Amino acid dipepetide frequency for Dehalococcoidia bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.564AlaAla: 15.564 ± 0.2	1.071AlaCys: 1.071 ± 0.039	6.432AlaAsp: 6.432 ± 0.097	7.797AlaGlu: 7.797 ± 0.123	4.008AlaPhe: 4.008 ± 0.088	11.052AlaGly: 11.052 ± 0.121	2.016AlaHis: 2.016 ± 0.056	5.979AlaIle: 5.979 ± 0.087	1.985AlaLys: 1.985 ± 0.049	12.505AlaLeu: 12.505 ± 0.149	2.837AlaMet: 2.837 ± 0.059	2.566AlaAsn: 2.566 ± 0.051	5.063AlaPro: 5.063 ± 0.082	3.222AlaGln: 3.222 ± 0.06	9.051AlaArg: 9.051 ± 0.113	6.725AlaSer: 6.725 ± 0.098	6.161AlaThr: 6.161 ± 0.097	9.288AlaVal: 9.288 ± 0.108	1.489AlaTrp: 1.489 ± 0.043	2.363AlaTyr: 2.363 ± 0.051	0.001AlaXaa: 0.001 ± 0.001
Cys	0.799CysAla: 0.799 ± 0.03	0.112CysCys: 0.112 ± 0.013	0.544CysAsp: 0.544 ± 0.029	0.52CysGlu: 0.52 ± 0.026	0.303CysPhe: 0.303 ± 0.018	1.069CysGly: 1.069 ± 0.039	0.199CysHis: 0.199 ± 0.015	0.299CysIle: 0.299 ± 0.02	0.128CysLys: 0.128 ± 0.012	0.807CysLeu: 0.807 ± 0.031	0.121CysMet: 0.121 ± 0.013	0.248CysAsn: 0.248 ± 0.021	0.527CysPro: 0.527 ± 0.03	0.255CysGln: 0.255 ± 0.019	0.704CysArg: 0.704 ± 0.03	0.481CysSer: 0.481 ± 0.027	0.426CysThr: 0.426 ± 0.023	0.558CysVal: 0.558 ± 0.031	0.108CysTrp: 0.108 ± 0.011	0.195CysTyr: 0.195 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.352AspAla: 6.352 ± 0.092	0.483AspCys: 0.483 ± 0.024	4.429AspAsp: 4.429 ± 0.1	4.847AspGlu: 4.847 ± 0.085	2.301AspPhe: 2.301 ± 0.057	5.767AspGly: 5.767 ± 0.107	1.241AspHis: 1.241 ± 0.043	2.766AspIle: 2.766 ± 0.053	1.007AspLys: 1.007 ± 0.034	6.419AspLeu: 6.419 ± 0.098	1.052AspMet: 1.052 ± 0.032	1.372AspAsn: 1.372 ± 0.046	3.555AspPro: 3.555 ± 0.063	1.798AspGln: 1.798 ± 0.041	4.362AspArg: 4.362 ± 0.069	2.994AspSer: 2.994 ± 0.062	2.561AspThr: 2.561 ± 0.063	4.81AspVal: 4.81 ± 0.076	0.938AspTrp: 0.938 ± 0.038	1.566AspTyr: 1.566 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	8.413GluAla: 8.413 ± 0.117	0.426GluCys: 0.426 ± 0.025	3.718GluAsp: 3.718 ± 0.07	4.924GluGlu: 4.924 ± 0.101	2.08GluPhe: 2.08 ± 0.054	5.494GluGly: 5.494 ± 0.091	1.376GluHis: 1.376 ± 0.037	3.578GluIle: 3.578 ± 0.079	1.649GluLys: 1.649 ± 0.048	6.448GluLeu: 6.448 ± 0.096	1.603GluMet: 1.603 ± 0.045	1.458GluAsn: 1.458 ± 0.043	3.393GluPro: 3.393 ± 0.086	2.44GluGln: 2.44 ± 0.057	5.862GluArg: 5.862 ± 0.103	3.616GluSer: 3.616 ± 0.061	3.288GluThr: 3.288 ± 0.071	5.415GluVal: 5.415 ± 0.086	0.889GluTrp: 0.889 ± 0.031	1.433GluTyr: 1.433 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.989PheAla: 3.989 ± 0.075	0.36PheCys: 0.36 ± 0.02	2.358PheAsp: 2.358 ± 0.049	2.371PheGlu: 2.371 ± 0.052	1.313PhePhe: 1.313 ± 0.053	3.416PheGly: 3.416 ± 0.062	0.705PheHis: 0.705 ± 0.026	1.588PheIle: 1.588 ± 0.047	0.828PheLys: 0.828 ± 0.032	3.361PheLeu: 3.361 ± 0.077	0.66PheMet: 0.66 ± 0.032	0.99PheAsn: 0.99 ± 0.032	1.62PhePro: 1.62 ± 0.044	0.978PheGln: 0.978 ± 0.034	2.14PheArg: 2.14 ± 0.051	2.065PheSer: 2.065 ± 0.055	1.749PheThr: 1.749 ± 0.045	2.919PheVal: 2.919 ± 0.06	0.543PheTrp: 0.543 ± 0.026	0.969PheTyr: 0.969 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	9.173GlyAla: 9.173 ± 0.125	0.829GlyCys: 0.829 ± 0.034	5.379GlyAsp: 5.379 ± 0.086	5.618GlyGlu: 5.618 ± 0.083	3.413GlyPhe: 3.413 ± 0.065	8.164GlyGly: 8.164 ± 0.141	1.873GlyHis: 1.873 ± 0.05	4.351GlyIle: 4.351 ± 0.073	2.365GlyLys: 2.365 ± 0.061	8.938GlyLeu: 8.938 ± 0.111	2.007GlyMet: 2.007 ± 0.05	2.173GlyAsn: 2.173 ± 0.059	4.059GlyPro: 4.059 ± 0.076	3.032GlyGln: 3.032 ± 0.064	7.215GlyArg: 7.215 ± 0.101	5.505GlySer: 5.505 ± 0.094	4.429GlyThr: 4.429 ± 0.076	7.144GlyVal: 7.144 ± 0.102	1.387GlyTrp: 1.387 ± 0.044	2.503GlyTyr: 2.503 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.965HisAla: 1.965 ± 0.048	0.227HisCys: 0.227 ± 0.02	1.214HisAsp: 1.214 ± 0.036	1.296HisGlu: 1.296 ± 0.039	0.702HisPhe: 0.702 ± 0.034	1.818HisGly: 1.818 ± 0.049	0.585HisHis: 0.585 ± 0.028	0.851HisIle: 0.851 ± 0.033	0.369HisLys: 0.369 ± 0.024	1.989HisLeu: 1.989 ± 0.054	0.378HisMet: 0.378 ± 0.021	0.518HisAsn: 0.518 ± 0.025	1.35HisPro: 1.35 ± 0.04	0.654HisGln: 0.654 ± 0.029	1.471HisArg: 1.471 ± 0.043	1.012HisSer: 1.012 ± 0.033	0.887HisThr: 0.887 ± 0.03	1.436HisVal: 1.436 ± 0.044	0.283HisTrp: 0.283 ± 0.017	0.609HisTyr: 0.609 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.026IleAla: 6.026 ± 0.082	0.451IleCys: 0.451 ± 0.025	3.323IleAsp: 3.323 ± 0.073	3.909IleGlu: 3.909 ± 0.078	1.672IlePhe: 1.672 ± 0.053	4.269IleGly: 4.269 ± 0.079	0.881IleHis: 0.881 ± 0.032	1.994IleIle: 1.994 ± 0.055	1.154IleLys: 1.154 ± 0.043	3.985IleLeu: 3.985 ± 0.068	0.707IleMet: 0.707 ± 0.03	1.383IleAsn: 1.383 ± 0.039	2.528IlePro: 2.528 ± 0.058	1.292IleGln: 1.292 ± 0.034	3.029IleArg: 3.029 ± 0.064	2.688IleSer: 2.688 ± 0.065	2.46IleThr: 2.46 ± 0.061	4.212IleVal: 4.212 ± 0.07	0.519IleTrp: 0.519 ± 0.025	1.07IleTyr: 1.07 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	2.661LysAla: 2.661 ± 0.059	0.115LysCys: 0.115 ± 0.012	1.193LysAsp: 1.193 ± 0.041	1.445LysGlu: 1.445 ± 0.051	0.569LysPhe: 0.569 ± 0.029	1.823LysGly: 1.823 ± 0.053	0.488LysHis: 0.488 ± 0.022	0.975LysIle: 0.975 ± 0.033	0.708LysLys: 0.708 ± 0.03	2.135LysLeu: 2.135 ± 0.055	0.463LysMet: 0.463 ± 0.024	0.499LysAsn: 0.499 ± 0.024	1.331LysPro: 1.331 ± 0.042	0.867LysGln: 0.867 ± 0.034	1.844LysArg: 1.844 ± 0.043	1.161LysSer: 1.161 ± 0.039	1.204LysThr: 1.204 ± 0.047	1.819LysVal: 1.819 ± 0.046	0.227LysTrp: 0.227 ± 0.015	0.503LysTyr: 0.503 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.253LeuAla: 13.253 ± 0.15	0.76LeuCys: 0.76 ± 0.034	6.484LeuAsp: 6.484 ± 0.09	6.08LeuGlu: 6.08 ± 0.109	3.166LeuPhe: 3.166 ± 0.069	8.746LeuGly: 8.746 ± 0.113	1.812LeuHis: 1.812 ± 0.043	4.459LeuIle: 4.459 ± 0.078	2.589LeuLys: 2.589 ± 0.06	10.274LeuLeu: 10.274 ± 0.137	1.995LeuMet: 1.995 ± 0.049	2.325LeuAsn: 2.325 ± 0.054	5.56LeuPro: 5.56 ± 0.092	3.001LeuGln: 3.001 ± 0.071	7.572LeuArg: 7.572 ± 0.102	5.909LeuSer: 5.909 ± 0.095	5.208LeuThr: 5.208 ± 0.079	8.376LeuVal: 8.376 ± 0.119	1.066LeuTrp: 1.066 ± 0.033	2.04LeuTyr: 2.04 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.793MetAla: 2.793 ± 0.062	0.129MetCys: 0.129 ± 0.013	1.164MetAsp: 1.164 ± 0.041	1.186MetGlu: 1.186 ± 0.037	0.536MetPhe: 0.536 ± 0.026	1.634MetGly: 1.634 ± 0.041	0.399MetHis: 0.399 ± 0.021	0.967MetIle: 0.967 ± 0.032	0.704MetLys: 0.704 ± 0.027	2.046MetLeu: 2.046 ± 0.058	0.507MetMet: 0.507 ± 0.026	0.626MetAsn: 0.626 ± 0.029	1.303MetPro: 1.303 ± 0.045	0.596MetGln: 0.596 ± 0.027	1.605MetArg: 1.605 ± 0.045	1.351MetSer: 1.351 ± 0.04	1.481MetThr: 1.481 ± 0.043	1.602MetVal: 1.602 ± 0.045	0.205MetTrp: 0.205 ± 0.016	0.347MetTyr: 0.347 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.558AsnAla: 2.558 ± 0.057	0.277AsnCys: 0.277 ± 0.023	1.477AsnAsp: 1.477 ± 0.051	1.471AsnGlu: 1.471 ± 0.04	0.912AsnPhe: 0.912 ± 0.031	2.159AsnGly: 2.159 ± 0.059	0.533AsnHis: 0.533 ± 0.024	1.155AsnIle: 1.155 ± 0.04	0.513AsnLys: 0.513 ± 0.024	2.508AsnLeu: 2.508 ± 0.05	0.43AsnMet: 0.43 ± 0.024	0.631AsnAsn: 0.631 ± 0.031	1.791AsnPro: 1.791 ± 0.041	0.739AsnGln: 0.739 ± 0.029	1.695AsnArg: 1.695 ± 0.049	1.225AsnSer: 1.225 ± 0.039	1.069AsnThr: 1.069 ± 0.04	2.012AsnVal: 2.012 ± 0.048	0.373AsnTrp: 0.373 ± 0.024	0.591AsnTyr: 0.591 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	6.384ProAla: 6.384 ± 0.111	0.344ProCys: 0.344 ± 0.02	3.806ProAsp: 3.806 ± 0.076	4.186ProGlu: 4.186 ± 0.076	1.889ProPhe: 1.889 ± 0.046	5.657ProGly: 5.657 ± 0.098	1.059ProHis: 1.059 ± 0.039	2.263ProIle: 2.263 ± 0.052	0.911ProLys: 0.911 ± 0.034	4.864ProLeu: 4.864 ± 0.069	1.077ProMet: 1.077 ± 0.037	1.25ProAsn: 1.25 ± 0.042	3.281ProPro: 3.281 ± 0.084	1.564ProGln: 1.564 ± 0.049	3.521ProArg: 3.521 ± 0.062	3.0ProSer: 3.0 ± 0.064	2.926ProThr: 2.926 ± 0.074	4.096ProVal: 4.096 ± 0.072	0.748ProTrp: 0.748 ± 0.032	1.267ProTyr: 1.267 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	3.784GlnAla: 3.784 ± 0.067	0.203GlnCys: 0.203 ± 0.014	1.532GlnAsp: 1.532 ± 0.046	1.945GlnGlu: 1.945 ± 0.048	0.984GlnPhe: 0.984 ± 0.036	2.365GlnGly: 2.365 ± 0.05	0.651GlnHis: 0.651 ± 0.026	1.513GlnIle: 1.513 ± 0.043	0.758GlnLys: 0.758 ± 0.028	3.053GlnLeu: 3.053 ± 0.062	0.731GlnMet: 0.731 ± 0.031	0.62GlnAsn: 0.62 ± 0.028	1.862GlnPro: 1.862 ± 0.046	1.225GlnGln: 1.225 ± 0.045	2.73GlnArg: 2.73 ± 0.059	1.641GlnSer: 1.641 ± 0.046	1.505GlnThr: 1.505 ± 0.033	2.604GlnVal: 2.604 ± 0.058	0.4GlnTrp: 0.4 ± 0.023	0.68GlnTyr: 0.68 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	8.026ArgAla: 8.026 ± 0.11	0.666ArgCys: 0.666 ± 0.031	4.221ArgAsp: 4.221 ± 0.076	5.273ArgGlu: 5.273 ± 0.096	2.725ArgPhe: 2.725 ± 0.053	5.741ArgGly: 5.741 ± 0.09	1.581ArgHis: 1.581 ± 0.048	3.632ArgIle: 3.632 ± 0.062	1.746ArgLys: 1.746 ± 0.049	8.303ArgLeu: 8.303 ± 0.12	1.742ArgMet: 1.742 ± 0.049	1.765ArgAsn: 1.765 ± 0.051	4.208ArgPro: 4.208 ± 0.069	2.72ArgGln: 2.72 ± 0.059	7.197ArgArg: 7.197 ± 0.122	4.445ArgSer: 4.445 ± 0.069	3.512ArgThr: 3.512 ± 0.079	5.785ArgVal: 5.785 ± 0.085	1.212ArgTrp: 1.212 ± 0.042	1.976ArgTyr: 1.976 ± 0.052	0.002ArgXaa: 0.002 ± 0.002
Ser	6.212SerAla: 6.212 ± 0.098	0.471SerCys: 0.471 ± 0.025	3.381SerAsp: 3.381 ± 0.061	3.47SerGlu: 3.47 ± 0.08	2.211SerPhe: 2.211 ± 0.054	5.784SerGly: 5.784 ± 0.097	1.041SerHis: 1.041 ± 0.032	2.768SerIle: 2.768 ± 0.064	1.083SerLys: 1.083 ± 0.037	5.658SerLeu: 5.658 ± 0.086	1.325SerMet: 1.325 ± 0.042	1.31SerAsn: 1.31 ± 0.044	3.518SerPro: 3.518 ± 0.07	1.613SerGln: 1.613 ± 0.044	4.297SerArg: 4.297 ± 0.08	3.466SerSer: 3.466 ± 0.069	2.954SerThr: 2.954 ± 0.064	4.205SerVal: 4.205 ± 0.068	0.873SerTrp: 0.873 ± 0.03	1.344SerTyr: 1.344 ± 0.047	0.001SerXaa: 0.001 ± 0.001
Thr	5.88ThrAla: 5.88 ± 0.083	0.408ThrCys: 0.408 ± 0.023	2.764ThrAsp: 2.764 ± 0.064	2.983ThrGlu: 2.983 ± 0.067	1.824ThrPhe: 1.824 ± 0.048	4.844ThrGly: 4.844 ± 0.081	0.931ThrHis: 0.931 ± 0.033	2.643ThrIle: 2.643 ± 0.066	0.951ThrLys: 0.951 ± 0.038	5.057ThrLeu: 5.057 ± 0.082	1.144ThrMet: 1.144 ± 0.037	1.241ThrAsn: 1.241 ± 0.04	3.283ThrPro: 3.283 ± 0.074	1.3ThrGln: 1.3 ± 0.041	3.415ThrArg: 3.415 ± 0.073	3.024ThrSer: 3.024 ± 0.065	3.003ThrThr: 3.003 ± 0.067	4.303ThrVal: 4.303 ± 0.081	0.734ThrTrp: 0.734 ± 0.03	1.216ThrTyr: 1.216 ± 0.04	0.002ThrXaa: 0.002 ± 0.002
Val	9.804ValAla: 9.804 ± 0.117	0.679ValCys: 0.679 ± 0.027	4.994ValAsp: 4.994 ± 0.076	5.765ValGlu: 5.765 ± 0.086	2.906ValPhe: 2.906 ± 0.069	6.564ValGly: 6.564 ± 0.089	1.458ValHis: 1.458 ± 0.042	4.198ValIle: 4.198 ± 0.077	1.757ValLys: 1.757 ± 0.056	8.179ValLeu: 8.179 ± 0.11	1.624ValMet: 1.624 ± 0.044	2.198ValAsn: 2.198 ± 0.054	3.976ValPro: 3.976 ± 0.068	2.129ValGln: 2.129 ± 0.052	5.522ValArg: 5.522 ± 0.073	4.603ValSer: 4.603 ± 0.082	4.32ValThr: 4.32 ± 0.082	7.368ValVal: 7.368 ± 0.106	0.817ValTrp: 0.817 ± 0.031	1.719ValTyr: 1.719 ± 0.051	0.001ValXaa: 0.001 ± 0.001
Trp	1.215TrpAla: 1.215 ± 0.039	0.115TrpCys: 0.115 ± 0.013	0.768TrpAsp: 0.768 ± 0.032	0.816TrpGlu: 0.816 ± 0.034	0.507TrpPhe: 0.507 ± 0.024	0.982TrpGly: 0.982 ± 0.036	0.312TrpHis: 0.312 ± 0.021	0.589TrpIle: 0.589 ± 0.028	0.366TrpLys: 0.366 ± 0.022	1.575TrpLeu: 1.575 ± 0.047	0.322TrpMet: 0.322 ± 0.02	0.378TrpAsn: 0.378 ± 0.022	0.69TrpPro: 0.69 ± 0.036	0.54TrpGln: 0.54 ± 0.025	1.288TrpArg: 1.288 ± 0.041	0.829TrpSer: 0.829 ± 0.034	0.704TrpThr: 0.704 ± 0.029	0.842TrpVal: 0.842 ± 0.032	0.22TrpTrp: 0.22 ± 0.018	0.331TrpTyr: 0.331 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.324TyrAla: 2.324 ± 0.053	0.277TyrCys: 0.277 ± 0.017	1.439TyrAsp: 1.439 ± 0.044	1.602TyrGlu: 1.602 ± 0.045	0.901TyrPhe: 0.901 ± 0.037	2.205TyrGly: 2.205 ± 0.055	0.47TyrHis: 0.47 ± 0.024	0.986TyrIle: 0.986 ± 0.034	0.46TyrLys: 0.46 ± 0.023	2.571TyrLeu: 2.571 ± 0.061	0.455TyrMet: 0.455 ± 0.024	0.566TyrAsn: 0.566 ± 0.029	1.193TyrPro: 1.193 ± 0.038	0.821TyrGln: 0.821 ± 0.029	1.958TyrArg: 1.958 ± 0.042	1.247TyrSer: 1.247 ± 0.04	1.104TyrThr: 1.104 ± 0.041	1.788TyrVal: 1.788 ± 0.048	0.357TyrTrp: 0.357 ± 0.022	0.629TyrTyr: 0.629 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.017XaaXaa: 0.017 ± 0.007

Statistics based on 2903 proteins (842137 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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