Amino acid dipepetide frequency for Bacteroides sp. CAG:709

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.416AlaAla: 8.416 ± 0.133	1.028AlaCys: 1.028 ± 0.04	5.435AlaAsp: 5.435 ± 0.088	5.72AlaGlu: 5.72 ± 0.105	3.343AlaPhe: 3.343 ± 0.075	6.832AlaGly: 6.832 ± 0.108	1.242AlaHis: 1.242 ± 0.036	4.538AlaIle: 4.538 ± 0.079	4.653AlaLys: 4.653 ± 0.083	7.207AlaLeu: 7.207 ± 0.106	2.252AlaMet: 2.252 ± 0.057	2.921AlaAsn: 2.921 ± 0.058	2.695AlaPro: 2.695 ± 0.06	2.227AlaGln: 2.227 ± 0.05	3.374AlaArg: 3.374 ± 0.083	5.479AlaSer: 5.479 ± 0.092	3.89AlaThr: 3.89 ± 0.068	6.067AlaVal: 6.067 ± 0.1	0.857AlaTrp: 0.857 ± 0.034	2.921AlaTyr: 2.921 ± 0.061	0.012AlaXaa: 0.012 ± 0.004
Cys	0.978CysAla: 0.978 ± 0.04	0.229CysCys: 0.229 ± 0.017	0.827CysAsp: 0.827 ± 0.035	0.751CysGlu: 0.751 ± 0.03	0.548CysPhe: 0.548 ± 0.028	1.325CysGly: 1.325 ± 0.045	0.316CysHis: 0.316 ± 0.025	0.84CysIle: 0.84 ± 0.034	0.74CysLys: 0.74 ± 0.029	1.01CysLeu: 1.01 ± 0.034	0.277CysMet: 0.277 ± 0.021	0.547CysAsn: 0.547 ± 0.025	0.631CysPro: 0.631 ± 0.031	0.335CysGln: 0.335 ± 0.023	0.81CysArg: 0.81 ± 0.035	0.983CysSer: 0.983 ± 0.035	0.762CysThr: 0.762 ± 0.043	0.84CysVal: 0.84 ± 0.037	0.152CysTrp: 0.152 ± 0.013	0.529CysTyr: 0.529 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	4.869AspAla: 4.869 ± 0.09	0.775AspCys: 0.775 ± 0.033	3.095AspAsp: 3.095 ± 0.067	3.862AspGlu: 3.862 ± 0.069	3.16AspPhe: 3.16 ± 0.061	5.681AspGly: 5.681 ± 0.117	0.824AspHis: 0.824 ± 0.033	4.514AspIle: 4.514 ± 0.08	4.237AspLys: 4.237 ± 0.08	4.549AspLeu: 4.549 ± 0.074	1.828AspMet: 1.828 ± 0.055	3.119AspAsn: 3.119 ± 0.07	2.32AspPro: 2.32 ± 0.057	1.205AspGln: 1.205 ± 0.043	2.714AspArg: 2.714 ± 0.056	3.739AspSer: 3.739 ± 0.086	2.804AspThr: 2.804 ± 0.064	3.997AspVal: 3.997 ± 0.066	1.026AspTrp: 1.026 ± 0.036	2.861AspTyr: 2.861 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	4.886GluAla: 4.886 ± 0.087	0.748GluCys: 0.748 ± 0.029	3.591GluAsp: 3.591 ± 0.069	4.127GluGlu: 4.127 ± 0.086	2.58GluPhe: 2.58 ± 0.064	4.353GluGly: 4.353 ± 0.079	1.055GluHis: 1.055 ± 0.036	4.523GluIle: 4.523 ± 0.074	4.849GluLys: 4.849 ± 0.078	5.278GluLeu: 5.278 ± 0.085	1.892GluMet: 1.892 ± 0.05	3.43GluAsn: 3.43 ± 0.065	2.06GluPro: 2.06 ± 0.054	1.839GluGln: 1.839 ± 0.051	2.943GluArg: 2.943 ± 0.067	3.622GluSer: 3.622 ± 0.067	3.302GluThr: 3.302 ± 0.07	3.969GluVal: 3.969 ± 0.074	0.805GluTrp: 0.805 ± 0.035	2.602GluTyr: 2.602 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.445PheAla: 3.445 ± 0.073	0.665PheCys: 0.665 ± 0.03	2.844PheAsp: 2.844 ± 0.065	2.31PheGlu: 2.31 ± 0.061	1.865PhePhe: 1.865 ± 0.058	3.615PheGly: 3.615 ± 0.076	0.8PheHis: 0.8 ± 0.033	2.807PheIle: 2.807 ± 0.068	2.344PheLys: 2.344 ± 0.061	3.393PheLeu: 3.393 ± 0.069	1.253PheMet: 1.253 ± 0.042	2.244PheAsn: 2.244 ± 0.059	1.746PhePro: 1.746 ± 0.049	1.079PheGln: 1.079 ± 0.037	2.47PheArg: 2.47 ± 0.066	3.643PheSer: 3.643 ± 0.09	2.63PheThr: 2.63 ± 0.062	2.877PheVal: 2.877 ± 0.065	0.602PheTrp: 0.602 ± 0.031	1.737PheTyr: 1.737 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	5.422GlyAla: 5.422 ± 0.091	1.172GlyCys: 1.172 ± 0.049	4.092GlyAsp: 4.092 ± 0.068	4.546GlyGlu: 4.546 ± 0.089	3.364GlyPhe: 3.364 ± 0.063	5.396GlyGly: 5.396 ± 0.119	1.42GlyHis: 1.42 ± 0.049	5.343GlyIle: 5.343 ± 0.097	5.775GlyLys: 5.775 ± 0.088	6.044GlyLeu: 6.044 ± 0.096	2.214GlyMet: 2.214 ± 0.052	3.783GlyAsn: 3.783 ± 0.087	1.588GlyPro: 1.588 ± 0.046	2.199GlyGln: 2.199 ± 0.05	3.644GlyArg: 3.644 ± 0.061	4.711GlySer: 4.711 ± 0.09	4.781GlyThr: 4.781 ± 0.09	5.277GlyVal: 5.277 ± 0.084	1.095GlyTrp: 1.095 ± 0.038	3.564GlyTyr: 3.564 ± 0.072	0.007GlyXaa: 0.007 ± 0.003
His	1.109HisAla: 1.109 ± 0.039	0.296HisCys: 0.296 ± 0.019	1.037HisAsp: 1.037 ± 0.037	0.973HisGlu: 0.973 ± 0.038	0.92HisPhe: 0.92 ± 0.035	1.286HisGly: 1.286 ± 0.04	0.392HisHis: 0.392 ± 0.024	1.287HisIle: 1.287 ± 0.04	0.969HisLys: 0.969 ± 0.034	1.418HisLeu: 1.418 ± 0.048	0.307HisMet: 0.307 ± 0.019	0.851HisAsn: 0.851 ± 0.034	0.852HisPro: 0.852 ± 0.037	0.445HisGln: 0.445 ± 0.018	0.804HisArg: 0.804 ± 0.031	1.04HisSer: 1.04 ± 0.033	0.806HisThr: 0.806 ± 0.034	1.055HisVal: 1.055 ± 0.037	0.197HisTrp: 0.197 ± 0.014	0.8HisTyr: 0.8 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.413IleAla: 5.413 ± 0.088	1.026IleCys: 1.026 ± 0.038	4.524IleAsp: 4.524 ± 0.076	3.896IleGlu: 3.896 ± 0.071	2.671IlePhe: 2.671 ± 0.063	4.48IleGly: 4.48 ± 0.083	1.041IleHis: 1.041 ± 0.032	4.063IleIle: 4.063 ± 0.087	3.42IleLys: 3.42 ± 0.072	5.157IleLeu: 5.157 ± 0.1	1.504IleMet: 1.504 ± 0.05	2.753IleAsn: 2.753 ± 0.064	3.02IlePro: 3.02 ± 0.066	1.634IleGln: 1.634 ± 0.044	3.303IleArg: 3.303 ± 0.07	4.983IleSer: 4.983 ± 0.091	3.609IleThr: 3.609 ± 0.072	4.512IleVal: 4.512 ± 0.076	0.706IleTrp: 0.706 ± 0.035	2.43IleTyr: 2.43 ± 0.054	0.001IleXaa: 0.001 ± 0.001
Lys	5.26LysAla: 5.26 ± 0.1	0.628LysCys: 0.628 ± 0.029	4.109LysAsp: 4.109 ± 0.074	4.445LysGlu: 4.445 ± 0.092	2.607LysPhe: 2.607 ± 0.061	4.373LysGly: 4.373 ± 0.081	0.997LysHis: 0.997 ± 0.039	4.157LysIle: 4.157 ± 0.071	4.164LysLys: 4.164 ± 0.079	4.736LysLeu: 4.736 ± 0.079	2.139LysMet: 2.139 ± 0.061	3.173LysAsn: 3.173 ± 0.066	2.231LysPro: 2.231 ± 0.052	1.604LysGln: 1.604 ± 0.045	2.643LysArg: 2.643 ± 0.058	3.983LysSer: 3.983 ± 0.068	3.661LysThr: 3.661 ± 0.077	4.626LysVal: 4.626 ± 0.084	0.897LysTrp: 0.897 ± 0.036	2.939LysTyr: 2.939 ± 0.063	0.0LysXaa: 0.0 ± 0.0
Leu	6.778LeuAla: 6.778 ± 0.095	1.214LeuCys: 1.214 ± 0.04	4.921LeuAsp: 4.921 ± 0.081	4.875LeuGlu: 4.875 ± 0.078	3.582LeuPhe: 3.582 ± 0.086	5.841LeuGly: 5.841 ± 0.093	1.458LeuHis: 1.458 ± 0.041	4.368LeuIle: 4.368 ± 0.083	5.781LeuLys: 5.781 ± 0.09	6.656LeuLeu: 6.656 ± 0.117	2.383LeuMet: 2.383 ± 0.058	3.77LeuAsn: 3.77 ± 0.074	3.676LeuPro: 3.676 ± 0.077	2.418LeuGln: 2.418 ± 0.058	4.085LeuArg: 4.085 ± 0.068	6.543LeuSer: 6.543 ± 0.101	4.997LeuThr: 4.997 ± 0.086	5.085LeuVal: 5.085 ± 0.085	0.926LeuTrp: 0.926 ± 0.033	3.119LeuTyr: 3.119 ± 0.067	0.001LeuXaa: 0.001 ± 0.001
Met	2.401MetAla: 2.401 ± 0.057	0.297MetCys: 0.297 ± 0.018	1.619MetAsp: 1.619 ± 0.048	1.804MetGlu: 1.804 ± 0.046	1.169MetPhe: 1.169 ± 0.042	1.629MetGly: 1.629 ± 0.047	0.417MetHis: 0.417 ± 0.021	1.585MetIle: 1.585 ± 0.048	2.351MetLys: 2.351 ± 0.055	2.542MetLeu: 2.542 ± 0.071	0.866MetMet: 0.866 ± 0.033	1.53MetAsn: 1.53 ± 0.043	1.275MetPro: 1.275 ± 0.036	0.784MetGln: 0.784 ± 0.031	1.362MetArg: 1.362 ± 0.043	2.094MetSer: 2.094 ± 0.052	1.803MetThr: 1.803 ± 0.051	1.672MetVal: 1.672 ± 0.042	0.269MetTrp: 0.269 ± 0.02	0.876MetTyr: 0.876 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	4.127AsnAla: 4.127 ± 0.069	0.59AsnCys: 0.59 ± 0.032	2.635AsnAsp: 2.635 ± 0.065	2.576AsnGlu: 2.576 ± 0.051	1.938AsnPhe: 1.938 ± 0.053	3.905AsnGly: 3.905 ± 0.08	0.77AsnHis: 0.77 ± 0.03	3.469AsnIle: 3.469 ± 0.071	2.445AsnLys: 2.445 ± 0.053	3.702AsnLeu: 3.702 ± 0.072	1.283AsnMet: 1.283 ± 0.045	2.083AsnAsn: 2.083 ± 0.062	2.372AsnPro: 2.372 ± 0.057	1.089AsnGln: 1.089 ± 0.034	1.925AsnArg: 1.925 ± 0.052	2.835AsnSer: 2.835 ± 0.06	2.566AsnThr: 2.566 ± 0.06	3.709AsnVal: 3.709 ± 0.075	0.667AsnTrp: 0.667 ± 0.029	2.098AsnTyr: 2.098 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	3.416ProAla: 3.416 ± 0.07	0.421ProCys: 0.421 ± 0.023	3.032ProAsp: 3.032 ± 0.064	3.845ProGlu: 3.845 ± 0.076	1.738ProPhe: 1.738 ± 0.048	2.872ProGly: 2.872 ± 0.064	0.601ProHis: 0.601 ± 0.025	1.899ProIle: 1.899 ± 0.054	1.949ProLys: 1.949 ± 0.043	2.861ProLeu: 2.861 ± 0.062	0.973ProMet: 0.973 ± 0.034	1.344ProAsn: 1.344 ± 0.042	0.66ProPro: 0.66 ± 0.029	1.177ProGln: 1.177 ± 0.041	1.323ProArg: 1.323 ± 0.041	2.694ProSer: 2.694 ± 0.059	1.711ProThr: 1.711 ± 0.046	3.395ProVal: 3.395 ± 0.065	0.476ProTrp: 0.476 ± 0.023	1.744ProTyr: 1.744 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	2.05GlnAla: 2.05 ± 0.05	0.313GlnCys: 0.313 ± 0.018	1.516GlnAsp: 1.516 ± 0.043	1.746GlnGlu: 1.746 ± 0.048	1.196GlnPhe: 1.196 ± 0.036	1.653GlnGly: 1.653 ± 0.053	0.459GlnHis: 0.459 ± 0.025	1.916GlnIle: 1.916 ± 0.046	1.909GlnLys: 1.909 ± 0.049	2.233GlnLeu: 2.233 ± 0.057	0.924GlnMet: 0.924 ± 0.035	1.435GlnAsn: 1.435 ± 0.047	0.983GlnPro: 0.983 ± 0.035	0.919GlnGln: 0.919 ± 0.035	1.166GlnArg: 1.166 ± 0.041	1.548GlnSer: 1.548 ± 0.05	1.645GlnThr: 1.645 ± 0.046	1.772GlnVal: 1.772 ± 0.04	0.388GlnTrp: 0.388 ± 0.023	1.183GlnTyr: 1.183 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	3.083ArgAla: 3.083 ± 0.063	0.585ArgCys: 0.585 ± 0.03	2.559ArgAsp: 2.559 ± 0.068	2.922ArgGlu: 2.922 ± 0.062	2.255ArgPhe: 2.255 ± 0.055	2.8ArgGly: 2.8 ± 0.063	1.092ArgHis: 1.092 ± 0.045	3.433ArgIle: 3.433 ± 0.069	3.379ArgLys: 3.379 ± 0.08	4.114ArgLeu: 4.114 ± 0.068	1.47ArgMet: 1.47 ± 0.043	2.445ArgAsn: 2.445 ± 0.06	1.681ArgPro: 1.681 ± 0.049	1.543ArgGln: 1.543 ± 0.046	2.501ArgArg: 2.501 ± 0.068	2.594ArgSer: 2.594 ± 0.064	2.716ArgThr: 2.716 ± 0.063	2.746ArgVal: 2.746 ± 0.046	0.685ArgTrp: 0.685 ± 0.028	2.194ArgTyr: 2.194 ± 0.056	0.002ArgXaa: 0.002 ± 0.002
Ser	5.44SerAla: 5.44 ± 0.083	1.078SerCys: 1.078 ± 0.036	4.184SerAsp: 4.184 ± 0.07	3.914SerGlu: 3.914 ± 0.071	3.27SerPhe: 3.27 ± 0.065	6.12SerGly: 6.12 ± 0.097	1.09SerHis: 1.09 ± 0.033	4.398SerIle: 4.398 ± 0.079	3.467SerLys: 3.467 ± 0.062	5.992SerLeu: 5.992 ± 0.121	1.978SerMet: 1.978 ± 0.055	2.596SerAsn: 2.596 ± 0.059	2.554SerPro: 2.554 ± 0.055	1.806SerGln: 1.806 ± 0.049	3.281SerArg: 3.281 ± 0.065	5.064SerSer: 5.064 ± 0.103	3.36SerThr: 3.36 ± 0.078	4.998SerVal: 4.998 ± 0.081	0.95SerTrp: 0.95 ± 0.041	3.05SerTyr: 3.05 ± 0.075	0.002SerXaa: 0.002 ± 0.002
Thr	4.67ThrAla: 4.67 ± 0.075	0.601ThrCys: 0.601 ± 0.03	3.631ThrAsp: 3.631 ± 0.063	3.116ThrGlu: 3.116 ± 0.063	2.7ThrPhe: 2.7 ± 0.065	4.847ThrGly: 4.847 ± 0.079	0.833ThrHis: 0.833 ± 0.034	3.507ThrIle: 3.507 ± 0.079	2.917ThrLys: 2.917 ± 0.063	5.136ThrLeu: 5.136 ± 0.085	1.4ThrMet: 1.4 ± 0.038	2.025ThrAsn: 2.025 ± 0.055	2.665ThrPro: 2.665 ± 0.059	1.318ThrGln: 1.318 ± 0.04	2.306ThrArg: 2.306 ± 0.058	3.654ThrSer: 3.654 ± 0.086	2.992ThrThr: 2.992 ± 0.067	4.309ThrVal: 4.309 ± 0.089	0.851ThrTrp: 0.851 ± 0.038	2.205ThrTyr: 2.205 ± 0.053	0.005ThrXaa: 0.005 ± 0.002
Val	5.321ValAla: 5.321 ± 0.096	1.008ValCys: 1.008 ± 0.039	3.888ValAsp: 3.888 ± 0.071	4.036ValGlu: 4.036 ± 0.078	2.926ValPhe: 2.926 ± 0.068	4.2ValGly: 4.2 ± 0.074	1.028ValHis: 1.028 ± 0.038	4.368ValIle: 4.368 ± 0.077	4.67ValLys: 4.67 ± 0.083	5.869ValLeu: 5.869 ± 0.094	1.844ValMet: 1.844 ± 0.051	3.679ValAsn: 3.679 ± 0.068	2.966ValPro: 2.966 ± 0.057	1.717ValGln: 1.717 ± 0.048	3.449ValArg: 3.449 ± 0.071	5.432ValSer: 5.432 ± 0.082	4.384ValThr: 4.384 ± 0.081	4.541ValVal: 4.541 ± 0.084	0.797ValTrp: 0.797 ± 0.036	2.663ValTyr: 2.663 ± 0.063	0.002ValXaa: 0.002 ± 0.002
Trp	0.87TrpAla: 0.87 ± 0.03	0.196TrpCys: 0.196 ± 0.016	0.777TrpAsp: 0.777 ± 0.033	0.702TrpGlu: 0.702 ± 0.031	0.644TrpPhe: 0.644 ± 0.028	0.958TrpGly: 0.958 ± 0.043	0.268TrpHis: 0.268 ± 0.02	0.682TrpIle: 0.682 ± 0.03	0.964TrpLys: 0.964 ± 0.035	1.163TrpLeu: 1.163 ± 0.046	0.404TrpMet: 0.404 ± 0.021	0.815TrpAsn: 0.815 ± 0.028	0.392TrpPro: 0.392 ± 0.024	0.48TrpGln: 0.48 ± 0.027	0.613TrpArg: 0.613 ± 0.025	0.871TrpSer: 0.871 ± 0.04	0.836TrpThr: 0.836 ± 0.033	0.623TrpVal: 0.623 ± 0.025	0.24TrpTrp: 0.24 ± 0.018	0.576TrpTyr: 0.576 ± 0.031	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.154TyrAla: 3.154 ± 0.071	0.559TyrCys: 0.559 ± 0.025	2.859TyrAsp: 2.859 ± 0.069	2.285TyrGlu: 2.285 ± 0.049	1.894TyrPhe: 1.894 ± 0.046	3.27TyrGly: 3.27 ± 0.068	0.742TyrHis: 0.742 ± 0.034	2.451TyrIle: 2.451 ± 0.05	2.39TyrLys: 2.39 ± 0.055	3.414TyrLeu: 3.414 ± 0.074	1.154TyrMet: 1.154 ± 0.04	2.239TyrAsn: 2.239 ± 0.061	1.759TyrPro: 1.759 ± 0.055	1.133TyrGln: 1.133 ± 0.042	2.079TyrArg: 2.079 ± 0.058	3.074TyrSer: 3.074 ± 0.065	2.434TyrThr: 2.434 ± 0.068	2.716TyrVal: 2.716 ± 0.056	0.486TyrTrp: 0.486 ± 0.027	1.86TyrTyr: 1.86 ± 0.057	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.004XaaAsp: 0.004 ± 0.002	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.002	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.004XaaLeu: 0.004 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.004XaaPro: 0.004 ± 0.002	0.001XaaGln: 0.001 ± 0.002	0.005XaaArg: 0.005 ± 0.002	0.002XaaSer: 0.002 ± 0.002	0.0XaaThr: 0.0 ± 0.0	0.004XaaVal: 0.004 ± 0.002	0.002XaaTrp: 0.002 ± 0.002	0.0XaaTyr: 0.0 ± 0.0	0.037XaaXaa: 0.037 ± 0.009

Statistics based on 2178 proteins (817153 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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