Amino acid dipepetide frequency for Liparis tanakae (Tanaka s snailfish)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.4AlaAla: 9.4 ± 0.046	1.472AlaCys: 1.472 ± 0.01	3.4AlaAsp: 3.4 ± 0.015	4.912AlaGlu: 4.912 ± 0.023	2.22AlaPhe: 2.22 ± 0.013	5.997AlaGly: 5.997 ± 0.026	1.877AlaHis: 1.877 ± 0.012	2.151AlaIle: 2.151 ± 0.013	2.678AlaLys: 2.678 ± 0.016	7.059AlaLeu: 7.059 ± 0.024	1.619AlaMet: 1.619 ± 0.012	1.858AlaAsn: 1.858 ± 0.013	4.934AlaPro: 4.934 ± 0.027	2.89AlaGln: 2.89 ± 0.017	4.55AlaArg: 4.55 ± 0.021	6.546AlaSer: 6.546 ± 0.028	3.685AlaThr: 3.685 ± 0.02	5.607AlaVal: 5.607 ± 0.023	0.819AlaTrp: 0.819 ± 0.008	1.182AlaTyr: 1.182 ± 0.011	0.001AlaXaa: 0.001 ± 0.0
Cys	1.26CysAla: 1.26 ± 0.01	0.828CysCys: 0.828 ± 0.01	0.974CysAsp: 0.974 ± 0.01	1.07CysGlu: 1.07 ± 0.012	0.854CysPhe: 0.854 ± 0.008	1.728CysGly: 1.728 ± 0.013	0.624CysHis: 0.624 ± 0.008	0.764CysIle: 0.764 ± 0.008	0.83CysLys: 0.83 ± 0.009	2.062CysLeu: 2.062 ± 0.014	0.477CysMet: 0.477 ± 0.007	0.634CysAsn: 0.634 ± 0.008	1.329CysPro: 1.329 ± 0.013	0.857CysGln: 0.857 ± 0.009	1.724CysArg: 1.724 ± 0.012	2.518CysSer: 2.518 ± 0.014	1.129CysThr: 1.129 ± 0.011	1.665CysVal: 1.665 ± 0.016	0.4CysTrp: 0.4 ± 0.006	0.486CysTyr: 0.486 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	3.329AspAla: 3.329 ± 0.019	0.925AspCys: 0.925 ± 0.009	2.97AspAsp: 2.97 ± 0.04	3.381AspGlu: 3.381 ± 0.02	1.613AspPhe: 1.613 ± 0.012	4.014AspGly: 4.014 ± 0.019	1.187AspHis: 1.187 ± 0.012	1.877AspIle: 1.877 ± 0.014	1.962AspLys: 1.962 ± 0.014	4.298AspLeu: 4.298 ± 0.021	1.122AspMet: 1.122 ± 0.01	1.432AspAsn: 1.432 ± 0.014	2.811AspPro: 2.811 ± 0.019	1.852AspGln: 1.852 ± 0.017	3.059AspArg: 3.059 ± 0.017	3.826AspSer: 3.826 ± 0.021	2.429AspThr: 2.429 ± 0.015	3.302AspVal: 3.302 ± 0.019	0.636AspTrp: 0.636 ± 0.007	1.064AspTyr: 1.064 ± 0.011	0.0AspXaa: 0.0 ± 0.0
Glu	5.169GluAla: 5.169 ± 0.024	0.95GluCys: 0.95 ± 0.01	4.042GluAsp: 4.042 ± 0.026	9.892GluGlu: 9.892 ± 0.078	1.401GluPhe: 1.401 ± 0.011	4.777GluGly: 4.777 ± 0.022	1.469GluHis: 1.469 ± 0.012	1.983GluIle: 1.983 ± 0.014	3.836GluLys: 3.836 ± 0.026	5.377GluLeu: 5.377 ± 0.026	1.585GluMet: 1.585 ± 0.011	2.049GluAsn: 2.049 ± 0.016	3.21GluPro: 3.21 ± 0.02	2.834GluGln: 2.834 ± 0.019	5.33GluArg: 5.33 ± 0.027	4.086GluSer: 4.086 ± 0.019	3.366GluThr: 3.366 ± 0.019	4.225GluVal: 4.225 ± 0.026	0.6GluTrp: 0.6 ± 0.006	1.092GluTyr: 1.092 ± 0.011	0.001GluXaa: 0.001 ± 0.0
Phe	1.622PheAla: 1.622 ± 0.01	0.887PheCys: 0.887 ± 0.01	1.311PheAsp: 1.311 ± 0.012	1.392PheGlu: 1.392 ± 0.013	1.586PhePhe: 1.586 ± 0.033	1.906PheGly: 1.906 ± 0.013	0.917PheHis: 0.917 ± 0.008	1.534PheIle: 1.534 ± 0.014	1.361PheLys: 1.361 ± 0.012	3.557PheLeu: 3.557 ± 0.019	0.781PheMet: 0.781 ± 0.009	1.095PheAsn: 1.095 ± 0.009	1.862PhePro: 1.862 ± 0.013	1.251PheGln: 1.251 ± 0.01	1.874PheArg: 1.874 ± 0.013	3.29PheSer: 3.29 ± 0.021	2.039PheThr: 2.039 ± 0.014	1.841PheVal: 1.841 ± 0.013	0.481PheTrp: 0.481 ± 0.005	0.856PheTyr: 0.856 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	5.922GlyAla: 5.922 ± 0.029	1.47GlyCys: 1.47 ± 0.012	3.567GlyAsp: 3.567 ± 0.018	4.909GlyGlu: 4.909 ± 0.021	2.232GlyPhe: 2.232 ± 0.015	8.849GlyGly: 8.849 ± 0.047	2.039GlyHis: 2.039 ± 0.013	2.08GlyIle: 2.08 ± 0.014	3.078GlyLys: 3.078 ± 0.016	6.26GlyLeu: 6.26 ± 0.026	1.525GlyMet: 1.525 ± 0.012	2.18GlyAsn: 2.18 ± 0.014	4.426GlyPro: 4.426 ± 0.028	2.963GlyGln: 2.963 ± 0.017	5.924GlyArg: 5.924 ± 0.028	6.411GlySer: 6.411 ± 0.026	3.471GlyThr: 3.471 ± 0.02	4.962GlyVal: 4.962 ± 0.024	0.9GlyTrp: 0.9 ± 0.008	1.426GlyTyr: 1.426 ± 0.013	0.001GlyXaa: 0.001 ± 0.0
His	1.853HisAla: 1.853 ± 0.012	0.698HisCys: 0.698 ± 0.008	1.03HisAsp: 1.03 ± 0.009	1.219HisGlu: 1.219 ± 0.01	0.98HisPhe: 0.98 ± 0.009	2.087HisGly: 2.087 ± 0.014	1.305HisHis: 1.305 ± 0.017	1.109HisIle: 1.109 ± 0.009	1.105HisLys: 1.105 ± 0.01	2.977HisLeu: 2.977 ± 0.018	0.707HisMet: 0.707 ± 0.007	0.906HisAsn: 0.906 ± 0.01	1.734HisPro: 1.734 ± 0.013	1.412HisGln: 1.412 ± 0.012	2.353HisArg: 2.353 ± 0.014	2.379HisSer: 2.379 ± 0.014	1.728HisThr: 1.728 ± 0.016	1.756HisVal: 1.756 ± 0.013	0.388HisTrp: 0.388 ± 0.007	0.661HisTyr: 0.661 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	1.937IleAla: 1.937 ± 0.013	0.857IleCys: 0.857 ± 0.009	1.48IleAsp: 1.48 ± 0.014	1.676IleGlu: 1.676 ± 0.014	1.314IlePhe: 1.314 ± 0.011	1.981IleGly: 1.981 ± 0.014	1.057IleHis: 1.057 ± 0.011	2.322IleIle: 2.322 ± 0.051	1.791IleLys: 1.791 ± 0.017	3.257IleLeu: 3.257 ± 0.015	0.905IleMet: 0.905 ± 0.008	1.355IleAsn: 1.355 ± 0.013	1.951IlePro: 1.951 ± 0.014	1.591IleGln: 1.591 ± 0.013	2.241IleArg: 2.241 ± 0.013	3.104IleSer: 3.104 ± 0.018	2.229IleThr: 2.229 ± 0.021	1.987IleVal: 1.987 ± 0.015	0.449IleTrp: 0.449 ± 0.006	0.915IleTyr: 0.915 ± 0.01	0.0IleXaa: 0.0 ± 0.0
Lys	3.162LysAla: 3.162 ± 0.018	0.79LysCys: 0.79 ± 0.009	2.395LysAsp: 2.395 ± 0.017	4.0LysGlu: 4.0 ± 0.03	1.034LysPhe: 1.034 ± 0.009	2.809LysGly: 2.809 ± 0.018	1.208LysHis: 1.208 ± 0.009	1.598LysIle: 1.598 ± 0.013	5.705LysLys: 5.705 ± 0.092	3.672LysLeu: 3.672 ± 0.02	1.33LysMet: 1.33 ± 0.011	1.744LysAsn: 1.744 ± 0.023	2.475LysPro: 2.475 ± 0.015	1.987LysGln: 1.987 ± 0.015	3.671LysArg: 3.671 ± 0.019	3.131LysSer: 3.131 ± 0.019	2.658LysThr: 2.658 ± 0.02	2.761LysVal: 2.761 ± 0.019	0.472LysTrp: 0.472 ± 0.006	0.99LysTyr: 0.99 ± 0.009	0.001LysXaa: 0.001 ± 0.0
Leu	6.158LeuAla: 6.158 ± 0.025	2.307LeuCys: 2.307 ± 0.014	4.183LeuAsp: 4.183 ± 0.022	5.499LeuGlu: 5.499 ± 0.029	3.165LeuPhe: 3.165 ± 0.017	5.766LeuGly: 5.766 ± 0.025	3.189LeuHis: 3.189 ± 0.019	3.136LeuIle: 3.136 ± 0.017	4.448LeuLys: 4.448 ± 0.019	10.93LeuLeu: 10.93 ± 0.047	2.328LeuMet: 2.328 ± 0.016	2.823LeuAsn: 2.823 ± 0.019	5.7LeuPro: 5.7 ± 0.025	5.32LeuGln: 5.32 ± 0.024	6.829LeuArg: 6.829 ± 0.027	8.28LeuSer: 8.28 ± 0.032	4.984LeuThr: 4.984 ± 0.022	5.748LeuVal: 5.748 ± 0.027	1.321LeuTrp: 1.321 ± 0.012	2.012LeuTyr: 2.012 ± 0.015	0.001LeuXaa: 0.001 ± 0.0
Met	1.994MetAla: 1.994 ± 0.012	0.506MetCys: 0.506 ± 0.006	1.266MetAsp: 1.266 ± 0.012	1.944MetGlu: 1.944 ± 0.014	0.799MetPhe: 0.799 ± 0.01	1.437MetGly: 1.437 ± 0.009	0.511MetHis: 0.511 ± 0.007	0.73MetIle: 0.73 ± 0.009	1.541MetLys: 1.541 ± 0.014	2.041MetLeu: 2.041 ± 0.014	1.339MetMet: 1.339 ± 0.057	0.821MetAsn: 0.821 ± 0.011	1.121MetPro: 1.121 ± 0.011	0.956MetGln: 0.956 ± 0.01	1.507MetArg: 1.507 ± 0.013	2.103MetSer: 2.103 ± 0.014	1.326MetThr: 1.326 ± 0.011	1.56MetVal: 1.56 ± 0.018	0.345MetTrp: 0.345 ± 0.006	0.513MetTyr: 0.513 ± 0.007	0.0MetXaa: 0.0 ± 0.0
Asn	1.938AsnAla: 1.938 ± 0.015	0.635AsnCys: 0.635 ± 0.009	1.243AsnAsp: 1.243 ± 0.011	1.58AsnGlu: 1.58 ± 0.013	0.956AsnPhe: 0.956 ± 0.009	2.215AsnGly: 2.215 ± 0.016	0.905AsnHis: 0.905 ± 0.012	1.464AsnIle: 1.464 ± 0.017	1.836AsnLys: 1.836 ± 0.024	2.62AsnLeu: 2.62 ± 0.02	0.911AsnMet: 0.911 ± 0.01	1.555AsnAsn: 1.555 ± 0.023	1.826AsnPro: 1.826 ± 0.014	1.403AsnGln: 1.403 ± 0.013	2.024AsnArg: 2.024 ± 0.014	2.454AsnSer: 2.454 ± 0.016	2.013AsnThr: 2.013 ± 0.015	1.877AsnVal: 1.877 ± 0.019	0.378AsnTrp: 0.378 ± 0.006	0.739AsnTyr: 0.739 ± 0.008	0.0AsnXaa: 0.0 ± 0.0
Pro	5.36ProAla: 5.36 ± 0.027	1.227ProCys: 1.227 ± 0.012	2.85ProAsp: 2.85 ± 0.015	3.894ProGlu: 3.894 ± 0.02	1.685ProPhe: 1.685 ± 0.011	5.014ProGly: 5.014 ± 0.03	1.751ProHis: 1.751 ± 0.015	1.602ProIle: 1.602 ± 0.013	2.048ProLys: 2.048 ± 0.019	5.761ProLeu: 5.761 ± 0.024	1.136ProMet: 1.136 ± 0.011	1.558ProAsn: 1.558 ± 0.013	6.852ProPro: 6.852 ± 0.05	2.696ProGln: 2.696 ± 0.023	4.344ProArg: 4.344 ± 0.021	6.117ProSer: 6.117 ± 0.027	3.214ProThr: 3.214 ± 0.021	4.15ProVal: 4.15 ± 0.019	0.696ProTrp: 0.696 ± 0.007	1.079ProTyr: 1.079 ± 0.012	0.001ProXaa: 0.001 ± 0.0
Gln	2.984GlnAla: 2.984 ± 0.017	0.786GlnCys: 0.786 ± 0.008	2.015GlnAsp: 2.015 ± 0.015	3.125GlnGlu: 3.125 ± 0.023	1.012GlnPhe: 1.012 ± 0.009	2.724GlnGly: 2.724 ± 0.016	1.472GlnHis: 1.472 ± 0.013	1.467GlnIle: 1.467 ± 0.013	2.019GlnLys: 2.019 ± 0.015	4.251GlnLeu: 4.251 ± 0.022	1.026GlnMet: 1.026 ± 0.009	1.43GlnAsn: 1.43 ± 0.015	2.625GlnPro: 2.625 ± 0.019	3.147GlnGln: 3.147 ± 0.03	3.958GlnArg: 3.958 ± 0.022	3.368GlnSer: 3.368 ± 0.019	2.553GlnThr: 2.553 ± 0.017	2.717GlnVal: 2.717 ± 0.016	0.515GlnTrp: 0.515 ± 0.008	0.842GlnTyr: 0.842 ± 0.009	0.0GlnXaa: 0.0 ± 0.0
Arg	5.143ArgAla: 5.143 ± 0.021	1.709ArgCys: 1.709 ± 0.012	3.401ArgAsp: 3.401 ± 0.021	4.769ArgGlu: 4.769 ± 0.023	1.97ArgPhe: 1.97 ± 0.014	6.179ArgGly: 6.179 ± 0.029	2.182ArgHis: 2.182 ± 0.015	2.116ArgIle: 2.116 ± 0.014	3.557ArgLys: 3.557 ± 0.017	6.811ArgLeu: 6.811 ± 0.027	1.69ArgMet: 1.69 ± 0.012	2.005ArgAsn: 2.005 ± 0.011	4.639ArgPro: 4.639 ± 0.022	3.081ArgGln: 3.081 ± 0.02	8.262ArgArg: 8.262 ± 0.043	6.292ArgSer: 6.292 ± 0.026	3.71ArgThr: 3.71 ± 0.02	4.352ArgVal: 4.352 ± 0.02	0.991ArgTrp: 0.991 ± 0.008	1.412ArgTyr: 1.412 ± 0.01	0.001ArgXaa: 0.001 ± 0.0
Ser	6.575SerAla: 6.575 ± 0.025	2.233SerCys: 2.233 ± 0.013	3.885SerAsp: 3.885 ± 0.023	4.633SerGlu: 4.633 ± 0.026	3.046SerPhe: 3.046 ± 0.02	6.588SerGly: 6.588 ± 0.027	2.354SerHis: 2.354 ± 0.013	2.852SerIle: 2.852 ± 0.017	3.104SerLys: 3.104 ± 0.017	8.348SerLeu: 8.348 ± 0.031	1.886SerMet: 1.886 ± 0.016	2.366SerAsn: 2.366 ± 0.015	6.555SerPro: 6.555 ± 0.033	3.489SerGln: 3.489 ± 0.017	6.319SerArg: 6.319 ± 0.024	11.721SerSer: 11.721 ± 0.045	4.824SerThr: 4.824 ± 0.022	5.595SerVal: 5.595 ± 0.02	1.246SerTrp: 1.246 ± 0.012	1.657SerTyr: 1.657 ± 0.014	0.0SerXaa: 0.0 ± 0.0
Thr	4.419ThrAla: 4.419 ± 0.02	1.328ThrCys: 1.328 ± 0.012	2.546ThrAsp: 2.546 ± 0.015	3.464ThrGlu: 3.464 ± 0.02	1.801ThrPhe: 1.801 ± 0.016	4.153ThrGly: 4.153 ± 0.02	1.674ThrHis: 1.674 ± 0.016	1.807ThrIle: 1.807 ± 0.018	2.14ThrLys: 2.14 ± 0.018	5.042ThrLeu: 5.042 ± 0.025	1.303ThrMet: 1.303 ± 0.012	1.552ThrAsn: 1.552 ± 0.015	3.794ThrPro: 3.794 ± 0.02	2.23ThrGln: 2.23 ± 0.015	3.643ThrArg: 3.643 ± 0.02	5.07ThrSer: 5.07 ± 0.024	3.372ThrThr: 3.372 ± 0.031	3.579ThrVal: 3.579 ± 0.021	0.749ThrTrp: 0.749 ± 0.009	1.041ThrTyr: 1.041 ± 0.01	0.001ThrXaa: 0.001 ± 0.0
Val	4.664ValAla: 4.664 ± 0.024	1.767ValCys: 1.767 ± 0.016	2.985ValAsp: 2.985 ± 0.02	4.051ValGlu: 4.051 ± 0.022	2.462ValPhe: 2.462 ± 0.015	4.279ValGly: 4.279 ± 0.023	1.823ValHis: 1.823 ± 0.012	2.357ValIle: 2.357 ± 0.014	2.928ValLys: 2.928 ± 0.018	6.486ValLeu: 6.486 ± 0.026	1.745ValMet: 1.745 ± 0.019	2.009ValAsn: 2.009 ± 0.016	3.537ValPro: 3.537 ± 0.02	2.741ValGln: 2.741 ± 0.016	3.976ValArg: 3.976 ± 0.02	5.575ValSer: 5.575 ± 0.024	3.913ValThr: 3.913 ± 0.023	4.934ValVal: 4.934 ± 0.033	0.841ValTrp: 0.841 ± 0.01	1.47ValTyr: 1.47 ± 0.015	0.001ValXaa: 0.001 ± 0.0
Trp	0.848TrpAla: 0.848 ± 0.008	0.272TrpCys: 0.272 ± 0.004	0.586TrpAsp: 0.586 ± 0.008	0.762TrpGlu: 0.762 ± 0.007	0.456TrpPhe: 0.456 ± 0.008	0.758TrpGly: 0.758 ± 0.008	0.267TrpHis: 0.267 ± 0.005	0.49TrpIle: 0.49 ± 0.006	0.685TrpLys: 0.685 ± 0.008	1.252TrpLeu: 1.252 ± 0.011	0.4TrpMet: 0.4 ± 0.005	0.43TrpAsn: 0.43 ± 0.005	0.612TrpPro: 0.612 ± 0.006	0.465TrpGln: 0.465 ± 0.006	1.231TrpArg: 1.231 ± 0.01	1.204TrpSer: 1.204 ± 0.012	0.842TrpThr: 0.842 ± 0.009	0.713TrpVal: 0.713 ± 0.007	0.232TrpTrp: 0.232 ± 0.004	0.268TrpTyr: 0.268 ± 0.004	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.121TyrAla: 1.121 ± 0.009	0.565TyrCys: 0.565 ± 0.008	0.961TyrAsp: 0.961 ± 0.011	1.103TyrGlu: 1.103 ± 0.01	0.856TyrPhe: 0.856 ± 0.008	1.331TyrGly: 1.331 ± 0.012	0.576TyrHis: 0.576 ± 0.007	0.958TyrIle: 0.958 ± 0.012	0.939TyrLys: 0.939 ± 0.01	2.068TyrLeu: 2.068 ± 0.017	0.546TyrMet: 0.546 ± 0.007	0.77TyrAsn: 0.77 ± 0.01	1.041TyrPro: 1.041 ± 0.01	0.874TyrGln: 0.874 ± 0.01	1.454TyrArg: 1.454 ± 0.013	1.798TyrSer: 1.798 ± 0.011	1.22TyrThr: 1.22 ± 0.015	1.212TyrVal: 1.212 ± 0.011	0.314TyrTrp: 0.314 ± 0.005	0.697TyrTyr: 0.697 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.035XaaXaa: 0.035 ± 0.005

Statistics based on 68164 proteins (15190440 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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