Amino acid dipepetide frequency for Nocardioides simplex (Arthrobacter simplex)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.778AlaAla: 21.778 ± 0.169	1.033AlaCys: 1.033 ± 0.028	9.291AlaAsp: 9.291 ± 0.089	8.249AlaGlu: 8.249 ± 0.093	3.537AlaPhe: 3.537 ± 0.046	13.703AlaGly: 13.703 ± 0.108	2.653AlaHis: 2.653 ± 0.043	4.679AlaIle: 4.679 ± 0.056	2.566AlaLys: 2.566 ± 0.049	14.413AlaLeu: 14.413 ± 0.128	2.585AlaMet: 2.585 ± 0.04	2.006AlaAsn: 2.006 ± 0.04	7.23AlaPro: 7.23 ± 0.081	3.546AlaGln: 3.546 ± 0.05	9.741AlaArg: 9.741 ± 0.1	6.289AlaSer: 6.289 ± 0.068	8.311AlaThr: 8.311 ± 0.077	12.517AlaVal: 12.517 ± 0.097	2.07AlaTrp: 2.07 ± 0.038	2.496AlaTyr: 2.496 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.976CysAla: 0.976 ± 0.022	0.078CysCys: 0.078 ± 0.007	0.456CysAsp: 0.456 ± 0.018	0.317CysGlu: 0.317 ± 0.012	0.213CysPhe: 0.213 ± 0.01	0.856CysGly: 0.856 ± 0.021	0.172CysHis: 0.172 ± 0.011	0.189CysIle: 0.189 ± 0.01	0.103CysLys: 0.103 ± 0.008	0.654CysLeu: 0.654 ± 0.018	0.098CysMet: 0.098 ± 0.008	0.149CysAsn: 0.149 ± 0.009	0.467CysPro: 0.467 ± 0.019	0.168CysGln: 0.168 ± 0.01	0.57CysArg: 0.57 ± 0.019	0.441CysSer: 0.441 ± 0.017	0.507CysThr: 0.507 ± 0.021	0.598CysVal: 0.598 ± 0.02	0.111CysTrp: 0.111 ± 0.008	0.156CysTyr: 0.156 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.487AspAla: 8.487 ± 0.08	0.384AspCys: 0.384 ± 0.018	5.18AspAsp: 5.18 ± 0.066	4.52AspGlu: 4.52 ± 0.061	1.551AspPhe: 1.551 ± 0.032	6.742AspGly: 6.742 ± 0.075	1.507AspHis: 1.507 ± 0.031	1.815AspIle: 1.815 ± 0.037	1.167AspLys: 1.167 ± 0.034	7.401AspLeu: 7.401 ± 0.074	0.722AspMet: 0.722 ± 0.022	0.952AspAsn: 0.952 ± 0.024	4.718AspPro: 4.718 ± 0.061	1.827AspGln: 1.827 ± 0.032	4.935AspArg: 4.935 ± 0.052	2.176AspSer: 2.176 ± 0.045	2.701AspThr: 2.701 ± 0.04	6.129AspVal: 6.129 ± 0.055	0.944AspTrp: 0.944 ± 0.022	1.21AspTyr: 1.21 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.767GluAla: 6.767 ± 0.071	0.322GluCys: 0.322 ± 0.016	2.495GluAsp: 2.495 ± 0.049	2.697GluGlu: 2.697 ± 0.044	1.316GluPhe: 1.316 ± 0.029	3.992GluGly: 3.992 ± 0.05	1.647GluHis: 1.647 ± 0.037	2.466GluIle: 2.466 ± 0.04	1.288GluLys: 1.288 ± 0.034	6.36GluLeu: 6.36 ± 0.069	0.914GluMet: 0.914 ± 0.024	0.932GluAsn: 0.932 ± 0.023	3.286GluPro: 3.286 ± 0.083	2.146GluGln: 2.146 ± 0.036	5.202GluArg: 5.202 ± 0.058	2.318GluSer: 2.318 ± 0.036	2.72GluThr: 2.72 ± 0.044	5.234GluVal: 5.234 ± 0.061	0.735GluTrp: 0.735 ± 0.02	0.932GluTyr: 0.932 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.773PheAla: 3.773 ± 0.047	0.25PheCys: 0.25 ± 0.012	1.939PheAsp: 1.939 ± 0.037	1.415PheGlu: 1.415 ± 0.034	0.811PhePhe: 0.811 ± 0.021	2.913PheGly: 2.913 ± 0.042	0.564PheHis: 0.564 ± 0.017	0.701PheIle: 0.701 ± 0.021	0.461PheLys: 0.461 ± 0.02	2.401PheLeu: 2.401 ± 0.041	0.361PheMet: 0.361 ± 0.015	0.571PheAsn: 0.571 ± 0.02	1.297PhePro: 1.297 ± 0.028	0.663PheGln: 0.663 ± 0.021	1.753PheArg: 1.753 ± 0.03	1.354PheSer: 1.354 ± 0.03	1.872PheThr: 1.872 ± 0.041	2.521PheVal: 2.521 ± 0.038	0.417PheTrp: 0.417 ± 0.017	0.572PheTyr: 0.572 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	11.523GlyAla: 11.523 ± 0.104	0.801GlyCys: 0.801 ± 0.022	5.605GlyAsp: 5.605 ± 0.066	4.887GlyGlu: 4.887 ± 0.058	2.898GlyPhe: 2.898 ± 0.048	8.66GlyGly: 8.66 ± 0.127	2.052GlyHis: 2.052 ± 0.039	3.709GlyIle: 3.709 ± 0.046	2.261GlyLys: 2.261 ± 0.049	9.741GlyLeu: 9.741 ± 0.083	1.868GlyMet: 1.868 ± 0.036	1.762GlyAsn: 1.762 ± 0.037	4.786GlyPro: 4.786 ± 0.051	2.57GlyGln: 2.57 ± 0.038	7.291GlyArg: 7.291 ± 0.068	5.288GlySer: 5.288 ± 0.067	6.455GlyThr: 6.455 ± 0.083	8.243GlyVal: 8.243 ± 0.074	1.757GlyTrp: 1.757 ± 0.035	2.264GlyTyr: 2.264 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.622HisAla: 2.622 ± 0.04	0.171HisCys: 0.171 ± 0.011	1.527HisAsp: 1.527 ± 0.031	1.166HisGlu: 1.166 ± 0.024	0.566HisPhe: 0.566 ± 0.016	2.158HisGly: 2.158 ± 0.042	0.706HisHis: 0.706 ± 0.023	0.488HisIle: 0.488 ± 0.019	0.283HisLys: 0.283 ± 0.014	2.362HisLeu: 2.362 ± 0.041	0.25HisMet: 0.25 ± 0.012	0.31HisAsn: 0.31 ± 0.013	1.613HisPro: 1.613 ± 0.036	0.612HisGln: 0.612 ± 0.02	1.893HisArg: 1.893 ± 0.043	0.753HisSer: 0.753 ± 0.023	0.989HisThr: 0.989 ± 0.025	1.937HisVal: 1.937 ± 0.035	0.301HisTrp: 0.301 ± 0.013	0.453HisTyr: 0.453 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	5.322IleAla: 5.322 ± 0.065	0.288IleCys: 0.288 ± 0.012	2.705IleAsp: 2.705 ± 0.044	2.209IleGlu: 2.209 ± 0.044	0.808IlePhe: 0.808 ± 0.022	3.79IleGly: 3.79 ± 0.049	0.589IleHis: 0.589 ± 0.017	0.958IleIle: 0.958 ± 0.027	0.757IleLys: 0.757 ± 0.026	2.454IleLeu: 2.454 ± 0.042	0.415IleMet: 0.415 ± 0.016	0.748IleAsn: 0.748 ± 0.021	1.8IlePro: 1.8 ± 0.031	0.733IleGln: 0.733 ± 0.019	2.213IleArg: 2.213 ± 0.034	1.755IleSer: 1.755 ± 0.031	2.271IleThr: 2.271 ± 0.04	3.182IleVal: 3.182 ± 0.053	0.383IleTrp: 0.383 ± 0.014	0.589IleTyr: 0.589 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	2.649LysAla: 2.649 ± 0.046	0.101LysCys: 0.101 ± 0.008	1.147LysAsp: 1.147 ± 0.031	0.966LysGlu: 0.966 ± 0.025	0.441LysPhe: 0.441 ± 0.016	1.598LysGly: 1.598 ± 0.037	0.406LysHis: 0.406 ± 0.015	0.874LysIle: 0.874 ± 0.026	0.818LysLys: 0.818 ± 0.037	1.701LysLeu: 1.701 ± 0.039	0.356LysMet: 0.356 ± 0.015	0.457LysAsn: 0.457 ± 0.02	1.167LysPro: 1.167 ± 0.032	0.625LysGln: 0.625 ± 0.022	1.317LysArg: 1.317 ± 0.031	1.01LysSer: 1.01 ± 0.029	1.113LysThr: 1.113 ± 0.027	2.123LysVal: 2.123 ± 0.047	0.234LysTrp: 0.234 ± 0.012	0.423LysTyr: 0.423 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	16.077LeuAla: 16.077 ± 0.141	0.742LeuCys: 0.742 ± 0.019	7.39LeuAsp: 7.39 ± 0.065	4.684LeuGlu: 4.684 ± 0.06	2.272LeuPhe: 2.272 ± 0.044	10.012LeuGly: 10.012 ± 0.097	2.021LeuHis: 2.021 ± 0.039	2.773LeuIle: 2.773 ± 0.047	1.698LeuLys: 1.698 ± 0.037	11.057LeuLeu: 11.057 ± 0.13	1.491LeuMet: 1.491 ± 0.03	1.534LeuAsn: 1.534 ± 0.033	5.978LeuPro: 5.978 ± 0.055	2.275LeuGln: 2.275 ± 0.043	8.008LeuArg: 8.008 ± 0.092	5.047LeuSer: 5.047 ± 0.066	6.748LeuThr: 6.748 ± 0.058	10.768LeuVal: 10.768 ± 0.11	1.197LeuTrp: 1.197 ± 0.029	1.49LeuTyr: 1.49 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.083MetAla: 2.083 ± 0.032	0.12MetCys: 0.12 ± 0.009	0.77MetAsp: 0.77 ± 0.021	0.638MetGlu: 0.638 ± 0.021	0.446MetPhe: 0.446 ± 0.016	1.236MetGly: 1.236 ± 0.03	0.305MetHis: 0.305 ± 0.015	0.68MetIle: 0.68 ± 0.022	0.398MetLys: 0.398 ± 0.017	1.74MetLeu: 1.74 ± 0.034	0.316MetMet: 0.316 ± 0.015	0.38MetAsn: 0.38 ± 0.015	0.966MetPro: 0.966 ± 0.023	0.428MetGln: 0.428 ± 0.014	1.288MetArg: 1.288 ± 0.025	1.37MetSer: 1.37 ± 0.024	1.68MetThr: 1.68 ± 0.029	1.377MetVal: 1.377 ± 0.029	0.181MetTrp: 0.181 ± 0.009	0.279MetTyr: 0.279 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.201AsnAla: 2.201 ± 0.04	0.134AsnCys: 0.134 ± 0.009	1.091AsnAsp: 1.091 ± 0.029	0.798AsnGlu: 0.798 ± 0.022	0.457AsnPhe: 0.457 ± 0.017	1.83AsnGly: 1.83 ± 0.045	0.369AsnHis: 0.369 ± 0.015	0.626AsnIle: 0.626 ± 0.021	0.36AsnLys: 0.36 ± 0.016	1.762AsnLeu: 1.762 ± 0.036	0.268AsnMet: 0.268 ± 0.013	0.411AsnAsn: 0.411 ± 0.014	1.414AsnPro: 1.414 ± 0.041	0.552AsnGln: 0.552 ± 0.018	1.154AsnArg: 1.154 ± 0.027	0.712AsnSer: 0.712 ± 0.024	0.941AsnThr: 0.941 ± 0.03	1.493AsnVal: 1.493 ± 0.032	0.22AsnTrp: 0.22 ± 0.011	0.378AsnTyr: 0.378 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	8.618ProAla: 8.618 ± 0.093	0.323ProCys: 0.323 ± 0.014	4.587ProAsp: 4.587 ± 0.051	3.91ProGlu: 3.91 ± 0.073	1.505ProPhe: 1.505 ± 0.036	6.154ProGly: 6.154 ± 0.067	1.132ProHis: 1.132 ± 0.027	1.668ProIle: 1.668 ± 0.037	1.002ProLys: 1.002 ± 0.027	5.042ProLeu: 5.042 ± 0.056	0.968ProMet: 0.968 ± 0.025	0.839ProAsn: 0.839 ± 0.025	3.088ProPro: 3.088 ± 0.061	1.449ProGln: 1.449 ± 0.037	3.676ProArg: 3.676 ± 0.055	2.972ProSer: 2.972 ± 0.044	3.671ProThr: 3.671 ± 0.054	5.572ProVal: 5.572 ± 0.073	0.926ProTrp: 0.926 ± 0.029	1.188ProTyr: 1.188 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.456GlnAla: 3.456 ± 0.052	0.143GlnCys: 0.143 ± 0.01	1.139GlnAsp: 1.139 ± 0.025	1.249GlnGlu: 1.249 ± 0.031	0.659GlnPhe: 0.659 ± 0.02	2.087GlnGly: 2.087 ± 0.039	0.65GlnHis: 0.65 ± 0.019	1.056GlnIle: 1.056 ± 0.026	0.533GlnLys: 0.533 ± 0.018	2.967GlnLeu: 2.967 ± 0.039	0.488GlnMet: 0.488 ± 0.016	0.461GlnAsn: 0.461 ± 0.017	1.65GlnPro: 1.65 ± 0.035	1.193GlnGln: 1.193 ± 0.032	2.4GlnArg: 2.4 ± 0.044	1.096GlnSer: 1.096 ± 0.027	1.312GlnThr: 1.312 ± 0.027	3.011GlnVal: 3.011 ± 0.042	0.439GlnTrp: 0.439 ± 0.017	0.524GlnTyr: 0.524 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.579ArgAla: 9.579 ± 0.089	0.488ArgCys: 0.488 ± 0.017	4.433ArgAsp: 4.433 ± 0.055	4.189ArgGlu: 4.189 ± 0.057	2.247ArgPhe: 2.247 ± 0.037	5.618ArgGly: 5.618 ± 0.059	1.838ArgHis: 1.838 ± 0.044	3.154ArgIle: 3.154 ± 0.044	1.409ArgLys: 1.409 ± 0.032	8.198ArgLeu: 8.198 ± 0.097	1.739ArgMet: 1.739 ± 0.035	1.306ArgAsn: 1.306 ± 0.03	4.418ArgPro: 4.418 ± 0.057	2.044ArgGln: 2.044 ± 0.037	7.457ArgArg: 7.457 ± 0.098	3.934ArgSer: 3.934 ± 0.051	4.905ArgThr: 4.905 ± 0.062	6.193ArgVal: 6.193 ± 0.066	1.384ArgTrp: 1.384 ± 0.028	1.712ArgTyr: 1.712 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.454SerAla: 6.454 ± 0.058	0.394SerCys: 0.394 ± 0.016	2.846SerAsp: 2.846 ± 0.042	2.188SerGlu: 2.188 ± 0.038	1.531SerPhe: 1.531 ± 0.029	5.604SerGly: 5.604 ± 0.066	0.887SerHis: 0.887 ± 0.024	1.789SerIle: 1.789 ± 0.037	0.912SerLys: 0.912 ± 0.027	4.61SerLeu: 4.61 ± 0.045	1.101SerMet: 1.101 ± 0.023	0.872SerAsn: 0.872 ± 0.024	2.888SerPro: 2.888 ± 0.041	1.141SerGln: 1.141 ± 0.027	3.336SerArg: 3.336 ± 0.041	2.914SerSer: 2.914 ± 0.048	3.183SerThr: 3.183 ± 0.05	4.24SerVal: 4.24 ± 0.05	0.898SerTrp: 0.898 ± 0.023	1.363SerTyr: 1.363 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	8.295ThrAla: 8.295 ± 0.089	0.484ThrCys: 0.484 ± 0.022	3.741ThrAsp: 3.741 ± 0.047	2.969ThrGlu: 2.969 ± 0.044	1.843ThrPhe: 1.843 ± 0.03	6.587ThrGly: 6.587 ± 0.075	1.127ThrHis: 1.127 ± 0.026	2.27ThrIle: 2.27 ± 0.037	1.197ThrLys: 1.197 ± 0.03	5.938ThrLeu: 5.938 ± 0.056	0.925ThrMet: 0.925 ± 0.027	1.077ThrAsn: 1.077 ± 0.032	4.241ThrPro: 4.241 ± 0.068	1.379ThrGln: 1.379 ± 0.03	3.766ThrArg: 3.766 ± 0.053	3.42ThrSer: 3.42 ± 0.049	4.526ThrThr: 4.526 ± 0.061	5.911ThrVal: 5.911 ± 0.085	1.085ThrTrp: 1.085 ± 0.026	1.491ThrTyr: 1.491 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	13.774ValAla: 13.774 ± 0.118	0.68ValCys: 0.68 ± 0.022	6.132ValAsp: 6.132 ± 0.066	5.089ValGlu: 5.089 ± 0.051	2.297ValPhe: 2.297 ± 0.043	7.844ValGly: 7.844 ± 0.075	1.876ValHis: 1.876 ± 0.035	3.077ValIle: 3.077 ± 0.05	1.665ValLys: 1.665 ± 0.039	10.528ValLeu: 10.528 ± 0.094	1.342ValMet: 1.342 ± 0.029	1.711ValAsn: 1.711 ± 0.04	5.533ValPro: 5.533 ± 0.057	2.077ValGln: 2.077 ± 0.034	7.348ValArg: 7.348 ± 0.071	4.367ValSer: 4.367 ± 0.053	6.233ValThr: 6.233 ± 0.082	10.906ValVal: 10.906 ± 0.108	1.131ValTrp: 1.131 ± 0.026	1.486ValTyr: 1.486 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.694TrpAla: 1.694 ± 0.036	0.162TrpCys: 0.162 ± 0.01	0.824TrpAsp: 0.824 ± 0.021	0.679TrpGlu: 0.679 ± 0.02	0.538TrpPhe: 0.538 ± 0.018	1.049TrpGly: 1.049 ± 0.023	0.33TrpHis: 0.33 ± 0.014	0.58TrpIle: 0.58 ± 0.018	0.319TrpLys: 0.319 ± 0.013	1.815TrpLeu: 1.815 ± 0.036	0.28TrpMet: 0.28 ± 0.012	0.348TrpAsn: 0.348 ± 0.014	0.753TrpPro: 0.753 ± 0.021	0.53TrpGln: 0.53 ± 0.016	1.274TrpArg: 1.274 ± 0.027	0.98TrpSer: 0.98 ± 0.028	1.065TrpThr: 1.065 ± 0.03	1.192TrpVal: 1.192 ± 0.028	0.356TrpTrp: 0.356 ± 0.017	0.302TrpTyr: 0.302 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.566TyrAla: 2.566 ± 0.037	0.18TyrCys: 0.18 ± 0.012	1.772TyrAsp: 1.772 ± 0.039	0.951TyrGlu: 0.951 ± 0.026	0.671TyrPhe: 0.671 ± 0.021	1.989TyrGly: 1.989 ± 0.035	0.33TyrHis: 0.33 ± 0.015	0.416TyrIle: 0.416 ± 0.018	0.327TyrLys: 0.327 ± 0.015	2.118TyrLeu: 2.118 ± 0.039	0.195TyrMet: 0.195 ± 0.01	0.345TyrAsn: 0.345 ± 0.015	0.997TyrPro: 0.997 ± 0.025	0.557TyrGln: 0.557 ± 0.018	1.619TyrArg: 1.619 ± 0.033	0.953TyrSer: 0.953 ± 0.024	1.069TyrThr: 1.069 ± 0.035	1.95TyrVal: 1.95 ± 0.032	0.301TyrTrp: 0.301 ± 0.015	0.456TyrTyr: 0.456 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5426 proteins (1722844 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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