Amino acid dipepetide frequency for Butyrivibrio crossotus CAG:259

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.977AlaAla: 5.977 ± 0.121	0.982AlaCys: 0.982 ± 0.046	4.693AlaAsp: 4.693 ± 0.091	4.475AlaGlu: 4.475 ± 0.093	2.671AlaPhe: 2.671 ± 0.071	5.85AlaGly: 5.85 ± 0.111	0.921AlaHis: 0.921 ± 0.04	5.327AlaIle: 5.327 ± 0.125	5.003AlaLys: 5.003 ± 0.104	5.813AlaLeu: 5.813 ± 0.097	2.119AlaMet: 2.119 ± 0.07	2.421AlaAsn: 2.421 ± 0.069	1.663AlaPro: 1.663 ± 0.066	1.323AlaGln: 1.323 ± 0.05	2.458AlaArg: 2.458 ± 0.07	3.559AlaSer: 3.559 ± 0.086	3.322AlaThr: 3.322 ± 0.105	5.861AlaVal: 5.861 ± 0.107	0.365AlaTrp: 0.365 ± 0.024	2.639AlaTyr: 2.639 ± 0.07	0.002AlaXaa: 0.002 ± 0.002
Cys	0.861CysAla: 0.861 ± 0.042	0.232CysCys: 0.232 ± 0.023	0.974CysAsp: 0.974 ± 0.038	0.907CysGlu: 0.907 ± 0.039	0.61CysPhe: 0.61 ± 0.029	1.35CysGly: 1.35 ± 0.052	0.311CysHis: 0.311 ± 0.022	1.227CysIle: 1.227 ± 0.048	0.941CysLys: 0.941 ± 0.042	0.956CysLeu: 0.956 ± 0.037	0.442CysMet: 0.442 ± 0.027	0.771CysAsn: 0.771 ± 0.036	0.504CysPro: 0.504 ± 0.036	0.267CysGln: 0.267 ± 0.021	0.581CysArg: 0.581 ± 0.029	0.829CysSer: 0.829 ± 0.042	0.745CysThr: 0.745 ± 0.034	0.942CysVal: 0.942 ± 0.039	0.068CysTrp: 0.068 ± 0.01	0.583CysTyr: 0.583 ± 0.032	0.0CysXaa: 0.0 ± 0.0
Asp	3.74AspAla: 3.74 ± 0.093	0.766AspCys: 0.766 ± 0.037	3.843AspAsp: 3.843 ± 0.093	5.351AspGlu: 5.351 ± 0.11	2.845AspPhe: 2.845 ± 0.063	4.595AspGly: 4.595 ± 0.097	0.628AspHis: 0.628 ± 0.039	6.117AspIle: 6.117 ± 0.107	5.565AspLys: 5.565 ± 0.101	4.004AspLeu: 4.004 ± 0.095	2.167AspMet: 2.167 ± 0.053	3.962AspAsn: 3.962 ± 0.082	1.346AspPro: 1.346 ± 0.051	0.701AspGln: 0.701 ± 0.034	2.602AspArg: 2.602 ± 0.073	3.608AspSer: 3.608 ± 0.08	3.371AspThr: 3.371 ± 0.08	4.383AspVal: 4.383 ± 0.09	0.4AspTrp: 0.4 ± 0.031	3.262AspTyr: 3.262 ± 0.074	0.0AspXaa: 0.0 ± 0.0
Glu	4.814GluAla: 4.814 ± 0.103	0.937GluCys: 0.937 ± 0.043	4.339GluAsp: 4.339 ± 0.095	6.172GluGlu: 6.172 ± 0.13	2.79GluPhe: 2.79 ± 0.067	3.741GluGly: 3.741 ± 0.083	1.23GluHis: 1.23 ± 0.052	6.261GluIle: 6.261 ± 0.081	6.662GluLys: 6.662 ± 0.127	6.692GluLeu: 6.692 ± 0.124	2.059GluMet: 2.059 ± 0.053	4.385GluAsn: 4.385 ± 0.087	1.789GluPro: 1.789 ± 0.064	2.078GluGln: 2.078 ± 0.068	2.777GluArg: 2.777 ± 0.072	3.533GluSer: 3.533 ± 0.075	3.592GluThr: 3.592 ± 0.083	4.264GluVal: 4.264 ± 0.093	0.481GluTrp: 0.481 ± 0.027	3.694GluTyr: 3.694 ± 0.093	0.0GluXaa: 0.0 ± 0.0
Phe	2.872PheAla: 2.872 ± 0.08	0.65PheCys: 0.65 ± 0.032	2.795PheAsp: 2.795 ± 0.066	2.749PheGlu: 2.749 ± 0.07	1.889PhePhe: 1.889 ± 0.073	2.852PheGly: 2.852 ± 0.064	0.591PheHis: 0.591 ± 0.034	3.61PheIle: 3.61 ± 0.094	2.795PheLys: 2.795 ± 0.071	3.325PheLeu: 3.325 ± 0.084	1.228PheMet: 1.228 ± 0.049	2.272PheAsn: 2.272 ± 0.068	1.163PhePro: 1.163 ± 0.048	0.747PheGln: 0.747 ± 0.029	1.605PheArg: 1.605 ± 0.053	2.877PheSer: 2.877 ± 0.077	2.518PheThr: 2.518 ± 0.062	3.003PheVal: 3.003 ± 0.068	0.245PheTrp: 0.245 ± 0.021	1.756PheTyr: 1.756 ± 0.056	0.002PheXaa: 0.002 ± 0.002
Gly	4.274GlyAla: 4.274 ± 0.099	1.126GlyCys: 1.126 ± 0.048	3.703GlyAsp: 3.703 ± 0.082	4.067GlyGlu: 4.067 ± 0.084	3.082GlyPhe: 3.082 ± 0.069	4.369GlyGly: 4.369 ± 0.113	1.25GlyHis: 1.25 ± 0.05	6.951GlyIle: 6.951 ± 0.119	5.61GlyLys: 5.61 ± 0.093	5.408GlyLeu: 5.408 ± 0.092	2.42GlyMet: 2.42 ± 0.068	3.794GlyAsn: 3.794 ± 0.086	1.176GlyPro: 1.176 ± 0.049	1.595GlyGln: 1.595 ± 0.05	3.147GlyArg: 3.147 ± 0.07	3.908GlySer: 3.908 ± 0.085	4.08GlyThr: 4.08 ± 0.096	4.615GlyVal: 4.615 ± 0.087	0.47GlyTrp: 0.47 ± 0.035	3.328GlyTyr: 3.328 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	0.802HisAla: 0.802 ± 0.034	0.265HisCys: 0.265 ± 0.022	0.86HisAsp: 0.86 ± 0.043	0.887HisGlu: 0.887 ± 0.037	0.764HisPhe: 0.764 ± 0.036	1.08HisGly: 1.08 ± 0.046	0.308HisHis: 0.308 ± 0.035	1.433HisIle: 1.433 ± 0.043	1.087HisLys: 1.087 ± 0.045	1.136HisLeu: 1.136 ± 0.043	0.431HisMet: 0.431 ± 0.022	0.89HisAsn: 0.89 ± 0.041	0.645HisPro: 0.645 ± 0.038	0.307HisGln: 0.307 ± 0.024	0.601HisArg: 0.601 ± 0.032	0.901HisSer: 0.901 ± 0.041	0.802HisThr: 0.802 ± 0.032	0.817HisVal: 0.817 ± 0.036	0.102HisTrp: 0.102 ± 0.013	0.678HisTyr: 0.678 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.133IleAla: 6.133 ± 0.113	1.433IleCys: 1.433 ± 0.051	5.254IleAsp: 5.254 ± 0.099	5.691IleGlu: 5.691 ± 0.094	3.516IlePhe: 3.516 ± 0.099	5.406IleGly: 5.406 ± 0.105	1.257IleHis: 1.257 ± 0.044	7.813IleIle: 7.813 ± 0.156	6.649IleLys: 6.649 ± 0.101	7.237IleLeu: 7.237 ± 0.13	2.448IleMet: 2.448 ± 0.068	4.869IleAsn: 4.869 ± 0.105	3.22IlePro: 3.22 ± 0.07	1.702IleGln: 1.702 ± 0.054	3.427IleArg: 3.427 ± 0.082	6.053IleSer: 6.053 ± 0.118	5.271IleThr: 5.271 ± 0.107	5.92IleVal: 5.92 ± 0.107	0.515IleTrp: 0.515 ± 0.031	3.581IleTyr: 3.581 ± 0.096	0.0IleXaa: 0.0 ± 0.0
Lys	5.534LysAla: 5.534 ± 0.106	0.867LysCys: 0.867 ± 0.034	5.343LysAsp: 5.343 ± 0.104	7.267LysGlu: 7.267 ± 0.118	2.318LysPhe: 2.318 ± 0.061	4.661LysGly: 4.661 ± 0.083	1.047LysHis: 1.047 ± 0.045	6.488LysIle: 6.488 ± 0.113	7.359LysLys: 7.359 ± 0.126	5.648LysLeu: 5.648 ± 0.1	2.32LysMet: 2.32 ± 0.052	4.777LysAsn: 4.777 ± 0.097	1.953LysPro: 1.953 ± 0.051	1.906LysGln: 1.906 ± 0.061	2.973LysArg: 2.973 ± 0.076	4.269LysSer: 4.269 ± 0.088	4.232LysThr: 4.232 ± 0.08	5.198LysVal: 5.198 ± 0.09	0.537LysTrp: 0.537 ± 0.032	3.797LysTyr: 3.797 ± 0.084	0.0LysXaa: 0.0 ± 0.0
Leu	5.854LeuAla: 5.854 ± 0.093	1.327LeuCys: 1.327 ± 0.046	4.904LeuAsp: 4.904 ± 0.088	4.993LeuGlu: 4.993 ± 0.095	3.54LeuPhe: 3.54 ± 0.087	5.066LeuGly: 5.066 ± 0.089	1.255LeuHis: 1.255 ± 0.049	6.674LeuIle: 6.674 ± 0.12	6.474LeuLys: 6.474 ± 0.105	6.849LeuLeu: 6.849 ± 0.134	2.364LeuMet: 2.364 ± 0.069	4.25LeuAsn: 4.25 ± 0.081	2.79LeuPro: 2.79 ± 0.07	1.827LeuGln: 1.827 ± 0.057	3.154LeuArg: 3.154 ± 0.081	5.861LeuSer: 5.861 ± 0.12	4.658LeuThr: 4.658 ± 0.094	5.24LeuVal: 5.24 ± 0.096	0.51LeuTrp: 0.51 ± 0.031	3.128LeuTyr: 3.128 ± 0.08	0.0LeuXaa: 0.0 ± 0.0
Met	2.28MetAla: 2.28 ± 0.062	0.384MetCys: 0.384 ± 0.027	2.022MetAsp: 2.022 ± 0.065	2.281MetGlu: 2.281 ± 0.069	1.123MetPhe: 1.123 ± 0.046	1.962MetGly: 1.962 ± 0.052	0.342MetHis: 0.342 ± 0.025	2.361MetIle: 2.361 ± 0.061	2.636MetLys: 2.636 ± 0.065	2.52MetLeu: 2.52 ± 0.075	0.88MetMet: 0.88 ± 0.043	1.682MetAsn: 1.682 ± 0.057	0.99MetPro: 0.99 ± 0.036	0.693MetGln: 0.693 ± 0.032	1.066MetArg: 1.066 ± 0.044	1.981MetSer: 1.981 ± 0.057	1.676MetThr: 1.676 ± 0.049	1.902MetVal: 1.902 ± 0.057	0.165MetTrp: 0.165 ± 0.016	1.087MetTyr: 1.087 ± 0.046	0.0MetXaa: 0.0 ± 0.0
Asn	3.197AsnAla: 3.197 ± 0.076	0.696AsnCys: 0.696 ± 0.033	3.106AsnAsp: 3.106 ± 0.067	3.667AsnGlu: 3.667 ± 0.073	1.975AsnPhe: 1.975 ± 0.059	4.22AsnGly: 4.22 ± 0.098	0.796AsnHis: 0.796 ± 0.035	5.265AsnIle: 5.265 ± 0.109	3.918AsnLys: 3.918 ± 0.087	4.18AsnLeu: 4.18 ± 0.086	1.606AsnMet: 1.606 ± 0.053	3.468AsnAsn: 3.468 ± 0.102	2.037AsnPro: 2.037 ± 0.056	1.122AsnGln: 1.122 ± 0.043	2.262AsnArg: 2.262 ± 0.071	3.1AsnSer: 3.1 ± 0.075	2.985AsnThr: 2.985 ± 0.072	3.753AsnVal: 3.753 ± 0.082	0.361AsnTrp: 0.361 ± 0.022	2.478AsnTyr: 2.478 ± 0.074	0.0AsnXaa: 0.0 ± 0.0
Pro	2.021ProAla: 2.021 ± 0.065	0.404ProCys: 0.404 ± 0.025	2.335ProAsp: 2.335 ± 0.062	2.909ProGlu: 2.909 ± 0.088	1.311ProPhe: 1.311 ± 0.046	2.013ProGly: 2.013 ± 0.056	0.454ProHis: 0.454 ± 0.026	1.833ProIle: 1.833 ± 0.053	1.671ProLys: 1.671 ± 0.057	2.202ProLeu: 2.202 ± 0.063	0.686ProMet: 0.686 ± 0.037	1.045ProAsn: 1.045 ± 0.04	0.581ProPro: 0.581 ± 0.03	0.723ProGln: 0.723 ± 0.044	0.805ProArg: 0.805 ± 0.04	1.703ProSer: 1.703 ± 0.048	1.354ProThr: 1.354 ± 0.05	3.112ProVal: 3.112 ± 0.065	0.214ProTrp: 0.214 ± 0.022	1.336ProTyr: 1.336 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	1.522GlnAla: 1.522 ± 0.049	0.281GlnCys: 0.281 ± 0.02	1.028GlnAsp: 1.028 ± 0.044	1.354GlnGlu: 1.354 ± 0.049	0.836GlnPhe: 0.836 ± 0.039	1.354GlnGly: 1.354 ± 0.05	0.291GlnHis: 0.291 ± 0.021	2.002GlnIle: 2.002 ± 0.056	1.876GlnLys: 1.876 ± 0.052	1.759GlnLeu: 1.759 ± 0.056	0.799GlnMet: 0.799 ± 0.032	1.265GlnAsn: 1.265 ± 0.048	0.594GlnPro: 0.594 ± 0.04	0.567GlnGln: 0.567 ± 0.035	0.899GlnArg: 0.899 ± 0.043	1.238GlnSer: 1.238 ± 0.044	1.277GlnThr: 1.277 ± 0.051	1.487GlnVal: 1.487 ± 0.048	0.175GlnTrp: 0.175 ± 0.02	1.052GlnTyr: 1.052 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	2.026ArgAla: 2.026 ± 0.052	0.494ArgCys: 0.494 ± 0.029	2.28ArgAsp: 2.28 ± 0.068	3.006ArgGlu: 3.006 ± 0.075	1.717ArgPhe: 1.717 ± 0.052	2.08ArgGly: 2.08 ± 0.059	0.697ArgHis: 0.697 ± 0.036	3.73ArgIle: 3.73 ± 0.071	3.46ArgLys: 3.46 ± 0.075	3.489ArgLeu: 3.489 ± 0.074	1.339ArgMet: 1.339 ± 0.049	2.456ArgAsn: 2.456 ± 0.066	1.098ArgPro: 1.098 ± 0.043	1.22ArgGln: 1.22 ± 0.043	1.713ArgArg: 1.713 ± 0.059	1.838ArgSer: 1.838 ± 0.047	2.083ArgThr: 2.083 ± 0.064	2.353ArgVal: 2.353 ± 0.064	0.248ArgTrp: 0.248 ± 0.02	1.926ArgTyr: 1.926 ± 0.059	0.0ArgXaa: 0.0 ± 0.0
Ser	3.827SerAla: 3.827 ± 0.08	0.745SerCys: 0.745 ± 0.038	4.102SerAsp: 4.102 ± 0.082	4.377SerGlu: 4.377 ± 0.081	2.752SerPhe: 2.752 ± 0.067	5.033SerGly: 5.033 ± 0.108	0.942SerHis: 0.942 ± 0.037	4.725SerIle: 4.725 ± 0.108	4.231SerLys: 4.231 ± 0.092	4.995SerLeu: 4.995 ± 0.092	1.81SerMet: 1.81 ± 0.057	2.733SerAsn: 2.733 ± 0.068	1.463SerPro: 1.463 ± 0.047	1.377SerGln: 1.377 ± 0.042	2.49SerArg: 2.49 ± 0.067	3.737SerSer: 3.737 ± 0.098	2.909SerThr: 2.909 ± 0.073	4.711SerVal: 4.711 ± 0.086	0.386SerTrp: 0.386 ± 0.027	2.763SerTyr: 2.763 ± 0.069	0.002SerXaa: 0.002 ± 0.001
Thr	3.981ThrAla: 3.981 ± 0.094	0.618ThrCys: 0.618 ± 0.033	3.854ThrAsp: 3.854 ± 0.074	4.059ThrGlu: 4.059 ± 0.096	2.213ThrPhe: 2.213 ± 0.065	5.089ThrGly: 5.089 ± 0.093	0.817ThrHis: 0.817 ± 0.036	4.472ThrIle: 4.472 ± 0.095	3.397ThrLys: 3.397 ± 0.077	4.477ThrLeu: 4.477 ± 0.096	1.408ThrMet: 1.408 ± 0.047	2.188ThrAsn: 2.188 ± 0.07	2.038ThrPro: 2.038 ± 0.059	1.058ThrGln: 1.058 ± 0.042	1.875ThrArg: 1.875 ± 0.055	3.171ThrSer: 3.171 ± 0.078	3.147ThrThr: 3.147 ± 0.094	4.742ThrVal: 4.742 ± 0.109	0.335ThrTrp: 0.335 ± 0.028	2.389ThrTyr: 2.389 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	4.79ValAla: 4.79 ± 0.1	1.125ValCys: 1.125 ± 0.045	4.223ValAsp: 4.223 ± 0.09	4.278ValGlu: 4.278 ± 0.089	3.166ValPhe: 3.166 ± 0.087	4.02ValGly: 4.02 ± 0.083	0.898ValHis: 0.898 ± 0.039	6.704ValIle: 6.704 ± 0.107	5.519ValLys: 5.519 ± 0.103	6.018ValLeu: 6.018 ± 0.097	2.03ValMet: 2.03 ± 0.057	3.748ValAsn: 3.748 ± 0.073	2.291ValPro: 2.291 ± 0.065	1.3ValGln: 1.3 ± 0.045	2.78ValArg: 2.78 ± 0.079	4.712ValSer: 4.712 ± 0.095	4.537ValThr: 4.537 ± 0.105	5.192ValVal: 5.192 ± 0.097	0.475ValTrp: 0.475 ± 0.03	3.034ValTyr: 3.034 ± 0.074	0.0ValXaa: 0.0 ± 0.0
Trp	0.343TrpAla: 0.343 ± 0.025	0.102TrpCys: 0.102 ± 0.015	0.4TrpAsp: 0.4 ± 0.028	0.432TrpGlu: 0.432 ± 0.028	0.305TrpPhe: 0.305 ± 0.022	0.404TrpGly: 0.404 ± 0.024	0.13TrpHis: 0.13 ± 0.015	0.561TrpIle: 0.561 ± 0.03	0.569TrpLys: 0.569 ± 0.031	0.607TrpLeu: 0.607 ± 0.029	0.195TrpMet: 0.195 ± 0.017	0.467TrpAsn: 0.467 ± 0.032	0.143TrpPro: 0.143 ± 0.017	0.199TrpGln: 0.199 ± 0.017	0.232TrpArg: 0.232 ± 0.018	0.329TrpSer: 0.329 ± 0.027	0.303TrpThr: 0.303 ± 0.024	0.337TrpVal: 0.337 ± 0.021	0.062TrpTrp: 0.062 ± 0.01	0.319TrpTyr: 0.319 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.596TyrAla: 2.596 ± 0.06	0.667TyrCys: 0.667 ± 0.03	3.197TyrAsp: 3.197 ± 0.08	3.367TyrGlu: 3.367 ± 0.073	2.118TyrPhe: 2.118 ± 0.058	3.23TyrGly: 3.23 ± 0.07	0.629TyrHis: 0.629 ± 0.033	3.84TyrIle: 3.84 ± 0.089	3.073TyrLys: 3.073 ± 0.08	3.405TyrLeu: 3.405 ± 0.085	1.281TyrMet: 1.281 ± 0.047	2.749TyrAsn: 2.749 ± 0.079	1.231TyrPro: 1.231 ± 0.048	0.944TyrGln: 0.944 ± 0.045	1.806TyrArg: 1.806 ± 0.059	2.901TyrSer: 2.901 ± 0.081	2.464TyrThr: 2.464 ± 0.072	3.011TyrVal: 3.011 ± 0.075	0.324TyrTrp: 0.324 ± 0.024	2.183TyrTyr: 2.183 ± 0.084	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.002XaaGlu: 0.002 ± 0.002	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.002XaaLys: 0.002 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.006XaaXaa: 0.006 ± 0.005

Statistics based on 1976 proteins (629432 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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