Amino acid dipepetide frequency for Coprobacillus sp. CAG:698

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.257AlaAla: 2.257 ± 0.121
0.805AlaCys: 0.805 ± 0.045
2.162AlaAsp: 2.162 ± 0.069
2.395AlaGlu: 2.395 ± 0.125
2.463AlaPhe: 2.463 ± 0.078
2.587AlaGly: 2.587 ± 0.086
0.663AlaHis: 0.663 ± 0.038
5.061AlaIle: 5.061 ± 0.12
4.414AlaLys: 4.414 ± 0.12
5.126AlaLeu: 5.126 ± 0.099
1.169AlaMet: 1.169 ± 0.048
2.818AlaAsn: 2.818 ± 0.073
1.07AlaPro: 1.07 ± 0.048
1.138AlaGln: 1.138 ± 0.05
1.644AlaArg: 1.644 ± 0.061
3.5AlaSer: 3.5 ± 0.088
2.607AlaThr: 2.607 ± 0.086
2.885AlaVal: 2.885 ± 0.09
0.269AlaTrp: 0.269 ± 0.026
2.239AlaTyr: 2.239 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
0.706CysAla: 0.706 ± 0.039
0.185CysCys: 0.185 ± 0.022
1.013CysAsp: 1.013 ± 0.046
1.061CysGlu: 1.061 ± 0.045
0.688CysPhe: 0.688 ± 0.038
1.11CysGly: 1.11 ± 0.049
0.283CysHis: 0.283 ± 0.022
1.117CysIle: 1.117 ± 0.053
1.208CysLys: 1.208 ± 0.051
1.291CysLeu: 1.291 ± 0.05
0.278CysMet: 0.278 ± 0.022
0.93CysAsn: 0.93 ± 0.039
0.495CysPro: 0.495 ± 0.028
0.262CysGln: 0.262 ± 0.021
0.373CysArg: 0.373 ± 0.024
0.791CysSer: 0.791 ± 0.04
0.701CysThr: 0.701 ± 0.047
0.941CysVal: 0.941 ± 0.043
0.084CysTrp: 0.084 ± 0.013
0.701CysTyr: 0.701 ± 0.042
0.0CysXaa: 0.0 ± 0.0
Asp
2.84AspAla: 2.84 ± 0.082
0.746AspCys: 0.746 ± 0.042
3.656AspAsp: 3.656 ± 0.089
5.405AspGlu: 5.405 ± 0.117
2.989AspPhe: 2.989 ± 0.08
3.681AspGly: 3.681 ± 0.11
0.581AspHis: 0.581 ± 0.031
5.64AspIle: 5.64 ± 0.109
5.567AspLys: 5.567 ± 0.1
5.319AspLeu: 5.319 ± 0.106
1.205AspMet: 1.205 ± 0.047
3.754AspAsn: 3.754 ± 0.077
1.368AspPro: 1.368 ± 0.057
0.723AspGln: 0.723 ± 0.039
1.517AspArg: 1.517 ± 0.058
3.286AspSer: 3.286 ± 0.083
2.535AspThr: 2.535 ± 0.068
3.799AspVal: 3.799 ± 0.093
0.316AspTrp: 0.316 ± 0.023
3.835AspTyr: 3.835 ± 0.09
0.0AspXaa: 0.0 ± 0.0
Glu
3.575GluAla: 3.575 ± 0.121
0.825GluCys: 0.825 ± 0.042
3.535GluAsp: 3.535 ± 0.087
6.578GluGlu: 6.578 ± 0.128
3.069GluPhe: 3.069 ± 0.067
3.607GluGly: 3.607 ± 0.099
0.835GluHis: 0.835 ± 0.041
7.313GluIle: 7.313 ± 0.133
8.485GluLys: 8.485 ± 0.157
6.361GluLeu: 6.361 ± 0.107
1.958GluMet: 1.958 ± 0.06
6.094GluAsn: 6.094 ± 0.104
1.253GluPro: 1.253 ± 0.049
1.42GluGln: 1.42 ± 0.058
2.139GluArg: 2.139 ± 0.071
3.578GluSer: 3.578 ± 0.072
3.697GluThr: 3.697 ± 0.091
5.113GluVal: 5.113 ± 0.116
0.454GluTrp: 0.454 ± 0.033
4.071GluTyr: 4.071 ± 0.098
0.0GluXaa: 0.0 ± 0.0
Phe
2.248PheAla: 2.248 ± 0.066
0.561PheCys: 0.561 ± 0.031
3.223PheAsp: 3.223 ± 0.075
3.458PheGlu: 3.458 ± 0.089
1.927PhePhe: 1.927 ± 0.071
2.662PheGly: 2.662 ± 0.064
0.52PheHis: 0.52 ± 0.029
4.47PheIle: 4.47 ± 0.108
3.993PheLys: 3.993 ± 0.085
4.011PheLeu: 4.011 ± 0.104
1.131PheMet: 1.131 ± 0.05
2.637PheAsn: 2.637 ± 0.077
1.199PhePro: 1.199 ± 0.053
0.886PheGln: 0.886 ± 0.039
1.219PheArg: 1.219 ± 0.042
3.41PheSer: 3.41 ± 0.085
2.576PheThr: 2.576 ± 0.082
3.06PheVal: 3.06 ± 0.09
0.251PheTrp: 0.251 ± 0.022
2.123PheTyr: 2.123 ± 0.064
0.0PheXaa: 0.0 ± 0.0
Gly
2.906GlyAla: 2.906 ± 0.095
0.914GlyCys: 0.914 ± 0.047
3.001GlyAsp: 3.001 ± 0.079
3.711GlyGlu: 3.711 ± 0.106
2.68GlyPhe: 2.68 ± 0.08
3.372GlyGly: 3.372 ± 0.098
0.884GlyHis: 0.884 ± 0.04
5.465GlyIle: 5.465 ± 0.119
5.73GlyLys: 5.73 ± 0.096
5.072GlyLeu: 5.072 ± 0.113
1.3GlyMet: 1.3 ± 0.047
3.15GlyAsn: 3.15 ± 0.084
0.9GlyPro: 0.9 ± 0.04
1.151GlyGln: 1.151 ± 0.053
1.755GlyArg: 1.755 ± 0.065
3.457GlySer: 3.457 ± 0.084
3.457GlyThr: 3.457 ± 0.097
3.881GlyVal: 3.881 ± 0.097
0.497GlyTrp: 0.497 ± 0.041
3.249GlyTyr: 3.249 ± 0.088
0.0GlyXaa: 0.0 ± 0.0
His
0.633HisAla: 0.633 ± 0.036
0.188HisCys: 0.188 ± 0.019
0.69HisAsp: 0.69 ± 0.038
0.767HisGlu: 0.767 ± 0.038
0.644HisPhe: 0.644 ± 0.034
0.816HisGly: 0.816 ± 0.04
0.251HisHis: 0.251 ± 0.023
1.242HisIle: 1.242 ± 0.045
1.072HisLys: 1.072 ± 0.048
1.146HisLeu: 1.146 ± 0.05
0.301HisMet: 0.301 ± 0.021
0.902HisAsn: 0.902 ± 0.047
0.515HisPro: 0.515 ± 0.035
0.281HisGln: 0.281 ± 0.021
0.468HisArg: 0.468 ± 0.03
0.744HisSer: 0.744 ± 0.04
0.631HisThr: 0.631 ± 0.036
0.694HisVal: 0.694 ± 0.035
0.057HisTrp: 0.057 ± 0.009
0.705HisTyr: 0.705 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
4.774IleAla: 4.774 ± 0.116
1.714IleCys: 1.714 ± 0.054
6.44IleAsp: 6.44 ± 0.115
6.693IleGlu: 6.693 ± 0.125
4.048IlePhe: 4.048 ± 0.095
5.301IleGly: 5.301 ± 0.12
1.103IleHis: 1.103 ± 0.037
10.11IleIle: 10.11 ± 0.209
8.995IleLys: 8.995 ± 0.137
8.041IleLeu: 8.041 ± 0.15
2.029IleMet: 2.029 ± 0.066
7.44IleAsn: 7.44 ± 0.134
2.784IlePro: 2.784 ± 0.08
1.691IleGln: 1.691 ± 0.053
2.738IleArg: 2.738 ± 0.082
6.899IleSer: 6.899 ± 0.149
5.859IleThr: 5.859 ± 0.116
6.345IleVal: 6.345 ± 0.12
0.428IleTrp: 0.428 ± 0.026
4.486IleTyr: 4.486 ± 0.101
0.002IleXaa: 0.002 ± 0.002
Lys
4.697LysAla: 4.697 ± 0.124
1.176LysCys: 1.176 ± 0.06
6.151LysAsp: 6.151 ± 0.105
9.011LysGlu: 9.011 ± 0.159
3.127LysPhe: 3.127 ± 0.072
4.686LysGly: 4.686 ± 0.1
1.067LysHis: 1.067 ± 0.041
9.208LysIle: 9.208 ± 0.143
9.256LysLys: 9.256 ± 0.16
7.772LysLeu: 7.772 ± 0.125
2.829LysMet: 2.829 ± 0.072
6.755LysAsn: 6.755 ± 0.119
2.071LysPro: 2.071 ± 0.071
2.13LysGln: 2.13 ± 0.06
2.917LysArg: 2.917 ± 0.078
4.685LysSer: 4.685 ± 0.089
5.022LysThr: 5.022 ± 0.084
6.598LysVal: 6.598 ± 0.117
0.696LysTrp: 0.696 ± 0.041
5.644LysTyr: 5.644 ± 0.112
0.0LysXaa: 0.0 ± 0.0
Leu
4.346LeuAla: 4.346 ± 0.099
1.382LeuCys: 1.382 ± 0.05
5.502LeuAsp: 5.502 ± 0.103
6.754LeuGlu: 6.754 ± 0.115
4.387LeuPhe: 4.387 ± 0.107
5.264LeuGly: 5.264 ± 0.111
1.099LeuHis: 1.099 ± 0.047
7.958LeuIle: 7.958 ± 0.161
8.387LeuLys: 8.387 ± 0.138
8.286LeuLeu: 8.286 ± 0.169
2.098LeuMet: 2.098 ± 0.068
5.888LeuAsn: 5.888 ± 0.115
2.63LeuPro: 2.63 ± 0.078
1.92LeuGln: 1.92 ± 0.06
2.632LeuArg: 2.632 ± 0.075
6.718LeuSer: 6.718 ± 0.124
4.973LeuThr: 4.973 ± 0.107
5.69LeuVal: 5.69 ± 0.123
0.502LeuTrp: 0.502 ± 0.033
4.086LeuTyr: 4.086 ± 0.101
0.0LeuXaa: 0.0 ± 0.0
Met
1.336MetAla: 1.336 ± 0.051
0.321MetCys: 0.321 ± 0.024
1.176MetAsp: 1.176 ± 0.05
1.386MetGlu: 1.386 ± 0.046
1.153MetPhe: 1.153 ± 0.05
1.251MetGly: 1.251 ± 0.05
0.355MetHis: 0.355 ± 0.026
2.318MetIle: 2.318 ± 0.067
2.438MetLys: 2.438 ± 0.074
2.133MetLeu: 2.133 ± 0.061
0.572MetMet: 0.572 ± 0.031
1.648MetAsn: 1.648 ± 0.069
0.78MetPro: 0.78 ± 0.043
0.563MetGln: 0.563 ± 0.037
0.78MetArg: 0.78 ± 0.04
1.33MetSer: 1.33 ± 0.05
1.19MetThr: 1.19 ± 0.049
1.273MetVal: 1.273 ± 0.045
0.136MetTrp: 0.136 ± 0.018
1.137MetTyr: 1.137 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
2.996AsnAla: 2.996 ± 0.091
0.896AsnCys: 0.896 ± 0.043
4.296AsnAsp: 4.296 ± 0.1
5.188AsnGlu: 5.188 ± 0.108
2.528AsnPhe: 2.528 ± 0.077
4.14AsnGly: 4.14 ± 0.104
0.861AsnHis: 0.861 ± 0.043
6.845AsnIle: 6.845 ± 0.135
6.623AsnLys: 6.623 ± 0.105
5.864AsnLeu: 5.864 ± 0.114
1.526AsnMet: 1.526 ± 0.052
5.167AsnAsn: 5.167 ± 0.139
2.105AsnPro: 2.105 ± 0.062
1.463AsnGln: 1.463 ± 0.05
1.845AsnArg: 1.845 ± 0.057
3.817AsnSer: 3.817 ± 0.107
3.22AsnThr: 3.22 ± 0.082
4.491AsnVal: 4.491 ± 0.095
0.375AsnTrp: 0.375 ± 0.025
4.023AsnTyr: 4.023 ± 0.099
0.0AsnXaa: 0.0 ± 0.0
Pro
1.051ProAla: 1.051 ± 0.054
0.317ProCys: 0.317 ± 0.025
1.232ProAsp: 1.232 ± 0.052
1.915ProGlu: 1.915 ± 0.07
1.336ProPhe: 1.336 ± 0.048
1.271ProGly: 1.271 ± 0.054
0.416ProHis: 0.416 ± 0.028
2.365ProIle: 2.365 ± 0.069
2.033ProLys: 2.033 ± 0.063
2.332ProLeu: 2.332 ± 0.073
0.527ProMet: 0.527 ± 0.031
1.648ProAsn: 1.648 ± 0.052
0.378ProPro: 0.378 ± 0.027
0.757ProGln: 0.757 ± 0.036
0.708ProArg: 0.708 ± 0.038
1.748ProSer: 1.748 ± 0.054
1.599ProThr: 1.599 ± 0.055
1.562ProVal: 1.562 ± 0.064
0.174ProTrp: 0.174 ± 0.016
1.341ProTyr: 1.341 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
1.07GlnAla: 1.07 ± 0.049
0.181GlnCys: 0.181 ± 0.017
1.033GlnAsp: 1.033 ± 0.046
1.588GlnGlu: 1.588 ± 0.057
0.818GlnPhe: 0.818 ± 0.041
1.237GlnGly: 1.237 ± 0.053
0.199GlnHis: 0.199 ± 0.018
2.22GlnIle: 2.22 ± 0.069
2.32GlnLys: 2.32 ± 0.067
1.562GlnLeu: 1.562 ± 0.052
0.721GlnMet: 0.721 ± 0.037
1.52GlnAsn: 1.52 ± 0.057
0.335GlnPro: 0.335 ± 0.025
0.382GlnGln: 0.382 ± 0.027
0.828GlnArg: 0.828 ± 0.04
1.242GlnSer: 1.242 ± 0.046
1.271GlnThr: 1.271 ± 0.048
1.406GlnVal: 1.406 ± 0.052
0.147GlnTrp: 0.147 ± 0.018
0.972GlnTyr: 0.972 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
1.384ArgAla: 1.384 ± 0.059
0.423ArgCys: 0.423 ± 0.03
1.508ArgAsp: 1.508 ± 0.056
2.189ArgGlu: 2.189 ± 0.076
1.312ArgPhe: 1.312 ± 0.044
1.642ArgGly: 1.642 ± 0.054
0.43ArgHis: 0.43 ± 0.028
3.112ArgIle: 3.112 ± 0.083
3.177ArgLys: 3.177 ± 0.084
2.648ArgLeu: 2.648 ± 0.082
0.746ArgMet: 0.746 ± 0.037
2.026ArgAsn: 2.026 ± 0.066
0.674ArgPro: 0.674 ± 0.037
0.699ArgGln: 0.699 ± 0.03
1.183ArgArg: 1.183 ± 0.053
1.578ArgSer: 1.578 ± 0.05
1.508ArgThr: 1.508 ± 0.06
1.881ArgVal: 1.881 ± 0.061
0.147ArgTrp: 0.147 ± 0.014
1.474ArgTyr: 1.474 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
2.505SerAla: 2.505 ± 0.071
0.83SerCys: 0.83 ± 0.046
3.571SerAsp: 3.571 ± 0.083
4.249SerGlu: 4.249 ± 0.093
3.638SerPhe: 3.638 ± 0.092
3.901SerGly: 3.901 ± 0.091
0.92SerHis: 0.92 ± 0.041
6.07SerIle: 6.07 ± 0.131
6.019SerLys: 6.019 ± 0.123
6.406SerLeu: 6.406 ± 0.147
1.327SerMet: 1.327 ± 0.05
3.914SerAsn: 3.914 ± 0.104
1.309SerPro: 1.309 ± 0.053
1.637SerGln: 1.637 ± 0.055
1.861SerArg: 1.861 ± 0.064
4.656SerSer: 4.656 ± 0.118
2.933SerThr: 2.933 ± 0.08
3.715SerVal: 3.715 ± 0.092
0.457SerTrp: 0.457 ± 0.034
3.243SerTyr: 3.243 ± 0.085
0.0SerXaa: 0.0 ± 0.0
Thr
2.146ThrAla: 2.146 ± 0.078
0.841ThrCys: 0.841 ± 0.047
2.745ThrAsp: 2.745 ± 0.078
3.197ThrGlu: 3.197 ± 0.091
2.802ThrPhe: 2.802 ± 0.07
3.385ThrGly: 3.385 ± 0.099
0.753ThrHis: 0.753 ± 0.031
6.002ThrIle: 6.002 ± 0.12
4.86ThrLys: 4.86 ± 0.091
5.09ThrLeu: 5.09 ± 0.105
1.034ThrMet: 1.034 ± 0.042
3.625ThrAsn: 3.625 ± 0.094
1.648ThrPro: 1.648 ± 0.056
1.108ThrGln: 1.108 ± 0.045
1.538ThrArg: 1.538 ± 0.059
3.613ThrSer: 3.613 ± 0.088
2.858ThrThr: 2.858 ± 0.1
3.281ThrVal: 3.281 ± 0.095
0.321ThrTrp: 0.321 ± 0.027
2.766ThrTyr: 2.766 ± 0.09
0.0ThrXaa: 0.0 ± 0.0
Val
2.951ValAla: 2.951 ± 0.094
1.176ValCys: 1.176 ± 0.044
3.844ValAsp: 3.844 ± 0.079
3.898ValGlu: 3.898 ± 0.103
3.173ValPhe: 3.173 ± 0.07
3.519ValGly: 3.519 ± 0.077
0.717ValHis: 0.717 ± 0.035
6.357ValIle: 6.357 ± 0.117
5.807ValLys: 5.807 ± 0.113
6.3ValLeu: 6.3 ± 0.113
1.355ValMet: 1.355 ± 0.056
4.267ValAsn: 4.267 ± 0.092
1.696ValPro: 1.696 ± 0.065
1.275ValGln: 1.275 ± 0.049
1.963ValArg: 1.963 ± 0.065
4.611ValSer: 4.611 ± 0.1
3.91ValThr: 3.91 ± 0.115
4.419ValVal: 4.419 ± 0.104
0.393ValTrp: 0.393 ± 0.031
2.999ValTyr: 2.999 ± 0.08
0.0ValXaa: 0.0 ± 0.0
Trp
0.29TrpAla: 0.29 ± 0.023
0.104TrpCys: 0.104 ± 0.014
0.351TrpAsp: 0.351 ± 0.027
0.385TrpGlu: 0.385 ± 0.026
0.337TrpPhe: 0.337 ± 0.031
0.344TrpGly: 0.344 ± 0.026
0.127TrpHis: 0.127 ± 0.016
0.586TrpIle: 0.586 ± 0.035
0.493TrpLys: 0.493 ± 0.033
0.574TrpLeu: 0.574 ± 0.041
0.136TrpMet: 0.136 ± 0.015
0.445TrpAsn: 0.445 ± 0.03
0.125TrpPro: 0.125 ± 0.014
0.169TrpGln: 0.169 ± 0.016
0.14TrpArg: 0.14 ± 0.017
0.371TrpSer: 0.371 ± 0.029
0.303TrpThr: 0.303 ± 0.031
0.339TrpVal: 0.339 ± 0.024
0.088TrpTrp: 0.088 ± 0.011
0.373TrpTyr: 0.373 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.562TyrAla: 2.562 ± 0.078
0.633TyrCys: 0.633 ± 0.034
3.63TyrAsp: 3.63 ± 0.085
4.132TyrGlu: 4.132 ± 0.103
2.447TyrPhe: 2.447 ± 0.076
2.754TyrGly: 2.754 ± 0.087
0.683TyrHis: 0.683 ± 0.032
4.459TyrIle: 4.459 ± 0.096
4.622TyrLys: 4.622 ± 0.112
5.169TyrLeu: 5.169 ± 0.107
1.033TyrMet: 1.033 ± 0.042
3.639TyrAsn: 3.639 ± 0.104
1.373TyrPro: 1.373 ± 0.048
1.398TyrGln: 1.398 ± 0.052
1.493TyrArg: 1.493 ± 0.052
3.127TyrSer: 3.127 ± 0.087
2.763TyrThr: 2.763 ± 0.082
3.258TyrVal: 3.258 ± 0.087
0.29TyrTrp: 0.29 ± 0.028
3.028TyrTyr: 3.028 ± 0.094
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.002XaaVal: 0.002 ± 0.002
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.002XaaXaa: 0.002 ± 0.002
Statistics based on 1615 proteins (557781 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski