAla: 5.626 ± 0.079	0.314ProCys: 0.314 ± 0.016	3.907ProAsp: 3.907 ± 0.064	3.757ProGlu: 3.757 ± 0.065	1.984ProPhe: 1.984 ± 0.04	4.541ProGly: 4.541 ± 0.061	1.029ProHis: 1.029 ± 0.03	2.163ProIle: 2.163 ± 0.044	1.687ProLys: 1.687 ± 0.04	4.454ProLeu: 4.454 ± 0.063	1.193ProMet: 1.193 ± 0.031	1.292ProAsn: 1.292 ± 0.033	2.007ProPro: 2.007 ± 0.047	1.547ProGln: 1.547 ± 0.034	2.469ProArg: 2.469 ± 0.041	2.779ProSer: 2.779 ± 0.05	2.151ProThr: 2.151 ± 0.04	4.354ProVal: 4.354 ± 0.064	0.646ProTrp: 0.646 ± 0.025	1.128ProTyr: 1.128 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.028GlnAla: 4.028 ± 0.057	0.239GlnCys: 0.239 ± 0.013	1.503GlnAsp: 1.503 ± 0.04	1.448GlnGlu: 1.448 ± 0.037	1.144GlnPhe: 1.144 ± 0.029	2.257GlnGly: 2.257 ± 0.048	0.561GlnHis: 0.561 ± 0.02	1.988GlnIle: 1.988 ± 0.042	1.091GlnLys: 1.091 ± 0.031	2.814GlnLeu: 2.814 ± 0.051	1.061GlnMet: 1.061 ± 0.032	0.904GlnAsn: 0.904 ± 0.027	1.61GlnPro: 1.61 ± 0.038	1.075GlnGln: 1.075 ± 0.037	2.068GlnArg: 2.068 ± 0.045	2.063GlnSer: 2.063 ± 0.044	1.95GlnThr: 1.95 ± 0.035	2.173GlnVal: 2.173 ± 0.04	0.405GlnTrp: 0.405 ± 0.017	0.532GlnTyr: 0.532 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.017ArgAla: 7.017 ± 0.078	0.454ArgCys: 0.454 ± 0.02	3.875ArgAsp: 3.875 ± 0.056	3.842ArgGlu: 3.842 ± 0.061	2.894ArgPhe: 2.894 ± 0.048	4.328ArgGly: 4.328 ± 0.061	1.537ArgHis: 1.537 ± 0.033	4.041ArgIle: 4.041 ± 0.062	2.528ArgLys: 2.528 ± 0.046	7.139ArgLeu: 7.139 ± 0.08	1.921ArgMet: 1.921 ± 0.039	1.919ArgAsn: 1.919 ± 0.039	3.129ArgPro: 3.129 ± 0.046	2.322ArgGln: 2.322 ± 0.042	4.5ArgArg: 4.5 ± 0.072	3.614ArgSer: 3.614 ± 0.056	3.213ArgThr: 3.213 ± 0.047	4.196ArgVal: 4.196 ± 0.055	0.77ArgTrp: 0.77 ± 0.024	1.581ArgTyr: 1.581 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.495SerAla: 6.495 ± 0.087	0.461SerCys: 0.461 ± 0.021	3.527SerAsp: 3.527 ± 0.071	3.392SerGlu: 3.392 ± 0.054	2.449SerPhe: 2.449 ± 0.046	6.19SerGly: 6.19 ± 0.07	1.219SerHis: 1.219 ± 0.03	3.177SerIle: 3.177 ± 0.048	1.946SerLys: 1.946 ± 0.041	5.542SerLeu: 5.542 ± 0.06	1.615SerMet: 1.615 ± 0.037	1.687SerAsn: 1.687 ± 0.048	2.689SerPro: 2.689 ± 0.05	1.861SerGln: 1.861 ± 0.038	3.755SerArg: 3.755 ± 0.05	3.308SerSer: 3.308 ± 0.06	2.801SerThr: 2.801 ± 0.051	4.313SerVal: 4.313 ± 0.054	0.772SerTrp: 0.772 ± 0.024	1.391SerTyr: 1.391 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.019ThrAla: 6.019 ± 0.078	0.457ThrCys: 0.457 ± 0.02	2.942ThrAsp: 2.942 ± 0.055	2.82ThrGlu: 2.82 ± 0.047	1.834ThrPhe: 1.834 ± 0.039	5.427ThrGly: 5.427 ± 0.068	1.038ThrHis: 1.038 ± 0.03	2.989ThrIle: 2.989 ± 0.057	1.523ThrLys: 1.523 ± 0.038	5.503ThrLeu: 5.503 ± 0.062	1.391ThrMet: 1.391 ± 0.038	1.372ThrAsn: 1.372 ± 0.037	3.108ThrPro: 3.108 ± 0.054	1.433ThrGln: 1.433 ± 0.031	3.252ThrArg: 3.252 ± 0.051	3.022ThrSer: 3.022 ± 0.053	2.716ThrThr: 2.716 ± 0.048	4.229ThrVal: 4.229 ± 0.061	0.654ThrTrp: 0.654 ± 0.026	1.159ThrTyr: 1.159 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.478ValAla: 8.478 ± 0.097	0.645ValCys: 0.645 ± 0.023	4.132ValAsp: 4.132 ± 0.061	4.532ValGlu: 4.532 ± 0.07	3.083ValPhe: 3.083 ± 0.05	5.176ValGly: 5.176 ± 0.068	1.386ValHis: 1.386 ± 0.036	4.355ValIle: 4.355 ± 0.064	2.225ValLys: 2.225 ± 0.045	7.21ValLeu: 7.21 ± 0.085	2.035ValMet: 2.035 ± 0.043	2.096ValAsn: 2.096 ± 0.046	3.49ValPro: 3.49 ± 0.052	1.894ValGln: 1.894 ± 0.039	4.604ValArg: 4.604 ± 0.069	4.934ValSer: 4.934 ± 0.058	4.338ValThr: 4.338 ± 0.072	5.438ValVal: 5.438 ± 0.078	0.879ValTrp: 0.879 ± 0.026	1.44ValTyr: 1.44 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.167TrpAla: 1.167 ± 0.029	0.127TrpCys: 0.127 ± 0.011	0.688TrpAsp: 0.688 ± 0.024	0.572TrpGlu: 0.572 ± 0.02	0.574TrpPhe: 0.574 ± 0.022	0.845TrpGly: 0.845 ± 0.024	0.317TrpHis: 0.317 ± 0.015	0.645TrpIle: 0.645 ± 0.024	0.482TrpLys: 0.482 ± 0.019	1.548TrpLeu: 1.548 ± 0.037	0.38TrpMet: 0.38 ± 0.018	0.442TrpAsn: 0.442 ± 0.02	0.701TrpPro: 0.701 ± 0.022	0.542TrpGln: 0.542 ± 0.021	1.032TrpArg: 1.032 ± 0.03	0.86TrpSer: 0.86 ± 0.023	0.692TrpThr: 0.692 ± 0.023	0.794TrpVal: 0.794 ± 0.023	0.213TrpTrp: 0.213 ± 0.014	0.294TrpTyr: 0.294 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.272TyrAla: 2.272 ± 0.046	0.258TyrCys: 0.258 ± 0.015	1.493TyrAsp: 1.493 ± 0.04	1.23TyrGlu: 1.23 ± 0.035	0.961TyrPhe: 0.961 ± 0.03	2.122TyrGly: 2.122 ± 0.047	0.489TyrHis: 0.489 ± 0.018	0.94TyrIle: 0.94 ± 0.025	0.663TyrLys: 0.663 ± 0.022	2.232TyrLeu: 2.232 ± 0.035	0.492TyrMet: 0.492 ± 0.02	0.594TyrAsn: 0.594 ± 0.022	1.097TyrPro: 1.097 ± 0.031	0.783TyrGln: 0.783 ± 0.025	1.589TyrArg: 1.589 ± 0.034	1.289TyrSer: 1.289 ± 0.039	1.076TyrThr: 1.076 ± 0.029	1.546TyrVal: 1.546 ± 0.033	0.338TyrTrp: 0.338 ± 0.017	0.557TyrTyr: 0.557 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4185 proteins (1320306 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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