Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)

Taxonomy: Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus; Human alphaherpesvirus 1

Average proteome isoelectric point is 7.07

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 77 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>sp|P08392|ICP4_HHV11 Major viral transcription factor ICP4 OS=Human herpesvirus 1 (strain 17) OX=10299 GN=ICP4 PE=1 SV=1
MM1 pKa = 7.97DD2 pKa = 5.67LLVDD6 pKa = 4.15EE7 pKa = 5.76LFADD11 pKa = 4.29MNADD15 pKa = 3.63GASPPPPRR23 pKa = 11.84PAGGPKK29 pKa = 8.47NTPAAPPLYY38 pKa = 9.66ATGRR42 pKa = 11.84LSQAQLMPSPPMPVPPAALFNRR64 pKa = 11.84LLDD67 pKa = 4.24DD68 pKa = 4.82LGFSAGPALCTMLDD82 pKa = 3.31TWNEE86 pKa = 4.08DD87 pKa = 3.39LFSALPTNADD97 pKa = 4.16LYY99 pKa = 10.72RR100 pKa = 11.84EE101 pKa = 4.37CKK103 pKa = 9.8FLSTLPSDD111 pKa = 3.77VVEE114 pKa = 4.41WGDD117 pKa = 3.38AYY119 pKa = 11.29VPEE122 pKa = 4.45RR123 pKa = 11.84TQIDD127 pKa = 3.18IRR129 pKa = 11.84AHH131 pKa = 5.99GDD133 pKa = 3.29VAFPTLPATRR143 pKa = 11.84DD144 pKa = 3.59GLGLYY149 pKa = 10.03YY150 pKa = 10.38EE151 pKa = 4.24ALSRR155 pKa = 11.84FFHH158 pKa = 6.56AEE160 pKa = 3.02LRR162 pKa = 11.84ARR164 pKa = 11.84EE165 pKa = 3.89EE166 pKa = 4.02SYY168 pKa = 9.67RR169 pKa = 11.84TVLANFCSALYY180 pKa = 9.82RR181 pKa = 11.84YY182 pKa = 9.56LRR184 pKa = 11.84ASVRR188 pKa = 11.84QLHH191 pKa = 5.87RR192 pKa = 11.84QAHH195 pKa = 4.64MRR197 pKa = 11.84GRR199 pKa = 11.84DD200 pKa = 3.25RR201 pKa = 11.84DD202 pKa = 3.74LGEE205 pKa = 4.07MLRR208 pKa = 11.84ATIADD213 pKa = 3.86RR214 pKa = 11.84YY215 pKa = 8.55YY216 pKa = 11.06RR217 pKa = 11.84EE218 pKa = 3.99TARR221 pKa = 11.84LARR224 pKa = 11.84VLFLHH229 pKa = 7.13LYY231 pKa = 10.43LFLTRR236 pKa = 11.84EE237 pKa = 4.38ILWAAYY243 pKa = 9.3AEE245 pKa = 4.24QMMRR249 pKa = 11.84PDD251 pKa = 6.0LFDD254 pKa = 4.82CLCCDD259 pKa = 4.03LEE261 pKa = 4.33SWRR264 pKa = 11.84QLAGLFQPFMFVNGALTVRR283 pKa = 11.84GVPIEE288 pKa = 3.76ARR290 pKa = 11.84RR291 pKa = 11.84LRR293 pKa = 11.84EE294 pKa = 3.74LNHH297 pKa = 6.26IRR299 pKa = 11.84EE300 pKa = 4.48HH301 pKa = 6.62LNLPLVRR308 pKa = 11.84SAATEE313 pKa = 4.05EE314 pKa = 4.29PGAPLTTPPTLHH326 pKa = 6.67GNQARR331 pKa = 11.84ASGYY335 pKa = 10.28FMVLIRR341 pKa = 11.84AKK343 pKa = 10.19LDD345 pKa = 3.45SYY347 pKa = 11.91SSFTTSPSEE356 pKa = 3.72AVMRR360 pKa = 11.84EE361 pKa = 3.85HH362 pKa = 7.26AYY364 pKa = 10.74SRR366 pKa = 11.84ARR368 pKa = 11.84TKK370 pKa = 11.08NNYY373 pKa = 9.6GSTIEE378 pKa = 4.57GLLDD382 pKa = 5.03LPDD385 pKa = 4.99DD386 pKa = 4.89DD387 pKa = 5.62APEE390 pKa = 4.23EE391 pKa = 4.33AGLAAPRR398 pKa = 11.84LSFLPAGHH406 pKa = 6.02TRR408 pKa = 11.84RR409 pKa = 11.84LSTAPPTDD417 pKa = 3.06VSLGDD422 pKa = 3.75EE423 pKa = 4.16LHH425 pKa = 7.34LDD427 pKa = 4.01GEE429 pKa = 4.85DD430 pKa = 3.13VAMAHH435 pKa = 7.2ADD437 pKa = 3.53ALDD440 pKa = 4.82DD441 pKa = 4.82FDD443 pKa = 7.35LDD445 pKa = 3.79MLGDD449 pKa = 4.16GDD451 pKa = 4.27SPGPGFTPHH460 pKa = 7.46DD461 pKa = 4.07SAPYY465 pKa = 9.65GALDD469 pKa = 3.39MADD472 pKa = 4.37FEE474 pKa = 4.54FEE476 pKa = 4.81QMFTDD481 pKa = 3.78ALGIDD486 pKa = 4.23EE487 pKa = 4.57YY488 pKa = 11.73GGG490 pKa = 3.43

Molecular weight: 54.35 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>sp|P10234|DUT_HHV11 Deoxyuridine 5'-triphosphate nucleotidohydrolase OS=Human herpesvirus 1 (strain 17) OX=10299 GN=DUT PE=3 SV=1
MM1 pKa = 7.08TSRR4 pKa = 11.84RR5 pKa = 11.84SVKK8 pKa = 9.91SGPRR12 pKa = 11.84EE13 pKa = 3.94VPRR16 pKa = 11.84DD17 pKa = 3.7EE18 pKa = 5.67YY19 pKa = 11.42EE20 pKa = 4.01DD21 pKa = 4.8LYY23 pKa = 9.79YY24 pKa = 10.73TPSSGMASPDD34 pKa = 3.65SPPDD38 pKa = 3.3TSRR41 pKa = 11.84RR42 pKa = 11.84GALQTRR48 pKa = 11.84SRR50 pKa = 11.84QRR52 pKa = 11.84GEE54 pKa = 3.87VRR56 pKa = 11.84FVQYY60 pKa = 10.87DD61 pKa = 3.49EE62 pKa = 5.07SDD64 pKa = 3.58YY65 pKa = 11.75ALYY68 pKa = 10.61GGSSSEE74 pKa = 4.18DD75 pKa = 3.52DD76 pKa = 3.62EE77 pKa = 5.61HH78 pKa = 8.45PEE80 pKa = 3.91VPRR83 pKa = 11.84TRR85 pKa = 11.84RR86 pKa = 11.84PVSGAVLSGPGPARR100 pKa = 11.84APPPPAGSGGAGRR113 pKa = 11.84TPTTAPRR120 pKa = 11.84APRR123 pKa = 11.84TQRR126 pKa = 11.84VATKK130 pKa = 10.67APAAPAAEE138 pKa = 4.35TTRR141 pKa = 11.84GRR143 pKa = 11.84KK144 pKa = 8.6SAQPEE149 pKa = 4.16SAALPDD155 pKa = 4.48APASTAPTRR164 pKa = 11.84SKK166 pKa = 10.07TPAQGLARR174 pKa = 11.84KK175 pKa = 8.77LHH177 pKa = 6.51FSTAPPNPDD186 pKa = 3.71APWTPRR192 pKa = 11.84VAGFNKK198 pKa = 9.92RR199 pKa = 11.84VFCAAVGRR207 pKa = 11.84LAAMHH212 pKa = 6.39ARR214 pKa = 11.84MAAVQLWDD222 pKa = 3.36MSRR225 pKa = 11.84PRR227 pKa = 11.84TDD229 pKa = 3.27EE230 pKa = 4.46DD231 pKa = 3.98LNEE234 pKa = 4.24LLGITTIRR242 pKa = 11.84VTVCEE247 pKa = 4.57GKK249 pKa = 10.09NLLQRR254 pKa = 11.84ANEE257 pKa = 4.1LVNPDD262 pKa = 3.04VVQDD266 pKa = 3.4VDD268 pKa = 3.24AATATRR274 pKa = 11.84GRR276 pKa = 11.84SAASRR281 pKa = 11.84PTEE284 pKa = 4.06RR285 pKa = 11.84PRR287 pKa = 11.84APARR291 pKa = 11.84SASRR295 pKa = 11.84PRR297 pKa = 11.84RR298 pKa = 11.84PVEE301 pKa = 3.64

Molecular weight: 32.25 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

73

4

77

39997

88

3164

519.4

56.09

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

12.538 ± 0.449

1.815 ± 0.112

5.308 ± 0.13

4.838 ± 0.135

3.41 ± 0.162

7.873 ± 0.201

2.528 ± 0.099

2.85 ± 0.157

1.758 ± 0.128

9.683 ± 0.26

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.72 ± 0.102

2.293 ± 0.148

8.918 ± 0.363

3.083 ± 0.142

8.406 ± 0.201

6.238 ± 0.209

6.013 ± 0.198

7.026 ± 0.185

1.158 ± 0.069

2.545 ± 0.138
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski