Amino acid dipepetide frequency for Vibrio phage VMJ710

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.878AlaAla: 3.878 ± 0.58
0.801AlaCys: 0.801 ± 0.153
2.866AlaAsp: 2.866 ± 0.372
3.709AlaGlu: 3.709 ± 0.451
2.15AlaPhe: 2.15 ± 0.29
3.119AlaGly: 3.119 ± 0.39
0.97AlaHis: 0.97 ± 0.209
3.836AlaIle: 3.836 ± 0.398
4.173AlaLys: 4.173 ± 0.44
4.384AlaLeu: 4.384 ± 0.475
1.265AlaMet: 1.265 ± 0.245
2.066AlaAsn: 2.066 ± 0.349
1.644AlaPro: 1.644 ± 0.262
1.56AlaGln: 1.56 ± 0.285
2.276AlaArg: 2.276 ± 0.297
3.204AlaSer: 3.204 ± 0.451
3.288AlaThr: 3.288 ± 0.375
2.909AlaVal: 2.909 ± 0.373
0.801AlaTrp: 0.801 ± 0.17
2.108AlaTyr: 2.108 ± 0.308
0.0AlaXaa: 0.0 ± 0.0
Cys
0.885CysAla: 0.885 ± 0.217
0.379CysCys: 0.379 ± 0.133
0.717CysAsp: 0.717 ± 0.205
1.391CysGlu: 1.391 ± 0.285
0.506CysPhe: 0.506 ± 0.129
1.686CysGly: 1.686 ± 0.333
0.422CysHis: 0.422 ± 0.146
0.759CysIle: 0.759 ± 0.172
1.475CysLys: 1.475 ± 0.259
1.012CysLeu: 1.012 ± 0.274
0.464CysMet: 0.464 ± 0.148
0.927CysAsn: 0.927 ± 0.234
0.801CysPro: 0.801 ± 0.183
0.464CysGln: 0.464 ± 0.137
0.97CysArg: 0.97 ± 0.156
1.433CysSer: 1.433 ± 0.395
0.801CysThr: 0.801 ± 0.195
1.265CysVal: 1.265 ± 0.213
0.169CysTrp: 0.169 ± 0.092
0.843CysTyr: 0.843 ± 0.188
0.0CysXaa: 0.0 ± 0.0
Asp
2.192AspAla: 2.192 ± 0.271
1.138AspCys: 1.138 ± 0.185
2.613AspAsp: 2.613 ± 0.417
4.468AspGlu: 4.468 ± 0.402
3.33AspPhe: 3.33 ± 0.419
4.974AspGly: 4.974 ± 0.466
1.138AspHis: 1.138 ± 0.224
4.51AspIle: 4.51 ± 0.467
5.311AspLys: 5.311 ± 0.547
5.522AspLeu: 5.522 ± 0.523
1.265AspMet: 1.265 ± 0.322
3.33AspAsn: 3.33 ± 0.344
1.813AspPro: 1.813 ± 0.289
1.391AspGln: 1.391 ± 0.287
2.318AspArg: 2.318 ± 0.3
4.131AspSer: 4.131 ± 0.415
3.499AspThr: 3.499 ± 0.331
4.595AspVal: 4.595 ± 0.432
1.138AspTrp: 1.138 ± 0.24
3.288AspTyr: 3.288 ± 0.37
0.0AspXaa: 0.0 ± 0.0
Glu
4.257GluAla: 4.257 ± 0.52
1.096GluCys: 1.096 ± 0.211
6.618GluAsp: 6.618 ± 0.523
6.871GluGlu: 6.871 ± 0.766
2.74GluPhe: 2.74 ± 0.349
5.101GluGly: 5.101 ± 0.485
1.475GluHis: 1.475 ± 0.258
4.553GluIle: 4.553 ± 0.511
5.733GluLys: 5.733 ± 0.435
6.112GluLeu: 6.112 ± 0.464
1.813GluMet: 1.813 ± 0.254
3.625GluAsn: 3.625 ± 0.367
1.77GluPro: 1.77 ± 0.315
2.487GluGln: 2.487 ± 0.328
3.204GluArg: 3.204 ± 0.381
4.805GluSer: 4.805 ± 0.416
2.74GluThr: 2.74 ± 0.319
5.396GluVal: 5.396 ± 0.519
1.012GluTrp: 1.012 ± 0.201
3.246GluTyr: 3.246 ± 0.36
0.0GluXaa: 0.0 ± 0.0
Phe
2.192PheAla: 2.192 ± 0.363
0.759PheCys: 0.759 ± 0.182
3.499PheAsp: 3.499 ± 0.374
3.33PheGlu: 3.33 ± 0.323
1.56PhePhe: 1.56 ± 0.267
3.035PheGly: 3.035 ± 0.427
0.927PheHis: 0.927 ± 0.165
2.613PheIle: 2.613 ± 0.368
3.836PheLys: 3.836 ± 0.399
3.077PheLeu: 3.077 ± 0.333
0.801PheMet: 0.801 ± 0.165
1.897PheAsn: 1.897 ± 0.281
1.56PhePro: 1.56 ± 0.268
1.265PheGln: 1.265 ± 0.217
1.686PheArg: 1.686 ± 0.259
3.035PheSer: 3.035 ± 0.334
3.33PheThr: 3.33 ± 0.355
2.951PheVal: 2.951 ± 0.322
0.927PheTrp: 0.927 ± 0.244
1.475PheTyr: 1.475 ± 0.283
0.0PheXaa: 0.0 ± 0.0
Gly
2.993GlyAla: 2.993 ± 0.407
1.18GlyCys: 1.18 ± 0.218
4.047GlyAsp: 4.047 ± 0.352
4.553GlyGlu: 4.553 ± 0.477
3.414GlyPhe: 3.414 ± 0.398
4.468GlyGly: 4.468 ± 0.583
0.717GlyHis: 0.717 ± 0.165
3.92GlyIle: 3.92 ± 0.393
5.227GlyLys: 5.227 ± 0.522
5.101GlyLeu: 5.101 ± 0.575
1.349GlyMet: 1.349 ± 0.205
3.794GlyAsn: 3.794 ± 0.427
0.295GlyPro: 0.295 ± 0.11
2.066GlyGln: 2.066 ± 0.291
2.698GlyArg: 2.698 ± 0.357
4.005GlySer: 4.005 ± 0.483
4.047GlyThr: 4.047 ± 0.438
5.986GlyVal: 5.986 ± 0.566
1.686GlyTrp: 1.686 ± 0.221
3.667GlyTyr: 3.667 ± 0.42
0.0GlyXaa: 0.0 ± 0.0
His
0.59HisAla: 0.59 ± 0.15
0.379HisCys: 0.379 ± 0.138
0.97HisAsp: 0.97 ± 0.177
1.054HisGlu: 1.054 ± 0.17
1.054HisPhe: 1.054 ± 0.235
1.138HisGly: 1.138 ± 0.194
0.295HisHis: 0.295 ± 0.111
1.644HisIle: 1.644 ± 0.272
1.939HisLys: 1.939 ± 0.3
1.433HisLeu: 1.433 ± 0.178
0.422HisMet: 0.422 ± 0.114
1.096HisAsn: 1.096 ± 0.182
0.674HisPro: 0.674 ± 0.175
0.927HisGln: 0.927 ± 0.212
0.801HisArg: 0.801 ± 0.187
1.475HisSer: 1.475 ± 0.277
1.222HisThr: 1.222 ± 0.254
1.054HisVal: 1.054 ± 0.223
0.169HisTrp: 0.169 ± 0.103
0.801HisTyr: 0.801 ± 0.169
0.0HisXaa: 0.0 ± 0.0
Ile
3.077IleAla: 3.077 ± 0.313
0.97IleCys: 0.97 ± 0.191
4.047IleAsp: 4.047 ± 0.381
3.962IleGlu: 3.962 ± 0.386
2.403IlePhe: 2.403 ± 0.295
3.246IleGly: 3.246 ± 0.427
1.265IleHis: 1.265 ± 0.325
3.836IleIle: 3.836 ± 0.401
6.492IleLys: 6.492 ± 0.448
4.595IleLeu: 4.595 ± 0.402
1.18IleMet: 1.18 ± 0.212
3.372IleAsn: 3.372 ± 0.335
2.993IlePro: 2.993 ± 0.324
1.855IleGln: 1.855 ± 0.301
3.204IleArg: 3.204 ± 0.376
4.047IleSer: 4.047 ± 0.426
4.089IleThr: 4.089 ± 0.51
3.92IleVal: 3.92 ± 0.462
0.548IleTrp: 0.548 ± 0.146
2.445IleTyr: 2.445 ± 0.313
0.0IleXaa: 0.0 ± 0.0
Lys
4.51LysAla: 4.51 ± 0.503
1.138LysCys: 1.138 ± 0.213
6.028LysAsp: 6.028 ± 0.475
6.07LysGlu: 6.07 ± 0.545
3.372LysPhe: 3.372 ± 0.363
6.07LysGly: 6.07 ± 0.586
2.108LysHis: 2.108 ± 0.253
4.679LysIle: 4.679 ± 0.504
3.962LysLys: 3.962 ± 0.426
6.997LysLeu: 6.997 ± 0.683
1.77LysMet: 1.77 ± 0.247
3.457LysAsn: 3.457 ± 0.374
2.361LysPro: 2.361 ± 0.333
3.246LysGln: 3.246 ± 0.382
4.215LysArg: 4.215 ± 0.419
5.733LysSer: 5.733 ± 0.525
3.836LysThr: 3.836 ± 0.38
5.564LysVal: 5.564 ± 0.423
0.885LysTrp: 0.885 ± 0.206
4.51LysTyr: 4.51 ± 0.467
0.0LysXaa: 0.0 ± 0.0
Leu
4.553LeuAla: 4.553 ± 0.508
1.602LeuCys: 1.602 ± 0.201
5.817LeuAsp: 5.817 ± 0.6
6.702LeuGlu: 6.702 ± 0.479
3.204LeuPhe: 3.204 ± 0.384
5.269LeuGly: 5.269 ± 0.508
1.349LeuHis: 1.349 ± 0.286
4.468LeuIle: 4.468 ± 0.442
5.859LeuLys: 5.859 ± 0.501
6.239LeuLeu: 6.239 ± 0.511
2.192LeuMet: 2.192 ± 0.343
5.143LeuAsn: 5.143 ± 0.455
3.33LeuPro: 3.33 ± 0.455
2.909LeuGln: 2.909 ± 0.346
3.878LeuArg: 3.878 ± 0.4
7.293LeuSer: 7.293 ± 0.675
4.805LeuThr: 4.805 ± 0.593
4.637LeuVal: 4.637 ± 0.382
1.265LeuTrp: 1.265 ± 0.269
3.288LeuTyr: 3.288 ± 0.416
0.0LeuXaa: 0.0 ± 0.0
Met
1.644MetAla: 1.644 ± 0.316
0.253MetCys: 0.253 ± 0.101
1.054MetAsp: 1.054 ± 0.213
1.518MetGlu: 1.518 ± 0.318
1.012MetPhe: 1.012 ± 0.194
1.18MetGly: 1.18 ± 0.225
0.295MetHis: 0.295 ± 0.115
1.518MetIle: 1.518 ± 0.263
2.234MetLys: 2.234 ± 0.328
1.939MetLeu: 1.939 ± 0.302
0.927MetMet: 0.927 ± 0.179
1.433MetAsn: 1.433 ± 0.282
0.801MetPro: 0.801 ± 0.195
1.18MetGln: 1.18 ± 0.201
1.138MetArg: 1.138 ± 0.311
2.234MetSer: 2.234 ± 0.26
1.349MetThr: 1.349 ± 0.247
1.18MetVal: 1.18 ± 0.218
0.084MetTrp: 0.084 ± 0.064
0.885MetTyr: 0.885 ± 0.226
0.0MetXaa: 0.0 ± 0.0
Asn
2.656AsnAla: 2.656 ± 0.417
0.801AsnCys: 0.801 ± 0.21
2.866AsnAsp: 2.866 ± 0.298
2.698AsnGlu: 2.698 ± 0.261
2.445AsnPhe: 2.445 ± 0.311
4.047AsnGly: 4.047 ± 0.412
1.56AsnHis: 1.56 ± 0.281
3.92AsnIle: 3.92 ± 0.445
4.384AsnLys: 4.384 ± 0.551
4.342AsnLeu: 4.342 ± 0.424
1.222AsnMet: 1.222 ± 0.221
3.035AsnAsn: 3.035 ± 0.368
2.192AsnPro: 2.192 ± 0.304
2.108AsnGln: 2.108 ± 0.28
2.066AsnArg: 2.066 ± 0.318
3.246AsnSer: 3.246 ± 0.396
2.866AsnThr: 2.866 ± 0.364
2.656AsnVal: 2.656 ± 0.277
0.717AsnTrp: 0.717 ± 0.18
2.276AsnTyr: 2.276 ± 0.276
0.0AsnXaa: 0.0 ± 0.0
Pro
1.644ProAla: 1.644 ± 0.295
0.674ProCys: 0.674 ± 0.164
2.361ProAsp: 2.361 ± 0.262
2.866ProGlu: 2.866 ± 0.293
1.855ProPhe: 1.855 ± 0.257
0.211ProGly: 0.211 ± 0.093
1.138ProHis: 1.138 ± 0.237
1.77ProIle: 1.77 ± 0.3
2.361ProLys: 2.361 ± 0.399
2.192ProLeu: 2.192 ± 0.394
0.801ProMet: 0.801 ± 0.182
1.602ProAsn: 1.602 ± 0.271
0.843ProPro: 0.843 ± 0.242
1.307ProGln: 1.307 ± 0.247
1.138ProArg: 1.138 ± 0.241
2.108ProSer: 2.108 ± 0.316
1.897ProThr: 1.897 ± 0.308
2.824ProVal: 2.824 ± 0.419
0.464ProTrp: 0.464 ± 0.135
1.602ProTyr: 1.602 ± 0.27
0.0ProXaa: 0.0 ± 0.0
Gln
2.108GlnAla: 2.108 ± 0.321
0.337GlnCys: 0.337 ± 0.119
2.15GlnAsp: 2.15 ± 0.317
4.005GlnGlu: 4.005 ± 0.474
1.054GlnPhe: 1.054 ± 0.221
2.15GlnGly: 2.15 ± 0.301
0.885GlnHis: 0.885 ± 0.183
2.15GlnIle: 2.15 ± 0.312
2.613GlnLys: 2.613 ± 0.373
2.318GlnLeu: 2.318 ± 0.383
0.843GlnMet: 0.843 ± 0.193
1.518GlnAsn: 1.518 ± 0.248
0.843GlnPro: 0.843 ± 0.172
2.023GlnGln: 2.023 ± 0.313
1.77GlnArg: 1.77 ± 0.287
2.361GlnSer: 2.361 ± 0.266
1.307GlnThr: 1.307 ± 0.247
2.445GlnVal: 2.445 ± 0.299
0.506GlnTrp: 0.506 ± 0.161
1.602GlnTyr: 1.602 ± 0.33
0.0GlnXaa: 0.0 ± 0.0
Arg
1.728ArgAla: 1.728 ± 0.343
1.222ArgCys: 1.222 ± 0.244
2.023ArgAsp: 2.023 ± 0.341
3.372ArgGlu: 3.372 ± 0.445
2.15ArgPhe: 2.15 ± 0.306
3.161ArgGly: 3.161 ± 0.377
0.632ArgHis: 0.632 ± 0.174
2.318ArgIle: 2.318 ± 0.288
3.246ArgLys: 3.246 ± 0.469
4.426ArgLeu: 4.426 ± 0.496
1.391ArgMet: 1.391 ± 0.24
2.487ArgAsn: 2.487 ± 0.315
1.307ArgPro: 1.307 ± 0.236
1.855ArgGln: 1.855 ± 0.228
1.728ArgArg: 1.728 ± 0.325
3.204ArgSer: 3.204 ± 0.395
1.897ArgThr: 1.897 ± 0.264
2.698ArgVal: 2.698 ± 0.379
0.674ArgTrp: 0.674 ± 0.141
2.023ArgTyr: 2.023 ± 0.251
0.0ArgXaa: 0.0 ± 0.0
Ser
3.372SerAla: 3.372 ± 0.392
1.054SerCys: 1.054 ± 0.23
4.173SerAsp: 4.173 ± 0.368
4.932SerGlu: 4.932 ± 0.497
3.499SerPhe: 3.499 ± 0.412
5.185SerGly: 5.185 ± 0.535
1.012SerHis: 1.012 ± 0.193
4.131SerIle: 4.131 ± 0.465
6.576SerLys: 6.576 ± 0.479
6.618SerLeu: 6.618 ± 0.59
1.56SerMet: 1.56 ± 0.25
3.541SerAsn: 3.541 ± 0.313
1.855SerPro: 1.855 ± 0.258
2.023SerGln: 2.023 ± 0.308
2.993SerArg: 2.993 ± 0.356
5.522SerSer: 5.522 ± 0.607
3.667SerThr: 3.667 ± 0.549
4.679SerVal: 4.679 ± 0.467
1.012SerTrp: 1.012 ± 0.21
3.246SerTyr: 3.246 ± 0.343
0.0SerXaa: 0.0 ± 0.0
Thr
3.288ThrAla: 3.288 ± 0.436
0.927ThrCys: 0.927 ± 0.218
2.234ThrAsp: 2.234 ± 0.329
3.667ThrGlu: 3.667 ± 0.392
2.613ThrPhe: 2.613 ± 0.381
4.215ThrGly: 4.215 ± 0.475
1.096ThrHis: 1.096 ± 0.15
4.005ThrIle: 4.005 ± 0.508
4.047ThrLys: 4.047 ± 0.533
5.859ThrLeu: 5.859 ± 0.494
1.602ThrMet: 1.602 ± 0.242
2.866ThrAsn: 2.866 ± 0.414
2.993ThrPro: 2.993 ± 0.34
1.433ThrGln: 1.433 ± 0.238
2.276ThrArg: 2.276 ± 0.326
3.667ThrSer: 3.667 ± 0.453
3.414ThrThr: 3.414 ± 0.453
3.794ThrVal: 3.794 ± 0.384
0.632ThrTrp: 0.632 ± 0.143
2.361ThrTyr: 2.361 ± 0.338
0.0ThrXaa: 0.0 ± 0.0
Val
3.33ValAla: 3.33 ± 0.431
1.349ValCys: 1.349 ± 0.308
4.51ValAsp: 4.51 ± 0.367
5.564ValGlu: 5.564 ± 0.463
2.866ValPhe: 2.866 ± 0.332
4.047ValGly: 4.047 ± 0.416
0.801ValHis: 0.801 ± 0.188
3.709ValIle: 3.709 ± 0.452
5.733ValLys: 5.733 ± 0.523
5.522ValLeu: 5.522 ± 0.432
1.686ValMet: 1.686 ± 0.258
3.625ValAsn: 3.625 ± 0.392
1.813ValPro: 1.813 ± 0.274
2.656ValGln: 2.656 ± 0.367
2.276ValArg: 2.276 ± 0.278
4.932ValSer: 4.932 ± 0.44
4.932ValThr: 4.932 ± 0.553
5.143ValVal: 5.143 ± 0.58
0.801ValTrp: 0.801 ± 0.194
2.74ValTyr: 2.74 ± 0.365
0.0ValXaa: 0.0 ± 0.0
Trp
0.337TrpAla: 0.337 ± 0.101
0.295TrpCys: 0.295 ± 0.108
0.717TrpAsp: 0.717 ± 0.187
1.138TrpGlu: 1.138 ± 0.201
0.548TrpPhe: 0.548 ± 0.165
0.464TrpGly: 0.464 ± 0.145
0.169TrpHis: 0.169 ± 0.097
0.632TrpIle: 0.632 ± 0.157
1.602TrpLys: 1.602 ± 0.297
1.475TrpLeu: 1.475 ± 0.271
0.548TrpMet: 0.548 ± 0.142
0.632TrpAsn: 0.632 ± 0.176
0.253TrpPro: 0.253 ± 0.089
0.59TrpGln: 0.59 ± 0.164
0.464TrpArg: 0.464 ± 0.145
1.054TrpSer: 1.054 ± 0.25
0.801TrpThr: 0.801 ± 0.192
1.56TrpVal: 1.56 ± 0.28
0.169TrpTrp: 0.169 ± 0.091
0.548TrpTyr: 0.548 ± 0.153
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.77TyrAla: 1.77 ± 0.274
1.012TyrCys: 1.012 ± 0.219
2.656TyrAsp: 2.656 ± 0.337
2.782TyrGlu: 2.782 ± 0.361
1.981TyrPhe: 1.981 ± 0.331
2.445TyrGly: 2.445 ± 0.334
0.885TyrHis: 0.885 ± 0.17
2.571TyrIle: 2.571 ± 0.309
3.709TyrLys: 3.709 ± 0.472
4.637TyrLeu: 4.637 ± 0.49
0.717TyrMet: 0.717 ± 0.174
2.656TyrAsn: 2.656 ± 0.443
1.518TyrPro: 1.518 ± 0.223
1.644TyrGln: 1.644 ± 0.249
2.445TyrArg: 2.445 ± 0.314
3.161TyrSer: 3.161 ± 0.399
3.204TyrThr: 3.204 ± 0.425
2.782TyrVal: 2.782 ± 0.397
0.337TyrTrp: 0.337 ± 0.122
2.318TyrTyr: 2.318 ± 0.299
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 89 proteins (23724 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski