Amino acid dipepetide frequency for Trypanosoma cruzi (strain CL Brener)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.26AlaAla: 11.26 ± 0.068	1.808AlaCys: 1.808 ± 0.021	3.508AlaAsp: 3.508 ± 0.024	6.005AlaGlu: 6.005 ± 0.069	2.955AlaPhe: 2.955 ± 0.02	5.588AlaGly: 5.588 ± 0.037	1.755AlaHis: 1.755 ± 0.016	3.109AlaIle: 3.109 ± 0.019	3.303AlaLys: 3.303 ± 0.028	8.975AlaLeu: 8.975 ± 0.045	2.432AlaMet: 2.432 ± 0.016	2.531AlaAsn: 2.531 ± 0.017	4.325AlaPro: 4.325 ± 0.036	2.814AlaGln: 2.814 ± 0.031	4.758AlaArg: 4.758 ± 0.027	7.304AlaSer: 7.304 ± 0.034	5.278AlaThr: 5.278 ± 0.028	7.745AlaVal: 7.745 ± 0.045	0.911AlaTrp: 0.911 ± 0.012	1.756AlaTyr: 1.756 ± 0.015	0.0AlaXaa: 0.0 ± 0.0
Cys	2.033CysAla: 2.033 ± 0.017	0.755CysCys: 0.755 ± 0.012	1.117CysAsp: 1.117 ± 0.012	1.055CysGlu: 1.055 ± 0.012	1.004CysPhe: 1.004 ± 0.012	1.871CysGly: 1.871 ± 0.016	0.481CysHis: 0.481 ± 0.008	0.823CysIle: 0.823 ± 0.01	0.637CysLys: 0.637 ± 0.009	1.765CysLeu: 1.765 ± 0.017	0.476CysMet: 0.476 ± 0.011	0.716CysAsn: 0.716 ± 0.009	0.884CysPro: 0.884 ± 0.01	0.512CysGln: 0.512 ± 0.007	1.403CysArg: 1.403 ± 0.014	1.59CysSer: 1.59 ± 0.014	1.151CysThr: 1.151 ± 0.011	2.178CysVal: 2.178 ± 0.021	0.211CysTrp: 0.211 ± 0.005	0.553CysTyr: 0.553 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	5.345AspAla: 5.345 ± 0.029	0.861AspCys: 0.861 ± 0.011	3.551AspAsp: 3.551 ± 0.034	3.897AspGlu: 3.897 ± 0.026	1.56AspPhe: 1.56 ± 0.014	4.996AspGly: 4.996 ± 0.031	0.853AspHis: 0.853 ± 0.009	1.981AspIle: 1.981 ± 0.018	1.757AspLys: 1.757 ± 0.017	3.383AspLeu: 3.383 ± 0.023	1.047AspMet: 1.047 ± 0.01	1.742AspAsn: 1.742 ± 0.018	2.212AspPro: 2.212 ± 0.017	0.976AspGln: 0.976 ± 0.011	2.365AspArg: 2.365 ± 0.02	3.344AspSer: 3.344 ± 0.022	2.699AspThr: 2.699 ± 0.018	4.436AspVal: 4.436 ± 0.025	0.49AspTrp: 0.49 ± 0.006	1.083AspTyr: 1.083 ± 0.013	0.0AspXaa: 0.0 ± 0.0
Glu	6.154GluAla: 6.154 ± 0.05	1.036GluCys: 1.036 ± 0.011	3.706GluAsp: 3.706 ± 0.027	8.26GluGlu: 8.26 ± 0.073	1.888GluPhe: 1.888 ± 0.017	4.95GluGly: 4.95 ± 0.027	1.332GluHis: 1.332 ± 0.013	2.302GluIle: 2.302 ± 0.02	4.581GluLys: 4.581 ± 0.038	6.047GluLeu: 6.047 ± 0.037	1.867GluMet: 1.867 ± 0.017	2.784GluAsn: 2.784 ± 0.024	2.283GluPro: 2.283 ± 0.036	2.513GluGln: 2.513 ± 0.023	5.089GluArg: 5.089 ± 0.044	4.425GluSer: 4.425 ± 0.025	3.499GluThr: 3.499 ± 0.02	4.506GluVal: 4.506 ± 0.026	0.811GluTrp: 0.811 ± 0.01	1.544GluTyr: 1.544 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	3.001PheAla: 3.001 ± 0.021	0.93PheCys: 0.93 ± 0.011	1.85PheAsp: 1.85 ± 0.015	1.693PheGlu: 1.693 ± 0.017	2.367PhePhe: 2.367 ± 0.024	2.315PheGly: 2.315 ± 0.019	0.875PheHis: 0.875 ± 0.01	1.556PheIle: 1.556 ± 0.017	0.976PheLys: 0.976 ± 0.013	4.096PheLeu: 4.096 ± 0.027	0.789PheMet: 0.789 ± 0.01	1.029PheAsn: 1.029 ± 0.011	1.829PhePro: 1.829 ± 0.015	1.057PheGln: 1.057 ± 0.01	1.995PheArg: 1.995 ± 0.016	3.329PheSer: 3.329 ± 0.021	2.077PheThr: 2.077 ± 0.018	3.013PheVal: 3.013 ± 0.022	0.402PheTrp: 0.402 ± 0.007	1.124PheTyr: 1.124 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	5.949GlyAla: 5.949 ± 0.041	1.599GlyCys: 1.599 ± 0.018	4.004GlyAsp: 4.004 ± 0.026	4.672GlyGlu: 4.672 ± 0.025	2.182GlyPhe: 2.182 ± 0.018	7.673GlyGly: 7.673 ± 0.071	1.358GlyHis: 1.358 ± 0.014	2.65GlyIle: 2.65 ± 0.019	3.248GlyLys: 3.248 ± 0.024	4.814GlyLeu: 4.814 ± 0.025	1.628GlyMet: 1.628 ± 0.015	3.132GlyAsn: 3.132 ± 0.025	2.418GlyPro: 2.418 ± 0.017	1.714GlyGln: 1.714 ± 0.015	4.25GlyArg: 4.25 ± 0.022	6.323GlySer: 6.323 ± 0.047	4.263GlyThr: 4.263 ± 0.028	5.892GlyVal: 5.892 ± 0.042	0.749GlyTrp: 0.749 ± 0.011	1.504GlyTyr: 1.504 ± 0.016	0.0GlyXaa: 0.0 ± 0.0
His	2.12HisAla: 2.12 ± 0.016	0.642HisCys: 0.642 ± 0.009	1.176HisAsp: 1.176 ± 0.011	1.54HisGlu: 1.54 ± 0.016	1.022HisPhe: 1.022 ± 0.011	1.731HisGly: 1.731 ± 0.015	0.867HisHis: 0.867 ± 0.013	0.946HisIle: 0.946 ± 0.01	0.774HisLys: 0.774 ± 0.009	2.228HisLeu: 2.228 ± 0.017	0.533HisMet: 0.533 ± 0.007	0.848HisAsn: 0.848 ± 0.01	1.287HisPro: 1.287 ± 0.014	0.846HisGln: 0.846 ± 0.009	1.706HisArg: 1.706 ± 0.015	1.829HisSer: 1.829 ± 0.015	1.381HisThr: 1.381 ± 0.013	2.007HisVal: 2.007 ± 0.015	0.311HisTrp: 0.311 ± 0.006	0.648HisTyr: 0.648 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	3.18IleAla: 3.18 ± 0.018	0.734IleCys: 0.734 ± 0.011	1.86IleAsp: 1.86 ± 0.017	2.149IleGlu: 2.149 ± 0.02	1.485IlePhe: 1.485 ± 0.012	2.284IleGly: 2.284 ± 0.017	1.013IleHis: 1.013 ± 0.012	1.673IleIle: 1.673 ± 0.017	1.33IleLys: 1.33 ± 0.015	3.431IleLeu: 3.431 ± 0.025	0.791IleMet: 0.791 ± 0.01	1.216IleAsn: 1.216 ± 0.012	2.131IlePro: 2.131 ± 0.019	1.298IleGln: 1.298 ± 0.013	2.341IleArg: 2.341 ± 0.018	2.982IleSer: 2.982 ± 0.019	2.269IleThr: 2.269 ± 0.02	2.946IleVal: 2.946 ± 0.02	0.324IleTrp: 0.324 ± 0.005	1.077IleTyr: 1.077 ± 0.011	0.0IleXaa: 0.0 ± 0.0
Lys	3.181LysAla: 3.181 ± 0.033	0.645LysCys: 0.645 ± 0.008	2.321LysAsp: 2.321 ± 0.02	4.09LysGlu: 4.09 ± 0.032	1.053LysPhe: 1.053 ± 0.012	2.944LysGly: 2.944 ± 0.023	0.96LysHis: 0.96 ± 0.011	1.482LysIle: 1.482 ± 0.014	3.51LysLys: 3.51 ± 0.035	3.483LysLeu: 3.483 ± 0.033	1.118LysMet: 1.118 ± 0.011	1.924LysAsn: 1.924 ± 0.017	1.763LysPro: 1.763 ± 0.033	1.711LysGln: 1.711 ± 0.02	3.269LysArg: 3.269 ± 0.026	2.761LysSer: 2.761 ± 0.023	2.455LysThr: 2.455 ± 0.018	2.361LysVal: 2.361 ± 0.022	0.521LysTrp: 0.521 ± 0.007	1.081LysTyr: 1.081 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	6.797LeuAla: 6.797 ± 0.045	2.395LeuCys: 2.395 ± 0.017	3.814LeuAsp: 3.814 ± 0.022	5.841LeuGlu: 5.841 ± 0.039	3.779LeuPhe: 3.779 ± 0.025	4.871LeuGly: 4.871 ± 0.027	2.764LeuHis: 2.764 ± 0.017	3.074LeuIle: 3.074 ± 0.022	3.483LeuLys: 3.483 ± 0.027	12.208LeuLeu: 12.208 ± 0.056	2.241LeuMet: 2.241 ± 0.016	2.883LeuAsn: 2.883 ± 0.018	5.322LeuPro: 5.322 ± 0.029	4.596LeuGln: 4.596 ± 0.029	7.885LeuArg: 7.885 ± 0.039	8.015LeuSer: 8.015 ± 0.036	5.044LeuThr: 5.044 ± 0.027	6.436LeuVal: 6.436 ± 0.033	1.33LeuTrp: 1.33 ± 0.012	2.553LeuTyr: 2.553 ± 0.02	0.0LeuXaa: 0.0 ± 0.0
Met	1.969MetAla: 1.969 ± 0.016	0.485MetCys: 0.485 ± 0.007	1.289MetAsp: 1.289 ± 0.012	1.806MetGlu: 1.806 ± 0.017	0.678MetPhe: 0.678 ± 0.008	1.356MetGly: 1.356 ± 0.015	0.69MetHis: 0.69 ± 0.01	0.734MetIle: 0.734 ± 0.009	1.125MetLys: 1.125 ± 0.011	2.336MetLeu: 2.336 ± 0.016	1.036MetMet: 1.036 ± 0.01	0.96MetAsn: 0.96 ± 0.009	1.256MetPro: 1.256 ± 0.013	1.082MetGln: 1.082 ± 0.011	1.965MetArg: 1.965 ± 0.016	1.827MetSer: 1.827 ± 0.015	1.515MetThr: 1.515 ± 0.012	1.323MetVal: 1.323 ± 0.013	0.31MetTrp: 0.31 ± 0.006	0.598MetTyr: 0.598 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.331AsnAla: 3.331 ± 0.022	0.699AsnCys: 0.699 ± 0.009	2.089AsnAsp: 2.089 ± 0.013	2.557AsnGlu: 2.557 ± 0.024	1.175AsnPhe: 1.175 ± 0.012	2.953AsnGly: 2.953 ± 0.019	0.691AsnHis: 0.691 ± 0.009	1.501AsnIle: 1.501 ± 0.014	1.66AsnLys: 1.66 ± 0.014	2.397AsnLeu: 2.397 ± 0.017	0.852AsnMet: 0.852 ± 0.01	1.9AsnAsn: 1.9 ± 0.02	1.595AsnPro: 1.595 ± 0.015	0.883AsnGln: 0.883 ± 0.009	1.98AsnArg: 1.98 ± 0.014	2.913AsnSer: 2.913 ± 0.022	2.393AsnThr: 2.393 ± 0.017	2.734AsnVal: 2.734 ± 0.019	0.362AsnTrp: 0.362 ± 0.007	0.853AsnTyr: 0.853 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	4.026ProAla: 4.026 ± 0.04	0.838ProCys: 0.838 ± 0.01	1.796ProAsp: 1.796 ± 0.015	2.808ProGlu: 2.808 ± 0.02	1.922ProPhe: 1.922 ± 0.017	2.562ProGly: 2.562 ± 0.022	1.35ProHis: 1.35 ± 0.013	1.685ProIle: 1.685 ± 0.014	1.906ProLys: 1.906 ± 0.039	5.119ProLeu: 5.119 ± 0.026	0.989ProMet: 0.989 ± 0.011	1.58ProAsn: 1.58 ± 0.012	4.387ProPro: 4.387 ± 0.042	2.086ProGln: 2.086 ± 0.018	2.933ProArg: 2.933 ± 0.023	4.923ProSer: 4.923 ± 0.034	3.374ProThr: 3.374 ± 0.027	3.596ProVal: 3.596 ± 0.024	0.524ProTrp: 0.524 ± 0.008	1.078ProTyr: 1.078 ± 0.011	0.0ProXaa: 0.0 ± 0.0
Gln	2.306GlnAla: 2.306 ± 0.02	0.665GlnCys: 0.665 ± 0.009	1.233GlnAsp: 1.233 ± 0.012	2.844GlnGlu: 2.844 ± 0.025	1.068GlnPhe: 1.068 ± 0.012	1.888GlnGly: 1.888 ± 0.016	1.156GlnHis: 1.156 ± 0.012	1.164GlnIle: 1.164 ± 0.01	1.969GlnLys: 1.969 ± 0.021	3.934GlnLeu: 3.934 ± 0.029	0.869GlnMet: 0.869 ± 0.009	1.28GlnAsn: 1.28 ± 0.013	1.702GlnPro: 1.702 ± 0.017	3.015GlnGln: 3.015 ± 0.039	3.618GlnArg: 3.618 ± 0.034	2.485GlnSer: 2.485 ± 0.019	1.834GlnThr: 1.834 ± 0.017	1.85GlnVal: 1.85 ± 0.016	0.503GlnTrp: 0.503 ± 0.008	0.883GlnTyr: 0.883 ± 0.01	0.0GlnXaa: 0.0 ± 0.0
Arg	4.902ArgAla: 4.902 ± 0.032	1.595ArgCys: 1.595 ± 0.014	3.359ArgAsp: 3.359 ± 0.026	5.252ArgGlu: 5.252 ± 0.044	2.262ArgPhe: 2.262 ± 0.017	4.492ArgGly: 4.492 ± 0.025	2.151ArgHis: 2.151 ± 0.018	2.592ArgIle: 2.592 ± 0.019	2.9ArgLys: 2.9 ± 0.03	6.434ArgLeu: 6.434 ± 0.038	1.696ArgMet: 1.696 ± 0.016	2.382ArgAsn: 2.382 ± 0.016	2.76ArgPro: 2.76 ± 0.018	2.966ArgGln: 2.966 ± 0.027	6.664ArgArg: 6.664 ± 0.053	4.758ArgSer: 4.758 ± 0.028	3.112ArgThr: 3.112 ± 0.02	5.164ArgVal: 5.164 ± 0.025	0.913ArgTrp: 0.913 ± 0.011	1.696ArgTyr: 1.696 ± 0.015	0.0ArgXaa: 0.0 ± 0.0
Ser	6.774SerAla: 6.774 ± 0.033	1.644SerCys: 1.644 ± 0.017	3.729SerAsp: 3.729 ± 0.022	4.198SerGlu: 4.198 ± 0.028	3.084SerPhe: 3.084 ± 0.023	6.441SerGly: 6.441 ± 0.046	2.009SerHis: 2.009 ± 0.017	3.018SerIle: 3.018 ± 0.019	2.712SerLys: 2.712 ± 0.022	7.856SerLeu: 7.856 ± 0.032	1.794SerMet: 1.794 ± 0.016	2.692SerAsn: 2.692 ± 0.022	4.478SerPro: 4.478 ± 0.031	2.635SerGln: 2.635 ± 0.017	4.954SerArg: 4.954 ± 0.023	8.799SerSer: 8.799 ± 0.05	5.255SerThr: 5.255 ± 0.033	6.539SerVal: 6.539 ± 0.05	0.994SerTrp: 0.994 ± 0.012	1.589SerTyr: 1.589 ± 0.015	0.0SerXaa: 0.0 ± 0.0
Thr	5.981ThrAla: 5.981 ± 0.036	0.981ThrCys: 0.981 ± 0.011	2.534ThrAsp: 2.534 ± 0.018	3.782ThrGlu: 3.782 ± 0.024	1.956ThrPhe: 1.956 ± 0.018	3.76ThrGly: 3.76 ± 0.024	1.437ThrHis: 1.437 ± 0.014	2.259ThrIle: 2.259 ± 0.017	2.265ThrLys: 2.265 ± 0.021	5.557ThrLeu: 5.557 ± 0.029	1.258ThrMet: 1.258 ± 0.013	2.109ThrAsn: 2.109 ± 0.015	3.581ThrPro: 3.581 ± 0.028	1.938ThrGln: 1.938 ± 0.016	3.333ThrArg: 3.333 ± 0.017	4.689ThrSer: 4.689 ± 0.026	5.61ThrThr: 5.61 ± 0.081	5.055ThrVal: 5.055 ± 0.034	0.67ThrTrp: 0.67 ± 0.009	1.054ThrTyr: 1.054 ± 0.01	0.0ThrXaa: 0.0 ± 0.0
Val	7.004ValAla: 7.004 ± 0.043	1.944ValCys: 1.944 ± 0.016	3.878ValAsp: 3.878 ± 0.024	4.934ValGlu: 4.934 ± 0.023	3.336ValPhe: 3.336 ± 0.028	4.895ValGly: 4.895 ± 0.031	1.76ValHis: 1.76 ± 0.014	2.486ValIle: 2.486 ± 0.019	2.983ValLys: 2.983 ± 0.023	8.074ValLeu: 8.074 ± 0.047	1.856ValMet: 1.856 ± 0.015	2.401ValAsn: 2.401 ± 0.016	3.876ValPro: 3.876 ± 0.023	2.453ValGln: 2.453 ± 0.017	4.751ValArg: 4.751 ± 0.023	6.317ValSer: 6.317 ± 0.036	4.704ValThr: 4.704 ± 0.038	6.746ValVal: 6.746 ± 0.046	0.881ValTrp: 0.881 ± 0.009	1.902ValTyr: 1.902 ± 0.016	0.0ValXaa: 0.0 ± 0.0
Trp	0.755TrpAla: 0.755 ± 0.01	0.395TrpCys: 0.395 ± 0.006	0.531TrpAsp: 0.531 ± 0.008	0.763TrpGlu: 0.763 ± 0.011	0.338TrpPhe: 0.338 ± 0.007	0.745TrpGly: 0.745 ± 0.01	0.333TrpHis: 0.333 ± 0.007	0.417TrpIle: 0.417 ± 0.008	0.675TrpLys: 0.675 ± 0.009	1.117TrpLeu: 1.117 ± 0.011	0.41TrpMet: 0.41 ± 0.006	0.459TrpAsn: 0.459 ± 0.006	0.401TrpPro: 0.401 ± 0.007	0.456TrpGln: 0.456 ± 0.007	1.202TrpArg: 1.202 ± 0.015	0.886TrpSer: 0.886 ± 0.01	0.637TrpThr: 0.637 ± 0.008	0.729TrpVal: 0.729 ± 0.01	0.231TrpTrp: 0.231 ± 0.006	0.303TrpTyr: 0.303 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.054TyrAla: 2.054 ± 0.018	0.564TyrCys: 0.564 ± 0.008	1.234TyrAsp: 1.234 ± 0.012	1.429TyrGlu: 1.429 ± 0.014	1.189TyrPhe: 1.189 ± 0.012	1.707TyrGly: 1.707 ± 0.018	0.608TyrHis: 0.608 ± 0.008	1.064TyrIle: 1.064 ± 0.011	0.84TyrLys: 0.84 ± 0.011	2.074TyrLeu: 2.074 ± 0.017	0.658TyrMet: 0.658 ± 0.008	0.95TyrAsn: 0.95 ± 0.01	0.992TyrPro: 0.992 ± 0.013	0.716TyrGln: 0.716 ± 0.009	1.589TyrArg: 1.589 ± 0.016	1.697TyrSer: 1.697 ± 0.015	1.258TyrThr: 1.258 ± 0.012	1.922TyrVal: 1.922 ± 0.017	0.335TyrTrp: 0.335 ± 0.007	0.761TyrTyr: 0.761 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 19243 proteins (9671180 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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