Amino acid dipepetide frequency for Pseudogymnoascus sp. VKM F-4515 (FW-2607)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.84AlaAla: 9.84 ± 0.072	1.06AlaCys: 1.06 ± 0.015	4.399AlaAsp: 4.399 ± 0.031	5.371AlaGlu: 5.371 ± 0.046	3.1AlaPhe: 3.1 ± 0.027	6.141AlaGly: 6.141 ± 0.045	1.723AlaHis: 1.723 ± 0.016	4.591AlaIle: 4.591 ± 0.038	4.394AlaLys: 4.394 ± 0.04	7.835AlaLeu: 7.835 ± 0.045	1.993AlaMet: 1.993 ± 0.02	3.114AlaAsn: 3.114 ± 0.027	5.114AlaPro: 5.114 ± 0.044	3.372AlaGln: 3.372 ± 0.03	4.867AlaArg: 4.867 ± 0.036	7.194AlaSer: 7.194 ± 0.041	5.622AlaThr: 5.622 ± 0.035	5.54AlaVal: 5.54 ± 0.044	1.115AlaTrp: 1.115 ± 0.016	2.165AlaTyr: 2.165 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.976CysAla: 0.976 ± 0.016	0.262CysCys: 0.262 ± 0.008	0.672CysAsp: 0.672 ± 0.012	0.606CysGlu: 0.606 ± 0.013	0.53CysPhe: 0.53 ± 0.01	1.016CysGly: 1.016 ± 0.016	0.326CysHis: 0.326 ± 0.009	0.725CysIle: 0.725 ± 0.011	0.517CysLys: 0.517 ± 0.011	1.204CysLeu: 1.204 ± 0.016	0.27CysMet: 0.27 ± 0.007	0.435CysAsn: 0.435 ± 0.009	0.635CysPro: 0.635 ± 0.013	0.435CysGln: 0.435 ± 0.01	0.721CysArg: 0.721 ± 0.012	0.91CysSer: 0.91 ± 0.016	0.707CysThr: 0.707 ± 0.012	0.759CysVal: 0.759 ± 0.013	0.2CysTrp: 0.2 ± 0.007	0.367CysTyr: 0.367 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.844AspAla: 4.844 ± 0.031	0.622AspCys: 0.622 ± 0.013	4.152AspAsp: 4.152 ± 0.042	4.525AspGlu: 4.525 ± 0.038	2.184AspPhe: 2.184 ± 0.022	4.278AspGly: 4.278 ± 0.036	1.138AspHis: 1.138 ± 0.015	3.228AspIle: 3.228 ± 0.025	2.44AspLys: 2.44 ± 0.025	4.846AspLeu: 4.846 ± 0.035	1.245AspMet: 1.245 ± 0.015	1.981AspAsn: 1.981 ± 0.02	3.058AspPro: 3.058 ± 0.022	1.688AspGln: 1.688 ± 0.02	2.864AspArg: 2.864 ± 0.025	4.091AspSer: 4.091 ± 0.032	3.005AspThr: 3.005 ± 0.025	3.675AspVal: 3.675 ± 0.031	0.847AspTrp: 0.847 ± 0.015	1.593AspTyr: 1.593 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.744GluAla: 5.744 ± 0.044	0.627GluCys: 0.627 ± 0.012	4.176GluAsp: 4.176 ± 0.041	5.715GluGlu: 5.715 ± 0.061	1.986GluPhe: 1.986 ± 0.022	4.287GluGly: 4.287 ± 0.029	1.295GluHis: 1.295 ± 0.018	3.121GluIle: 3.121 ± 0.026	3.726GluLys: 3.726 ± 0.034	5.197GluLeu: 5.197 ± 0.038	1.503GluMet: 1.503 ± 0.017	2.311GluAsn: 2.311 ± 0.023	2.735GluPro: 2.735 ± 0.041	2.299GluGln: 2.299 ± 0.031	3.982GluArg: 3.982 ± 0.038	4.351GluSer: 4.351 ± 0.029	3.464GluThr: 3.464 ± 0.03	3.846GluVal: 3.846 ± 0.033	0.881GluTrp: 0.881 ± 0.015	1.729GluTyr: 1.729 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.052PheAla: 3.052 ± 0.026	0.557PheCys: 0.557 ± 0.011	2.222PheAsp: 2.222 ± 0.019	2.17PheGlu: 2.17 ± 0.02	1.541PhePhe: 1.541 ± 0.022	2.889PheGly: 2.889 ± 0.026	0.843PheHis: 0.843 ± 0.012	1.854PheIle: 1.854 ± 0.021	1.593PheLys: 1.593 ± 0.019	3.295PheLeu: 3.295 ± 0.029	0.781PheMet: 0.781 ± 0.012	1.416PheAsn: 1.416 ± 0.016	1.873PhePro: 1.873 ± 0.021	1.353PheGln: 1.353 ± 0.015	1.822PheArg: 1.822 ± 0.018	2.882PheSer: 2.882 ± 0.027	2.135PheThr: 2.135 ± 0.022	2.336PheVal: 2.336 ± 0.022	0.613PheTrp: 0.613 ± 0.011	1.077PheTyr: 1.077 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.862GlyAla: 5.862 ± 0.048	0.909GlyCys: 0.909 ± 0.015	3.863GlyAsp: 3.863 ± 0.028	4.137GlyGlu: 4.137 ± 0.033	2.829GlyPhe: 2.829 ± 0.025	6.691GlyGly: 6.691 ± 0.073	1.669GlyHis: 1.669 ± 0.019	3.723GlyIle: 3.723 ± 0.03	3.72GlyLys: 3.72 ± 0.031	6.149GlyLeu: 6.149 ± 0.04	1.675GlyMet: 1.675 ± 0.02	2.73GlyAsn: 2.73 ± 0.026	3.349GlyPro: 3.349 ± 0.027	2.587GlyGln: 2.587 ± 0.026	4.207GlyArg: 4.207 ± 0.037	5.815GlySer: 5.815 ± 0.043	4.129GlyThr: 4.129 ± 0.03	4.636GlyVal: 4.636 ± 0.032	1.207GlyTrp: 1.207 ± 0.017	2.147GlyTyr: 2.147 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	1.755HisAla: 1.755 ± 0.019	0.318HisCys: 0.318 ± 0.009	1.237HisAsp: 1.237 ± 0.019	1.233HisGlu: 1.233 ± 0.017	0.874HisPhe: 0.874 ± 0.012	1.673HisGly: 1.673 ± 0.019	0.753HisHis: 0.753 ± 0.013	1.24HisIle: 1.24 ± 0.016	0.947HisLys: 0.947 ± 0.014	2.098HisLeu: 2.098 ± 0.021	0.454HisMet: 0.454 ± 0.009	0.867HisAsn: 0.867 ± 0.014	1.57HisPro: 1.57 ± 0.017	0.935HisGln: 0.935 ± 0.013	1.402HisArg: 1.402 ± 0.018	1.737HisSer: 1.737 ± 0.021	1.291HisThr: 1.291 ± 0.016	1.352HisVal: 1.352 ± 0.017	0.33HisTrp: 0.33 ± 0.008	0.678HisTyr: 0.678 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.463IleAla: 4.463 ± 0.031	0.764IleCys: 0.764 ± 0.013	2.962IleAsp: 2.962 ± 0.024	3.017IleGlu: 3.017 ± 0.027	2.045IlePhe: 2.045 ± 0.023	3.361IleGly: 3.361 ± 0.029	1.173IleHis: 1.173 ± 0.015	2.739IleIle: 2.739 ± 0.028	2.349IleLys: 2.349 ± 0.022	4.625IleLeu: 4.625 ± 0.035	1.074IleMet: 1.074 ± 0.016	1.933IleAsn: 1.933 ± 0.021	3.098IlePro: 3.098 ± 0.024	1.918IleGln: 1.918 ± 0.018	2.759IleArg: 2.759 ± 0.025	4.064IleSer: 4.064 ± 0.028	3.096IleThr: 3.096 ± 0.023	3.252IleVal: 3.252 ± 0.028	0.741IleTrp: 0.741 ± 0.013	1.489IleTyr: 1.489 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.517LysAla: 4.517 ± 0.038	0.536LysCys: 0.536 ± 0.012	2.814LysAsp: 2.814 ± 0.025	3.565LysGlu: 3.565 ± 0.041	1.539LysPhe: 1.539 ± 0.016	3.261LysGly: 3.261 ± 0.029	1.09LysHis: 1.09 ± 0.015	2.394LysIle: 2.394 ± 0.023	3.397LysLys: 3.397 ± 0.045	4.235LysLeu: 4.235 ± 0.035	1.049LysMet: 1.049 ± 0.016	1.798LysAsn: 1.798 ± 0.023	2.682LysPro: 2.682 ± 0.026	1.746LysGln: 1.746 ± 0.02	3.356LysArg: 3.356 ± 0.034	3.726LysSer: 3.726 ± 0.033	2.914LysThr: 2.914 ± 0.026	2.971LysVal: 2.971 ± 0.029	0.694LysTrp: 0.694 ± 0.011	1.444LysTyr: 1.444 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	7.829LeuAla: 7.829 ± 0.04	1.178LeuCys: 1.178 ± 0.016	5.014LeuAsp: 5.014 ± 0.034	5.525LeuGlu: 5.525 ± 0.04	3.183LeuPhe: 3.183 ± 0.025	6.017LeuGly: 6.017 ± 0.041	2.133LeuHis: 2.133 ± 0.024	3.983LeuIle: 3.983 ± 0.032	4.336LeuLys: 4.336 ± 0.038	8.332LeuLeu: 8.332 ± 0.063	1.723LeuMet: 1.723 ± 0.019	3.119LeuAsn: 3.119 ± 0.023	5.405LeuPro: 5.405 ± 0.034	3.689LeuGln: 3.689 ± 0.033	5.508LeuArg: 5.508 ± 0.039	7.216LeuSer: 7.216 ± 0.041	4.799LeuThr: 4.799 ± 0.031	5.287LeuVal: 5.287 ± 0.037	1.176LeuTrp: 1.176 ± 0.018	2.328LeuTyr: 2.328 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.225MetAla: 2.225 ± 0.02	0.238MetCys: 0.238 ± 0.007	1.257MetAsp: 1.257 ± 0.017	1.344MetGlu: 1.344 ± 0.018	0.74MetPhe: 0.74 ± 0.011	1.58MetGly: 1.58 ± 0.019	0.479MetHis: 0.479 ± 0.01	0.991MetIle: 0.991 ± 0.014	1.045MetLys: 1.045 ± 0.015	1.821MetLeu: 1.821 ± 0.022	0.565MetMet: 0.565 ± 0.01	0.789MetAsn: 0.789 ± 0.013	1.207MetPro: 1.207 ± 0.017	0.813MetGln: 0.813 ± 0.013	1.241MetArg: 1.241 ± 0.017	1.84MetSer: 1.84 ± 0.018	1.243MetThr: 1.243 ± 0.017	1.342MetVal: 1.342 ± 0.015	0.263MetTrp: 0.263 ± 0.008	0.517MetTyr: 0.517 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.165AsnAla: 3.165 ± 0.031	0.467AsnCys: 0.467 ± 0.012	1.977AsnAsp: 1.977 ± 0.019	2.056AsnGlu: 2.056 ± 0.02	1.419AsnPhe: 1.419 ± 0.017	3.153AsnGly: 3.153 ± 0.03	0.835AsnHis: 0.835 ± 0.012	2.207AsnIle: 2.207 ± 0.023	1.615AsnLys: 1.615 ± 0.019	3.242AsnLeu: 3.242 ± 0.026	0.86AsnMet: 0.86 ± 0.012	1.575AsnAsn: 1.575 ± 0.023	2.408AsnPro: 2.408 ± 0.022	1.314AsnGln: 1.314 ± 0.019	1.927AsnArg: 1.927 ± 0.016	2.927AsnSer: 2.927 ± 0.023	2.29AsnThr: 2.29 ± 0.021	2.304AsnVal: 2.304 ± 0.021	0.553AsnTrp: 0.553 ± 0.009	1.103AsnTyr: 1.103 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.219ProAla: 5.219 ± 0.047	0.503ProCys: 0.503 ± 0.011	2.95ProAsp: 2.95 ± 0.023	3.634ProGlu: 3.634 ± 0.033	1.923ProPhe: 1.923 ± 0.019	3.871ProGly: 3.871 ± 0.028	1.31ProHis: 1.31 ± 0.019	2.655ProIle: 2.655 ± 0.024	2.761ProLys: 2.761 ± 0.026	4.71ProLeu: 4.71 ± 0.034	1.031ProMet: 1.031 ± 0.016	2.209ProAsn: 2.209 ± 0.024	4.952ProPro: 4.952 ± 0.061	2.411ProGln: 2.411 ± 0.031	3.354ProArg: 3.354 ± 0.032	5.733ProSer: 5.733 ± 0.046	4.219ProThr: 4.219 ± 0.034	3.481ProVal: 3.481 ± 0.035	0.716ProTrp: 0.716 ± 0.012	1.451ProTyr: 1.451 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.292GlnAla: 3.292 ± 0.032	0.435GlnCys: 0.435 ± 0.009	1.924GlnAsp: 1.924 ± 0.021	2.286GlnGlu: 2.286 ± 0.028	1.232GlnPhe: 1.232 ± 0.015	2.529GlnGly: 2.529 ± 0.025	1.004GlnHis: 1.004 ± 0.015	1.855GlnIle: 1.855 ± 0.017	1.935GlnLys: 1.935 ± 0.022	3.37GlnLeu: 3.37 ± 0.027	0.843GlnMet: 0.843 ± 0.014	1.572GlnAsn: 1.572 ± 0.019	2.39GlnPro: 2.39 ± 0.029	2.364GlnGln: 2.364 ± 0.057	2.504GlnArg: 2.504 ± 0.025	2.936GlnSer: 2.936 ± 0.033	2.228GlnThr: 2.228 ± 0.02	2.02GlnVal: 2.02 ± 0.02	0.546GlnTrp: 0.546 ± 0.011	1.169GlnTyr: 1.169 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	4.742ArgAla: 4.742 ± 0.032	0.723ArgCys: 0.723 ± 0.013	3.271ArgAsp: 3.271 ± 0.032	3.845ArgGlu: 3.845 ± 0.039	1.959ArgPhe: 1.959 ± 0.019	3.938ArgGly: 3.938 ± 0.035	1.508ArgHis: 1.508 ± 0.018	2.855ArgIle: 2.855 ± 0.025	3.388ArgLys: 3.388 ± 0.024	5.143ArgLeu: 5.143 ± 0.033	1.256ArgMet: 1.256 ± 0.016	2.225ArgAsn: 2.225 ± 0.021	3.272ArgPro: 3.272 ± 0.029	2.507ArgGln: 2.507 ± 0.026	4.875ArgArg: 4.875 ± 0.05	4.498ArgSer: 4.498 ± 0.038	3.194ArgThr: 3.194 ± 0.027	3.334ArgVal: 3.334 ± 0.024	0.851ArgTrp: 0.851 ± 0.014	1.552ArgTyr: 1.552 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.694SerAla: 6.694 ± 0.04	0.889SerCys: 0.889 ± 0.014	4.196SerAsp: 4.196 ± 0.03	4.178SerGlu: 4.178 ± 0.031	2.947SerPhe: 2.947 ± 0.029	5.706SerGly: 5.706 ± 0.039	1.858SerHis: 1.858 ± 0.019	4.193SerIle: 4.193 ± 0.036	3.824SerLys: 3.824 ± 0.032	7.061SerLeu: 7.061 ± 0.042	1.694SerMet: 1.694 ± 0.019	3.099SerAsn: 3.099 ± 0.031	5.38SerPro: 5.38 ± 0.048	3.159SerGln: 3.159 ± 0.029	4.751SerArg: 4.751 ± 0.04	8.246SerSer: 8.246 ± 0.069	5.631SerThr: 5.631 ± 0.045	4.495SerVal: 4.495 ± 0.031	1.082SerTrp: 1.082 ± 0.014	2.1SerTyr: 2.1 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.41ThrAla: 5.41 ± 0.034	0.762ThrCys: 0.762 ± 0.013	2.908ThrAsp: 2.908 ± 0.025	3.228ThrGlu: 3.228 ± 0.033	2.236ThrPhe: 2.236 ± 0.022	4.282ThrGly: 4.282 ± 0.031	1.287ThrHis: 1.287 ± 0.02	3.312ThrIle: 3.312 ± 0.027	2.752ThrLys: 2.752 ± 0.028	5.274ThrLeu: 5.274 ± 0.032	1.245ThrMet: 1.245 ± 0.016	2.206ThrAsn: 2.206 ± 0.024	4.457ThrPro: 4.457 ± 0.034	2.023ThrGln: 2.023 ± 0.02	3.053ThrArg: 3.053 ± 0.027	5.396ThrSer: 5.396 ± 0.039	4.626ThrThr: 4.626 ± 0.044	3.731ThrVal: 3.731 ± 0.031	0.843ThrTrp: 0.843 ± 0.012	1.646ThrTyr: 1.646 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.621ValAla: 5.621 ± 0.04	0.791ValCys: 0.791 ± 0.014	3.782ValAsp: 3.782 ± 0.031	4.132ValGlu: 4.132 ± 0.034	2.343ValPhe: 2.343 ± 0.024	4.243ValGly: 4.243 ± 0.032	1.29ValHis: 1.29 ± 0.014	3.034ValIle: 3.034 ± 0.024	3.019ValLys: 3.019 ± 0.026	5.52ValLeu: 5.52 ± 0.036	1.331ValMet: 1.331 ± 0.016	2.205ValAsn: 2.205 ± 0.021	3.461ValPro: 3.461 ± 0.03	2.237ValGln: 2.237 ± 0.021	3.302ValArg: 3.302 ± 0.029	4.479ValSer: 4.479 ± 0.03	3.517ValThr: 3.517 ± 0.034	4.498ValVal: 4.498 ± 0.037	0.85ValTrp: 0.85 ± 0.013	1.678ValTyr: 1.678 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.173TrpAla: 1.173 ± 0.016	0.192TrpCys: 0.192 ± 0.006	0.887TrpAsp: 0.887 ± 0.016	0.851TrpGlu: 0.851 ± 0.014	0.527TrpPhe: 0.527 ± 0.012	0.995TrpGly: 0.995 ± 0.016	0.329TrpHis: 0.329 ± 0.008	0.745TrpIle: 0.745 ± 0.016	0.781TrpLys: 0.781 ± 0.014	1.261TrpLeu: 1.261 ± 0.017	0.356TrpMet: 0.356 ± 0.008	0.604TrpAsn: 0.604 ± 0.013	0.605TrpPro: 0.605 ± 0.012	0.515TrpGln: 0.515 ± 0.01	0.903TrpArg: 0.903 ± 0.014	1.011TrpSer: 1.011 ± 0.014	0.892TrpThr: 0.892 ± 0.013	0.901TrpVal: 0.901 ± 0.014	0.269TrpTrp: 0.269 ± 0.008	0.407TrpTyr: 0.407 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.129TyrAla: 2.129 ± 0.021	0.441TyrCys: 0.441 ± 0.009	1.639TyrAsp: 1.639 ± 0.021	1.556TyrGlu: 1.556 ± 0.022	1.167TyrPhe: 1.167 ± 0.016	2.121TyrGly: 2.121 ± 0.025	0.703TyrHis: 0.703 ± 0.012	1.474TyrIle: 1.474 ± 0.018	1.187TyrLys: 1.187 ± 0.015	2.564TyrLeu: 2.564 ± 0.024	0.592TyrMet: 0.592 ± 0.009	1.211TyrAsn: 1.211 ± 0.017	1.442TyrPro: 1.442 ± 0.019	1.068TyrGln: 1.068 ± 0.016	1.537TyrArg: 1.537 ± 0.017	2.132TyrSer: 2.132 ± 0.022	1.675TyrThr: 1.675 ± 0.021	1.574TyrVal: 1.574 ± 0.018	0.427TyrTrp: 0.427 ± 0.01	0.941TyrTyr: 0.941 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10675 proteins (5316900 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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