Amino acid dipepetide frequency for Beihai picorna-like virus 18

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.084AlaAla: 5.084 ± 0.538
2.179AlaCys: 2.179 ± 0.649
2.905AlaAsp: 2.905 ± 0.696
2.905AlaGlu: 2.905 ± 0.111
2.905AlaPhe: 2.905 ± 0.696
2.905AlaGly: 2.905 ± 1.282
1.452AlaHis: 1.452 ± 0.348
2.905AlaIle: 2.905 ± 1.06
5.447AlaLys: 5.447 ± 0.743
5.81AlaLeu: 5.81 ± 2.12
3.994AlaMet: 3.994 ± 0.079
3.631AlaAsn: 3.631 ± 0.87
2.179AlaPro: 2.179 ± 0.063
1.816AlaGln: 1.816 ± 0.143
3.994AlaArg: 3.994 ± 0.665
3.631AlaSer: 3.631 ± 1.456
5.447AlaThr: 5.447 ± 0.428
5.084AlaVal: 5.084 ± 1.804
0.363AlaTrp: 0.363 ± 0.38
2.542AlaTyr: 2.542 ± 0.269
0.0AlaXaa: 0.0 ± 0.0
Cys
3.268CysAla: 3.268 ± 0.68
0.726CysCys: 0.726 ± 0.411
0.363CysAsp: 0.363 ± 0.38
0.363CysGlu: 0.363 ± 0.206
1.089CysPhe: 1.089 ± 0.032
1.089CysGly: 1.089 ± 0.617
0.363CysHis: 0.363 ± 0.206
1.452CysIle: 1.452 ± 0.348
0.726CysLys: 0.726 ± 0.411
0.363CysLeu: 0.363 ± 0.206
0.726CysMet: 0.726 ± 0.411
1.089CysAsn: 1.089 ± 0.032
1.816CysPro: 1.816 ± 0.443
0.363CysGln: 0.363 ± 0.206
1.452CysArg: 1.452 ± 0.237
1.816CysSer: 1.816 ± 0.143
1.089CysThr: 1.089 ± 0.032
2.905CysVal: 2.905 ± 0.474
0.726CysTrp: 0.726 ± 0.411
0.726CysTyr: 0.726 ± 0.411
0.0CysXaa: 0.0 ± 0.0
Asp
3.268AspAla: 3.268 ± 0.095
0.726AspCys: 0.726 ± 0.174
4.357AspAsp: 4.357 ± 1.045
3.994AspGlu: 3.994 ± 0.506
4.72AspPhe: 4.72 ± 0.332
1.816AspGly: 1.816 ± 0.728
1.089AspHis: 1.089 ± 0.617
3.994AspIle: 3.994 ± 1.836
2.542AspLys: 2.542 ± 0.269
5.81AspLeu: 5.81 ± 0.807
1.816AspMet: 1.816 ± 0.728
1.816AspAsn: 1.816 ± 0.728
3.994AspPro: 3.994 ± 1.25
0.726AspGln: 0.726 ± 0.759
2.542AspArg: 2.542 ± 0.854
4.72AspSer: 4.72 ± 1.503
3.631AspThr: 3.631 ± 0.87
6.899AspVal: 6.899 ± 1.566
1.089AspTrp: 1.089 ± 0.617
1.089AspTyr: 1.089 ± 0.617
0.0AspXaa: 0.0 ± 0.0
Glu
3.631GluAla: 3.631 ± 0.3
1.452GluCys: 1.452 ± 0.348
5.447GluAsp: 5.447 ± 0.743
3.268GluGlu: 3.268 ± 1.851
2.179GluPhe: 2.179 ± 0.063
1.089GluGly: 1.089 ± 0.032
1.452GluHis: 1.452 ± 0.823
2.542GluIle: 2.542 ± 0.317
3.268GluLys: 3.268 ± 0.491
5.084GluLeu: 5.084 ± 1.123
0.363GluMet: 0.363 ± 0.206
3.268GluAsn: 3.268 ± 0.095
0.726GluPro: 0.726 ± 0.174
1.816GluGln: 1.816 ± 0.143
4.357GluArg: 4.357 ± 1.297
3.631GluSer: 3.631 ± 0.285
4.357GluThr: 4.357 ± 0.712
5.81GluVal: 5.81 ± 0.363
2.905GluTrp: 2.905 ± 1.06
1.816GluTyr: 1.816 ± 0.143
0.0GluXaa: 0.0 ± 0.0
Phe
2.542PheAla: 2.542 ± 0.317
0.726PheCys: 0.726 ± 0.174
2.542PheAsp: 2.542 ± 0.269
1.816PheGlu: 1.816 ± 0.728
3.631PhePhe: 3.631 ± 2.041
3.994PheGly: 3.994 ± 0.079
2.179PheHis: 2.179 ± 1.108
0.363PheIle: 0.363 ± 0.206
2.542PheLys: 2.542 ± 0.269
2.905PheLeu: 2.905 ± 1.06
0.726PheMet: 0.726 ± 0.411
2.542PheAsn: 2.542 ± 0.269
1.452PhePro: 1.452 ± 0.348
2.179PheGln: 2.179 ± 0.063
4.357PheArg: 4.357 ± 1.045
3.631PheSer: 3.631 ± 0.285
1.816PheThr: 1.816 ± 0.443
2.905PheVal: 2.905 ± 0.696
0.363PheTrp: 0.363 ± 0.206
2.542PheTyr: 2.542 ± 0.317
0.0PheXaa: 0.0 ± 0.0
Gly
2.179GlyAla: 2.179 ± 0.063
1.089GlyCys: 1.089 ± 0.554
2.542GlyAsp: 2.542 ± 0.269
2.542GlyGlu: 2.542 ± 0.902
2.179GlyPhe: 2.179 ± 0.063
2.542GlyGly: 2.542 ± 0.902
0.363GlyHis: 0.363 ± 0.206
4.72GlyIle: 4.72 ± 0.332
2.905GlyLys: 2.905 ± 0.111
3.631GlyLeu: 3.631 ± 0.285
1.816GlyMet: 1.816 ± 0.143
3.994GlyAsn: 3.994 ± 0.665
1.089GlyPro: 1.089 ± 0.032
1.452GlyGln: 1.452 ± 0.237
3.268GlyArg: 3.268 ± 0.68
5.81GlySer: 5.81 ± 0.949
3.631GlyThr: 3.631 ± 2.041
6.173GlyVal: 6.173 ± 0.569
0.363GlyTrp: 0.363 ± 0.206
2.542GlyTyr: 2.542 ± 0.317
0.0GlyXaa: 0.0 ± 0.0
His
1.452HisAla: 1.452 ± 0.237
0.363HisCys: 0.363 ± 0.206
0.726HisAsp: 0.726 ± 0.411
0.726HisGlu: 0.726 ± 0.174
0.726HisPhe: 0.726 ± 0.411
1.816HisGly: 1.816 ± 1.028
0.0HisHis: 0.0 ± 0.0
1.816HisIle: 1.816 ± 0.143
1.816HisLys: 1.816 ± 0.143
1.452HisLeu: 1.452 ± 0.348
0.726HisMet: 0.726 ± 0.174
0.726HisAsn: 0.726 ± 0.411
2.179HisPro: 2.179 ± 0.063
0.363HisGln: 0.363 ± 0.206
0.726HisArg: 0.726 ± 0.411
1.816HisSer: 1.816 ± 1.028
1.089HisThr: 1.089 ± 0.554
3.268HisVal: 3.268 ± 1.076
0.363HisTrp: 0.363 ± 0.206
0.726HisTyr: 0.726 ± 0.174
0.0HisXaa: 0.0 ± 0.0
Ile
5.084IleAla: 5.084 ± 1.804
0.726IleCys: 0.726 ± 0.411
5.084IleAsp: 5.084 ± 0.538
2.905IleGlu: 2.905 ± 0.111
1.452IlePhe: 1.452 ± 0.934
2.905IleGly: 2.905 ± 1.282
1.089IleHis: 1.089 ± 0.554
2.542IleIle: 2.542 ± 0.854
1.816IleLys: 1.816 ± 0.443
4.357IleLeu: 4.357 ± 1.882
1.816IleMet: 1.816 ± 1.028
2.542IleAsn: 2.542 ± 0.269
2.905IlePro: 2.905 ± 1.282
1.089IleGln: 1.089 ± 0.554
3.631IleArg: 3.631 ± 1.471
3.268IleSer: 3.268 ± 0.68
4.72IleThr: 4.72 ± 0.332
4.72IleVal: 4.72 ± 0.253
0.0IleTrp: 0.0 ± 0.0
2.179IleTyr: 2.179 ± 0.649
0.0IleXaa: 0.0 ± 0.0
Lys
1.089LysAla: 1.089 ± 0.032
1.089LysCys: 1.089 ± 0.617
3.631LysAsp: 3.631 ± 2.057
5.81LysGlu: 5.81 ± 2.12
3.268LysPhe: 3.268 ± 1.662
2.542LysGly: 2.542 ± 0.902
2.542LysHis: 2.542 ± 0.854
2.542LysIle: 2.542 ± 0.854
3.994LysLys: 3.994 ± 1.091
1.816LysLeu: 1.816 ± 0.143
1.452LysMet: 1.452 ± 0.348
1.089LysAsn: 1.089 ± 1.139
3.631LysPro: 3.631 ± 1.471
1.452LysGln: 1.452 ± 0.237
5.447LysArg: 5.447 ± 1.013
5.084LysSer: 5.084 ± 1.123
2.905LysThr: 2.905 ± 1.645
1.816LysVal: 1.816 ± 0.443
1.089LysTrp: 1.089 ± 0.617
5.084LysTyr: 5.084 ± 0.538
0.0LysXaa: 0.0 ± 0.0
Leu
3.994LeuAla: 3.994 ± 1.091
2.542LeuCys: 2.542 ± 0.854
3.631LeuAsp: 3.631 ± 2.041
5.447LeuGlu: 5.447 ± 1.914
2.179LeuPhe: 2.179 ± 0.063
5.084LeuGly: 5.084 ± 1.123
2.179LeuHis: 2.179 ± 0.063
2.905LeuIle: 2.905 ± 1.06
5.81LeuLys: 5.81 ± 0.363
5.084LeuLeu: 5.084 ± 1.123
0.726LeuMet: 0.726 ± 0.127
2.179LeuAsn: 2.179 ± 0.063
6.173LeuPro: 6.173 ± 0.602
2.905LeuGln: 2.905 ± 1.867
2.542LeuArg: 2.542 ± 0.854
4.357LeuSer: 4.357 ± 0.712
6.899LeuThr: 6.899 ± 0.19
3.268LeuVal: 3.268 ± 0.095
0.0LeuTrp: 0.0 ± 0.0
1.452LeuTyr: 1.452 ± 0.348
0.0LeuXaa: 0.0 ± 0.0
Met
3.994MetAla: 3.994 ± 0.079
0.0MetCys: 0.0 ± 0.0
1.816MetAsp: 1.816 ± 0.143
1.452MetGlu: 1.452 ± 0.934
1.089MetPhe: 1.089 ± 0.032
3.631MetGly: 3.631 ± 0.3
0.363MetHis: 0.363 ± 0.206
2.542MetIle: 2.542 ± 0.317
1.452MetLys: 1.452 ± 0.237
1.452MetLeu: 1.452 ± 0.237
1.089MetMet: 1.089 ± 0.554
1.452MetAsn: 1.452 ± 0.823
0.0MetPro: 0.0 ± 0.0
0.726MetGln: 0.726 ± 0.174
0.363MetArg: 0.363 ± 0.206
3.631MetSer: 3.631 ± 0.3
1.816MetThr: 1.816 ± 0.143
0.363MetVal: 0.363 ± 0.206
0.0MetTrp: 0.0 ± 0.0
0.726MetTyr: 0.726 ± 0.174
0.0MetXaa: 0.0 ± 0.0
Asn
2.542AsnAla: 2.542 ± 0.269
2.905AsnCys: 2.905 ± 1.645
1.089AsnAsp: 1.089 ± 0.554
2.905AsnGlu: 2.905 ± 1.06
0.363AsnPhe: 0.363 ± 0.206
2.905AsnGly: 2.905 ± 1.282
0.363AsnHis: 0.363 ± 0.206
3.631AsnIle: 3.631 ± 0.285
3.268AsnLys: 3.268 ± 0.68
3.994AsnLeu: 3.994 ± 1.836
1.816AsnMet: 1.816 ± 0.443
2.542AsnAsn: 2.542 ± 0.854
2.179AsnPro: 2.179 ± 0.522
1.089AsnGln: 1.089 ± 0.032
0.726AsnArg: 0.726 ± 0.174
2.905AsnSer: 2.905 ± 0.111
2.905AsnThr: 2.905 ± 0.696
5.81AsnVal: 5.81 ± 3.149
0.363AsnTrp: 0.363 ± 0.206
2.179AsnTyr: 2.179 ± 0.522
0.0AsnXaa: 0.0 ± 0.0
Pro
5.084ProAla: 5.084 ± 1.219
0.0ProCys: 0.0 ± 0.0
2.905ProAsp: 2.905 ± 0.474
3.268ProGlu: 3.268 ± 0.68
1.452ProPhe: 1.452 ± 0.934
3.268ProGly: 3.268 ± 0.68
2.179ProHis: 2.179 ± 0.063
3.994ProIle: 3.994 ± 0.665
2.179ProLys: 2.179 ± 0.649
4.72ProLeu: 4.72 ± 0.253
0.726ProMet: 0.726 ± 0.174
2.179ProAsn: 2.179 ± 0.063
1.089ProPro: 1.089 ± 0.617
3.268ProGln: 3.268 ± 1.076
0.726ProArg: 0.726 ± 0.411
3.268ProSer: 3.268 ± 0.491
3.268ProThr: 3.268 ± 1.076
1.816ProVal: 1.816 ± 0.728
1.816ProTrp: 1.816 ± 1.899
0.726ProTyr: 0.726 ± 0.411
0.0ProXaa: 0.0 ± 0.0
Gln
2.542GlnAla: 2.542 ± 0.269
0.363GlnCys: 0.363 ± 0.38
1.089GlnAsp: 1.089 ± 0.032
2.542GlnGlu: 2.542 ± 0.317
1.089GlnPhe: 1.089 ± 0.617
1.816GlnGly: 1.816 ± 0.143
0.726GlnHis: 0.726 ± 0.411
1.089GlnIle: 1.089 ± 0.617
1.452GlnLys: 1.452 ± 0.348
0.726GlnLeu: 0.726 ± 0.411
1.816GlnMet: 1.816 ± 1.313
1.089GlnAsn: 1.089 ± 0.554
0.363GlnPro: 0.363 ± 0.38
0.726GlnGln: 0.726 ± 0.411
1.816GlnArg: 1.816 ± 0.728
3.631GlnSer: 3.631 ± 2.041
2.542GlnThr: 2.542 ± 0.269
3.268GlnVal: 3.268 ± 1.076
1.089GlnTrp: 1.089 ± 0.032
0.726GlnTyr: 0.726 ± 0.174
0.0GlnXaa: 0.0 ± 0.0
Arg
4.72ArgAla: 4.72 ± 0.253
1.452ArgCys: 1.452 ± 0.237
2.905ArgAsp: 2.905 ± 0.696
4.357ArgGlu: 4.357 ± 0.126
2.905ArgPhe: 2.905 ± 0.474
1.816ArgGly: 1.816 ± 0.728
1.816ArgHis: 1.816 ± 0.143
3.268ArgIle: 3.268 ± 0.68
3.631ArgLys: 3.631 ± 1.471
3.994ArgLeu: 3.994 ± 1.25
1.816ArgMet: 1.816 ± 0.443
2.542ArgAsn: 2.542 ± 0.269
2.905ArgPro: 2.905 ± 1.282
1.089ArgGln: 1.089 ± 0.617
1.816ArgArg: 1.816 ± 0.143
5.81ArgSer: 5.81 ± 0.363
2.542ArgThr: 2.542 ± 0.317
5.084ArgVal: 5.084 ± 1.708
0.363ArgTrp: 0.363 ± 0.206
1.816ArgTyr: 1.816 ± 0.728
0.0ArgXaa: 0.0 ± 0.0
Ser
3.631SerAla: 3.631 ± 0.285
1.089SerCys: 1.089 ± 0.617
5.447SerAsp: 5.447 ± 0.158
3.994SerGlu: 3.994 ± 0.506
4.357SerPhe: 4.357 ± 1.045
5.81SerGly: 5.81 ± 0.222
0.363SerHis: 0.363 ± 0.206
4.357SerIle: 4.357 ± 0.712
4.357SerLys: 4.357 ± 1.297
5.81SerLeu: 5.81 ± 0.222
1.452SerMet: 1.452 ± 0.365
3.268SerAsn: 3.268 ± 1.076
4.357SerPro: 4.357 ± 0.459
3.268SerGln: 3.268 ± 0.491
2.905SerArg: 2.905 ± 0.696
2.542SerSer: 2.542 ± 0.269
5.084SerThr: 5.084 ± 2.294
7.988SerVal: 7.988 ± 0.427
1.452SerTrp: 1.452 ± 0.237
3.994SerTyr: 3.994 ± 0.506
0.0SerXaa: 0.0 ± 0.0
Thr
4.357ThrAla: 4.357 ± 0.126
1.816ThrCys: 1.816 ± 0.443
3.994ThrAsp: 3.994 ± 0.079
2.542ThrGlu: 2.542 ± 0.317
2.542ThrPhe: 2.542 ± 0.854
3.631ThrGly: 3.631 ± 0.886
0.726ThrHis: 0.726 ± 0.174
3.268ThrIle: 3.268 ± 1.662
3.268ThrLys: 3.268 ± 1.076
2.905ThrLeu: 2.905 ± 0.474
2.905ThrMet: 2.905 ± 0.474
3.631ThrAsn: 3.631 ± 0.285
5.447ThrPro: 5.447 ± 0.158
1.816ThrGln: 1.816 ± 0.443
3.994ThrArg: 3.994 ± 0.079
5.447ThrSer: 5.447 ± 0.158
4.72ThrThr: 4.72 ± 0.839
4.357ThrVal: 4.357 ± 1.045
1.089ThrTrp: 1.089 ± 0.032
2.179ThrTyr: 2.179 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
5.81ValAla: 5.81 ± 1.978
2.179ValCys: 2.179 ± 0.063
5.81ValAsp: 5.81 ± 0.807
5.447ValGlu: 5.447 ± 0.743
4.357ValPhe: 4.357 ± 0.712
2.905ValGly: 2.905 ± 0.474
2.905ValHis: 2.905 ± 0.474
2.905ValIle: 2.905 ± 0.474
2.905ValLys: 2.905 ± 1.06
5.084ValLeu: 5.084 ± 0.633
1.452ValMet: 1.452 ± 0.348
4.72ValAsn: 4.72 ± 1.424
3.631ValPro: 3.631 ± 0.87
3.268ValGln: 3.268 ± 1.662
6.899ValArg: 6.899 ± 0.395
5.81ValSer: 5.81 ± 0.363
3.631ValThr: 3.631 ± 0.285
6.899ValVal: 6.899 ± 3.117
1.452ValTrp: 1.452 ± 0.237
3.994ValTyr: 3.994 ± 1.25
0.0ValXaa: 0.0 ± 0.0
Trp
0.726TrpAla: 0.726 ± 0.174
0.726TrpCys: 0.726 ± 0.411
1.816TrpAsp: 1.816 ± 0.143
0.726TrpGlu: 0.726 ± 0.174
0.726TrpPhe: 0.726 ± 0.174
0.726TrpGly: 0.726 ± 0.411
0.0TrpHis: 0.0 ± 0.0
1.816TrpIle: 1.816 ± 0.443
0.363TrpLys: 0.363 ± 0.206
1.816TrpLeu: 1.816 ± 1.028
0.363TrpMet: 0.363 ± 0.206
1.452TrpAsn: 1.452 ± 0.237
0.363TrpPro: 0.363 ± 0.38
0.363TrpGln: 0.363 ± 0.38
1.452TrpArg: 1.452 ± 0.348
0.726TrpSer: 0.726 ± 0.411
0.363TrpThr: 0.363 ± 0.206
0.363TrpVal: 0.363 ± 0.206
1.089TrpTrp: 1.089 ± 0.617
0.363TrpTyr: 0.363 ± 0.38
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.179TyrAla: 2.179 ± 1.108
0.363TyrCys: 0.363 ± 0.38
2.542TyrAsp: 2.542 ± 0.317
1.452TyrGlu: 1.452 ± 0.823
2.542TyrPhe: 2.542 ± 0.317
2.542TyrGly: 2.542 ± 0.317
0.726TyrHis: 0.726 ± 0.174
2.179TyrIle: 2.179 ± 0.063
3.631TyrLys: 3.631 ± 1.471
2.542TyrLeu: 2.542 ± 0.269
0.0TyrMet: 0.0 ± 0.0
0.726TyrAsn: 0.726 ± 0.174
1.452TyrPro: 1.452 ± 0.237
0.726TyrGln: 0.726 ± 0.411
3.631TyrArg: 3.631 ± 0.87
4.357TyrSer: 4.357 ± 0.126
2.179TyrThr: 2.179 ± 0.063
3.268TyrVal: 3.268 ± 0.491
0.363TyrTrp: 0.363 ± 0.38
0.726TyrTyr: 0.726 ± 0.174
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2755 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski