Amino acid dipepetide frequency for Wenzhou picorna-like virus 5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.749AlaAla: 5.749 ± 0.429
1.15AlaCys: 1.15 ± 0.036
3.833AlaAsp: 3.833 ± 0.898
4.599AlaGlu: 4.599 ± 0.466
4.216AlaPhe: 4.216 ± 1.765
3.45AlaGly: 3.45 ± 0.109
1.533AlaHis: 1.533 ± 0.253
4.216AlaIle: 4.216 ± 1.765
3.45AlaLys: 3.45 ± 0.109
3.066AlaLeu: 3.066 ± 1.33
2.3AlaMet: 2.3 ± 1.296
4.216AlaAsn: 4.216 ± 2.517
4.983AlaPro: 4.983 ± 2.697
2.683AlaGln: 2.683 ± 0.901
1.533AlaArg: 1.533 ± 0.359
3.45AlaSer: 3.45 ± 0.502
7.666AlaThr: 7.666 ± 2.408
4.599AlaVal: 4.599 ± 0.466
1.15AlaTrp: 1.15 ± 0.575
1.533AlaTyr: 1.533 ± 0.253
0.0AlaXaa: 0.0 ± 0.0
Cys
2.3CysAla: 2.3 ± 0.685
0.383CysCys: 0.383 ± 0.396
0.767CysAsp: 0.767 ± 0.432
1.916CysGlu: 1.916 ± 1.08
0.767CysPhe: 0.767 ± 0.432
1.916CysGly: 1.916 ± 1.08
0.383CysHis: 0.383 ± 0.216
0.767CysIle: 0.767 ± 0.432
0.383CysLys: 0.383 ± 0.216
1.533CysLeu: 1.533 ± 0.864
1.15CysMet: 1.15 ± 0.036
0.383CysAsn: 0.383 ± 0.216
0.767CysPro: 0.767 ± 0.432
0.383CysGln: 0.383 ± 0.396
1.15CysArg: 1.15 ± 0.575
1.15CysSer: 1.15 ± 0.036
0.383CysThr: 0.383 ± 0.396
0.767CysVal: 0.767 ± 0.432
0.0CysTrp: 0.0 ± 0.0
1.15CysTyr: 1.15 ± 0.648
0.0CysXaa: 0.0 ± 0.0
Asp
4.216AspAla: 4.216 ± 1.294
1.15AspCys: 1.15 ± 0.036
2.683AspAsp: 2.683 ± 0.289
3.066AspGlu: 3.066 ± 0.718
4.216AspPhe: 4.216 ± 0.541
1.916AspGly: 1.916 ± 0.143
0.383AspHis: 0.383 ± 0.216
4.983AspIle: 4.983 ± 0.25
3.066AspLys: 3.066 ± 1.117
4.216AspLeu: 4.216 ± 1.153
0.383AspMet: 0.383 ± 0.216
3.45AspAsn: 3.45 ± 0.502
3.833AspPro: 3.833 ± 2.733
1.533AspGln: 1.533 ± 0.971
3.45AspArg: 3.45 ± 1.333
3.45AspSer: 3.45 ± 0.502
1.916AspThr: 1.916 ± 1.367
4.983AspVal: 4.983 ± 0.362
1.15AspTrp: 1.15 ± 0.648
1.15AspTyr: 1.15 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
5.749GluAla: 5.749 ± 0.182
1.15GluCys: 1.15 ± 0.036
4.216GluAsp: 4.216 ± 0.07
5.366GluGlu: 5.366 ± 0.578
2.3GluPhe: 2.3 ± 0.685
3.066GluGly: 3.066 ± 1.117
1.15GluHis: 1.15 ± 0.648
5.366GluIle: 5.366 ± 1.869
3.066GluLys: 3.066 ± 1.117
4.599GluLeu: 4.599 ± 0.466
1.533GluMet: 1.533 ± 0.872
1.916GluAsn: 1.916 ± 0.469
4.216GluPro: 4.216 ± 0.541
1.15GluGln: 1.15 ± 0.036
2.683GluArg: 2.683 ± 0.901
6.133GluSer: 6.133 ± 1.01
1.916GluThr: 1.916 ± 1.08
3.066GluVal: 3.066 ± 0.718
1.533GluTrp: 1.533 ± 0.253
2.683GluTyr: 2.683 ± 0.323
0.0GluXaa: 0.0 ± 0.0
Phe
3.066PheAla: 3.066 ± 0.718
0.767PheCys: 0.767 ± 0.432
3.066PheAsp: 3.066 ± 1.33
4.216PheGlu: 4.216 ± 0.07
3.45PhePhe: 3.45 ± 0.502
3.833PheGly: 3.833 ± 0.937
1.15PheHis: 1.15 ± 0.036
1.533PheIle: 1.533 ± 0.253
3.066PheLys: 3.066 ± 0.505
3.833PheLeu: 3.833 ± 0.937
2.3PheMet: 2.3 ± 1.296
1.15PheAsn: 1.15 ± 0.575
1.916PhePro: 1.916 ± 0.755
2.3PheGln: 2.3 ± 1.15
2.3PheArg: 2.3 ± 0.073
6.133PheSer: 6.133 ± 1.437
3.45PheThr: 3.45 ± 0.721
2.3PheVal: 2.3 ± 0.073
0.767PheTrp: 0.767 ± 0.18
1.916PheTyr: 1.916 ± 1.08
0.0PheXaa: 0.0 ± 0.0
Gly
3.833GlyAla: 3.833 ± 1.51
1.15GlyCys: 1.15 ± 0.036
4.599GlyAsp: 4.599 ± 0.146
3.833GlyGlu: 3.833 ± 0.898
3.066GlyPhe: 3.066 ± 0.505
2.683GlyGly: 2.683 ± 0.289
0.767GlyHis: 0.767 ± 0.18
0.767GlyIle: 0.767 ± 0.432
6.516GlyLys: 6.516 ± 2.449
4.983GlyLeu: 4.983 ± 0.974
1.533GlyMet: 1.533 ± 0.253
3.45GlyAsn: 3.45 ± 0.502
1.15GlyPro: 1.15 ± 1.187
2.683GlyGln: 2.683 ± 0.289
1.916GlyArg: 1.916 ± 0.755
3.833GlySer: 3.833 ± 0.937
3.45GlyThr: 3.45 ± 0.502
5.749GlyVal: 5.749 ± 1.653
0.383GlyTrp: 0.383 ± 0.216
1.15GlyTyr: 1.15 ± 0.036
0.0GlyXaa: 0.0 ± 0.0
His
1.916HisAla: 1.916 ± 0.143
0.0HisCys: 0.0 ± 0.0
1.533HisAsp: 1.533 ± 0.359
0.383HisGlu: 0.383 ± 0.216
1.916HisPhe: 1.916 ± 0.143
0.767HisGly: 0.767 ± 0.432
0.383HisHis: 0.383 ± 0.216
1.15HisIle: 1.15 ± 0.036
1.533HisLys: 1.533 ± 0.359
2.3HisLeu: 2.3 ± 1.296
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
1.15HisPro: 1.15 ± 0.648
0.383HisGln: 0.383 ± 0.216
1.533HisArg: 1.533 ± 0.971
1.15HisSer: 1.15 ± 0.648
0.767HisThr: 0.767 ± 0.432
1.533HisVal: 1.533 ± 0.253
1.15HisTrp: 1.15 ± 0.575
0.767HisTyr: 0.767 ± 0.432
0.0HisXaa: 0.0 ± 0.0
Ile
5.366IleAla: 5.366 ± 1.257
0.767IleCys: 0.767 ± 0.432
4.216IleAsp: 4.216 ± 0.541
4.216IleGlu: 4.216 ± 0.682
4.216IlePhe: 4.216 ± 0.682
4.216IleGly: 4.216 ± 0.682
1.15IleHis: 1.15 ± 0.036
3.066IleIle: 3.066 ± 0.107
1.533IleLys: 1.533 ± 0.253
4.216IleLeu: 4.216 ± 1.153
0.383IleMet: 0.383 ± 0.216
3.066IleAsn: 3.066 ± 0.107
2.683IlePro: 2.683 ± 0.289
2.3IleGln: 2.3 ± 1.296
2.3IleArg: 2.3 ± 0.073
1.916IleSer: 1.916 ± 0.469
3.066IleThr: 3.066 ± 0.107
3.45IleVal: 3.45 ± 0.109
0.383IleTrp: 0.383 ± 0.216
1.15IleTyr: 1.15 ± 0.648
0.0IleXaa: 0.0 ± 0.0
Lys
2.683LysAla: 2.683 ± 0.289
1.533LysCys: 1.533 ± 0.864
3.066LysAsp: 3.066 ± 1.728
3.45LysGlu: 3.45 ± 1.333
3.833LysPhe: 3.833 ± 0.937
5.366LysGly: 5.366 ± 0.578
1.15LysHis: 1.15 ± 0.575
4.216LysIle: 4.216 ± 1.294
2.683LysLys: 2.683 ± 1.512
4.983LysLeu: 4.983 ± 0.25
1.916LysMet: 1.916 ± 1.08
0.767LysAsn: 0.767 ± 0.432
1.533LysPro: 1.533 ± 0.253
2.683LysGln: 2.683 ± 0.289
4.599LysArg: 4.599 ± 1.369
1.916LysSer: 1.916 ± 1.08
3.45LysThr: 3.45 ± 0.721
4.599LysVal: 4.599 ± 0.466
0.383LysTrp: 0.383 ± 0.216
2.683LysTyr: 2.683 ± 0.901
0.0LysXaa: 0.0 ± 0.0
Leu
6.133LeuAla: 6.133 ± 0.398
1.533LeuCys: 1.533 ± 0.864
1.916LeuAsp: 1.916 ± 0.143
5.749LeuGlu: 5.749 ± 0.794
3.066LeuPhe: 3.066 ± 1.728
3.833LeuGly: 3.833 ± 0.937
0.767LeuHis: 0.767 ± 0.432
4.599LeuIle: 4.599 ± 1.981
6.516LeuLys: 6.516 ± 0.003
5.749LeuLeu: 5.749 ± 2.017
1.15LeuMet: 1.15 ± 0.036
4.599LeuAsn: 4.599 ± 2.301
5.749LeuPro: 5.749 ± 1.041
1.916LeuGln: 1.916 ± 0.469
5.366LeuArg: 5.366 ± 1.801
4.983LeuSer: 4.983 ± 0.362
7.666LeuThr: 7.666 ± 0.651
6.516LeuVal: 6.516 ± 0.003
1.916LeuTrp: 1.916 ± 0.755
1.916LeuTyr: 1.916 ± 0.143
0.0LeuXaa: 0.0 ± 0.0
Met
1.533MetAla: 1.533 ± 0.359
1.15MetCys: 1.15 ± 0.648
2.3MetAsp: 2.3 ± 0.685
0.767MetGlu: 0.767 ± 0.432
0.383MetPhe: 0.383 ± 0.396
2.3MetGly: 2.3 ± 0.073
0.383MetHis: 0.383 ± 0.216
1.916MetIle: 1.916 ± 0.469
4.599MetLys: 4.599 ± 0.146
2.3MetLeu: 2.3 ± 0.073
0.383MetMet: 0.383 ± 0.216
0.767MetAsn: 0.767 ± 0.432
1.916MetPro: 1.916 ± 0.143
0.0MetGln: 0.0 ± 0.0
0.767MetArg: 0.767 ± 0.432
2.3MetSer: 2.3 ± 0.685
0.767MetThr: 0.767 ± 0.432
1.15MetVal: 1.15 ± 0.648
0.767MetTrp: 0.767 ± 0.432
2.683MetTyr: 2.683 ± 0.934
0.0MetXaa: 0.0 ± 0.0
Asn
3.45AsnAla: 3.45 ± 0.502
0.383AsnCys: 0.383 ± 0.216
2.3AsnAsp: 2.3 ± 0.073
2.683AsnGlu: 2.683 ± 0.901
3.066AsnPhe: 3.066 ± 1.33
2.683AsnGly: 2.683 ± 2.158
2.3AsnHis: 2.3 ± 0.539
1.916AsnIle: 1.916 ± 0.143
1.533AsnLys: 1.533 ± 0.359
3.833AsnLeu: 3.833 ± 0.325
0.767AsnMet: 0.767 ± 0.432
0.767AsnAsn: 0.767 ± 0.18
4.216AsnPro: 4.216 ± 0.682
0.383AsnGln: 0.383 ± 0.216
1.533AsnArg: 1.533 ± 0.359
2.683AsnSer: 2.683 ± 0.289
3.45AsnThr: 3.45 ± 2.949
3.833AsnVal: 3.833 ± 0.325
0.767AsnTrp: 0.767 ± 0.18
2.3AsnTyr: 2.3 ± 1.15
0.0AsnXaa: 0.0 ± 0.0
Pro
3.45ProAla: 3.45 ± 1.114
0.383ProCys: 0.383 ± 0.396
2.3ProAsp: 2.3 ± 1.15
4.599ProGlu: 4.599 ± 0.146
2.3ProPhe: 2.3 ± 1.762
1.533ProGly: 1.533 ± 0.359
1.15ProHis: 1.15 ± 0.036
2.3ProIle: 2.3 ± 0.073
2.3ProLys: 2.3 ± 0.073
4.599ProLeu: 4.599 ± 0.146
2.3ProMet: 2.3 ± 0.302
1.533ProAsn: 1.533 ± 0.971
2.3ProPro: 2.3 ± 1.762
3.066ProGln: 3.066 ± 0.718
1.916ProArg: 1.916 ± 1.367
1.533ProSer: 1.533 ± 0.253
4.983ProThr: 4.983 ± 0.862
3.45ProVal: 3.45 ± 0.109
1.533ProTrp: 1.533 ± 0.359
3.066ProTyr: 3.066 ± 1.33
0.0ProXaa: 0.0 ± 0.0
Gln
3.066GlnAla: 3.066 ± 1.117
0.0GlnCys: 0.0 ± 0.0
3.066GlnAsp: 3.066 ± 1.33
1.533GlnGlu: 1.533 ± 0.359
1.533GlnPhe: 1.533 ± 0.253
0.0GlnGly: 0.0 ± 0.0
0.767GlnHis: 0.767 ± 0.18
0.767GlnIle: 0.767 ± 0.18
2.3GlnLys: 2.3 ± 0.685
2.683GlnLeu: 2.683 ± 0.901
1.15GlnMet: 1.15 ± 0.648
2.3GlnAsn: 2.3 ± 0.073
0.383GlnPro: 0.383 ± 0.396
1.916GlnGln: 1.916 ± 0.755
1.15GlnArg: 1.15 ± 0.575
3.45GlnSer: 3.45 ± 1.726
2.3GlnThr: 2.3 ± 0.685
2.3GlnVal: 2.3 ± 1.296
0.767GlnTrp: 0.767 ± 0.18
1.15GlnTyr: 1.15 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
3.066ArgAla: 3.066 ± 0.107
1.533ArgCys: 1.533 ± 0.864
1.533ArgAsp: 1.533 ± 0.864
3.066ArgGlu: 3.066 ± 0.505
1.916ArgPhe: 1.916 ± 1.367
3.833ArgGly: 3.833 ± 0.286
1.533ArgHis: 1.533 ± 0.253
2.683ArgIle: 2.683 ± 0.289
2.3ArgLys: 2.3 ± 0.685
3.833ArgLeu: 3.833 ± 0.286
2.683ArgMet: 2.683 ± 0.289
1.916ArgAsn: 1.916 ± 0.469
1.533ArgPro: 1.533 ± 0.971
0.767ArgGln: 0.767 ± 0.432
2.3ArgArg: 2.3 ± 1.296
4.216ArgSer: 4.216 ± 0.07
2.683ArgThr: 2.683 ± 0.289
4.599ArgVal: 4.599 ± 1.369
1.15ArgTrp: 1.15 ± 0.575
2.3ArgTyr: 2.3 ± 0.539
0.0ArgXaa: 0.0 ± 0.0
Ser
3.45SerAla: 3.45 ± 0.721
1.533SerCys: 1.533 ± 0.864
4.216SerAsp: 4.216 ± 0.07
2.3SerGlu: 2.3 ± 0.073
1.916SerPhe: 1.916 ± 0.755
7.666SerGly: 7.666 ± 1.796
1.15SerHis: 1.15 ± 0.036
3.45SerIle: 3.45 ± 0.109
5.749SerLys: 5.749 ± 2.629
6.899SerLeu: 6.899 ± 0.83
3.066SerMet: 3.066 ± 0.107
2.683SerAsn: 2.683 ± 0.289
2.683SerPro: 2.683 ± 0.289
1.916SerGln: 1.916 ± 1.367
2.683SerArg: 2.683 ± 0.323
6.899SerSer: 6.899 ± 0.393
4.599SerThr: 4.599 ± 1.689
4.983SerVal: 4.983 ± 0.25
0.767SerTrp: 0.767 ± 0.432
4.216SerTyr: 4.216 ± 1.905
0.0SerXaa: 0.0 ± 0.0
Thr
3.833ThrAla: 3.833 ± 1.51
0.383ThrCys: 0.383 ± 0.216
1.916ThrAsp: 1.916 ± 0.143
3.833ThrGlu: 3.833 ± 0.937
3.066ThrPhe: 3.066 ± 1.117
2.683ThrGly: 2.683 ± 0.934
1.533ThrHis: 1.533 ± 0.864
5.366ThrIle: 5.366 ± 0.645
2.3ThrLys: 2.3 ± 0.685
3.066ThrLeu: 3.066 ± 0.718
3.45ThrMet: 3.45 ± 1.114
4.983ThrAsn: 4.983 ± 1.473
3.066ThrPro: 3.066 ± 0.718
3.45ThrGln: 3.45 ± 1.944
2.683ThrArg: 2.683 ± 0.289
4.983ThrSer: 4.983 ± 1.473
4.599ThrThr: 4.599 ± 1.689
4.216ThrVal: 4.216 ± 1.294
1.15ThrTrp: 1.15 ± 0.036
3.066ThrTyr: 3.066 ± 0.718
0.0ThrXaa: 0.0 ± 0.0
Val
3.833ValAla: 3.833 ± 0.898
1.533ValCys: 1.533 ± 0.253
4.599ValAsp: 4.599 ± 1.078
2.683ValGlu: 2.683 ± 0.901
3.066ValPhe: 3.066 ± 0.107
3.45ValGly: 3.45 ± 0.109
0.767ValHis: 0.767 ± 0.432
2.683ValIle: 2.683 ± 0.289
1.533ValLys: 1.533 ± 0.253
7.282ValLeu: 7.282 ± 0.177
0.767ValMet: 0.767 ± 0.18
3.833ValAsn: 3.833 ± 0.325
4.983ValPro: 4.983 ± 0.862
1.533ValGln: 1.533 ± 0.971
5.366ValArg: 5.366 ± 1.801
8.432ValSer: 8.432 ± 0.752
3.066ValThr: 3.066 ± 0.107
4.216ValVal: 4.216 ± 0.682
1.916ValTrp: 1.916 ± 1.08
3.066ValTyr: 3.066 ± 0.718
0.0ValXaa: 0.0 ± 0.0
Trp
1.533TrpAla: 1.533 ± 0.359
0.383TrpCys: 0.383 ± 0.216
0.767TrpAsp: 0.767 ± 0.18
2.3TrpGlu: 2.3 ± 0.073
1.15TrpPhe: 1.15 ± 0.036
0.383TrpGly: 0.383 ± 0.216
1.15TrpHis: 1.15 ± 0.036
0.383TrpIle: 0.383 ± 0.216
1.15TrpLys: 1.15 ± 0.036
1.533TrpLeu: 1.533 ± 0.864
0.0TrpMet: 0.0 ± 0.0
1.15TrpAsn: 1.15 ± 1.187
0.0TrpPro: 0.0 ± 0.0
0.383TrpGln: 0.383 ± 0.216
1.15TrpArg: 1.15 ± 0.648
1.916TrpSer: 1.916 ± 0.755
0.0TrpThr: 0.0 ± 0.0
1.533TrpVal: 1.533 ± 0.359
0.383TrpTrp: 0.383 ± 0.216
1.15TrpTyr: 1.15 ± 0.648
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.15TyrAla: 1.15 ± 0.648
1.533TyrCys: 1.533 ± 0.253
2.3TyrAsp: 2.3 ± 0.539
2.683TyrGlu: 2.683 ± 0.323
3.066TyrPhe: 3.066 ± 1.33
1.916TyrGly: 1.916 ± 0.143
0.767TyrHis: 0.767 ± 0.18
1.533TyrIle: 1.533 ± 0.253
1.916TyrLys: 1.916 ± 0.755
6.133TyrLeu: 6.133 ± 0.213
1.533TyrMet: 1.533 ± 0.253
1.916TyrAsn: 1.916 ± 0.143
1.533TyrPro: 1.533 ± 0.253
1.15TyrGln: 1.15 ± 0.036
3.066TyrArg: 3.066 ± 1.33
2.3TyrSer: 2.3 ± 0.539
3.45TyrThr: 3.45 ± 0.721
0.767TyrVal: 0.767 ± 0.18
0.383TyrTrp: 0.383 ± 0.216
1.916TyrTyr: 1.916 ± 0.143
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2610 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski