Amino acid dipepetide frequency for Legionella wadsworthii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.828AlaAla: 5.828 ± 0.106	0.967AlaCys: 0.967 ± 0.036	3.103AlaAsp: 3.103 ± 0.05	3.99AlaGlu: 3.99 ± 0.061	3.134AlaPhe: 3.134 ± 0.076	4.727AlaGly: 4.727 ± 0.092	1.86AlaHis: 1.86 ± 0.042	5.595AlaIle: 5.595 ± 0.09	4.458AlaLys: 4.458 ± 0.07	8.522AlaLeu: 8.522 ± 0.113	1.892AlaMet: 1.892 ± 0.041	3.247AlaAsn: 3.247 ± 0.07	2.518AlaPro: 2.518 ± 0.055	3.407AlaGln: 3.407 ± 0.06	2.943AlaArg: 2.943 ± 0.063	4.603AlaSer: 4.603 ± 0.085	3.71AlaThr: 3.71 ± 0.084	4.459AlaVal: 4.459 ± 0.076	0.749AlaTrp: 0.749 ± 0.027	2.462AlaTyr: 2.462 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.81CysAla: 0.81 ± 0.029	0.213CysCys: 0.213 ± 0.014	0.599CysAsp: 0.599 ± 0.026	0.57CysGlu: 0.57 ± 0.024	0.732CysPhe: 0.732 ± 0.027	0.861CysGly: 0.861 ± 0.031	0.363CysHis: 0.363 ± 0.022	0.919CysIle: 0.919 ± 0.029	0.59CysLys: 0.59 ± 0.025	1.226CysLeu: 1.226 ± 0.038	0.282CysMet: 0.282 ± 0.017	0.483CysAsn: 0.483 ± 0.021	0.552CysPro: 0.552 ± 0.026	0.529CysGln: 0.529 ± 0.023	0.525CysArg: 0.525 ± 0.025	0.84CysSer: 0.84 ± 0.031	0.602CysThr: 0.602 ± 0.025	0.686CysVal: 0.686 ± 0.032	0.117CysTrp: 0.117 ± 0.01	0.477CysTyr: 0.477 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.361AspAla: 3.361 ± 0.062	0.596AspCys: 0.596 ± 0.024	2.033AspAsp: 2.033 ± 0.052	3.348AspGlu: 3.348 ± 0.067	2.465AspPhe: 2.465 ± 0.055	2.407AspGly: 2.407 ± 0.049	1.043AspHis: 1.043 ± 0.035	3.542AspIle: 3.542 ± 0.055	3.363AspLys: 3.363 ± 0.066	5.331AspLeu: 5.331 ± 0.101	1.063AspMet: 1.063 ± 0.035	2.22AspAsn: 2.22 ± 0.049	2.02AspPro: 2.02 ± 0.048	1.673AspGln: 1.673 ± 0.044	1.837AspArg: 1.837 ± 0.038	2.956AspSer: 2.956 ± 0.056	2.215AspThr: 2.215 ± 0.044	2.96AspVal: 2.96 ± 0.058	0.67AspTrp: 0.67 ± 0.025	1.993AspTyr: 1.993 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	4.237GluAla: 4.237 ± 0.079	0.59GluCys: 0.59 ± 0.022	2.687GluAsp: 2.687 ± 0.065	4.646GluGlu: 4.646 ± 0.095	2.457GluPhe: 2.457 ± 0.054	3.182GluGly: 3.182 ± 0.057	1.615GluHis: 1.615 ± 0.045	4.764GluIle: 4.764 ± 0.086	4.962GluLys: 4.962 ± 0.082	6.6GluLeu: 6.6 ± 0.082	1.599GluMet: 1.599 ± 0.043	3.229GluAsn: 3.229 ± 0.063	1.799GluPro: 1.799 ± 0.045	3.295GluGln: 3.295 ± 0.066	2.777GluArg: 2.777 ± 0.062	3.553GluSer: 3.553 ± 0.063	2.902GluThr: 2.902 ± 0.057	3.499GluVal: 3.499 ± 0.06	0.628GluTrp: 0.628 ± 0.028	1.944GluTyr: 1.944 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.432PheAla: 3.432 ± 0.063	0.692PheCys: 0.692 ± 0.026	2.402PheAsp: 2.402 ± 0.047	2.248PheGlu: 2.248 ± 0.047	2.761PhePhe: 2.761 ± 0.067	2.683PheGly: 2.683 ± 0.057	1.168PheHis: 1.168 ± 0.035	3.945PheIle: 3.945 ± 0.075	2.701PheLys: 2.701 ± 0.05	5.157PheLeu: 5.157 ± 0.095	1.013PheMet: 1.013 ± 0.034	2.529PheAsn: 2.529 ± 0.056	1.822PhePro: 1.822 ± 0.044	1.585PheGln: 1.585 ± 0.042	1.566PheArg: 1.566 ± 0.037	3.791PheSer: 3.791 ± 0.076	2.46PheThr: 2.46 ± 0.056	2.439PheVal: 2.439 ± 0.053	0.616PheTrp: 0.616 ± 0.027	1.912PheTyr: 1.912 ± 0.056	0.0PheXaa: 0.0 ± 0.0
Gly	4.313GlyAla: 4.313 ± 0.098	0.828GlyCys: 0.828 ± 0.031	2.685GlyAsp: 2.685 ± 0.055	3.16GlyGlu: 3.16 ± 0.063	3.246GlyPhe: 3.246 ± 0.062	4.045GlyGly: 4.045 ± 0.103	1.51GlyHis: 1.51 ± 0.037	5.275GlyIle: 5.275 ± 0.088	3.837GlyLys: 3.837 ± 0.064	6.335GlyLeu: 6.335 ± 0.086	1.746GlyMet: 1.746 ± 0.048	2.532GlyAsn: 2.532 ± 0.058	1.682GlyPro: 1.682 ± 0.045	2.282GlyGln: 2.282 ± 0.051	2.358GlyArg: 2.358 ± 0.054	3.848GlySer: 3.848 ± 0.073	3.182GlyThr: 3.182 ± 0.079	3.966GlyVal: 3.966 ± 0.078	0.866GlyTrp: 0.866 ± 0.032	2.487GlyTyr: 2.487 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.835HisAla: 1.835 ± 0.045	0.407HisCys: 0.407 ± 0.021	1.183HisAsp: 1.183 ± 0.038	1.453HisGlu: 1.453 ± 0.038	1.458HisPhe: 1.458 ± 0.036	1.618HisGly: 1.618 ± 0.039	0.948HisHis: 0.948 ± 0.032	1.706HisIle: 1.706 ± 0.048	1.163HisLys: 1.163 ± 0.034	3.038HisLeu: 3.038 ± 0.063	0.573HisMet: 0.573 ± 0.024	0.991HisAsn: 0.991 ± 0.033	1.344HisPro: 1.344 ± 0.034	1.406HisGln: 1.406 ± 0.04	1.134HisArg: 1.134 ± 0.036	1.716HisSer: 1.716 ± 0.046	1.155HisThr: 1.155 ± 0.032	1.409HisVal: 1.409 ± 0.033	0.403HisTrp: 0.403 ± 0.02	1.117HisTyr: 1.117 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.046IleAla: 6.046 ± 0.091	0.929IleCys: 0.929 ± 0.037	4.023IleAsp: 4.023 ± 0.065	4.942IleGlu: 4.942 ± 0.086	3.154IlePhe: 3.154 ± 0.059	4.651IleGly: 4.651 ± 0.089	2.119IleHis: 2.119 ± 0.046	5.607IleIle: 5.607 ± 0.102	5.121IleLys: 5.121 ± 0.081	7.85IleLeu: 7.85 ± 0.111	1.563IleMet: 1.563 ± 0.043	4.121IleAsn: 4.121 ± 0.068	3.687IlePro: 3.687 ± 0.057	3.237IleGln: 3.237 ± 0.064	2.966IleArg: 2.966 ± 0.049	5.404IleSer: 5.404 ± 0.081	4.071IleThr: 4.071 ± 0.07	4.002IleVal: 4.002 ± 0.066	0.691IleTrp: 0.691 ± 0.027	2.479IleTyr: 2.479 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.307LysAla: 4.307 ± 0.072	0.435LysCys: 0.435 ± 0.022	3.125LysAsp: 3.125 ± 0.067	5.208LysGlu: 5.208 ± 0.076	1.941LysPhe: 1.941 ± 0.04	3.377LysGly: 3.377 ± 0.055	1.443LysHis: 1.443 ± 0.037	5.217LysIle: 5.217 ± 0.091	5.78LysLys: 5.78 ± 0.094	5.877LysLeu: 5.877 ± 0.089	1.735LysMet: 1.735 ± 0.045	4.281LysAsn: 4.281 ± 0.077	2.708LysPro: 2.708 ± 0.05	3.194LysGln: 3.194 ± 0.059	2.764LysArg: 2.764 ± 0.05	4.036LysSer: 4.036 ± 0.069	3.602LysThr: 3.602 ± 0.065	3.24LysVal: 3.24 ± 0.054	0.616LysTrp: 0.616 ± 0.024	1.957LysTyr: 1.957 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	8.326LeuAla: 8.326 ± 0.093	1.358LeuCys: 1.358 ± 0.034	5.176LeuAsp: 5.176 ± 0.069	6.046LeuGlu: 6.046 ± 0.082	5.467LeuPhe: 5.467 ± 0.096	6.574LeuGly: 6.574 ± 0.103	2.564LeuHis: 2.564 ± 0.05	8.572LeuIle: 8.572 ± 0.108	7.097LeuLys: 7.097 ± 0.093	11.564LeuLeu: 11.564 ± 0.159	2.672LeuMet: 2.672 ± 0.056	5.877LeuAsn: 5.877 ± 0.083	4.914LeuPro: 4.914 ± 0.08	4.338LeuGln: 4.338 ± 0.079	4.269LeuArg: 4.269 ± 0.068	8.187LeuSer: 8.187 ± 0.102	5.805LeuThr: 5.805 ± 0.085	5.763LeuVal: 5.763 ± 0.084	1.074LeuTrp: 1.074 ± 0.036	3.267LeuTyr: 3.267 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	1.946MetAla: 1.946 ± 0.041	0.199MetCys: 0.199 ± 0.014	1.281MetAsp: 1.281 ± 0.036	1.353MetGlu: 1.353 ± 0.035	0.804MetPhe: 0.804 ± 0.028	1.551MetGly: 1.551 ± 0.041	0.634MetHis: 0.634 ± 0.024	1.704MetIle: 1.704 ± 0.046	1.728MetLys: 1.728 ± 0.049	2.361MetLeu: 2.361 ± 0.057	0.735MetMet: 0.735 ± 0.028	1.462MetAsn: 1.462 ± 0.043	1.078MetPro: 1.078 ± 0.033	1.081MetGln: 1.081 ± 0.031	1.122MetArg: 1.122 ± 0.032	1.693MetSer: 1.693 ± 0.042	1.365MetThr: 1.365 ± 0.033	1.515MetVal: 1.515 ± 0.045	0.179MetTrp: 0.179 ± 0.012	0.601MetTyr: 0.601 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.308AsnAla: 3.308 ± 0.062	0.566AsnCys: 0.566 ± 0.029	2.189AsnAsp: 2.189 ± 0.05	3.142AsnGlu: 3.142 ± 0.054	2.199AsnPhe: 2.199 ± 0.049	2.607AsnGly: 2.607 ± 0.059	1.523AsnHis: 1.523 ± 0.049	3.459AsnIle: 3.459 ± 0.076	3.457AsnLys: 3.457 ± 0.075	5.186AsnLeu: 5.186 ± 0.082	1.068AsnMet: 1.068 ± 0.037	2.685AsnAsn: 2.685 ± 0.066	2.905AsnPro: 2.905 ± 0.063	2.791AsnGln: 2.791 ± 0.052	1.98AsnArg: 1.98 ± 0.043	3.261AsnSer: 3.261 ± 0.058	2.655AsnThr: 2.655 ± 0.059	2.377AsnVal: 2.377 ± 0.057	0.675AsnTrp: 0.675 ± 0.025	2.015AsnTyr: 2.015 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	2.599ProAla: 2.599 ± 0.058	0.42ProCys: 0.42 ± 0.021	2.213ProAsp: 2.213 ± 0.05	3.184ProGlu: 3.184 ± 0.059	1.995ProPhe: 1.995 ± 0.042	2.696ProGly: 2.696 ± 0.073	1.068ProHis: 1.068 ± 0.033	3.013ProIle: 3.013 ± 0.062	2.417ProLys: 2.417 ± 0.051	4.383ProLeu: 4.383 ± 0.063	0.959ProMet: 0.959 ± 0.031	1.999ProAsn: 1.999 ± 0.053	1.57ProPro: 1.57 ± 0.039	1.861ProGln: 1.861 ± 0.043	1.342ProArg: 1.342 ± 0.035	2.766ProSer: 2.766 ± 0.06	2.107ProThr: 2.107 ± 0.069	2.895ProVal: 2.895 ± 0.058	0.497ProTrp: 0.497 ± 0.023	1.477ProTyr: 1.477 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.302GlnAla: 3.302 ± 0.068	0.512GlnCys: 0.512 ± 0.023	1.844GlnAsp: 1.844 ± 0.046	2.851GlnGlu: 2.851 ± 0.059	2.177GlnPhe: 2.177 ± 0.046	2.55GlnGly: 2.55 ± 0.05	1.138GlnHis: 1.138 ± 0.037	3.402GlnIle: 3.402 ± 0.062	3.202GlnLys: 3.202 ± 0.064	5.118GlnLeu: 5.118 ± 0.073	1.102GlnMet: 1.102 ± 0.033	2.248GlnAsn: 2.248 ± 0.05	1.486GlnPro: 1.486 ± 0.056	2.416GlnGln: 2.416 ± 0.06	1.873GlnArg: 1.873 ± 0.041	2.878GlnSer: 2.878 ± 0.061	2.15GlnThr: 2.15 ± 0.053	2.497GlnVal: 2.497 ± 0.052	0.64GlnTrp: 0.64 ± 0.026	1.578GlnTyr: 1.578 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.747ArgAla: 2.747 ± 0.058	0.458ArgCys: 0.458 ± 0.02	2.078ArgAsp: 2.078 ± 0.05	2.672ArgGlu: 2.672 ± 0.064	2.076ArgPhe: 2.076 ± 0.054	2.232ArgGly: 2.232 ± 0.05	1.072ArgHis: 1.072 ± 0.032	3.309ArgIle: 3.309 ± 0.059	2.549ArgLys: 2.549 ± 0.046	4.453ArgLeu: 4.453 ± 0.082	1.002ArgMet: 1.002 ± 0.036	1.956ArgAsn: 1.956 ± 0.044	1.363ArgPro: 1.363 ± 0.045	1.787ArgGln: 1.787 ± 0.042	1.835ArgArg: 1.835 ± 0.054	2.35ArgSer: 2.35 ± 0.045	1.954ArgThr: 1.954 ± 0.044	2.454ArgVal: 2.454 ± 0.048	0.515ArgTrp: 0.515 ± 0.026	1.622ArgTyr: 1.622 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	4.457SerAla: 4.457 ± 0.079	0.831SerCys: 0.831 ± 0.031	2.995SerAsp: 2.995 ± 0.06	3.733SerGlu: 3.733 ± 0.07	3.387SerPhe: 3.387 ± 0.058	4.475SerGly: 4.475 ± 0.079	1.719SerHis: 1.719 ± 0.042	5.245SerIle: 5.245 ± 0.078	4.02SerLys: 4.02 ± 0.07	8.023SerLeu: 8.023 ± 0.095	1.815SerMet: 1.815 ± 0.032	3.122SerAsn: 3.122 ± 0.066	2.872SerPro: 2.872 ± 0.053	2.889SerGln: 2.889 ± 0.058	2.749SerArg: 2.749 ± 0.057	4.869SerSer: 4.869 ± 0.089	3.333SerThr: 3.333 ± 0.07	3.673SerVal: 3.673 ± 0.062	0.836SerTrp: 0.836 ± 0.029	2.405SerTyr: 2.405 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	3.87ThrAla: 3.87 ± 0.08	0.614ThrCys: 0.614 ± 0.03	2.267ThrAsp: 2.267 ± 0.05	2.736ThrGlu: 2.736 ± 0.058	2.139ThrPhe: 2.139 ± 0.049	3.515ThrGly: 3.515 ± 0.068	1.47ThrHis: 1.47 ± 0.035	3.758ThrIle: 3.758 ± 0.063	2.688ThrLys: 2.688 ± 0.057	6.056ThrLeu: 6.056 ± 0.082	1.118ThrMet: 1.118 ± 0.033	2.228ThrAsn: 2.228 ± 0.049	2.799ThrPro: 2.799 ± 0.072	2.359ThrGln: 2.359 ± 0.058	2.092ThrArg: 2.092 ± 0.042	3.373ThrSer: 3.373 ± 0.056	2.809ThrThr: 2.809 ± 0.06	3.275ThrVal: 3.275 ± 0.065	0.555ThrTrp: 0.555 ± 0.027	1.708ThrTyr: 1.708 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	4.397ValAla: 4.397 ± 0.081	0.708ValCys: 0.708 ± 0.025	3.033ValAsp: 3.033 ± 0.057	3.192ValGlu: 3.192 ± 0.068	2.682ValPhe: 2.682 ± 0.056	3.501ValGly: 3.501 ± 0.064	1.425ValHis: 1.425 ± 0.041	4.521ValIle: 4.521 ± 0.075	3.286ValLys: 3.286 ± 0.064	6.245ValLeu: 6.245 ± 0.101	1.45ValMet: 1.45 ± 0.044	2.834ValAsn: 2.834 ± 0.062	2.257ValPro: 2.257 ± 0.041	2.145ValGln: 2.145 ± 0.046	2.229ValArg: 2.229 ± 0.05	4.111ValSer: 4.111 ± 0.066	3.136ValThr: 3.136 ± 0.065	3.709ValVal: 3.709 ± 0.073	0.565ValTrp: 0.565 ± 0.023	1.851ValTyr: 1.851 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.667TrpAla: 0.667 ± 0.028	0.155TrpCys: 0.155 ± 0.013	0.533TrpAsp: 0.533 ± 0.022	0.583TrpGlu: 0.583 ± 0.023	0.64TrpPhe: 0.64 ± 0.025	0.746TrpGly: 0.746 ± 0.028	0.357TrpHis: 0.357 ± 0.02	0.924TrpIle: 0.924 ± 0.033	0.592TrpLys: 0.592 ± 0.024	1.389TrpLeu: 1.389 ± 0.038	0.325TrpMet: 0.325 ± 0.02	0.559TrpAsn: 0.559 ± 0.023	0.445TrpPro: 0.445 ± 0.025	0.635TrpGln: 0.635 ± 0.024	0.521TrpArg: 0.521 ± 0.023	0.754TrpSer: 0.754 ± 0.028	0.502TrpThr: 0.502 ± 0.02	0.711TrpVal: 0.711 ± 0.026	0.16TrpTrp: 0.16 ± 0.014	0.363TrpTyr: 0.363 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.388TyrAla: 2.388 ± 0.049	0.497TyrCys: 0.497 ± 0.021	1.644TyrAsp: 1.644 ± 0.042	1.909TyrGlu: 1.909 ± 0.045	2.009TyrPhe: 2.009 ± 0.05	2.187TyrGly: 2.187 ± 0.051	1.018TyrHis: 1.018 ± 0.032	2.186TyrIle: 2.186 ± 0.046	1.832TyrLys: 1.832 ± 0.046	4.197TyrLeu: 4.197 ± 0.078	0.68TyrMet: 0.68 ± 0.026	1.444TyrAsn: 1.444 ± 0.037	1.64TyrPro: 1.64 ± 0.043	2.052TyrGln: 2.052 ± 0.048	1.599TyrArg: 1.599 ± 0.043	2.458TyrSer: 2.458 ± 0.055	1.717TyrThr: 1.717 ± 0.041	1.748TyrVal: 1.748 ± 0.042	0.511TyrTrp: 0.511 ± 0.021	1.43TyrTyr: 1.43 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3179 proteins (1046041 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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