Amino acid dipepetide frequency for Sporolactobacillus laevolacticus DSM 442

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.729AlaAla: 6.729 ± 0.096	0.728AlaCys: 0.728 ± 0.027	4.074AlaAsp: 4.074 ± 0.067	4.729AlaGlu: 4.729 ± 0.081	3.614AlaPhe: 3.614 ± 0.063	5.398AlaGly: 5.398 ± 0.081	1.525AlaHis: 1.525 ± 0.039	5.988AlaIle: 5.988 ± 0.078	4.621AlaLys: 4.621 ± 0.074	7.963AlaLeu: 7.963 ± 0.101	2.09AlaMet: 2.09 ± 0.045	2.774AlaAsn: 2.774 ± 0.056	2.305AlaPro: 2.305 ± 0.06	2.721AlaGln: 2.721 ± 0.059	3.085AlaArg: 3.085 ± 0.068	4.481AlaSer: 4.481 ± 0.074	3.459AlaThr: 3.459 ± 0.068	5.697AlaVal: 5.697 ± 0.082	0.651AlaTrp: 0.651 ± 0.025	2.485AlaTyr: 2.485 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.668CysAla: 0.668 ± 0.027	0.126CysCys: 0.126 ± 0.013	0.454CysAsp: 0.454 ± 0.024	0.447CysGlu: 0.447 ± 0.023	0.38CysPhe: 0.38 ± 0.018	0.842CysGly: 0.842 ± 0.032	0.226CysHis: 0.226 ± 0.015	0.579CysIle: 0.579 ± 0.025	0.356CysLys: 0.356 ± 0.022	0.873CysLeu: 0.873 ± 0.03	0.228CysMet: 0.228 ± 0.016	0.285CysAsn: 0.285 ± 0.02	0.433CysPro: 0.433 ± 0.021	0.267CysGln: 0.267 ± 0.018	0.426CysArg: 0.426 ± 0.026	0.591CysSer: 0.591 ± 0.022	0.476CysThr: 0.476 ± 0.022	0.534CysVal: 0.534 ± 0.025	0.097CysTrp: 0.097 ± 0.011	0.318CysTyr: 0.318 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.788AspAla: 3.788 ± 0.061	0.461AspCys: 0.461 ± 0.025	2.671AspAsp: 2.671 ± 0.069	3.951AspGlu: 3.951 ± 0.076	2.413AspPhe: 2.413 ± 0.049	3.555AspGly: 3.555 ± 0.071	1.536AspHis: 1.536 ± 0.043	3.554AspIle: 3.554 ± 0.062	3.06AspLys: 3.06 ± 0.062	5.348AspLeu: 5.348 ± 0.083	1.306AspMet: 1.306 ± 0.03	1.779AspAsn: 1.779 ± 0.046	2.262AspPro: 2.262 ± 0.049	2.776AspGln: 2.776 ± 0.061	2.753AspArg: 2.753 ± 0.06	2.814AspSer: 2.814 ± 0.053	2.529AspThr: 2.529 ± 0.051	3.799AspVal: 3.799 ± 0.063	0.642AspTrp: 0.642 ± 0.025	2.359AspTyr: 2.359 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	4.765GluAla: 4.765 ± 0.09	0.44GluCys: 0.44 ± 0.023	3.021GluAsp: 3.021 ± 0.064	4.539GluGlu: 4.539 ± 0.084	1.959GluPhe: 1.959 ± 0.047	3.51GluGly: 3.51 ± 0.069	1.663GluHis: 1.663 ± 0.042	4.226GluIle: 4.226 ± 0.073	5.737GluLys: 5.737 ± 0.078	6.141GluLeu: 6.141 ± 0.09	1.835GluMet: 1.835 ± 0.042	3.086GluAsn: 3.086 ± 0.059	1.842GluPro: 1.842 ± 0.044	3.119GluGln: 3.119 ± 0.064	3.4GluArg: 3.4 ± 0.073	3.315GluSer: 3.315 ± 0.063	3.546GluThr: 3.546 ± 0.053	3.649GluVal: 3.649 ± 0.056	0.702GluTrp: 0.702 ± 0.028	1.576GluTyr: 1.576 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.195PheAla: 3.195 ± 0.059	0.487PheCys: 0.487 ± 0.023	2.601PheAsp: 2.601 ± 0.052	2.373PheGlu: 2.373 ± 0.046	2.512PhePhe: 2.512 ± 0.058	3.432PheGly: 3.432 ± 0.072	1.054PheHis: 1.054 ± 0.035	3.647PheIle: 3.647 ± 0.083	2.258PheLys: 2.258 ± 0.053	4.487PheLeu: 4.487 ± 0.085	1.104PheMet: 1.104 ± 0.034	1.83PheAsn: 1.83 ± 0.049	1.635PhePro: 1.635 ± 0.043	1.648PheGln: 1.648 ± 0.043	1.754PheArg: 1.754 ± 0.042	3.586PheSer: 3.586 ± 0.061	2.458PheThr: 2.458 ± 0.052	3.155PheVal: 3.155 ± 0.074	0.524PheTrp: 0.524 ± 0.023	1.761PheTyr: 1.761 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	5.01GlyAla: 5.01 ± 0.076	0.655GlyCys: 0.655 ± 0.03	3.109GlyAsp: 3.109 ± 0.068	3.732GlyGlu: 3.732 ± 0.066	3.388GlyPhe: 3.388 ± 0.069	4.725GlyGly: 4.725 ± 0.082	1.498GlyHis: 1.498 ± 0.039	5.603GlyIle: 5.603 ± 0.081	5.048GlyLys: 5.048 ± 0.072	6.772GlyLeu: 6.772 ± 0.097	2.142GlyMet: 2.142 ± 0.046	2.734GlyAsn: 2.734 ± 0.06	1.737GlyPro: 1.737 ± 0.046	2.43GlyGln: 2.43 ± 0.048	3.013GlyArg: 3.013 ± 0.061	4.262GlySer: 4.262 ± 0.07	4.138GlyThr: 4.138 ± 0.075	4.802GlyVal: 4.802 ± 0.079	0.836GlyTrp: 0.836 ± 0.032	2.938GlyTyr: 2.938 ± 0.064	0.001GlyXaa: 0.001 ± 0.001
His	1.641HisAla: 1.641 ± 0.041	0.26HisCys: 0.26 ± 0.016	1.154HisAsp: 1.154 ± 0.035	1.324HisGlu: 1.324 ± 0.039	1.278HisPhe: 1.278 ± 0.035	1.571HisGly: 1.571 ± 0.041	0.682HisHis: 0.682 ± 0.027	1.508HisIle: 1.508 ± 0.044	1.016HisLys: 1.016 ± 0.031	2.468HisLeu: 2.468 ± 0.048	0.583HisMet: 0.583 ± 0.023	0.753HisAsn: 0.753 ± 0.029	1.268HisPro: 1.268 ± 0.04	1.067HisGln: 1.067 ± 0.032	0.983HisArg: 0.983 ± 0.031	1.379HisSer: 1.379 ± 0.04	1.017HisThr: 1.017 ± 0.031	1.63HisVal: 1.63 ± 0.045	0.28HisTrp: 0.28 ± 0.018	1.022HisTyr: 1.022 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.192IleAla: 6.192 ± 0.097	0.805IleCys: 0.805 ± 0.031	4.641IleAsp: 4.641 ± 0.074	4.607IleGlu: 4.607 ± 0.077	3.191IlePhe: 3.191 ± 0.072	5.955IleGly: 5.955 ± 0.09	1.737IleHis: 1.737 ± 0.039	5.332IleIle: 5.332 ± 0.098	4.5IleLys: 4.5 ± 0.076	6.752IleLeu: 6.752 ± 0.105	1.724IleMet: 1.724 ± 0.05	3.268IleAsn: 3.268 ± 0.056	3.086IlePro: 3.086 ± 0.056	2.789IleGln: 2.789 ± 0.056	3.507IleArg: 3.507 ± 0.062	4.948IleSer: 4.948 ± 0.084	3.896IleThr: 3.896 ± 0.066	5.413IleVal: 5.413 ± 0.084	0.67IleTrp: 0.67 ± 0.026	2.41IleTyr: 2.41 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.847LysAla: 4.847 ± 0.087	0.334LysCys: 0.334 ± 0.018	3.449LysAsp: 3.449 ± 0.069	4.81LysGlu: 4.81 ± 0.091	1.723LysPhe: 1.723 ± 0.041	4.003LysGly: 4.003 ± 0.063	1.292LysHis: 1.292 ± 0.034	4.69LysIle: 4.69 ± 0.07	6.168LysLys: 6.168 ± 0.087	5.776LysLeu: 5.776 ± 0.073	2.198LysMet: 2.198 ± 0.046	3.38LysAsn: 3.38 ± 0.067	2.231LysPro: 2.231 ± 0.046	3.039LysGln: 3.039 ± 0.056	3.331LysArg: 3.331 ± 0.059	3.739LysSer: 3.739 ± 0.069	3.738LysThr: 3.738 ± 0.066	4.245LysVal: 4.245 ± 0.063	0.742LysTrp: 0.742 ± 0.025	2.099LysTyr: 2.099 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	7.707LeuAla: 7.707 ± 0.093	0.902LeuCys: 0.902 ± 0.034	5.322LeuAsp: 5.322 ± 0.079	5.474LeuGlu: 5.474 ± 0.09	5.243LeuPhe: 5.243 ± 0.09	6.293LeuGly: 6.293 ± 0.109	2.069LeuHis: 2.069 ± 0.048	8.189LeuIle: 8.189 ± 0.11	6.475LeuLys: 6.475 ± 0.089	10.345LeuLeu: 10.345 ± 0.131	2.586LeuMet: 2.586 ± 0.053	4.726LeuAsn: 4.726 ± 0.072	4.008LeuPro: 4.008 ± 0.066	3.153LeuGln: 3.153 ± 0.061	4.019LeuArg: 4.019 ± 0.06	7.625LeuSer: 7.625 ± 0.089	5.884LeuThr: 5.884 ± 0.087	6.147LeuVal: 6.147 ± 0.088	0.854LeuTrp: 0.854 ± 0.032	3.021LeuTyr: 3.021 ± 0.056	0.001LeuXaa: 0.001 ± 0.001
Met	2.171MetAla: 2.171 ± 0.051	0.161MetCys: 0.161 ± 0.013	1.543MetAsp: 1.543 ± 0.041	1.549MetGlu: 1.549 ± 0.039	0.944MetPhe: 0.944 ± 0.03	1.685MetGly: 1.685 ± 0.042	0.502MetHis: 0.502 ± 0.024	2.419MetIle: 2.419 ± 0.055	2.105MetLys: 2.105 ± 0.042	2.533MetLeu: 2.533 ± 0.059	0.888MetMet: 0.888 ± 0.035	1.661MetAsn: 1.661 ± 0.041	1.134MetPro: 1.134 ± 0.032	0.899MetGln: 0.899 ± 0.031	1.212MetArg: 1.212 ± 0.037	1.781MetSer: 1.781 ± 0.035	1.71MetThr: 1.71 ± 0.043	1.668MetVal: 1.668 ± 0.039	0.174MetTrp: 0.174 ± 0.014	0.627MetTyr: 0.627 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.022AsnAla: 3.022 ± 0.056	0.318AsnCys: 0.318 ± 0.016	2.267AsnAsp: 2.267 ± 0.057	2.907AsnGlu: 2.907 ± 0.054	1.662AsnPhe: 1.662 ± 0.042	3.329AsnGly: 3.329 ± 0.078	1.214AsnHis: 1.214 ± 0.037	2.711AsnIle: 2.711 ± 0.058	2.761AsnLys: 2.761 ± 0.063	3.761AsnLeu: 3.761 ± 0.07	1.139AsnMet: 1.139 ± 0.039	1.863AsnAsn: 1.863 ± 0.055	2.12AsnPro: 2.12 ± 0.049	2.188AsnGln: 2.188 ± 0.053	2.12AsnArg: 2.12 ± 0.041	2.256AsnSer: 2.256 ± 0.052	2.071AsnThr: 2.071 ± 0.053	2.942AsnVal: 2.942 ± 0.065	0.537AsnTrp: 0.537 ± 0.022	1.773AsnTyr: 1.773 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	2.649ProAla: 2.649 ± 0.056	0.231ProCys: 0.231 ± 0.015	2.417ProAsp: 2.417 ± 0.051	3.003ProGlu: 3.003 ± 0.062	1.985ProPhe: 1.985 ± 0.048	2.391ProGly: 2.391 ± 0.052	0.751ProHis: 0.751 ± 0.03	2.819ProIle: 2.819 ± 0.059	2.188ProLys: 2.188 ± 0.041	3.656ProLeu: 3.656 ± 0.066	0.846ProMet: 0.846 ± 0.029	1.646ProAsn: 1.646 ± 0.035	0.968ProPro: 0.968 ± 0.037	1.221ProGln: 1.221 ± 0.033	1.147ProArg: 1.147 ± 0.035	2.411ProSer: 2.411 ± 0.055	1.806ProThr: 1.806 ± 0.039	2.994ProVal: 2.994 ± 0.054	0.376ProTrp: 0.376 ± 0.021	1.432ProTyr: 1.432 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.131GlnAla: 3.131 ± 0.064	0.248GlnCys: 0.248 ± 0.015	1.728GlnAsp: 1.728 ± 0.044	2.268GlnGlu: 2.268 ± 0.051	1.735GlnPhe: 1.735 ± 0.04	2.214GlnGly: 2.214 ± 0.046	0.821GlnHis: 0.821 ± 0.031	2.949GlnIle: 2.949 ± 0.056	2.901GlnLys: 2.901 ± 0.065	4.304GlnLeu: 4.304 ± 0.073	1.31GlnMet: 1.31 ± 0.036	1.832GlnAsn: 1.832 ± 0.043	1.475GlnPro: 1.475 ± 0.045	1.808GlnGln: 1.808 ± 0.049	1.716GlnArg: 1.716 ± 0.045	2.553GlnSer: 2.553 ± 0.058	2.274GlnThr: 2.274 ± 0.049	2.518GlnVal: 2.518 ± 0.051	0.473GlnTrp: 0.473 ± 0.024	1.229GlnTyr: 1.229 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.859ArgAla: 2.859 ± 0.051	0.335ArgCys: 0.335 ± 0.017	2.315ArgAsp: 2.315 ± 0.058	3.089ArgGlu: 3.089 ± 0.06	2.158ArgPhe: 2.158 ± 0.044	2.483ArgGly: 2.483 ± 0.05	1.005ArgHis: 1.005 ± 0.035	3.426ArgIle: 3.426 ± 0.061	3.257ArgLys: 3.257 ± 0.062	4.686ArgLeu: 4.686 ± 0.072	1.419ArgMet: 1.419 ± 0.039	1.884ArgAsn: 1.884 ± 0.049	1.58ArgPro: 1.58 ± 0.041	1.933ArgGln: 1.933 ± 0.048	2.386ArgArg: 2.386 ± 0.053	2.694ArgSer: 2.694 ± 0.052	2.413ArgThr: 2.413 ± 0.054	2.885ArgVal: 2.885 ± 0.054	0.468ArgTrp: 0.468 ± 0.023	1.67ArgTyr: 1.67 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.489SerAla: 4.489 ± 0.069	0.554SerCys: 0.554 ± 0.025	3.502SerAsp: 3.502 ± 0.062	4.004SerGlu: 4.004 ± 0.072	3.205SerPhe: 3.205 ± 0.068	5.293SerGly: 5.293 ± 0.09	1.344SerHis: 1.344 ± 0.039	4.862SerIle: 4.862 ± 0.068	3.734SerLys: 3.734 ± 0.07	6.377SerLeu: 6.377 ± 0.085	1.787SerMet: 1.787 ± 0.04	2.508SerAsn: 2.508 ± 0.058	2.19SerPro: 2.19 ± 0.051	2.158SerGln: 2.158 ± 0.058	2.735SerArg: 2.735 ± 0.049	4.221SerSer: 4.221 ± 0.086	3.119SerThr: 3.119 ± 0.059	4.636SerVal: 4.636 ± 0.072	0.712SerTrp: 0.712 ± 0.026	2.127SerTyr: 2.127 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	4.159ThrAla: 4.159 ± 0.069	0.424ThrCys: 0.424 ± 0.019	2.967ThrAsp: 2.967 ± 0.062	3.085ThrGlu: 3.085 ± 0.061	2.591ThrPhe: 2.591 ± 0.049	4.307ThrGly: 4.307 ± 0.064	1.181ThrHis: 1.181 ± 0.033	4.261ThrIle: 4.261 ± 0.075	3.08ThrLys: 3.08 ± 0.062	5.725ThrLeu: 5.725 ± 0.079	1.32ThrMet: 1.32 ± 0.035	2.164ThrAsn: 2.164 ± 0.051	2.146ThrPro: 2.146 ± 0.051	1.723ThrGln: 1.723 ± 0.037	2.012ThrArg: 2.012 ± 0.042	3.238ThrSer: 3.238 ± 0.072	2.758ThrThr: 2.758 ± 0.069	4.273ThrVal: 4.273 ± 0.075	0.504ThrTrp: 0.504 ± 0.023	1.867ThrTyr: 1.867 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	5.046ValAla: 5.046 ± 0.074	0.668ValCys: 0.668 ± 0.026	3.684ValAsp: 3.684 ± 0.074	3.66ValGlu: 3.66 ± 0.063	3.139ValPhe: 3.139 ± 0.064	4.445ValGly: 4.445 ± 0.078	1.546ValHis: 1.546 ± 0.043	5.52ValIle: 5.52 ± 0.082	4.064ValLys: 4.064 ± 0.067	7.081ValLeu: 7.081 ± 0.092	1.736ValMet: 1.736 ± 0.047	2.969ValAsn: 2.969 ± 0.064	2.797ValPro: 2.797 ± 0.054	2.457ValGln: 2.457 ± 0.053	3.092ValArg: 3.092 ± 0.069	4.852ValSer: 4.852 ± 0.071	4.129ValThr: 4.129 ± 0.071	4.671ValVal: 4.671 ± 0.079	0.637ValTrp: 0.637 ± 0.028	2.247ValTyr: 2.247 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.671TrpAla: 0.671 ± 0.031	0.094TrpCys: 0.094 ± 0.01	0.504TrpAsp: 0.504 ± 0.023	0.511TrpGlu: 0.511 ± 0.024	0.569TrpPhe: 0.569 ± 0.029	0.654TrpGly: 0.654 ± 0.029	0.282TrpHis: 0.282 ± 0.018	0.883TrpIle: 0.883 ± 0.033	0.64TrpLys: 0.64 ± 0.026	1.198TrpLeu: 1.198 ± 0.038	0.353TrpMet: 0.353 ± 0.021	0.505TrpAsn: 0.505 ± 0.024	0.295TrpPro: 0.295 ± 0.018	0.441TrpGln: 0.441 ± 0.02	0.521TrpArg: 0.521 ± 0.023	0.641TrpSer: 0.641 ± 0.03	0.572TrpThr: 0.572 ± 0.026	0.605TrpVal: 0.605 ± 0.026	0.138TrpTrp: 0.138 ± 0.013	0.341TrpTyr: 0.341 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.377TyrAla: 2.377 ± 0.054	0.374TyrCys: 0.374 ± 0.018	1.932TyrAsp: 1.932 ± 0.048	2.007TyrGlu: 2.007 ± 0.052	1.816TyrPhe: 1.816 ± 0.047	2.489TyrGly: 2.489 ± 0.052	0.957TyrHis: 0.957 ± 0.029	2.259TyrIle: 2.259 ± 0.048	1.865TyrLys: 1.865 ± 0.043	3.795TyrLeu: 3.795 ± 0.069	0.768TyrMet: 0.768 ± 0.028	1.314TyrAsn: 1.314 ± 0.039	1.426TyrPro: 1.426 ± 0.043	1.65TyrGln: 1.65 ± 0.038	1.73TyrArg: 1.73 ± 0.042	2.17TyrSer: 2.17 ± 0.049	1.792TyrThr: 1.792 ± 0.04	2.176TyrVal: 2.176 ± 0.048	0.404TyrTrp: 0.404 ± 0.02	1.379TyrTyr: 1.379 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.002XaaLys: 0.002 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3497 proteins (987640 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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