Amino acid dipepetide frequency for Nocardioides ganghwensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.477AlaAla: 19.477 ± 0.19
0.969AlaCys: 0.969 ± 0.031
8.717AlaAsp: 8.717 ± 0.1
8.17AlaGlu: 8.17 ± 0.088
3.423AlaPhe: 3.423 ± 0.055
12.409AlaGly: 12.409 ± 0.111
2.655AlaHis: 2.655 ± 0.043
4.239AlaIle: 4.239 ± 0.057
2.221AlaLys: 2.221 ± 0.051
13.287AlaLeu: 13.287 ± 0.142
2.781AlaMet: 2.781 ± 0.046
1.87AlaAsn: 1.87 ± 0.041
6.33AlaPro: 6.33 ± 0.092
3.366AlaGln: 3.366 ± 0.049
9.865AlaArg: 9.865 ± 0.1
6.546AlaSer: 6.546 ± 0.071
7.814AlaThr: 7.814 ± 0.077
11.887AlaVal: 11.887 ± 0.111
2.192AlaTrp: 2.192 ± 0.036
2.653AlaTyr: 2.653 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.821CysAla: 0.821 ± 0.024
0.093CysCys: 0.093 ± 0.009
0.489CysAsp: 0.489 ± 0.022
0.379CysGlu: 0.379 ± 0.018
0.222CysPhe: 0.222 ± 0.013
0.814CysGly: 0.814 ± 0.023
0.17CysHis: 0.17 ± 0.011
0.187CysIle: 0.187 ± 0.012
0.091CysLys: 0.091 ± 0.008
0.681CysLeu: 0.681 ± 0.023
0.111CysMet: 0.111 ± 0.009
0.136CysAsn: 0.136 ± 0.011
0.433CysPro: 0.433 ± 0.019
0.16CysGln: 0.16 ± 0.01
0.583CysArg: 0.583 ± 0.021
0.42CysSer: 0.42 ± 0.017
0.454CysThr: 0.454 ± 0.019
0.607CysVal: 0.607 ± 0.023
0.11CysTrp: 0.11 ± 0.011
0.136CysTyr: 0.136 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
8.383AspAla: 8.383 ± 0.1
0.366AspCys: 0.366 ± 0.014
5.093AspAsp: 5.093 ± 0.064
4.765AspGlu: 4.765 ± 0.065
1.776AspPhe: 1.776 ± 0.041
6.756AspGly: 6.756 ± 0.081
1.662AspHis: 1.662 ± 0.041
1.928AspIle: 1.928 ± 0.041
1.121AspLys: 1.121 ± 0.033
7.857AspLeu: 7.857 ± 0.075
0.909AspMet: 0.909 ± 0.028
1.053AspAsn: 1.053 ± 0.03
4.699AspPro: 4.699 ± 0.064
1.744AspGln: 1.744 ± 0.039
5.226AspArg: 5.226 ± 0.072
2.606AspSer: 2.606 ± 0.043
3.05AspThr: 3.05 ± 0.048
6.544AspVal: 6.544 ± 0.071
1.041AspTrp: 1.041 ± 0.03
1.243AspTyr: 1.243 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
7.701GluAla: 7.701 ± 0.091
0.333GluCys: 0.333 ± 0.016
3.423GluAsp: 3.423 ± 0.054
3.504GluGlu: 3.504 ± 0.062
1.432GluPhe: 1.432 ± 0.035
4.406GluGly: 4.406 ± 0.06
1.762GluHis: 1.762 ± 0.034
2.273GluIle: 2.273 ± 0.042
1.264GluLys: 1.264 ± 0.036
6.536GluLeu: 6.536 ± 0.075
1.087GluMet: 1.087 ± 0.03
0.81GluAsn: 0.81 ± 0.025
3.33GluPro: 3.33 ± 0.061
2.316GluGln: 2.316 ± 0.042
5.222GluArg: 5.222 ± 0.062
2.832GluSer: 2.832 ± 0.047
2.984GluThr: 2.984 ± 0.055
6.045GluVal: 6.045 ± 0.069
0.957GluTrp: 0.957 ± 0.031
0.801GluTyr: 0.801 ± 0.022
0.0GluXaa: 0.0 ± 0.0
Phe
3.556PheAla: 3.556 ± 0.055
0.261PheCys: 0.261 ± 0.015
2.095PheAsp: 2.095 ± 0.039
1.621PheGlu: 1.621 ± 0.036
0.902PhePhe: 0.902 ± 0.026
2.934PheGly: 2.934 ± 0.051
0.596PheHis: 0.596 ± 0.021
0.796PheIle: 0.796 ± 0.027
0.441PheLys: 0.441 ± 0.019
2.513PheLeu: 2.513 ± 0.047
0.449PheMet: 0.449 ± 0.018
0.525PheAsn: 0.525 ± 0.02
1.309PhePro: 1.309 ± 0.033
0.576PheGln: 0.576 ± 0.021
1.789PheArg: 1.789 ± 0.038
1.503PheSer: 1.503 ± 0.038
1.827PheThr: 1.827 ± 0.04
2.666PheVal: 2.666 ± 0.047
0.419PheTrp: 0.419 ± 0.019
0.581PheTyr: 0.581 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
10.346GlyAla: 10.346 ± 0.093
0.814GlyCys: 0.814 ± 0.025
5.872GlyAsp: 5.872 ± 0.078
5.312GlyGlu: 5.312 ± 0.059
2.936GlyPhe: 2.936 ± 0.044
8.008GlyGly: 8.008 ± 0.1
2.13GlyHis: 2.13 ± 0.036
3.562GlyIle: 3.562 ± 0.058
2.042GlyLys: 2.042 ± 0.044
9.267GlyLeu: 9.267 ± 0.088
2.026GlyMet: 2.026 ± 0.045
1.666GlyAsn: 1.666 ± 0.046
4.55GlyPro: 4.55 ± 0.054
2.555GlyGln: 2.555 ± 0.048
7.342GlyArg: 7.342 ± 0.084
5.509GlySer: 5.509 ± 0.069
5.958GlyThr: 5.958 ± 0.075
8.093GlyVal: 8.093 ± 0.092
1.841GlyTrp: 1.841 ± 0.038
1.985GlyTyr: 1.985 ± 0.039
0.0GlyXaa: 0.0 ± 0.0
His
2.696HisAla: 2.696 ± 0.044
0.166HisCys: 0.166 ± 0.012
1.757HisAsp: 1.757 ± 0.033
1.331HisGlu: 1.331 ± 0.029
0.585HisPhe: 0.585 ± 0.02
2.292HisGly: 2.292 ± 0.043
0.787HisHis: 0.787 ± 0.024
0.485HisIle: 0.485 ± 0.017
0.302HisLys: 0.302 ± 0.016
2.572HisLeu: 2.572 ± 0.049
0.306HisMet: 0.306 ± 0.013
0.349HisAsn: 0.349 ± 0.016
1.669HisPro: 1.669 ± 0.035
0.611HisGln: 0.611 ± 0.019
1.924HisArg: 1.924 ± 0.042
0.891HisSer: 0.891 ± 0.027
1.117HisThr: 1.117 ± 0.027
2.24HisVal: 2.24 ± 0.044
0.364HisTrp: 0.364 ± 0.018
0.425HisTyr: 0.425 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
4.594IleAla: 4.594 ± 0.069
0.262IleCys: 0.262 ± 0.013
2.596IleAsp: 2.596 ± 0.042
2.231IleGlu: 2.231 ± 0.043
0.758IlePhe: 0.758 ± 0.028
3.548IleGly: 3.548 ± 0.059
0.682IleHis: 0.682 ± 0.022
0.987IleIle: 0.987 ± 0.029
0.685IleLys: 0.685 ± 0.025
2.377IleLeu: 2.377 ± 0.041
0.445IleMet: 0.445 ± 0.019
0.715IleAsn: 0.715 ± 0.025
1.65IlePro: 1.65 ± 0.042
0.672IleGln: 0.672 ± 0.023
2.112IleArg: 2.112 ± 0.041
1.779IleSer: 1.779 ± 0.037
2.191IleThr: 2.191 ± 0.044
2.94IleVal: 2.94 ± 0.049
0.397IleTrp: 0.397 ± 0.018
0.538IleTyr: 0.538 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
2.404LysAla: 2.404 ± 0.049
0.094LysCys: 0.094 ± 0.008
1.122LysAsp: 1.122 ± 0.037
0.938LysGlu: 0.938 ± 0.032
0.422LysPhe: 0.422 ± 0.018
1.545LysGly: 1.545 ± 0.041
0.366LysHis: 0.366 ± 0.017
0.686LysIle: 0.686 ± 0.027
0.723LysLys: 0.723 ± 0.035
1.489LysLeu: 1.489 ± 0.041
0.351LysMet: 0.351 ± 0.016
0.427LysAsn: 0.427 ± 0.017
1.077LysPro: 1.077 ± 0.03
0.591LysGln: 0.591 ± 0.021
1.326LysArg: 1.326 ± 0.033
0.988LysSer: 0.988 ± 0.029
1.081LysThr: 1.081 ± 0.031
1.924LysVal: 1.924 ± 0.04
0.229LysTrp: 0.229 ± 0.015
0.394LysTyr: 0.394 ± 0.017
0.0LysXaa: 0.0 ± 0.0
Leu
15.27LeuAla: 15.27 ± 0.148
0.63LeuCys: 0.63 ± 0.021
7.445LeuAsp: 7.445 ± 0.071
5.659LeuGlu: 5.659 ± 0.064
2.363LeuPhe: 2.363 ± 0.044
9.614LeuGly: 9.614 ± 0.091
2.135LeuHis: 2.135 ± 0.043
2.463LeuIle: 2.463 ± 0.054
1.608LeuLys: 1.608 ± 0.043
10.403LeuLeu: 10.403 ± 0.12
1.685LeuMet: 1.685 ± 0.036
1.472LeuAsn: 1.472 ± 0.035
5.766LeuPro: 5.766 ± 0.065
2.188LeuGln: 2.188 ± 0.04
7.821LeuArg: 7.821 ± 0.091
5.06LeuSer: 5.06 ± 0.067
6.275LeuThr: 6.275 ± 0.066
11.031LeuVal: 11.031 ± 0.098
1.25LeuTrp: 1.25 ± 0.027
1.422LeuTyr: 1.422 ± 0.031
0.0LeuXaa: 0.0 ± 0.0
Met
2.332MetAla: 2.332 ± 0.047
0.14MetCys: 0.14 ± 0.01
0.948MetAsp: 0.948 ± 0.022
0.827MetGlu: 0.827 ± 0.026
0.487MetPhe: 0.487 ± 0.018
1.429MetGly: 1.429 ± 0.033
0.361MetHis: 0.361 ± 0.016
0.595MetIle: 0.595 ± 0.022
0.444MetLys: 0.444 ± 0.021
1.822MetLeu: 1.822 ± 0.039
0.331MetMet: 0.331 ± 0.016
0.361MetAsn: 0.361 ± 0.017
1.147MetPro: 1.147 ± 0.031
0.464MetGln: 0.464 ± 0.018
1.527MetArg: 1.527 ± 0.033
1.385MetSer: 1.385 ± 0.029
1.702MetThr: 1.702 ± 0.034
1.589MetVal: 1.589 ± 0.034
0.238MetTrp: 0.238 ± 0.013
0.275MetTyr: 0.275 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.023AsnAla: 2.023 ± 0.041
0.126AsnCys: 0.126 ± 0.009
1.075AsnAsp: 1.075 ± 0.037
0.789AsnGlu: 0.789 ± 0.026
0.493AsnPhe: 0.493 ± 0.019
1.617AsnGly: 1.617 ± 0.04
0.37AsnHis: 0.37 ± 0.019
0.604AsnIle: 0.604 ± 0.024
0.345AsnLys: 0.345 ± 0.017
1.687AsnLeu: 1.687 ± 0.039
0.249AsnMet: 0.249 ± 0.014
0.369AsnAsn: 0.369 ± 0.018
1.368AsnPro: 1.368 ± 0.037
0.472AsnGln: 0.472 ± 0.021
1.226AsnArg: 1.226 ± 0.032
0.731AsnSer: 0.731 ± 0.023
0.955AsnThr: 0.955 ± 0.029
1.418AsnVal: 1.418 ± 0.031
0.213AsnTrp: 0.213 ± 0.013
0.355AsnTyr: 0.355 ± 0.018
0.0AsnXaa: 0.0 ± 0.0
Pro
7.45ProAla: 7.45 ± 0.091
0.296ProCys: 0.296 ± 0.014
4.84ProAsp: 4.84 ± 0.069
3.942ProGlu: 3.942 ± 0.06
1.48ProPhe: 1.48 ± 0.035
5.83ProGly: 5.83 ± 0.08
1.306ProHis: 1.306 ± 0.032
1.526ProIle: 1.526 ± 0.034
0.849ProLys: 0.849 ± 0.03
4.682ProLeu: 4.682 ± 0.064
1.046ProMet: 1.046 ± 0.03
0.755ProAsn: 0.755 ± 0.022
2.926ProPro: 2.926 ± 0.056
1.402ProGln: 1.402 ± 0.03
3.885ProArg: 3.885 ± 0.063
3.095ProSer: 3.095 ± 0.055
3.629ProThr: 3.629 ± 0.074
5.342ProVal: 5.342 ± 0.066
0.983ProTrp: 0.983 ± 0.028
1.126ProTyr: 1.126 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
3.48GlnAla: 3.48 ± 0.059
0.153GlnCys: 0.153 ± 0.01
1.3GlnAsp: 1.3 ± 0.032
1.307GlnGlu: 1.307 ± 0.029
0.659GlnPhe: 0.659 ± 0.023
2.039GlnGly: 2.039 ± 0.037
0.647GlnHis: 0.647 ± 0.023
0.878GlnIle: 0.878 ± 0.028
0.519GlnLys: 0.519 ± 0.021
2.853GlnLeu: 2.853 ± 0.047
0.515GlnMet: 0.515 ± 0.016
0.411GlnAsn: 0.411 ± 0.019
1.623GlnPro: 1.623 ± 0.038
1.149GlnGln: 1.149 ± 0.036
2.379GlnArg: 2.379 ± 0.045
1.195GlnSer: 1.195 ± 0.031
1.309GlnThr: 1.309 ± 0.031
2.902GlnVal: 2.902 ± 0.045
0.47GlnTrp: 0.47 ± 0.016
0.495GlnTyr: 0.495 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
9.17ArgAla: 9.17 ± 0.11
0.499ArgCys: 0.499 ± 0.02
4.837ArgAsp: 4.837 ± 0.059
4.756ArgGlu: 4.756 ± 0.06
2.292ArgPhe: 2.292 ± 0.045
5.836ArgGly: 5.836 ± 0.07
2.026ArgHis: 2.026 ± 0.041
3.102ArgIle: 3.102 ± 0.049
1.467ArgLys: 1.467 ± 0.038
8.511ArgLeu: 8.511 ± 0.093
1.77ArgMet: 1.77 ± 0.035
1.3ArgAsn: 1.3 ± 0.031
4.435ArgPro: 4.435 ± 0.07
2.161ArgGln: 2.161 ± 0.043
7.776ArgArg: 7.776 ± 0.11
4.228ArgSer: 4.228 ± 0.046
4.97ArgThr: 4.97 ± 0.066
6.534ArgVal: 6.534 ± 0.067
1.431ArgTrp: 1.431 ± 0.03
1.456ArgTyr: 1.456 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
6.392SerAla: 6.392 ± 0.07
0.363SerCys: 0.363 ± 0.017
3.035SerAsp: 3.035 ± 0.048
2.598SerGlu: 2.598 ± 0.049
1.662SerPhe: 1.662 ± 0.033
5.711SerGly: 5.711 ± 0.073
1.121SerHis: 1.121 ± 0.032
1.706SerIle: 1.706 ± 0.035
0.824SerLys: 0.824 ± 0.027
5.155SerLeu: 5.155 ± 0.049
1.201SerMet: 1.201 ± 0.025
0.891SerAsn: 0.891 ± 0.025
3.133SerPro: 3.133 ± 0.047
1.302SerGln: 1.302 ± 0.032
3.969SerArg: 3.969 ± 0.05
3.136SerSer: 3.136 ± 0.061
3.53SerThr: 3.53 ± 0.057
4.562SerVal: 4.562 ± 0.059
0.932SerTrp: 0.932 ± 0.031
1.185SerTyr: 1.185 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
7.496ThrAla: 7.496 ± 0.086
0.519ThrCys: 0.519 ± 0.023
3.836ThrAsp: 3.836 ± 0.052
3.11ThrGlu: 3.11 ± 0.049
1.893ThrPhe: 1.893 ± 0.039
6.089ThrGly: 6.089 ± 0.063
1.271ThrHis: 1.271 ± 0.028
2.175ThrIle: 2.175 ± 0.047
1.045ThrLys: 1.045 ± 0.027
5.716ThrLeu: 5.716 ± 0.07
1.035ThrMet: 1.035 ± 0.028
1.076ThrAsn: 1.076 ± 0.036
3.933ThrPro: 3.933 ± 0.065
1.421ThrGln: 1.421 ± 0.032
4.179ThrArg: 4.179 ± 0.06
3.746ThrSer: 3.746 ± 0.059
4.299ThrThr: 4.299 ± 0.062
5.784ThrVal: 5.784 ± 0.077
1.109ThrTrp: 1.109 ± 0.03
1.509ThrTyr: 1.509 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
12.98ValAla: 12.98 ± 0.126
0.693ValCys: 0.693 ± 0.022
6.663ValAsp: 6.663 ± 0.07
5.966ValGlu: 5.966 ± 0.067
2.408ValPhe: 2.408 ± 0.046
8.001ValGly: 8.001 ± 0.083
2.121ValHis: 2.121 ± 0.038
2.973ValIle: 2.973 ± 0.053
1.559ValLys: 1.559 ± 0.035
10.393ValLeu: 10.393 ± 0.091
1.596ValMet: 1.596 ± 0.036
1.588ValAsn: 1.588 ± 0.038
5.312ValPro: 5.312 ± 0.063
2.134ValGln: 2.134 ± 0.043
7.575ValArg: 7.575 ± 0.08
4.771ValSer: 4.771 ± 0.064
6.049ValThr: 6.049 ± 0.073
11.29ValVal: 11.29 ± 0.118
1.25ValTrp: 1.25 ± 0.031
1.348ValTyr: 1.348 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.709TrpAla: 1.709 ± 0.037
0.175TrpCys: 0.175 ± 0.012
0.947TrpAsp: 0.947 ± 0.032
0.775TrpGlu: 0.775 ± 0.022
0.589TrpPhe: 0.589 ± 0.023
1.113TrpGly: 1.113 ± 0.028
0.376TrpHis: 0.376 ± 0.016
0.571TrpIle: 0.571 ± 0.021
0.31TrpLys: 0.31 ± 0.015
1.905TrpLeu: 1.905 ± 0.04
0.293TrpMet: 0.293 ± 0.014
0.361TrpAsn: 0.361 ± 0.018
0.791TrpPro: 0.791 ± 0.025
0.579TrpGln: 0.579 ± 0.02
1.385TrpArg: 1.385 ± 0.031
1.116TrpSer: 1.116 ± 0.03
1.103TrpThr: 1.103 ± 0.032
1.352TrpVal: 1.352 ± 0.031
0.429TrpTrp: 0.429 ± 0.018
0.285TrpTyr: 0.285 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.589TyrAla: 2.589 ± 0.046
0.147TyrCys: 0.147 ± 0.009
1.732TyrAsp: 1.732 ± 0.035
1.039TyrGlu: 1.039 ± 0.029
0.575TyrPhe: 0.575 ± 0.021
1.823TyrGly: 1.823 ± 0.042
0.326TyrHis: 0.326 ± 0.017
0.422TyrIle: 0.422 ± 0.017
0.32TyrLys: 0.32 ± 0.017
1.854TyrLeu: 1.854 ± 0.038
0.214TyrMet: 0.214 ± 0.011
0.351TyrAsn: 0.351 ± 0.019
0.906TyrPro: 0.906 ± 0.027
0.423TyrGln: 0.423 ± 0.02
1.447TyrArg: 1.447 ± 0.032
0.872TyrSer: 0.872 ± 0.024
0.943TyrThr: 0.943 ± 0.028
1.919TyrVal: 1.919 ± 0.038
0.309TyrTrp: 0.309 ± 0.014
0.439TyrTyr: 0.439 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4127 proteins (1368510 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski