Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)

Taxonomy: Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus; Human betaherpesvirus 6A

Average proteome isoelectric point is 7.01

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 112 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|A0A2N9DYZ3|A0A2N9DYZ3_HHV6U DR6 OS=Human herpesvirus 6A (strain Uganda-1102) OX=10370 GN=DR6 PE=4 SV=1
MM1 pKa = 7.46LLISKK6 pKa = 7.57TLFPIPRR13 pKa = 11.84GADD16 pKa = 3.4EE17 pKa = 4.53FWEE20 pKa = 4.66GTYY23 pKa = 10.44ILVVAFVLAFLVYY36 pKa = 10.69SDD38 pKa = 4.58FLSNLSPFGEE48 pKa = 4.32ILSSPCISTT57 pKa = 3.6

Molecular weight: 6.33 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>sp|Q77Z83|IE2_HHV6U Immediate-early protein 2 OS=Human herpesvirus 6A (strain Uganda-1102) OX=10370 GN=U90/U87/U86 PE=1 SV=2
MM1 pKa = 7.31ARR3 pKa = 11.84VMTRR7 pKa = 11.84GMARR11 pKa = 11.84VSTLATVRR19 pKa = 11.84VSTLARR25 pKa = 11.84ARR27 pKa = 11.84FSVRR31 pKa = 11.84DD32 pKa = 3.58SFMVSVIVGVRR43 pKa = 11.84VRR45 pKa = 11.84VDD47 pKa = 2.86VLVRR51 pKa = 11.84VNVLVRR57 pKa = 11.84ARR59 pKa = 11.84PRR61 pKa = 11.84VRR63 pKa = 11.84VRR65 pKa = 11.84ARR67 pKa = 11.84PRR69 pKa = 11.84VRR71 pKa = 11.84VRR73 pKa = 11.84VRR75 pKa = 11.84ARR77 pKa = 11.84PRR79 pKa = 11.84VRR81 pKa = 11.84VRR83 pKa = 11.84VRR85 pKa = 11.84ASPRR89 pKa = 11.84VRR91 pKa = 11.84VRR93 pKa = 11.84VITPPFFSPPGGFDD107 pKa = 3.61VIFKK111 pKa = 9.72TRR113 pKa = 11.84GIPSPGEE120 pKa = 3.71TVLDD124 pKa = 4.06KK125 pKa = 10.93KK126 pKa = 10.91VSRR129 pKa = 11.84PWRR132 pKa = 11.84GLTSRR137 pKa = 11.84RR138 pKa = 11.84GATMII143 pKa = 4.45

Molecular weight: 16.22 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

107

5

112

47695

54

2077

425.8

48.53

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.078 ± 0.118

2.847 ± 0.373

5.11 ± 0.166

5.646 ± 0.152

5.193 ± 0.194

4.286 ± 0.255

2.508 ± 0.088

6.508 ± 0.28

6.194 ± 0.258

9.804 ± 0.307

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

2.543 ± 0.131

5.474 ± 0.258

4.47 ± 0.24

3.589 ± 0.133

5.432 ± 0.321

8.265 ± 0.383

6.279 ± 0.241

6.357 ± 0.347

0.908 ± 0.071

3.508 ± 0.124
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski