Amino acid dipepetide frequency for Tepidimonas charontis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.253AlaAla: 22.253 ± 0.282
1.381AlaCys: 1.381 ± 0.047
7.184AlaAsp: 7.184 ± 0.102
7.39AlaGlu: 7.39 ± 0.112
4.055AlaPhe: 4.055 ± 0.06
10.32AlaGly: 10.32 ± 0.119
3.481AlaHis: 3.481 ± 0.085
5.148AlaIle: 5.148 ± 0.093
2.936AlaLys: 2.936 ± 0.082
17.873AlaLeu: 17.873 ± 0.231
3.143AlaMet: 3.143 ± 0.066
2.424AlaAsn: 2.424 ± 0.056
7.182AlaPro: 7.182 ± 0.138
6.971AlaGln: 6.971 ± 0.119
11.596AlaArg: 11.596 ± 0.157
5.937AlaSer: 5.937 ± 0.083
6.247AlaThr: 6.247 ± 0.099
10.373AlaVal: 10.373 ± 0.128
2.745AlaTrp: 2.745 ± 0.08
2.576AlaTyr: 2.576 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
1.377CysAla: 1.377 ± 0.045
0.137CysCys: 0.137 ± 0.014
0.58CysAsp: 0.58 ± 0.026
0.516CysGlu: 0.516 ± 0.025
0.257CysPhe: 0.257 ± 0.017
0.978CysGly: 0.978 ± 0.042
0.304CysHis: 0.304 ± 0.021
0.382CysIle: 0.382 ± 0.022
0.194CysLys: 0.194 ± 0.015
0.864CysLeu: 0.864 ± 0.035
0.172CysMet: 0.172 ± 0.015
0.228CysAsn: 0.228 ± 0.019
0.642CysPro: 0.642 ± 0.03
0.275CysGln: 0.275 ± 0.017
0.688CysArg: 0.688 ± 0.031
0.405CysSer: 0.405 ± 0.023
0.484CysThr: 0.484 ± 0.025
0.78CysVal: 0.78 ± 0.033
0.14CysTrp: 0.14 ± 0.012
0.189CysTyr: 0.189 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
7.985AspAla: 7.985 ± 0.106
0.457AspCys: 0.457 ± 0.026
3.151AspAsp: 3.151 ± 0.069
3.531AspGlu: 3.531 ± 0.076
1.78AspPhe: 1.78 ± 0.048
4.895AspGly: 4.895 ± 0.087
1.1AspHis: 1.1 ± 0.036
2.389AspIle: 2.389 ± 0.056
1.388AspLys: 1.388 ± 0.046
4.877AspLeu: 4.877 ± 0.079
0.996AspMet: 0.996 ± 0.033
1.024AspAsn: 1.024 ± 0.035
3.352AspPro: 3.352 ± 0.056
1.275AspGln: 1.275 ± 0.038
3.417AspArg: 3.417 ± 0.067
1.788AspSer: 1.788 ± 0.044
2.511AspThr: 2.511 ± 0.057
4.311AspVal: 4.311 ± 0.082
1.199AspTrp: 1.199 ± 0.044
1.226AspTyr: 1.226 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
7.836GluAla: 7.836 ± 0.108
0.402GluCys: 0.402 ± 0.023
2.036GluAsp: 2.036 ± 0.054
2.543GluGlu: 2.543 ± 0.068
1.48GluPhe: 1.48 ± 0.046
3.729GluGly: 3.729 ± 0.073
1.404GluHis: 1.404 ± 0.044
2.512GluIle: 2.512 ± 0.063
1.467GluLys: 1.467 ± 0.05
5.722GluLeu: 5.722 ± 0.103
1.09GluMet: 1.09 ± 0.039
0.913GluAsn: 0.913 ± 0.036
2.936GluPro: 2.936 ± 0.055
2.655GluGln: 2.655 ± 0.066
6.175GluArg: 6.175 ± 0.108
1.886GluSer: 1.886 ± 0.059
2.365GluThr: 2.365 ± 0.051
4.179GluVal: 4.179 ± 0.072
0.842GluTrp: 0.842 ± 0.035
1.066GluTyr: 1.066 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.864PheAla: 3.864 ± 0.071
0.328PheCys: 0.328 ± 0.023
2.41PheAsp: 2.41 ± 0.056
2.102PheGlu: 2.102 ± 0.051
1.112PhePhe: 1.112 ± 0.045
2.875PheGly: 2.875 ± 0.063
0.68PheHis: 0.68 ± 0.028
1.263PheIle: 1.263 ± 0.041
0.833PheLys: 0.833 ± 0.031
2.641PheLeu: 2.641 ± 0.061
0.582PheMet: 0.582 ± 0.027
0.851PheAsn: 0.851 ± 0.033
1.289PhePro: 1.289 ± 0.039
0.919PheGln: 0.919 ± 0.037
1.859PheArg: 1.859 ± 0.048
1.388PheSer: 1.388 ± 0.043
1.564PheThr: 1.564 ± 0.041
2.552PheVal: 2.552 ± 0.057
0.512PheTrp: 0.512 ± 0.02
0.786PheTyr: 0.786 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
9.677GlyAla: 9.677 ± 0.105
0.984GlyCys: 0.984 ± 0.035
3.941GlyAsp: 3.941 ± 0.077
4.241GlyGlu: 4.241 ± 0.08
2.699GlyPhe: 2.699 ± 0.058
6.429GlyGly: 6.429 ± 0.114
2.067GlyHis: 2.067 ± 0.053
3.457GlyIle: 3.457 ± 0.072
2.499GlyLys: 2.499 ± 0.073
8.707GlyLeu: 8.707 ± 0.109
1.961GlyMet: 1.961 ± 0.053
1.651GlyAsn: 1.651 ± 0.048
3.32GlyPro: 3.32 ± 0.072
3.471GlyGln: 3.471 ± 0.053
6.267GlyArg: 6.267 ± 0.099
3.671GlySer: 3.671 ± 0.071
3.957GlyThr: 3.957 ± 0.093
6.881GlyVal: 6.881 ± 0.095
1.822GlyTrp: 1.822 ± 0.06
2.114GlyTyr: 2.114 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
3.337HisAla: 3.337 ± 0.072
0.293HisCys: 0.293 ± 0.021
1.4HisAsp: 1.4 ± 0.047
1.249HisGlu: 1.249 ± 0.042
0.833HisPhe: 0.833 ± 0.034
2.448HisGly: 2.448 ± 0.063
0.725HisHis: 0.725 ± 0.033
1.057HisIle: 1.057 ± 0.034
0.519HisLys: 0.519 ± 0.024
2.465HisLeu: 2.465 ± 0.052
0.406HisMet: 0.406 ± 0.019
0.471HisAsn: 0.471 ± 0.026
1.871HisPro: 1.871 ± 0.051
0.76HisGln: 0.76 ± 0.031
1.826HisArg: 1.826 ± 0.055
0.907HisSer: 0.907 ± 0.032
1.372HisThr: 1.372 ± 0.043
1.804HisVal: 1.804 ± 0.043
0.518HisTrp: 0.518 ± 0.026
0.663HisTyr: 0.663 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.572IleAla: 5.572 ± 0.104
0.33IleCys: 0.33 ± 0.02
3.176IleAsp: 3.176 ± 0.059
3.323IleGlu: 3.323 ± 0.068
1.03IlePhe: 1.03 ± 0.042
3.84IleGly: 3.84 ± 0.07
0.901IleHis: 0.901 ± 0.032
1.482IleIle: 1.482 ± 0.051
1.182IleLys: 1.182 ± 0.05
3.111IleLeu: 3.111 ± 0.06
0.665IleMet: 0.665 ± 0.027
1.143IleAsn: 1.143 ± 0.036
1.853IlePro: 1.853 ± 0.046
1.245IleGln: 1.245 ± 0.038
2.766IleArg: 2.766 ± 0.067
1.661IleSer: 1.661 ± 0.047
2.201IleThr: 2.201 ± 0.057
3.499IleVal: 3.499 ± 0.073
0.418IleTrp: 0.418 ± 0.026
0.889IleTyr: 0.889 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
3.417LysAla: 3.417 ± 0.076
0.133LysCys: 0.133 ± 0.013
1.253LysAsp: 1.253 ± 0.049
1.2LysGlu: 1.2 ± 0.049
0.61LysPhe: 0.61 ± 0.027
1.949LysGly: 1.949 ± 0.065
0.517LysHis: 0.517 ± 0.023
1.119LysIle: 1.119 ± 0.039
0.94LysLys: 0.94 ± 0.048
2.518LysLeu: 2.518 ± 0.066
0.545LysMet: 0.545 ± 0.028
0.654LysAsn: 0.654 ± 0.033
1.539LysPro: 1.539 ± 0.045
0.819LysGln: 0.819 ± 0.037
2.072LysArg: 2.072 ± 0.06
1.192LysSer: 1.192 ± 0.046
1.477LysThr: 1.477 ± 0.048
1.97LysVal: 1.97 ± 0.067
0.289LysTrp: 0.289 ± 0.02
0.536LysTyr: 0.536 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
15.924LeuAla: 15.924 ± 0.19
1.03LeuCys: 1.03 ± 0.04
6.019LeuAsp: 6.019 ± 0.099
5.289LeuGlu: 5.289 ± 0.093
3.022LeuPhe: 3.022 ± 0.069
8.659LeuGly: 8.659 ± 0.109
2.818LeuHis: 2.818 ± 0.064
4.166LeuIle: 4.166 ± 0.085
2.852LeuLys: 2.852 ± 0.079
11.401LeuLeu: 11.401 ± 0.143
2.26LeuMet: 2.26 ± 0.056
2.219LeuAsn: 2.219 ± 0.059
6.735LeuPro: 6.735 ± 0.092
5.477LeuGln: 5.477 ± 0.104
9.548LeuArg: 9.548 ± 0.104
5.173LeuSer: 5.173 ± 0.085
5.477LeuThr: 5.477 ± 0.086
7.504LeuVal: 7.504 ± 0.118
1.8LeuTrp: 1.8 ± 0.062
2.119LeuTyr: 2.119 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.864MetAla: 2.864 ± 0.06
0.157MetCys: 0.157 ± 0.015
0.949MetAsp: 0.949 ± 0.033
0.916MetGlu: 0.916 ± 0.032
0.519MetPhe: 0.519 ± 0.027
1.635MetGly: 1.635 ± 0.052
0.481MetHis: 0.481 ± 0.028
0.828MetIle: 0.828 ± 0.036
0.737MetLys: 0.737 ± 0.029
2.208MetLeu: 2.208 ± 0.055
0.458MetMet: 0.458 ± 0.022
0.636MetAsn: 0.636 ± 0.03
1.273MetPro: 1.273 ± 0.042
0.899MetGln: 0.899 ± 0.034
1.724MetArg: 1.724 ± 0.046
1.287MetSer: 1.287 ± 0.041
1.341MetThr: 1.341 ± 0.04
1.407MetVal: 1.407 ± 0.036
0.225MetTrp: 0.225 ± 0.017
0.305MetTyr: 0.305 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
2.786AsnAla: 2.786 ± 0.054
0.207AsnCys: 0.207 ± 0.015
1.094AsnAsp: 1.094 ± 0.04
0.984AsnGlu: 0.984 ± 0.035
0.635AsnPhe: 0.635 ± 0.026
1.704AsnGly: 1.704 ± 0.048
0.454AsnHis: 0.454 ± 0.021
0.96AsnIle: 0.96 ± 0.039
0.571AsnLys: 0.571 ± 0.029
2.131AsnLeu: 2.131 ± 0.057
0.395AsnMet: 0.395 ± 0.022
0.543AsnAsn: 0.543 ± 0.028
1.63AsnPro: 1.63 ± 0.049
0.704AsnGln: 0.704 ± 0.031
1.602AsnArg: 1.602 ± 0.05
0.748AsnSer: 0.748 ± 0.034
1.134AsnThr: 1.134 ± 0.041
1.549AsnVal: 1.549 ± 0.049
0.334AsnTrp: 0.334 ± 0.021
0.446AsnTyr: 0.446 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
8.326ProAla: 8.326 ± 0.138
0.48ProCys: 0.48 ± 0.023
3.479ProAsp: 3.479 ± 0.071
3.259ProGlu: 3.259 ± 0.063
1.611ProPhe: 1.611 ± 0.044
4.558ProGly: 4.558 ± 0.086
1.475ProHis: 1.475 ± 0.048
1.94ProIle: 1.94 ± 0.053
1.282ProLys: 1.282 ± 0.041
5.829ProLeu: 5.829 ± 0.095
1.22ProMet: 1.22 ± 0.041
1.245ProAsn: 1.245 ± 0.035
3.554ProPro: 3.554 ± 0.084
2.442ProGln: 2.442 ± 0.056
3.69ProArg: 3.69 ± 0.072
2.84ProSer: 2.84 ± 0.069
3.036ProThr: 3.036 ± 0.066
4.475ProVal: 4.475 ± 0.087
1.117ProTrp: 1.117 ± 0.046
1.253ProTyr: 1.253 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
7.061GlnAla: 7.061 ± 0.122
0.334GlnCys: 0.334 ± 0.02
1.41GlnAsp: 1.41 ± 0.039
1.677GlnGlu: 1.677 ± 0.049
1.016GlnPhe: 1.016 ± 0.036
2.966GlnGly: 2.966 ± 0.06
1.112GlnHis: 1.112 ± 0.042
1.46GlnIle: 1.46 ± 0.041
0.871GlnLys: 0.871 ± 0.035
3.946GlnLeu: 3.946 ± 0.07
0.84GlnMet: 0.84 ± 0.035
0.593GlnAsn: 0.593 ± 0.028
2.824GlnPro: 2.824 ± 0.072
2.17GlnGln: 2.17 ± 0.062
5.746GlnArg: 5.746 ± 0.1
1.546GlnSer: 1.546 ± 0.041
2.164GlnThr: 2.164 ± 0.058
2.91GlnVal: 2.91 ± 0.061
0.799GlnTrp: 0.799 ± 0.032
0.7GlnTyr: 0.7 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
11.064ArgAla: 11.064 ± 0.147
0.843ArgCys: 0.843 ± 0.035
4.152ArgAsp: 4.152 ± 0.073
4.614ArgGlu: 4.614 ± 0.089
2.813ArgPhe: 2.813 ± 0.058
5.322ArgGly: 5.322 ± 0.083
2.467ArgHis: 2.467 ± 0.057
3.776ArgIle: 3.776 ± 0.074
1.825ArgLys: 1.825 ± 0.048
10.411ArgLeu: 10.411 ± 0.135
1.805ArgMet: 1.805 ± 0.045
1.595ArgAsn: 1.595 ± 0.044
4.183ArgPro: 4.183 ± 0.073
3.698ArgGln: 3.698 ± 0.069
6.923ArgArg: 6.923 ± 0.104
3.236ArgSer: 3.236 ± 0.064
3.719ArgThr: 3.719 ± 0.077
6.23ArgVal: 6.23 ± 0.105
1.946ArgTrp: 1.946 ± 0.057
2.117ArgTyr: 2.117 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
6.195SerAla: 6.195 ± 0.088
0.367SerCys: 0.367 ± 0.024
2.281SerAsp: 2.281 ± 0.05
2.053SerGlu: 2.053 ± 0.059
1.384SerPhe: 1.384 ± 0.043
4.341SerGly: 4.341 ± 0.073
0.919SerHis: 0.919 ± 0.036
1.743SerIle: 1.743 ± 0.049
0.986SerLys: 0.986 ± 0.042
4.204SerLeu: 4.204 ± 0.076
0.981SerMet: 0.981 ± 0.034
0.993SerAsn: 0.993 ± 0.038
2.601SerPro: 2.601 ± 0.058
1.33SerGln: 1.33 ± 0.044
3.019SerArg: 3.019 ± 0.058
2.172SerSer: 2.172 ± 0.07
2.335SerThr: 2.335 ± 0.057
3.352SerVal: 3.352 ± 0.061
0.636SerTrp: 0.636 ± 0.03
0.934SerTyr: 0.934 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
6.216ThrAla: 6.216 ± 0.094
0.395ThrCys: 0.395 ± 0.024
2.493ThrAsp: 2.493 ± 0.065
2.366ThrGlu: 2.366 ± 0.059
1.653ThrPhe: 1.653 ± 0.047
4.226ThrGly: 4.226 ± 0.09
1.196ThrHis: 1.196 ± 0.041
1.905ThrIle: 1.905 ± 0.052
1.002ThrLys: 1.002 ± 0.038
6.634ThrLeu: 6.634 ± 0.101
0.934ThrMet: 0.934 ± 0.031
0.946ThrAsn: 0.946 ± 0.037
3.886ThrPro: 3.886 ± 0.07
1.86ThrGln: 1.86 ± 0.051
3.517ThrArg: 3.517 ± 0.072
2.004ThrSer: 2.004 ± 0.057
2.517ThrThr: 2.517 ± 0.055
4.436ThrVal: 4.436 ± 0.072
0.737ThrTrp: 0.737 ± 0.029
1.034ThrTyr: 1.034 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
10.628ValAla: 10.628 ± 0.136
0.816ValCys: 0.816 ± 0.033
3.701ValAsp: 3.701 ± 0.065
4.228ValGlu: 4.228 ± 0.074
2.569ValPhe: 2.569 ± 0.064
5.834ValGly: 5.834 ± 0.095
1.829ValHis: 1.829 ± 0.05
3.236ValIle: 3.236 ± 0.066
1.88ValLys: 1.88 ± 0.055
8.871ValLeu: 8.871 ± 0.127
1.643ValMet: 1.643 ± 0.042
1.67ValAsn: 1.67 ± 0.045
4.301ValPro: 4.301 ± 0.081
3.375ValGln: 3.375 ± 0.065
6.432ValArg: 6.432 ± 0.097
3.286ValSer: 3.286 ± 0.071
4.099ValThr: 4.099 ± 0.081
6.711ValVal: 6.711 ± 0.104
1.277ValTrp: 1.277 ± 0.041
1.481ValTyr: 1.481 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
2.13TrpAla: 2.13 ± 0.058
0.237TrpCys: 0.237 ± 0.018
0.746TrpAsp: 0.746 ± 0.03
0.683TrpGlu: 0.683 ± 0.028
0.513TrpPhe: 0.513 ± 0.026
1.201TrpGly: 1.201 ± 0.044
0.489TrpHis: 0.489 ± 0.024
0.666TrpIle: 0.666 ± 0.029
0.3TrpLys: 0.3 ± 0.021
2.743TrpLeu: 2.743 ± 0.075
0.441TrpMet: 0.441 ± 0.022
0.304TrpAsn: 0.304 ± 0.019
1.012TrpPro: 1.012 ± 0.039
1.013TrpGln: 1.013 ± 0.038
2.024TrpArg: 2.024 ± 0.068
0.781TrpSer: 0.781 ± 0.027
0.786TrpThr: 0.786 ± 0.035
1.337TrpVal: 1.337 ± 0.045
0.505TrpTrp: 0.505 ± 0.029
0.319TrpTyr: 0.319 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.705TyrAla: 2.705 ± 0.061
0.28TyrCys: 0.28 ± 0.02
1.198TyrAsp: 1.198 ± 0.04
1.073TyrGlu: 1.073 ± 0.039
0.818TyrPhe: 0.818 ± 0.036
1.907TyrGly: 1.907 ± 0.054
0.506TyrHis: 0.506 ± 0.027
0.799TyrIle: 0.799 ± 0.031
0.484TyrLys: 0.484 ± 0.027
2.337TyrLeu: 2.337 ± 0.054
0.31TyrMet: 0.31 ± 0.017
0.51TyrAsn: 0.51 ± 0.026
1.126TyrPro: 1.126 ± 0.041
0.786TyrGln: 0.786 ± 0.031
1.847TyrArg: 1.847 ± 0.052
0.919TyrSer: 0.919 ± 0.033
1.171TyrThr: 1.171 ± 0.037
1.606TyrVal: 1.606 ± 0.047
0.371TyrTrp: 0.371 ± 0.024
0.539TyrTyr: 0.539 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2630 proteins (830006 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski