Amino acid dipepetide frequency for Mycobacterium phage SgtBeansprout

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.909AlaAla: 21.909 ± 1.759
1.093AlaCys: 1.093 ± 0.261
8.568AlaAsp: 8.568 ± 0.754
9.143AlaGlu: 9.143 ± 1.064
3.048AlaPhe: 3.048 ± 0.644
8.223AlaGly: 8.223 ± 0.842
2.76AlaHis: 2.76 ± 0.42
4.715AlaIle: 4.715 ± 0.493
4.428AlaLys: 4.428 ± 0.525
10.983AlaLeu: 10.983 ± 0.879
3.393AlaMet: 3.393 ± 0.448
3.45AlaAsn: 3.45 ± 0.549
6.44AlaPro: 6.44 ± 0.668
4.658AlaGln: 4.658 ± 0.56
8.971AlaArg: 8.971 ± 0.772
4.83AlaSer: 4.83 ± 0.602
6.383AlaThr: 6.383 ± 0.708
9.201AlaVal: 9.201 ± 1.023
2.53AlaTrp: 2.53 ± 0.345
2.588AlaTyr: 2.588 ± 0.448
0.0AlaXaa: 0.0 ± 0.0
Cys
1.265CysAla: 1.265 ± 0.355
0.115CysCys: 0.115 ± 0.075
0.69CysAsp: 0.69 ± 0.205
0.978CysGlu: 0.978 ± 0.261
0.058CysPhe: 0.058 ± 0.06
1.323CysGly: 1.323 ± 0.364
0.173CysHis: 0.173 ± 0.098
0.403CysIle: 0.403 ± 0.143
0.23CysLys: 0.23 ± 0.106
0.46CysLeu: 0.46 ± 0.176
0.23CysMet: 0.23 ± 0.107
0.23CysAsn: 0.23 ± 0.125
1.093CysPro: 1.093 ± 0.343
0.288CysGln: 0.288 ± 0.141
0.92CysArg: 0.92 ± 0.205
0.978CysSer: 0.978 ± 0.299
0.23CysThr: 0.23 ± 0.112
0.69CysVal: 0.69 ± 0.183
0.575CysTrp: 0.575 ± 0.2
0.173CysTyr: 0.173 ± 0.106
0.0CysXaa: 0.0 ± 0.0
Asp
7.476AspAla: 7.476 ± 0.574
0.863AspCys: 0.863 ± 0.227
5.578AspAsp: 5.578 ± 0.696
6.325AspGlu: 6.325 ± 0.684
1.438AspPhe: 1.438 ± 0.225
5.923AspGly: 5.923 ± 0.617
0.978AspHis: 0.978 ± 0.223
1.035AspIle: 1.035 ± 0.262
2.128AspLys: 2.128 ± 0.359
6.153AspLeu: 6.153 ± 0.685
1.553AspMet: 1.553 ± 0.365
1.725AspAsn: 1.725 ± 0.288
4.025AspPro: 4.025 ± 0.466
2.07AspGln: 2.07 ± 0.339
4.313AspArg: 4.313 ± 0.426
2.53AspSer: 2.53 ± 0.352
2.703AspThr: 2.703 ± 0.371
5.233AspVal: 5.233 ± 0.466
1.208AspTrp: 1.208 ± 0.281
1.38AspTyr: 1.38 ± 0.335
0.0AspXaa: 0.0 ± 0.0
Glu
7.706GluAla: 7.706 ± 0.877
1.035GluCys: 1.035 ± 0.266
3.22GluAsp: 3.22 ± 0.461
1.668GluGlu: 1.668 ± 0.307
1.898GluPhe: 1.898 ± 0.315
4.945GluGly: 4.945 ± 0.554
1.725GluHis: 1.725 ± 0.348
2.128GluIle: 2.128 ± 0.316
1.495GluLys: 1.495 ± 0.337
6.613GluLeu: 6.613 ± 0.517
1.38GluMet: 1.38 ± 0.29
1.15GluAsn: 1.15 ± 0.239
3.278GluPro: 3.278 ± 0.51
2.588GluGln: 2.588 ± 0.385
5.348GluArg: 5.348 ± 0.69
2.818GluSer: 2.818 ± 0.44
2.875GluThr: 2.875 ± 0.335
6.038GluVal: 6.038 ± 0.799
1.093GluTrp: 1.093 ± 0.263
2.07GluTyr: 2.07 ± 0.343
0.0GluXaa: 0.0 ± 0.0
Phe
2.473PheAla: 2.473 ± 0.428
0.288PheCys: 0.288 ± 0.118
3.048PheAsp: 3.048 ± 0.419
1.84PheGlu: 1.84 ± 0.284
0.575PhePhe: 0.575 ± 0.154
3.22PheGly: 3.22 ± 0.473
0.575PheHis: 0.575 ± 0.196
0.748PheIle: 0.748 ± 0.172
0.978PheLys: 0.978 ± 0.22
2.013PheLeu: 2.013 ± 0.278
0.403PheMet: 0.403 ± 0.136
1.265PheAsn: 1.265 ± 0.392
0.978PhePro: 0.978 ± 0.248
0.69PheGln: 0.69 ± 0.226
1.438PheArg: 1.438 ± 0.309
0.863PheSer: 0.863 ± 0.252
1.495PheThr: 1.495 ± 0.322
2.415PheVal: 2.415 ± 0.365
0.46PheTrp: 0.46 ± 0.145
0.69PheTyr: 0.69 ± 0.255
0.0PheXaa: 0.0 ± 0.0
Gly
9.028GlyAla: 9.028 ± 1.08
0.863GlyCys: 0.863 ± 0.282
5.463GlyAsp: 5.463 ± 0.541
5.118GlyGlu: 5.118 ± 0.468
1.898GlyPhe: 1.898 ± 0.292
9.143GlyGly: 9.143 ± 1.438
1.553GlyHis: 1.553 ± 0.317
2.818GlyIle: 2.818 ± 0.687
3.278GlyLys: 3.278 ± 0.551
6.671GlyLeu: 6.671 ± 0.771
1.495GlyMet: 1.495 ± 0.25
3.048GlyAsn: 3.048 ± 0.461
3.853GlyPro: 3.853 ± 0.748
2.645GlyGln: 2.645 ± 0.392
6.268GlyArg: 6.268 ± 0.663
5.175GlySer: 5.175 ± 0.647
5.98GlyThr: 5.98 ± 0.604
7.533GlyVal: 7.533 ± 0.575
2.645GlyTrp: 2.645 ± 0.403
2.358GlyTyr: 2.358 ± 0.388
0.0GlyXaa: 0.0 ± 0.0
His
2.588HisAla: 2.588 ± 0.509
0.403HisCys: 0.403 ± 0.172
1.208HisAsp: 1.208 ± 0.279
1.323HisGlu: 1.323 ± 0.251
0.633HisPhe: 0.633 ± 0.191
2.3HisGly: 2.3 ± 0.325
0.575HisHis: 0.575 ± 0.183
0.92HisIle: 0.92 ± 0.223
0.345HisLys: 0.345 ± 0.131
1.955HisLeu: 1.955 ± 0.308
0.575HisMet: 0.575 ± 0.194
0.633HisAsn: 0.633 ± 0.188
1.38HisPro: 1.38 ± 0.255
0.518HisGln: 0.518 ± 0.19
1.495HisArg: 1.495 ± 0.399
0.69HisSer: 0.69 ± 0.2
1.438HisThr: 1.438 ± 0.251
2.07HisVal: 2.07 ± 0.296
0.403HisTrp: 0.403 ± 0.161
0.69HisTyr: 0.69 ± 0.221
0.0HisXaa: 0.0 ± 0.0
Ile
5.405IleAla: 5.405 ± 0.511
0.173IleCys: 0.173 ± 0.1
2.933IleAsp: 2.933 ± 0.357
2.99IleGlu: 2.99 ± 0.471
0.92IlePhe: 0.92 ± 0.251
3.335IleGly: 3.335 ± 0.704
0.575IleHis: 0.575 ± 0.181
0.805IleIle: 0.805 ± 0.179
1.61IleLys: 1.61 ± 0.281
2.933IleLeu: 2.933 ± 0.365
0.403IleMet: 0.403 ± 0.133
1.208IleAsn: 1.208 ± 0.241
2.358IlePro: 2.358 ± 0.406
0.633IleGln: 0.633 ± 0.204
2.645IleArg: 2.645 ± 0.311
1.438IleSer: 1.438 ± 0.241
2.53IleThr: 2.53 ± 0.334
3.278IleVal: 3.278 ± 0.416
0.863IleTrp: 0.863 ± 0.21
0.518IleTyr: 0.518 ± 0.181
0.0IleXaa: 0.0 ± 0.0
Lys
4.37LysAla: 4.37 ± 0.655
0.46LysCys: 0.46 ± 0.163
1.093LysAsp: 1.093 ± 0.26
0.863LysGlu: 0.863 ± 0.233
1.495LysPhe: 1.495 ± 0.382
3.048LysGly: 3.048 ± 0.536
0.633LysHis: 0.633 ± 0.176
1.668LysIle: 1.668 ± 0.396
0.805LysLys: 0.805 ± 0.252
2.933LysLeu: 2.933 ± 0.428
0.69LysMet: 0.69 ± 0.179
0.518LysAsn: 0.518 ± 0.201
2.3LysPro: 2.3 ± 0.336
0.69LysGln: 0.69 ± 0.144
3.163LysArg: 3.163 ± 0.459
1.61LysSer: 1.61 ± 0.278
1.668LysThr: 1.668 ± 0.325
2.76LysVal: 2.76 ± 0.465
0.403LysTrp: 0.403 ± 0.16
0.805LysTyr: 0.805 ± 0.293
0.0LysXaa: 0.0 ± 0.0
Leu
12.191LeuAla: 12.191 ± 0.746
0.633LeuCys: 0.633 ± 0.206
7.361LeuAsp: 7.361 ± 0.714
3.278LeuGlu: 3.278 ± 0.454
2.128LeuPhe: 2.128 ± 0.375
6.383LeuGly: 6.383 ± 0.71
1.955LeuHis: 1.955 ± 0.304
3.508LeuIle: 3.508 ± 0.414
2.703LeuLys: 2.703 ± 0.485
5.06LeuLeu: 5.06 ± 0.62
1.495LeuMet: 1.495 ± 0.307
2.358LeuAsn: 2.358 ± 0.315
4.14LeuPro: 4.14 ± 0.541
3.163LeuGln: 3.163 ± 0.434
7.131LeuArg: 7.131 ± 0.659
5.865LeuSer: 5.865 ± 0.545
5.06LeuThr: 5.06 ± 0.573
5.348LeuVal: 5.348 ± 0.564
1.265LeuTrp: 1.265 ± 0.393
1.783LeuTyr: 1.783 ± 0.375
0.0LeuXaa: 0.0 ± 0.0
Met
2.588MetAla: 2.588 ± 0.345
0.173MetCys: 0.173 ± 0.098
0.863MetAsp: 0.863 ± 0.217
0.518MetGlu: 0.518 ± 0.176
0.92MetPhe: 0.92 ± 0.236
1.208MetGly: 1.208 ± 0.242
0.403MetHis: 0.403 ± 0.159
1.035MetIle: 1.035 ± 0.257
0.633MetLys: 0.633 ± 0.202
1.438MetLeu: 1.438 ± 0.339
0.288MetMet: 0.288 ± 0.126
0.575MetAsn: 0.575 ± 0.163
1.265MetPro: 1.265 ± 0.356
0.575MetGln: 0.575 ± 0.167
1.495MetArg: 1.495 ± 0.348
2.415MetSer: 2.415 ± 0.328
1.84MetThr: 1.84 ± 0.303
1.61MetVal: 1.61 ± 0.268
0.403MetTrp: 0.403 ± 0.119
0.69MetTyr: 0.69 ± 0.191
0.0MetXaa: 0.0 ± 0.0
Asn
4.14AsnAla: 4.14 ± 0.672
0.518AsnCys: 0.518 ± 0.176
1.093AsnAsp: 1.093 ± 0.229
1.208AsnGlu: 1.208 ± 0.261
0.575AsnPhe: 0.575 ± 0.184
3.565AsnGly: 3.565 ± 0.649
0.46AsnHis: 0.46 ± 0.149
0.805AsnIle: 0.805 ± 0.259
1.15AsnLys: 1.15 ± 0.323
2.128AsnLeu: 2.128 ± 0.369
0.748AsnMet: 0.748 ± 0.192
0.805AsnAsn: 0.805 ± 0.355
2.703AsnPro: 2.703 ± 0.391
0.575AsnGln: 0.575 ± 0.209
1.495AsnArg: 1.495 ± 0.249
1.438AsnSer: 1.438 ± 0.322
1.438AsnThr: 1.438 ± 0.296
2.07AsnVal: 2.07 ± 0.347
0.403AsnTrp: 0.403 ± 0.147
0.518AsnTyr: 0.518 ± 0.177
0.0AsnXaa: 0.0 ± 0.0
Pro
7.303ProAla: 7.303 ± 0.674
0.518ProCys: 0.518 ± 0.248
3.163ProAsp: 3.163 ± 0.475
4.715ProGlu: 4.715 ± 0.599
1.38ProPhe: 1.38 ± 0.286
5.923ProGly: 5.923 ± 0.511
1.323ProHis: 1.323 ± 0.251
2.3ProIle: 2.3 ± 0.382
1.61ProLys: 1.61 ± 0.251
4.14ProLeu: 4.14 ± 0.569
1.035ProMet: 1.035 ± 0.183
1.035ProAsn: 1.035 ± 0.304
2.99ProPro: 2.99 ± 0.474
1.208ProGln: 1.208 ± 0.527
3.278ProArg: 3.278 ± 0.505
2.933ProSer: 2.933 ± 0.524
2.818ProThr: 2.818 ± 0.401
5.75ProVal: 5.75 ± 0.725
1.208ProTrp: 1.208 ± 0.275
1.265ProTyr: 1.265 ± 0.248
0.0ProXaa: 0.0 ± 0.0
Gln
4.083GlnAla: 4.083 ± 0.619
0.173GlnCys: 0.173 ± 0.099
1.208GlnAsp: 1.208 ± 0.244
1.495GlnGlu: 1.495 ± 0.276
0.863GlnPhe: 0.863 ± 0.202
2.358GlnGly: 2.358 ± 0.353
1.265GlnHis: 1.265 ± 0.222
1.725GlnIle: 1.725 ± 0.277
0.805GlnLys: 0.805 ± 0.22
3.048GlnLeu: 3.048 ± 0.458
0.633GlnMet: 0.633 ± 0.203
0.633GlnAsn: 0.633 ± 0.271
2.185GlnPro: 2.185 ± 0.345
1.438GlnGln: 1.438 ± 0.267
2.703GlnArg: 2.703 ± 0.368
1.438GlnSer: 1.438 ± 0.357
1.725GlnThr: 1.725 ± 0.273
2.99GlnVal: 2.99 ± 0.371
0.46GlnTrp: 0.46 ± 0.15
1.093GlnTyr: 1.093 ± 0.218
0.0GlnXaa: 0.0 ± 0.0
Arg
7.246ArgAla: 7.246 ± 0.966
1.035ArgCys: 1.035 ± 0.353
4.025ArgAsp: 4.025 ± 0.431
4.543ArgGlu: 4.543 ± 0.556
2.588ArgPhe: 2.588 ± 0.361
5.118ArgGly: 5.118 ± 0.605
2.128ArgHis: 2.128 ± 0.476
3.508ArgIle: 3.508 ± 0.467
2.933ArgLys: 2.933 ± 0.53
6.44ArgLeu: 6.44 ± 0.634
2.358ArgMet: 2.358 ± 0.319
2.415ArgAsn: 2.415 ± 0.392
3.623ArgPro: 3.623 ± 0.579
2.933ArgGln: 2.933 ± 0.391
6.613ArgArg: 6.613 ± 0.886
4.428ArgSer: 4.428 ± 0.563
3.91ArgThr: 3.91 ± 0.468
5.808ArgVal: 5.808 ± 0.732
2.185ArgTrp: 2.185 ± 0.369
1.438ArgTyr: 1.438 ± 0.226
0.0ArgXaa: 0.0 ± 0.0
Ser
6.383SerAla: 6.383 ± 0.669
0.518SerCys: 0.518 ± 0.212
3.22SerAsp: 3.22 ± 0.49
2.53SerGlu: 2.53 ± 0.436
1.495SerPhe: 1.495 ± 0.276
5.233SerGly: 5.233 ± 0.727
1.15SerHis: 1.15 ± 0.318
2.128SerIle: 2.128 ± 0.335
1.208SerLys: 1.208 ± 0.264
4.37SerLeu: 4.37 ± 0.411
0.978SerMet: 0.978 ± 0.227
1.438SerAsn: 1.438 ± 0.257
2.99SerPro: 2.99 ± 0.411
1.668SerGln: 1.668 ± 0.229
4.198SerArg: 4.198 ± 0.479
3.335SerSer: 3.335 ± 0.502
2.703SerThr: 2.703 ± 0.424
4.255SerVal: 4.255 ± 0.524
1.265SerTrp: 1.265 ± 0.211
1.093SerTyr: 1.093 ± 0.252
0.0SerXaa: 0.0 ± 0.0
Thr
6.958ThrAla: 6.958 ± 0.73
0.46ThrCys: 0.46 ± 0.179
3.048ThrAsp: 3.048 ± 0.441
3.968ThrGlu: 3.968 ± 0.453
1.955ThrPhe: 1.955 ± 0.337
5.29ThrGly: 5.29 ± 0.524
1.553ThrHis: 1.553 ± 0.272
2.99ThrIle: 2.99 ± 0.392
1.898ThrLys: 1.898 ± 0.373
4.313ThrLeu: 4.313 ± 0.555
0.575ThrMet: 0.575 ± 0.182
1.495ThrAsn: 1.495 ± 0.268
3.278ThrPro: 3.278 ± 0.527
1.438ThrGln: 1.438 ± 0.298
3.68ThrArg: 3.68 ± 0.531
2.933ThrSer: 2.933 ± 0.53
2.703ThrThr: 2.703 ± 0.382
4.773ThrVal: 4.773 ± 0.485
1.208ThrTrp: 1.208 ± 0.224
1.208ThrTyr: 1.208 ± 0.25
0.0ThrXaa: 0.0 ± 0.0
Val
9.833ValAla: 9.833 ± 0.74
1.035ValCys: 1.035 ± 0.216
6.268ValAsp: 6.268 ± 0.59
6.901ValGlu: 6.901 ± 0.845
1.495ValPhe: 1.495 ± 0.321
6.268ValGly: 6.268 ± 0.56
1.725ValHis: 1.725 ± 0.348
3.048ValIle: 3.048 ± 0.375
2.53ValLys: 2.53 ± 0.382
6.498ValLeu: 6.498 ± 0.62
1.725ValMet: 1.725 ± 0.305
2.243ValAsn: 2.243 ± 0.348
5.405ValPro: 5.405 ± 0.627
2.185ValGln: 2.185 ± 0.337
5.463ValArg: 5.463 ± 0.628
3.565ValSer: 3.565 ± 0.624
5.693ValThr: 5.693 ± 0.629
7.476ValVal: 7.476 ± 0.778
1.955ValTrp: 1.955 ± 0.357
1.898ValTyr: 1.898 ± 0.274
0.0ValXaa: 0.0 ± 0.0
Trp
2.128TrpAla: 2.128 ± 0.38
0.345TrpCys: 0.345 ± 0.123
0.978TrpAsp: 0.978 ± 0.285
0.633TrpGlu: 0.633 ± 0.227
0.575TrpPhe: 0.575 ± 0.174
1.495TrpGly: 1.495 ± 0.305
0.403TrpHis: 0.403 ± 0.154
0.575TrpIle: 0.575 ± 0.167
0.403TrpLys: 0.403 ± 0.12
3.22TrpLeu: 3.22 ± 0.413
0.345TrpMet: 0.345 ± 0.141
0.805TrpAsn: 0.805 ± 0.221
0.805TrpPro: 0.805 ± 0.206
1.438TrpGln: 1.438 ± 0.266
2.473TrpArg: 2.473 ± 0.382
1.438TrpSer: 1.438 ± 0.271
0.805TrpThr: 0.805 ± 0.26
1.783TrpVal: 1.783 ± 0.388
0.518TrpTrp: 0.518 ± 0.159
0.46TrpTyr: 0.46 ± 0.142
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.243TyrAla: 2.243 ± 0.366
0.403TyrCys: 0.403 ± 0.149
1.61TyrAsp: 1.61 ± 0.298
1.035TyrGlu: 1.035 ± 0.258
0.518TyrPhe: 0.518 ± 0.187
2.53TyrGly: 2.53 ± 0.383
0.23TyrHis: 0.23 ± 0.117
0.69TyrIle: 0.69 ± 0.212
0.805TyrLys: 0.805 ± 0.247
1.438TyrLeu: 1.438 ± 0.308
0.575TyrMet: 0.575 ± 0.175
0.805TyrAsn: 0.805 ± 0.216
0.805TyrPro: 0.805 ± 0.218
0.92TyrGln: 0.92 ± 0.327
2.243TyrArg: 2.243 ± 0.38
1.438TyrSer: 1.438 ± 0.305
1.725TyrThr: 1.725 ± 0.351
2.128TyrVal: 2.128 ± 0.378
0.575TyrTrp: 0.575 ± 0.222
0.46TyrTyr: 0.46 ± 0.18
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 78 proteins (17391 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski