Amino acid dipepetide frequency for Arthrobacter psychrochitiniphilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.864AlaAla: 18.864 ± 0.23	0.785AlaCys: 0.785 ± 0.029	6.384AlaAsp: 6.384 ± 0.075	7.124AlaGlu: 7.124 ± 0.089	3.692AlaPhe: 3.692 ± 0.062	11.99AlaGly: 11.99 ± 0.11	2.5AlaHis: 2.5 ± 0.051	5.532AlaIle: 5.532 ± 0.071	4.281AlaLys: 4.281 ± 0.069	13.562AlaLeu: 13.562 ± 0.138	3.023AlaMet: 3.023 ± 0.047	3.139AlaAsn: 3.139 ± 0.057	6.157AlaPro: 6.157 ± 0.106	4.73AlaGln: 4.73 ± 0.068	6.81AlaArg: 6.81 ± 0.089	7.144AlaSer: 7.144 ± 0.084	7.435AlaThr: 7.435 ± 0.087	10.743AlaVal: 10.743 ± 0.125	1.634AlaTrp: 1.634 ± 0.041	2.184AlaTyr: 2.184 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.808CysAla: 0.808 ± 0.028	0.071CysCys: 0.071 ± 0.009	0.33CysAsp: 0.33 ± 0.016	0.322CysGlu: 0.322 ± 0.018	0.21CysPhe: 0.21 ± 0.012	0.706CysGly: 0.706 ± 0.029	0.157CysHis: 0.157 ± 0.011	0.27CysIle: 0.27 ± 0.016	0.154CysLys: 0.154 ± 0.012	0.549CysLeu: 0.549 ± 0.022	0.125CysMet: 0.125 ± 0.01	0.159CysAsn: 0.159 ± 0.012	0.354CysPro: 0.354 ± 0.019	0.226CysGln: 0.226 ± 0.013	0.35CysArg: 0.35 ± 0.016	0.432CysSer: 0.432 ± 0.02	0.44CysThr: 0.44 ± 0.021	0.461CysVal: 0.461 ± 0.022	0.101CysTrp: 0.101 ± 0.009	0.134CysTyr: 0.134 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.722AspAla: 6.722 ± 0.087	0.306AspCys: 0.306 ± 0.015	2.545AspAsp: 2.545 ± 0.05	3.003AspGlu: 3.003 ± 0.056	1.972AspPhe: 1.972 ± 0.043	5.068AspGly: 5.068 ± 0.082	1.114AspHis: 1.114 ± 0.031	2.381AspIle: 2.381 ± 0.052	1.452AspLys: 1.452 ± 0.04	5.27AspLeu: 5.27 ± 0.066	1.016AspMet: 1.016 ± 0.032	1.103AspAsn: 1.103 ± 0.034	3.517AspPro: 3.517 ± 0.057	1.588AspGln: 1.588 ± 0.04	2.682AspArg: 2.682 ± 0.055	3.084AspSer: 3.084 ± 0.059	2.691AspThr: 2.691 ± 0.059	4.365AspVal: 4.365 ± 0.066	0.837AspTrp: 0.837 ± 0.028	1.276AspTyr: 1.276 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.393GluAla: 6.393 ± 0.087	0.281GluCys: 0.281 ± 0.016	2.626GluAsp: 2.626 ± 0.054	3.04GluGlu: 3.04 ± 0.068	1.805GluPhe: 1.805 ± 0.044	3.786GluGly: 3.786 ± 0.059	1.477GluHis: 1.477 ± 0.037	2.891GluIle: 2.891 ± 0.05	1.917GluLys: 1.917 ± 0.045	6.875GluLeu: 6.875 ± 0.089	1.064GluMet: 1.064 ± 0.033	1.81GluAsn: 1.81 ± 0.045	2.662GluPro: 2.662 ± 0.045	2.341GluGln: 2.341 ± 0.046	3.615GluArg: 3.615 ± 0.065	3.347GluSer: 3.347 ± 0.056	2.805GluThr: 2.805 ± 0.051	4.184GluVal: 4.184 ± 0.063	0.663GluTrp: 0.663 ± 0.024	1.096GluTyr: 1.096 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.102PheAla: 4.102 ± 0.067	0.255PheCys: 0.255 ± 0.016	2.03PheAsp: 2.03 ± 0.043	1.688PheGlu: 1.688 ± 0.042	1.216PhePhe: 1.216 ± 0.04	3.234PheGly: 3.234 ± 0.058	0.652PheHis: 0.652 ± 0.026	1.503PheIle: 1.503 ± 0.04	0.929PheLys: 0.929 ± 0.031	3.177PheLeu: 3.177 ± 0.053	0.711PheMet: 0.711 ± 0.026	1.028PheAsn: 1.028 ± 0.027	1.518PhePro: 1.518 ± 0.035	0.892PheGln: 0.892 ± 0.028	1.611PheArg: 1.611 ± 0.036	2.364PheSer: 2.364 ± 0.05	2.293PheThr: 2.293 ± 0.049	2.546PheVal: 2.546 ± 0.054	0.465PheTrp: 0.465 ± 0.022	0.757PheTyr: 0.757 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.084GlyAla: 10.084 ± 0.107	0.615GlyCys: 0.615 ± 0.026	3.85GlyAsp: 3.85 ± 0.059	4.562GlyGlu: 4.562 ± 0.068	3.255GlyPhe: 3.255 ± 0.057	7.165GlyGly: 7.165 ± 0.095	1.909GlyHis: 1.909 ± 0.04	4.796GlyIle: 4.796 ± 0.071	3.111GlyLys: 3.111 ± 0.056	8.819GlyLeu: 8.819 ± 0.104	2.159GlyMet: 2.159 ± 0.044	2.387GlyAsn: 2.387 ± 0.054	3.819GlyPro: 3.819 ± 0.051	3.026GlyGln: 3.026 ± 0.062	5.038GlyArg: 5.038 ± 0.084	5.775GlySer: 5.775 ± 0.077	6.072GlyThr: 6.072 ± 0.077	7.153GlyVal: 7.153 ± 0.087	1.538GlyTrp: 1.538 ± 0.042	2.208GlyTyr: 2.208 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.286HisAla: 2.286 ± 0.051	0.159HisCys: 0.159 ± 0.012	1.146HisAsp: 1.146 ± 0.035	1.185HisGlu: 1.185 ± 0.033	0.726HisPhe: 0.726 ± 0.026	2.043HisGly: 2.043 ± 0.05	0.644HisHis: 0.644 ± 0.025	0.898HisIle: 0.898 ± 0.025	0.553HisLys: 0.553 ± 0.025	2.132HisLeu: 2.132 ± 0.054	0.434HisMet: 0.434 ± 0.016	0.54HisAsn: 0.54 ± 0.021	1.387HisPro: 1.387 ± 0.042	0.752HisGln: 0.752 ± 0.027	1.41HisArg: 1.41 ± 0.038	1.282HisSer: 1.282 ± 0.035	1.182HisThr: 1.182 ± 0.038	1.639HisVal: 1.639 ± 0.044	0.347HisTrp: 0.347 ± 0.016	0.502HisTyr: 0.502 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.097IleAla: 6.097 ± 0.075	0.349IleCys: 0.349 ± 0.017	2.8IleAsp: 2.8 ± 0.052	2.483IleGlu: 2.483 ± 0.043	1.662IlePhe: 1.662 ± 0.047	4.108IleGly: 4.108 ± 0.071	0.934IleHis: 0.934 ± 0.028	2.279IleIle: 2.279 ± 0.05	1.459IleLys: 1.459 ± 0.038	4.428IleLeu: 4.428 ± 0.065	1.017IleMet: 1.017 ± 0.031	1.51IleAsn: 1.51 ± 0.037	2.587IlePro: 2.587 ± 0.043	1.225IleGln: 1.225 ± 0.035	2.519IleArg: 2.519 ± 0.051	3.189IleSer: 3.189 ± 0.048	3.072IleThr: 3.072 ± 0.063	3.916IleVal: 3.916 ± 0.07	0.547IleTrp: 0.547 ± 0.024	0.962IleTyr: 0.962 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.828LysAla: 3.828 ± 0.074	0.124LysCys: 0.124 ± 0.012	1.818LysAsp: 1.818 ± 0.044	1.624LysGlu: 1.624 ± 0.043	1.03LysPhe: 1.03 ± 0.028	2.116LysGly: 2.116 ± 0.048	0.666LysHis: 0.666 ± 0.022	1.646LysIle: 1.646 ± 0.041	1.282LysLys: 1.282 ± 0.04	2.945LysLeu: 2.945 ± 0.051	0.797LysMet: 0.797 ± 0.025	1.087LysAsn: 1.087 ± 0.029	1.725LysPro: 1.725 ± 0.041	0.9LysGln: 0.9 ± 0.03	1.721LysArg: 1.721 ± 0.039	1.979LysSer: 1.979 ± 0.045	1.895LysThr: 1.895 ± 0.041	2.599LysVal: 2.599 ± 0.052	0.413LysTrp: 0.413 ± 0.02	0.795LysTyr: 0.795 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	14.593LeuAla: 14.593 ± 0.143	0.738LeuCys: 0.738 ± 0.025	5.715LeuAsp: 5.715 ± 0.088	5.599LeuGlu: 5.599 ± 0.081	3.03LeuPhe: 3.03 ± 0.058	9.171LeuGly: 9.171 ± 0.1	2.096LeuHis: 2.096 ± 0.042	4.76LeuIle: 4.76 ± 0.076	2.794LeuLys: 2.794 ± 0.056	10.802LeuLeu: 10.802 ± 0.148	2.198LeuMet: 2.198 ± 0.043	2.877LeuAsn: 2.877 ± 0.048	5.678LeuPro: 5.678 ± 0.067	2.812LeuGln: 2.812 ± 0.052	6.398LeuArg: 6.398 ± 0.085	6.894LeuSer: 6.894 ± 0.093	6.195LeuThr: 6.195 ± 0.077	8.515LeuVal: 8.515 ± 0.102	1.333LeuTrp: 1.333 ± 0.042	1.683LeuTyr: 1.683 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.036MetAla: 3.036 ± 0.054	0.132MetCys: 0.132 ± 0.011	1.156MetAsp: 1.156 ± 0.032	1.035MetGlu: 1.035 ± 0.033	0.677MetPhe: 0.677 ± 0.027	1.835MetGly: 1.835 ± 0.044	0.373MetHis: 0.373 ± 0.02	1.05MetIle: 1.05 ± 0.031	0.713MetLys: 0.713 ± 0.023	2.171MetLeu: 2.171 ± 0.04	0.469MetMet: 0.469 ± 0.022	0.757MetAsn: 0.757 ± 0.029	1.162MetPro: 1.162 ± 0.03	0.558MetGln: 0.558 ± 0.024	1.22MetArg: 1.22 ± 0.037	1.705MetSer: 1.705 ± 0.033	1.527MetThr: 1.527 ± 0.036	1.923MetVal: 1.923 ± 0.046	0.251MetTrp: 0.251 ± 0.015	0.365MetTyr: 0.365 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.32AsnAla: 3.32 ± 0.056	0.194AsnCys: 0.194 ± 0.013	1.405AsnAsp: 1.405 ± 0.037	1.389AsnGlu: 1.389 ± 0.04	0.982AsnPhe: 0.982 ± 0.028	2.573AsnGly: 2.573 ± 0.05	0.588AsnHis: 0.588 ± 0.023	1.303AsnIle: 1.303 ± 0.033	0.924AsnLys: 0.924 ± 0.027	2.551AsnLeu: 2.551 ± 0.049	0.598AsnMet: 0.598 ± 0.02	1.012AsnAsn: 1.012 ± 0.035	2.064AsnPro: 2.064 ± 0.052	0.952AsnGln: 0.952 ± 0.029	1.521AsnArg: 1.521 ± 0.039	1.762AsnSer: 1.762 ± 0.043	1.732AsnThr: 1.732 ± 0.046	2.141AsnVal: 2.141 ± 0.043	0.385AsnTrp: 0.385 ± 0.018	0.758AsnTyr: 0.758 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	7.354ProAla: 7.354 ± 0.108	0.222ProCys: 0.222 ± 0.013	3.108ProAsp: 3.108 ± 0.054	3.769ProGlu: 3.769 ± 0.065	1.634ProPhe: 1.634 ± 0.035	5.061ProGly: 5.061 ± 0.077	1.162ProHis: 1.162 ± 0.034	1.865ProIle: 1.865 ± 0.04	1.486ProLys: 1.486 ± 0.041	5.057ProLeu: 5.057 ± 0.073	1.083ProMet: 1.083 ± 0.033	1.391ProAsn: 1.391 ± 0.038	2.186ProPro: 2.186 ± 0.052	1.748ProGln: 1.748 ± 0.04	2.538ProArg: 2.538 ± 0.051	3.341ProSer: 3.341 ± 0.058	3.259ProThr: 3.259 ± 0.056	4.686ProVal: 4.686 ± 0.07	0.814ProTrp: 0.814 ± 0.028	1.069ProTyr: 1.069 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.134GlnAla: 4.134 ± 0.071	0.184GlnCys: 0.184 ± 0.011	1.608GlnAsp: 1.608 ± 0.038	1.82GlnGlu: 1.82 ± 0.044	0.968GlnPhe: 0.968 ± 0.031	2.659GlnGly: 2.659 ± 0.05	0.697GlnHis: 0.697 ± 0.028	1.639GlnIle: 1.639 ± 0.037	1.024GlnLys: 1.024 ± 0.03	3.734GlnLeu: 3.734 ± 0.061	0.726GlnMet: 0.726 ± 0.026	0.874GlnAsn: 0.874 ± 0.027	1.594GlnPro: 1.594 ± 0.044	1.469GlnGln: 1.469 ± 0.042	2.352GlnArg: 2.352 ± 0.047	1.883GlnSer: 1.883 ± 0.049	1.622GlnThr: 1.622 ± 0.034	2.508GlnVal: 2.508 ± 0.047	0.656GlnTrp: 0.656 ± 0.025	0.68GlnTyr: 0.68 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	6.276ArgAla: 6.276 ± 0.083	0.382ArgCys: 0.382 ± 0.019	2.932ArgAsp: 2.932 ± 0.051	3.553ArgGlu: 3.553 ± 0.063	1.939ArgPhe: 1.939 ± 0.039	4.279ArgGly: 4.279 ± 0.062	1.39ArgHis: 1.39 ± 0.028	3.012ArgIle: 3.012 ± 0.049	1.946ArgLys: 1.946 ± 0.041	5.932ArgLeu: 5.932 ± 0.08	1.393ArgMet: 1.393 ± 0.039	1.734ArgAsn: 1.734 ± 0.04	2.846ArgPro: 2.846 ± 0.054	1.962ArgGln: 1.962 ± 0.044	4.456ArgArg: 4.456 ± 0.067	3.66ArgSer: 3.66 ± 0.06	3.632ArgThr: 3.632 ± 0.059	4.155ArgVal: 4.155 ± 0.06	0.979ArgTrp: 0.979 ± 0.031	1.339ArgTyr: 1.339 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	7.805SerAla: 7.805 ± 0.099	0.422SerCys: 0.422 ± 0.022	2.908SerAsp: 2.908 ± 0.056	3.093SerGlu: 3.093 ± 0.056	2.051SerPhe: 2.051 ± 0.046	6.23SerGly: 6.23 ± 0.078	1.304SerHis: 1.304 ± 0.03	2.893SerIle: 2.893 ± 0.049	1.903SerLys: 1.903 ± 0.04	6.236SerLeu: 6.236 ± 0.078	1.597SerMet: 1.597 ± 0.038	1.873SerAsn: 1.873 ± 0.049	3.433SerPro: 3.433 ± 0.056	1.972SerGln: 1.972 ± 0.046	3.567SerArg: 3.567 ± 0.056	4.334SerSer: 4.334 ± 0.072	4.108SerThr: 4.108 ± 0.064	5.133SerVal: 5.133 ± 0.078	0.998SerTrp: 0.998 ± 0.031	1.596SerTyr: 1.596 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	7.938ThrAla: 7.938 ± 0.096	0.294ThrCys: 0.294 ± 0.016	3.116ThrAsp: 3.116 ± 0.051	3.162ThrGlu: 3.162 ± 0.056	2.023ThrPhe: 2.023 ± 0.046	5.739ThrGly: 5.739 ± 0.074	1.261ThrHis: 1.261 ± 0.036	2.823ThrIle: 2.823 ± 0.058	1.674ThrLys: 1.674 ± 0.043	6.342ThrLeu: 6.342 ± 0.077	1.26ThrMet: 1.26 ± 0.033	1.551ThrAsn: 1.551 ± 0.035	3.704ThrPro: 3.704 ± 0.067	1.784ThrGln: 1.784 ± 0.044	2.963ThrArg: 2.963 ± 0.055	3.689ThrSer: 3.689 ± 0.054	3.805ThrThr: 3.805 ± 0.069	5.591ThrVal: 5.591 ± 0.085	0.778ThrTrp: 0.778 ± 0.03	1.186ThrTyr: 1.186 ± 0.036	0.001ThrXaa: 0.001 ± 0.001
Val	10.327ValAla: 10.327 ± 0.101	0.572ValCys: 0.572 ± 0.023	4.623ValAsp: 4.623 ± 0.071	4.491ValGlu: 4.491 ± 0.067	2.674ValPhe: 2.674 ± 0.047	6.576ValGly: 6.576 ± 0.078	1.643ValHis: 1.643 ± 0.037	4.144ValIle: 4.144 ± 0.065	2.338ValLys: 2.338 ± 0.048	9.176ValLeu: 9.176 ± 0.114	1.727ValMet: 1.727 ± 0.035	2.211ValAsn: 2.211 ± 0.046	4.638ValPro: 4.638 ± 0.069	2.511ValGln: 2.511 ± 0.049	4.71ValArg: 4.71 ± 0.068	5.328ValSer: 5.328 ± 0.061	4.875ValThr: 4.875 ± 0.071	7.702ValVal: 7.702 ± 0.1	0.961ValTrp: 0.961 ± 0.032	1.426ValTyr: 1.426 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.48TrpAla: 1.48 ± 0.036	0.106TrpCys: 0.106 ± 0.009	0.743TrpAsp: 0.743 ± 0.029	0.684TrpGlu: 0.684 ± 0.027	0.556TrpPhe: 0.556 ± 0.023	1.01TrpGly: 1.01 ± 0.034	0.337TrpHis: 0.337 ± 0.018	0.71TrpIle: 0.71 ± 0.028	0.403TrpLys: 0.403 ± 0.018	1.844TrpLeu: 1.844 ± 0.042	0.363TrpMet: 0.363 ± 0.018	0.498TrpAsn: 0.498 ± 0.023	0.666TrpPro: 0.666 ± 0.024	0.637TrpGln: 0.637 ± 0.024	0.976TrpArg: 0.976 ± 0.029	0.886TrpSer: 0.886 ± 0.028	0.804TrpThr: 0.804 ± 0.027	1.041TrpVal: 1.041 ± 0.027	0.334TrpTrp: 0.334 ± 0.02	0.293TrpTyr: 0.293 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.266TyrAla: 2.266 ± 0.048	0.169TyrCys: 0.169 ± 0.013	1.149TyrAsp: 1.149 ± 0.032	1.052TyrGlu: 1.052 ± 0.031	0.865TyrPhe: 0.865 ± 0.025	1.992TyrGly: 1.992 ± 0.046	0.343TyrHis: 0.343 ± 0.018	0.749TyrIle: 0.749 ± 0.027	0.646TyrLys: 0.646 ± 0.024	2.276TyrLeu: 2.276 ± 0.045	0.354TyrMet: 0.354 ± 0.016	0.614TyrAsn: 0.614 ± 0.022	1.135TyrPro: 1.135 ± 0.035	0.747TyrGln: 0.747 ± 0.028	1.342TyrArg: 1.342 ± 0.033	1.378TyrSer: 1.378 ± 0.037	1.241TyrThr: 1.241 ± 0.041	1.652TyrVal: 1.652 ± 0.037	0.336TyrTrp: 0.336 ± 0.017	0.482TyrTyr: 0.482 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 3468 proteins (1151014 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---