Amino acid dipepetide frequency for Ikoma lyssavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.393AlaAla: 1.393 ± 0.922
0.836AlaCys: 0.836 ± 0.623
1.671AlaAsp: 1.671 ± 0.537
2.786AlaGlu: 2.786 ± 0.611
1.393AlaPhe: 1.393 ± 0.29
2.228AlaGly: 2.228 ± 1.303
0.836AlaHis: 0.836 ± 0.7
3.064AlaIle: 3.064 ± 1.194
2.228AlaLys: 2.228 ± 0.539
3.621AlaLeu: 3.621 ± 1.259
0.836AlaMet: 0.836 ± 0.627
2.228AlaAsn: 2.228 ± 0.938
1.114AlaPro: 1.114 ± 1.151
2.228AlaGln: 2.228 ± 0.466
2.507AlaArg: 2.507 ± 0.444
2.507AlaSer: 2.507 ± 0.398
1.671AlaThr: 1.671 ± 1.086
1.95AlaVal: 1.95 ± 0.549
0.557AlaTrp: 0.557 ± 0.303
1.114AlaTyr: 1.114 ± 0.776
0.0AlaXaa: 0.0 ± 0.0
Cys
1.114CysAla: 1.114 ± 0.601
0.557CysCys: 0.557 ± 0.338
1.114CysAsp: 1.114 ± 0.311
0.836CysGlu: 0.836 ± 0.888
0.279CysPhe: 0.279 ± 0.152
1.114CysGly: 1.114 ± 0.566
0.557CysHis: 0.557 ± 0.728
1.393CysIle: 1.393 ± 1.04
1.114CysLys: 1.114 ± 0.541
1.95CysLeu: 1.95 ± 0.468
0.0CysMet: 0.0 ± 0.0
0.836CysAsn: 0.836 ± 0.648
1.671CysPro: 1.671 ± 0.333
0.557CysGln: 0.557 ± 0.531
0.836CysArg: 0.836 ± 0.256
2.507CysSer: 2.507 ± 0.347
0.557CysThr: 0.557 ± 0.528
0.279CysVal: 0.279 ± 0.152
0.279CysTrp: 0.279 ± 0.152
0.836CysTyr: 0.836 ± 0.41
0.0CysXaa: 0.0 ± 0.0
Asp
1.393AspAla: 1.393 ± 0.406
1.114AspCys: 1.114 ± 0.321
4.457AspAsp: 4.457 ± 2.455
2.507AspGlu: 2.507 ± 0.714
2.786AspPhe: 2.786 ± 0.843
3.343AspGly: 3.343 ± 0.999
1.114AspHis: 1.114 ± 0.321
5.85AspIle: 5.85 ± 2.219
2.786AspLys: 2.786 ± 0.779
5.571AspLeu: 5.571 ± 1.029
1.671AspMet: 1.671 ± 0.525
2.786AspAsn: 2.786 ± 1.135
4.735AspPro: 4.735 ± 0.837
2.507AspGln: 2.507 ± 0.73
2.228AspArg: 2.228 ± 0.681
4.735AspSer: 4.735 ± 0.782
1.393AspThr: 1.393 ± 0.664
2.228AspVal: 2.228 ± 0.944
1.114AspTrp: 1.114 ± 0.601
1.95AspTyr: 1.95 ± 0.826
0.0AspXaa: 0.0 ± 0.0
Glu
2.507GluAla: 2.507 ± 0.941
1.114GluCys: 1.114 ± 0.311
6.128GluAsp: 6.128 ± 2.84
6.964GluGlu: 6.964 ± 3.141
3.9GluPhe: 3.9 ± 1.147
6.685GluGly: 6.685 ± 2.096
1.114GluHis: 1.114 ± 0.673
2.786GluIle: 2.786 ± 0.69
3.064GluLys: 3.064 ± 1.09
5.571GluLeu: 5.571 ± 0.921
2.507GluMet: 2.507 ± 1.033
1.114GluAsn: 1.114 ± 0.726
1.393GluPro: 1.393 ± 0.758
1.393GluGln: 1.393 ± 0.987
3.064GluArg: 3.064 ± 0.805
6.407GluSer: 6.407 ± 1.231
2.228GluThr: 2.228 ± 0.999
3.343GluVal: 3.343 ± 0.902
1.393GluTrp: 1.393 ± 0.351
1.95GluTyr: 1.95 ± 0.784
0.0GluXaa: 0.0 ± 0.0
Phe
1.393PheAla: 1.393 ± 0.824
0.836PheCys: 0.836 ± 0.884
1.95PheAsp: 1.95 ± 1.061
2.786PheGlu: 2.786 ± 1.143
2.786PhePhe: 2.786 ± 1.135
0.836PheGly: 0.836 ± 0.33
1.95PheHis: 1.95 ± 0.428
1.393PheIle: 1.393 ± 0.417
3.343PheLys: 3.343 ± 0.969
6.407PheLeu: 6.407 ± 1.473
1.114PheMet: 1.114 ± 0.329
2.786PheAsn: 2.786 ± 0.825
2.786PhePro: 2.786 ± 0.614
2.507PheGln: 2.507 ± 1.265
4.457PheArg: 4.457 ± 1.631
4.178PheSer: 4.178 ± 0.863
1.114PheThr: 1.114 ± 0.321
3.343PheVal: 3.343 ± 0.636
0.836PheTrp: 0.836 ± 0.623
0.836PheTyr: 0.836 ± 0.455
0.0PheXaa: 0.0 ± 0.0
Gly
2.507GlyAla: 2.507 ± 0.444
1.114GlyCys: 1.114 ± 0.321
2.507GlyAsp: 2.507 ± 0.545
2.786GlyGlu: 2.786 ± 2.028
1.95GlyPhe: 1.95 ± 0.866
3.064GlyGly: 3.064 ± 0.966
1.114GlyHis: 1.114 ± 0.701
4.178GlyIle: 4.178 ± 1.982
2.786GlyLys: 2.786 ± 0.918
8.357GlyLeu: 8.357 ± 0.816
0.557GlyMet: 0.557 ± 0.531
3.621GlyAsn: 3.621 ± 1.042
2.507GlyPro: 2.507 ± 0.819
2.507GlyGln: 2.507 ± 0.99
3.064GlyArg: 3.064 ± 0.414
4.457GlySer: 4.457 ± 1.357
3.343GlyThr: 3.343 ± 1.113
2.228GlyVal: 2.228 ± 0.985
0.279GlyTrp: 0.279 ± 0.152
3.343GlyTyr: 3.343 ± 1.142
0.0GlyXaa: 0.0 ± 0.0
His
0.836HisAla: 0.836 ± 0.33
0.279HisCys: 0.279 ± 0.152
0.836HisAsp: 0.836 ± 0.455
1.393HisGlu: 1.393 ± 0.382
1.671HisPhe: 1.671 ± 0.65
0.557HisGly: 0.557 ± 0.303
0.836HisHis: 0.836 ± 0.627
2.507HisIle: 2.507 ± 0.991
1.114HisLys: 1.114 ± 0.601
3.064HisLeu: 3.064 ± 1.255
0.557HisMet: 0.557 ± 0.301
0.279HisAsn: 0.279 ± 0.152
2.228HisPro: 2.228 ± 0.622
1.114HisGln: 1.114 ± 0.531
1.393HisArg: 1.393 ± 0.758
2.228HisSer: 2.228 ± 0.466
0.557HisThr: 0.557 ± 0.528
0.836HisVal: 0.836 ± 0.455
0.836HisTrp: 0.836 ± 0.455
1.114HisTyr: 1.114 ± 0.566
0.0HisXaa: 0.0 ± 0.0
Ile
2.228IleAla: 2.228 ± 0.629
1.95IleCys: 1.95 ± 0.614
5.014IleAsp: 5.014 ± 1.062
3.621IleGlu: 3.621 ± 0.759
2.786IlePhe: 2.786 ± 0.53
3.621IleGly: 3.621 ± 1.009
1.114IleHis: 1.114 ± 0.417
5.85IleIle: 5.85 ± 0.936
3.9IleLys: 3.9 ± 1.007
7.799IleLeu: 7.799 ± 1.747
1.393IleMet: 1.393 ± 0.382
2.786IleAsn: 2.786 ± 1.731
4.457IlePro: 4.457 ± 1.535
1.671IleGln: 1.671 ± 0.634
5.292IleArg: 5.292 ± 0.437
5.85IleSer: 5.85 ± 1.587
3.9IleThr: 3.9 ± 1.372
2.786IleVal: 2.786 ± 1.657
1.671IleTrp: 1.671 ± 0.583
1.671IleTyr: 1.671 ± 0.545
0.0IleXaa: 0.0 ± 0.0
Lys
1.114LysAla: 1.114 ± 0.417
0.836LysCys: 0.836 ± 0.648
3.621LysAsp: 3.621 ± 0.827
3.9LysGlu: 3.9 ± 0.172
1.114LysPhe: 1.114 ± 1.073
2.786LysGly: 2.786 ± 0.911
0.836LysHis: 0.836 ± 0.458
5.571LysIle: 5.571 ± 1.423
5.292LysLys: 5.292 ± 1.151
5.571LysLeu: 5.571 ± 1.525
3.064LysMet: 3.064 ± 0.547
1.393LysAsn: 1.393 ± 0.825
2.786LysPro: 2.786 ± 0.699
2.228LysGln: 2.228 ± 1.139
3.343LysArg: 3.343 ± 1.424
6.407LysSer: 6.407 ± 1.522
3.9LysThr: 3.9 ± 0.832
4.457LysVal: 4.457 ± 1.067
1.114LysTrp: 1.114 ± 0.311
1.393LysTyr: 1.393 ± 0.406
0.0LysXaa: 0.0 ± 0.0
Leu
3.9LeuAla: 3.9 ± 1.603
1.671LeuCys: 1.671 ± 0.664
5.85LeuAsp: 5.85 ± 0.779
6.685LeuGlu: 6.685 ± 0.79
3.9LeuPhe: 3.9 ± 1.098
4.178LeuGly: 4.178 ± 0.797
1.393LeuHis: 1.393 ± 0.552
7.242LeuIle: 7.242 ± 1.348
7.242LeuLys: 7.242 ± 1.1
8.635LeuLeu: 8.635 ± 1.376
3.9LeuMet: 3.9 ± 0.346
3.621LeuAsn: 3.621 ± 1.052
2.228LeuPro: 2.228 ± 0.784
3.343LeuGln: 3.343 ± 0.841
8.914LeuArg: 8.914 ± 1.192
12.535LeuSer: 12.535 ± 1.618
5.292LeuThr: 5.292 ± 0.889
7.242LeuVal: 7.242 ± 0.371
1.114LeuTrp: 1.114 ± 0.441
5.014LeuTyr: 5.014 ± 1.22
0.0LeuXaa: 0.0 ± 0.0
Met
1.393MetAla: 1.393 ± 0.661
0.836MetCys: 0.836 ± 0.41
1.393MetAsp: 1.393 ± 0.29
1.393MetGlu: 1.393 ± 0.797
1.671MetPhe: 1.671 ± 0.941
0.836MetGly: 0.836 ± 0.33
0.0MetHis: 0.0 ± 0.0
2.786MetIle: 2.786 ± 0.769
1.114MetLys: 1.114 ± 0.417
3.064MetLeu: 3.064 ± 0.966
1.114MetMet: 1.114 ± 0.311
1.393MetAsn: 1.393 ± 0.664
0.0MetPro: 0.0 ± 0.0
0.557MetGln: 0.557 ± 0.728
1.393MetArg: 1.393 ± 0.596
4.457MetSer: 4.457 ± 1.515
1.671MetThr: 1.671 ± 0.664
1.671MetVal: 1.671 ± 0.525
0.0MetTrp: 0.0 ± 0.0
0.279MetTyr: 0.279 ± 0.375
0.0MetXaa: 0.0 ± 0.0
Asn
1.393AsnAla: 1.393 ± 0.613
0.836AsnCys: 0.836 ± 0.57
0.836AsnAsp: 0.836 ± 0.455
2.786AsnGlu: 2.786 ± 0.566
3.621AsnPhe: 3.621 ± 0.649
1.95AsnGly: 1.95 ± 2.318
1.114AsnHis: 1.114 ± 0.321
4.178AsnIle: 4.178 ± 0.847
2.507AsnLys: 2.507 ± 0.907
5.014AsnLeu: 5.014 ± 1.801
0.836AsnMet: 0.836 ± 0.259
0.836AsnAsn: 0.836 ± 0.256
2.786AsnPro: 2.786 ± 0.569
0.836AsnGln: 0.836 ± 0.458
2.786AsnArg: 2.786 ± 0.924
4.457AsnSer: 4.457 ± 0.928
2.228AsnThr: 2.228 ± 1.026
1.95AsnVal: 1.95 ± 0.736
1.671AsnTrp: 1.671 ± 0.744
1.393AsnTyr: 1.393 ± 0.533
0.0AsnXaa: 0.0 ± 0.0
Pro
0.836ProAla: 0.836 ± 0.41
0.0ProCys: 0.0 ± 0.0
2.786ProAsp: 2.786 ± 0.683
5.85ProGlu: 5.85 ± 1.627
1.114ProPhe: 1.114 ± 0.417
2.507ProGly: 2.507 ± 1.335
1.671ProHis: 1.671 ± 0.941
3.343ProIle: 3.343 ± 0.73
1.95ProLys: 1.95 ± 1.061
5.571ProLeu: 5.571 ± 1.746
0.836ProMet: 0.836 ± 0.458
2.228ProAsn: 2.228 ± 0.815
2.228ProPro: 2.228 ± 1.103
0.279ProGln: 0.279 ± 0.152
1.671ProArg: 1.671 ± 0.545
5.292ProSer: 5.292 ± 1.44
2.228ProThr: 2.228 ± 0.833
2.228ProVal: 2.228 ± 0.579
0.557ProTrp: 0.557 ± 0.751
0.557ProTyr: 0.557 ± 0.528
0.0ProXaa: 0.0 ± 0.0
Gln
1.671GlnAla: 1.671 ± 0.692
0.836GlnCys: 0.836 ± 0.666
1.95GlnAsp: 1.95 ± 1.015
2.507GlnGlu: 2.507 ± 1.068
1.393GlnPhe: 1.393 ± 0.62
2.228GlnGly: 2.228 ± 0.581
0.557GlnHis: 0.557 ± 0.283
1.95GlnIle: 1.95 ± 1.007
2.507GlnLys: 2.507 ± 0.811
3.343GlnLeu: 3.343 ± 0.956
0.279GlnMet: 0.279 ± 0.152
1.95GlnAsn: 1.95 ± 0.624
0.279GlnPro: 0.279 ± 0.152
0.557GlnGln: 0.557 ± 0.303
2.228GlnArg: 2.228 ± 0.622
1.671GlnSer: 1.671 ± 0.489
1.95GlnThr: 1.95 ± 0.556
2.786GlnVal: 2.786 ± 0.463
0.557GlnTrp: 0.557 ± 0.531
0.836GlnTyr: 0.836 ± 0.33
0.0GlnXaa: 0.0 ± 0.0
Arg
1.95ArgAla: 1.95 ± 0.682
0.557ArgCys: 0.557 ± 0.303
3.064ArgAsp: 3.064 ± 1.03
3.9ArgGlu: 3.9 ± 0.863
3.343ArgPhe: 3.343 ± 0.795
4.178ArgGly: 4.178 ± 0.993
1.95ArgHis: 1.95 ± 0.531
2.786ArgIle: 2.786 ± 1.062
2.786ArgLys: 2.786 ± 0.757
4.178ArgLeu: 4.178 ± 0.671
2.786ArgMet: 2.786 ± 0.449
3.9ArgAsn: 3.9 ± 0.778
1.95ArgPro: 1.95 ± 0.868
2.228ArgGln: 2.228 ± 0.581
2.228ArgArg: 2.228 ± 1.024
6.407ArgSer: 6.407 ± 0.59
3.9ArgThr: 3.9 ± 0.668
4.457ArgVal: 4.457 ± 1.057
1.114ArgTrp: 1.114 ± 0.606
1.671ArgTyr: 1.671 ± 0.545
0.0ArgXaa: 0.0 ± 0.0
Ser
3.343SerAla: 3.343 ± 0.845
1.114SerCys: 1.114 ± 0.606
4.735SerAsp: 4.735 ± 0.681
7.242SerGlu: 7.242 ± 2.36
5.571SerPhe: 5.571 ± 0.658
5.014SerGly: 5.014 ± 0.656
3.064SerHis: 3.064 ± 0.854
5.292SerIle: 5.292 ± 1.277
6.128SerLys: 6.128 ± 1.091
11.978SerLeu: 11.978 ± 3.411
1.95SerMet: 1.95 ± 0.477
3.621SerAsn: 3.621 ± 1.192
4.735SerPro: 4.735 ± 0.79
3.343SerGln: 3.343 ± 0.805
7.242SerArg: 7.242 ± 0.887
7.521SerSer: 7.521 ± 2.336
3.9SerThr: 3.9 ± 1.088
5.014SerVal: 5.014 ± 0.225
2.228SerTrp: 2.228 ± 0.892
3.9SerTyr: 3.9 ± 0.821
0.0SerXaa: 0.0 ± 0.0
Thr
3.9ThrAla: 3.9 ± 1.759
1.393ThrCys: 1.393 ± 0.616
2.228ThrAsp: 2.228 ± 0.302
1.671ThrGlu: 1.671 ± 0.452
1.393ThrPhe: 1.393 ± 0.29
3.9ThrGly: 3.9 ± 1.581
2.228ThrHis: 2.228 ± 0.944
2.507ThrIle: 2.507 ± 0.786
1.671ThrLys: 1.671 ± 0.625
4.178ThrLeu: 4.178 ± 0.763
2.228ThrMet: 2.228 ± 0.766
2.228ThrAsn: 2.228 ± 0.456
1.671ThrPro: 1.671 ± 0.525
1.393ThrGln: 1.393 ± 0.758
2.786ThrArg: 2.786 ± 1.117
3.064ThrSer: 3.064 ± 1.1
3.343ThrThr: 3.343 ± 1.326
3.064ThrVal: 3.064 ± 1.13
1.671ThrTrp: 1.671 ± 0.489
2.786ThrTyr: 2.786 ± 0.579
0.0ThrXaa: 0.0 ± 0.0
Val
1.671ValAla: 1.671 ± 0.66
1.95ValCys: 1.95 ± 0.57
3.343ValAsp: 3.343 ± 0.587
1.671ValGlu: 1.671 ± 0.716
4.178ValPhe: 4.178 ± 0.924
4.178ValGly: 4.178 ± 1.513
1.671ValHis: 1.671 ± 0.333
3.621ValIle: 3.621 ± 0.722
4.178ValLys: 4.178 ± 1.475
5.014ValLeu: 5.014 ± 1.094
0.557ValMet: 0.557 ± 0.283
2.786ValAsn: 2.786 ± 0.463
2.786ValPro: 2.786 ± 0.628
1.671ValGln: 1.671 ± 0.545
1.671ValArg: 1.671 ± 0.681
5.85ValSer: 5.85 ± 0.989
3.621ValThr: 3.621 ± 0.772
4.178ValVal: 4.178 ± 1.208
0.557ValTrp: 0.557 ± 0.303
2.507ValTyr: 2.507 ± 0.347
0.0ValXaa: 0.0 ± 0.0
Trp
1.671TrpAla: 1.671 ± 1.122
0.279TrpCys: 0.279 ± 0.583
0.557TrpAsp: 0.557 ± 0.303
1.393TrpGlu: 1.393 ± 0.493
0.557TrpPhe: 0.557 ± 0.283
1.393TrpGly: 1.393 ± 0.758
0.557TrpHis: 0.557 ± 0.303
1.95TrpIle: 1.95 ± 0.389
1.393TrpLys: 1.393 ± 0.773
1.671TrpLeu: 1.671 ± 0.512
0.0TrpMet: 0.0 ± 0.0
1.114TrpAsn: 1.114 ± 0.441
0.557TrpPro: 0.557 ± 0.338
0.0TrpGln: 0.0 ± 0.0
0.557TrpArg: 0.557 ± 0.283
1.671TrpSer: 1.671 ± 0.664
1.114TrpThr: 1.114 ± 0.726
1.114TrpVal: 1.114 ± 0.311
0.0TrpTrp: 0.0 ± 0.0
0.279TrpTyr: 0.279 ± 0.152
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.557TyrAla: 0.557 ± 0.303
0.279TyrCys: 0.279 ± 0.375
2.228TyrAsp: 2.228 ± 0.456
2.228TyrGlu: 2.228 ± 1.109
2.228TyrPhe: 2.228 ± 0.553
1.671TyrGly: 1.671 ± 0.66
0.557TyrHis: 0.557 ± 0.303
1.114TyrIle: 1.114 ± 0.311
3.621TyrLys: 3.621 ± 0.674
3.343TyrLeu: 3.343 ± 0.665
0.557TyrMet: 0.557 ± 0.301
2.507TyrAsn: 2.507 ± 0.72
0.836TyrPro: 0.836 ± 0.41
1.114TyrGln: 1.114 ± 0.441
1.671TyrArg: 1.671 ± 0.525
4.735TyrSer: 4.735 ± 1.257
1.393TyrThr: 1.393 ± 1.394
2.507TyrVal: 2.507 ± 0.606
0.279TyrTrp: 0.279 ± 0.152
0.557TyrTyr: 0.557 ± 0.303
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (3591 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski