Amino acid dipepetide frequency for Nocardia brasiliensis ATCC 700358

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.703AlaAla: 22.703 ± 0.144	0.99AlaCys: 0.99 ± 0.021	8.884AlaAsp: 8.884 ± 0.065	8.921AlaGlu: 8.921 ± 0.067	3.463AlaPhe: 3.463 ± 0.036	12.448AlaGly: 12.448 ± 0.083	2.845AlaHis: 2.845 ± 0.03	5.157AlaIle: 5.157 ± 0.055	2.802AlaLys: 2.802 ± 0.038	14.01AlaLeu: 14.01 ± 0.1	2.658AlaMet: 2.658 ± 0.034	2.396AlaAsn: 2.396 ± 0.035	6.841AlaPro: 6.841 ± 0.072	4.377AlaGln: 4.377 ± 0.045	9.491AlaArg: 9.491 ± 0.065	5.133AlaSer: 5.133 ± 0.046	7.897AlaThr: 7.897 ± 0.06	12.095AlaVal: 12.095 ± 0.098	1.71AlaTrp: 1.71 ± 0.025	2.428AlaTyr: 2.428 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	1.177CysAla: 1.177 ± 0.023	0.09CysCys: 0.09 ± 0.007	0.443CysAsp: 0.443 ± 0.014	0.352CysGlu: 0.352 ± 0.012	0.213CysPhe: 0.213 ± 0.01	0.886CysGly: 0.886 ± 0.019	0.181CysHis: 0.181 ± 0.009	0.199CysIle: 0.199 ± 0.009	0.117CysLys: 0.117 ± 0.007	0.702CysLeu: 0.702 ± 0.016	0.113CysMet: 0.113 ± 0.006	0.127CysAsn: 0.127 ± 0.007	0.452CysPro: 0.452 ± 0.014	0.161CysGln: 0.161 ± 0.009	0.547CysArg: 0.547 ± 0.016	0.426CysSer: 0.426 ± 0.012	0.532CysThr: 0.532 ± 0.017	0.621CysVal: 0.621 ± 0.015	0.13CysTrp: 0.13 ± 0.007	0.182CysTyr: 0.182 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.538AspAla: 7.538 ± 0.056	0.428AspCys: 0.428 ± 0.013	3.56AspAsp: 3.56 ± 0.039	3.76AspGlu: 3.76 ± 0.04	1.78AspPhe: 1.78 ± 0.031	5.561AspGly: 5.561 ± 0.06	1.413AspHis: 1.413 ± 0.024	2.476AspIle: 2.476 ± 0.028	1.188AspLys: 1.188 ± 0.027	6.423AspLeu: 6.423 ± 0.059	0.877AspMet: 0.877 ± 0.02	1.188AspAsn: 1.188 ± 0.021	4.654AspPro: 4.654 ± 0.046	1.843AspGln: 1.843 ± 0.028	5.165AspArg: 5.165 ± 0.054	2.862AspSer: 2.862 ± 0.035	3.31AspThr: 3.31 ± 0.04	4.393AspVal: 4.393 ± 0.045	0.966AspTrp: 0.966 ± 0.018	1.445AspTyr: 1.445 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	5.614GluAla: 5.614 ± 0.054	0.354GluCys: 0.354 ± 0.014	2.085GluAsp: 2.085 ± 0.033	2.128GluGlu: 2.128 ± 0.033	2.088GluPhe: 2.088 ± 0.03	2.939GluGly: 2.939 ± 0.035	1.695GluHis: 1.695 ± 0.025	2.73GluIle: 2.73 ± 0.03	1.067GluLys: 1.067 ± 0.023	7.576GluLeu: 7.576 ± 0.067	0.94GluMet: 0.94 ± 0.02	1.061GluAsn: 1.061 ± 0.024	3.212GluPro: 3.212 ± 0.041	2.603GluGln: 2.603 ± 0.032	4.788GluArg: 4.788 ± 0.05	2.781GluSer: 2.781 ± 0.03	2.861GluThr: 2.861 ± 0.031	4.428GluVal: 4.428 ± 0.044	0.827GluTrp: 0.827 ± 0.018	1.244GluTyr: 1.244 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	4.44PheAla: 4.44 ± 0.049	0.259PheCys: 0.259 ± 0.009	2.565PheAsp: 2.565 ± 0.038	1.658PheGlu: 1.658 ± 0.029	0.937PhePhe: 0.937 ± 0.021	3.557PheGly: 3.557 ± 0.04	0.648PheHis: 0.648 ± 0.017	0.893PheIle: 0.893 ± 0.021	0.411PheLys: 0.411 ± 0.015	2.641PheLeu: 2.641 ± 0.037	0.415PheMet: 0.415 ± 0.011	0.56PheAsn: 0.56 ± 0.017	1.494PhePro: 1.494 ± 0.026	0.752PheGln: 0.752 ± 0.02	1.916PheArg: 1.916 ± 0.029	1.439PheSer: 1.439 ± 0.024	2.069PheThr: 2.069 ± 0.028	2.59PheVal: 2.59 ± 0.036	0.408PheTrp: 0.408 ± 0.013	0.654PheTyr: 0.654 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	10.919GlyAla: 10.919 ± 0.07	0.794GlyCys: 0.794 ± 0.018	4.614GlyAsp: 4.614 ± 0.051	4.239GlyGlu: 4.239 ± 0.042	3.035GlyPhe: 3.035 ± 0.038	7.474GlyGly: 7.474 ± 0.068	2.034GlyHis: 2.034 ± 0.032	4.048GlyIle: 4.048 ± 0.044	2.328GlyLys: 2.328 ± 0.031	8.873GlyLeu: 8.873 ± 0.076	1.974GlyMet: 1.974 ± 0.027	1.849GlyAsn: 1.849 ± 0.031	4.646GlyPro: 4.646 ± 0.05	2.563GlyGln: 2.563 ± 0.037	6.449GlyArg: 6.449 ± 0.052	4.985GlySer: 4.985 ± 0.055	5.759GlyThr: 5.759 ± 0.056	7.292GlyVal: 7.292 ± 0.05	1.606GlyTrp: 1.606 ± 0.025	2.451GlyTyr: 2.451 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.695HisAla: 2.695 ± 0.039	0.216HisCys: 0.216 ± 0.011	1.31HisAsp: 1.31 ± 0.023	1.142HisGlu: 1.142 ± 0.023	0.669HisPhe: 0.669 ± 0.015	2.217HisGly: 2.217 ± 0.033	0.66HisHis: 0.66 ± 0.019	0.787HisIle: 0.787 ± 0.02	0.308HisLys: 0.308 ± 0.01	2.234HisLeu: 2.234 ± 0.029	0.346HisMet: 0.346 ± 0.01	0.477HisAsn: 0.477 ± 0.014	1.714HisPro: 1.714 ± 0.027	0.653HisGln: 0.653 ± 0.015	2.084HisArg: 2.084 ± 0.03	1.089HisSer: 1.089 ± 0.021	1.318HisThr: 1.318 ± 0.023	1.503HisVal: 1.503 ± 0.026	0.342HisTrp: 0.342 ± 0.013	0.544HisTyr: 0.544 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	6.454IleAla: 6.454 ± 0.053	0.317IleCys: 0.317 ± 0.011	3.335IleAsp: 3.335 ± 0.039	2.666IleGlu: 2.666 ± 0.034	0.965IlePhe: 0.965 ± 0.02	4.474IleGly: 4.474 ± 0.043	0.714IleHis: 0.714 ± 0.019	1.277IleIle: 1.277 ± 0.024	0.682IleLys: 0.682 ± 0.017	3.008IleLeu: 3.008 ± 0.037	0.536IleMet: 0.536 ± 0.015	0.851IleAsn: 0.851 ± 0.015	2.307IlePro: 2.307 ± 0.034	0.888IleGln: 0.888 ± 0.018	2.753IleArg: 2.753 ± 0.035	2.078IleSer: 2.078 ± 0.028	2.676IleThr: 2.676 ± 0.034	3.599IleVal: 3.599 ± 0.042	0.455IleTrp: 0.455 ± 0.014	0.738IleTyr: 0.738 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.368LysAla: 2.368 ± 0.034	0.112LysCys: 0.112 ± 0.007	0.957LysAsp: 0.957 ± 0.021	0.849LysGlu: 0.849 ± 0.018	0.598LysPhe: 0.598 ± 0.016	1.291LysGly: 1.291 ± 0.025	0.446LysHis: 0.446 ± 0.013	0.915LysIle: 0.915 ± 0.018	0.549LysLys: 0.549 ± 0.019	2.044LysLeu: 2.044 ± 0.031	0.395LysMet: 0.395 ± 0.013	0.494LysAsn: 0.494 ± 0.015	1.288LysPro: 1.288 ± 0.024	0.759LysGln: 0.759 ± 0.019	1.28LysArg: 1.28 ± 0.025	1.125LysSer: 1.125 ± 0.02	1.189LysThr: 1.189 ± 0.024	1.681LysVal: 1.681 ± 0.031	0.294LysTrp: 0.294 ± 0.009	0.464LysTyr: 0.464 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.47LeuAla: 15.47 ± 0.109	0.871LeuCys: 0.871 ± 0.02	7.099LeuAsp: 7.099 ± 0.059	4.566LeuGlu: 4.566 ± 0.049	2.91LeuPhe: 2.91 ± 0.04	9.234LeuGly: 9.234 ± 0.068	2.241LeuHis: 2.241 ± 0.026	4.185LeuIle: 4.185 ± 0.048	1.349LeuLys: 1.349 ± 0.025	10.909LeuLeu: 10.909 ± 0.097	1.527LeuMet: 1.527 ± 0.025	1.857LeuAsn: 1.857 ± 0.027	6.329LeuPro: 6.329 ± 0.056	2.288LeuGln: 2.288 ± 0.029	8.768LeuArg: 8.768 ± 0.062	5.524LeuSer: 5.524 ± 0.045	6.864LeuThr: 6.864 ± 0.056	8.716LeuVal: 8.716 ± 0.069	1.245LeuTrp: 1.245 ± 0.027	1.749LeuTyr: 1.749 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.205MetAla: 2.205 ± 0.032	0.138MetCys: 0.138 ± 0.008	0.838MetAsp: 0.838 ± 0.017	0.6MetGlu: 0.6 ± 0.014	0.601MetPhe: 0.601 ± 0.014	1.233MetGly: 1.233 ± 0.025	0.403MetHis: 0.403 ± 0.015	0.874MetIle: 0.874 ± 0.021	0.381MetLys: 0.381 ± 0.012	1.958MetLeu: 1.958 ± 0.027	0.346MetMet: 0.346 ± 0.012	0.491MetAsn: 0.491 ± 0.013	1.1MetPro: 1.1 ± 0.021	0.503MetGln: 0.503 ± 0.012	1.457MetArg: 1.457 ± 0.022	1.325MetSer: 1.325 ± 0.021	1.593MetThr: 1.593 ± 0.023	1.502MetVal: 1.502 ± 0.024	0.245MetTrp: 0.245 ± 0.009	0.357MetTyr: 0.357 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.39AsnAla: 2.39 ± 0.037	0.161AsnCys: 0.161 ± 0.009	1.04AsnAsp: 1.04 ± 0.019	0.894AsnGlu: 0.894 ± 0.018	0.596AsnPhe: 0.596 ± 0.015	2.06AsnGly: 2.06 ± 0.032	0.406AsnHis: 0.406 ± 0.014	0.867AsnIle: 0.867 ± 0.019	0.411AsnLys: 0.411 ± 0.015	1.876AsnLeu: 1.876 ± 0.029	0.365AsnMet: 0.365 ± 0.013	0.518AsnAsn: 0.518 ± 0.017	1.548AsnPro: 1.548 ± 0.03	0.578AsnGln: 0.578 ± 0.015	1.506AsnArg: 1.506 ± 0.025	1.126AsnSer: 1.126 ± 0.022	1.207AsnThr: 1.207 ± 0.022	1.46AsnVal: 1.46 ± 0.023	0.349AsnTrp: 0.349 ± 0.012	0.502AsnTyr: 0.502 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	8.372ProAla: 8.372 ± 0.07	0.283ProCys: 0.283 ± 0.011	4.579ProAsp: 4.579 ± 0.046	4.041ProGlu: 4.041 ± 0.052	1.639ProPhe: 1.639 ± 0.03	5.924ProGly: 5.924 ± 0.059	1.196ProHis: 1.196 ± 0.022	2.249ProIle: 2.249 ± 0.03	1.203ProLys: 1.203 ± 0.021	5.13ProLeu: 5.13 ± 0.048	1.069ProMet: 1.069 ± 0.022	1.215ProAsn: 1.215 ± 0.021	3.376ProPro: 3.376 ± 0.075	1.829ProGln: 1.829 ± 0.036	3.6ProArg: 3.6 ± 0.044	2.926ProSer: 2.926 ± 0.038	3.441ProThr: 3.441 ± 0.047	5.19ProVal: 5.19 ± 0.054	0.857ProTrp: 0.857 ± 0.019	1.107ProTyr: 1.107 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.72GlnAla: 3.72 ± 0.043	0.197GlnCys: 0.197 ± 0.009	1.289GlnAsp: 1.289 ± 0.022	1.186GlnGlu: 1.186 ± 0.022	0.928GlnPhe: 0.928 ± 0.017	1.969GlnGly: 1.969 ± 0.027	0.762GlnHis: 0.762 ± 0.015	1.407GlnIle: 1.407 ± 0.023	0.466GlnLys: 0.466 ± 0.013	3.757GlnLeu: 3.757 ± 0.037	0.564GlnMet: 0.564 ± 0.014	0.556GlnAsn: 0.556 ± 0.016	1.947GlnPro: 1.947 ± 0.035	1.45GlnGln: 1.45 ± 0.03	2.873GlnArg: 2.873 ± 0.031	1.411GlnSer: 1.411 ± 0.025	1.443GlnThr: 1.443 ± 0.021	2.71GlnVal: 2.71 ± 0.039	0.575GlnTrp: 0.575 ± 0.013	0.647GlnTyr: 0.647 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	9.64ArgAla: 9.64 ± 0.074	0.565ArgCys: 0.565 ± 0.016	4.307ArgAsp: 4.307 ± 0.048	4.103ArgGlu: 4.103 ± 0.044	2.539ArgPhe: 2.539 ± 0.029	5.289ArgGly: 5.289 ± 0.046	1.841ArgHis: 1.841 ± 0.027	3.729ArgIle: 3.729 ± 0.039	1.703ArgLys: 1.703 ± 0.029	7.983ArgLeu: 7.983 ± 0.064	1.882ArgMet: 1.882 ± 0.025	1.651ArgAsn: 1.651 ± 0.025	4.319ArgPro: 4.319 ± 0.048	2.325ArgGln: 2.325 ± 0.028	6.773ArgArg: 6.773 ± 0.071	3.994ArgSer: 3.994 ± 0.037	5.069ArgThr: 5.069 ± 0.049	5.735ArgVal: 5.735 ± 0.051	1.455ArgTrp: 1.455 ± 0.025	1.911ArgTyr: 1.911 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	7.048SerAla: 7.048 ± 0.058	0.398SerCys: 0.398 ± 0.014	2.838SerAsp: 2.838 ± 0.036	2.326SerGlu: 2.326 ± 0.032	1.624SerPhe: 1.624 ± 0.026	5.56SerGly: 5.56 ± 0.053	0.883SerHis: 0.883 ± 0.018	2.039SerIle: 2.039 ± 0.03	1.045SerLys: 1.045 ± 0.02	4.432SerLeu: 4.432 ± 0.039	1.225SerMet: 1.225 ± 0.022	1.041SerAsn: 1.041 ± 0.021	2.769SerPro: 2.769 ± 0.035	1.174SerGln: 1.174 ± 0.026	3.448SerArg: 3.448 ± 0.037	2.702SerSer: 2.702 ± 0.038	3.362SerThr: 3.362 ± 0.043	4.212SerVal: 4.212 ± 0.042	0.893SerTrp: 0.893 ± 0.021	1.192SerTyr: 1.192 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.811ThrAla: 8.811 ± 0.062	0.414ThrCys: 0.414 ± 0.012	3.802ThrAsp: 3.802 ± 0.045	3.595ThrGlu: 3.595 ± 0.042	1.806ThrPhe: 1.806 ± 0.026	6.23ThrGly: 6.23 ± 0.049	1.186ThrHis: 1.186 ± 0.023	2.406ThrIle: 2.406 ± 0.033	1.227ThrLys: 1.227 ± 0.022	5.82ThrLeu: 5.82 ± 0.047	1.149ThrMet: 1.149 ± 0.02	1.134ThrAsn: 1.134 ± 0.02	4.057ThrPro: 4.057 ± 0.047	1.478ThrGln: 1.478 ± 0.025	3.864ThrArg: 3.864 ± 0.044	2.986ThrSer: 2.986 ± 0.038	4.024ThrThr: 4.024 ± 0.05	6.147ThrVal: 6.147 ± 0.052	0.822ThrTrp: 0.822 ± 0.016	1.296ThrTyr: 1.296 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	11.61ValAla: 11.61 ± 0.113	0.707ValCys: 0.707 ± 0.014	5.215ValAsp: 5.215 ± 0.045	4.335ValGlu: 4.335 ± 0.04	2.631ValPhe: 2.631 ± 0.033	6.608ValGly: 6.608 ± 0.055	1.88ValHis: 1.88 ± 0.03	3.309ValIle: 3.309 ± 0.039	1.27ValLys: 1.27 ± 0.024	10.003ValLeu: 10.003 ± 0.085	1.21ValMet: 1.21 ± 0.023	1.593ValAsn: 1.593 ± 0.026	5.09ValPro: 5.09 ± 0.055	2.223ValGln: 2.223 ± 0.03	6.652ValArg: 6.652 ± 0.053	4.206ValSer: 4.206 ± 0.05	5.428ValThr: 5.428 ± 0.045	8.098ValVal: 8.098 ± 0.07	1.026ValTrp: 1.026 ± 0.021	1.5ValTyr: 1.5 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.575TrpAla: 1.575 ± 0.024	0.146TrpCys: 0.146 ± 0.007	0.766TrpAsp: 0.766 ± 0.019	0.618TrpGlu: 0.618 ± 0.014	0.55TrpPhe: 0.55 ± 0.015	0.96TrpGly: 0.96 ± 0.02	0.408TrpHis: 0.408 ± 0.012	0.63TrpIle: 0.63 ± 0.016	0.289TrpLys: 0.289 ± 0.01	1.813TrpLeu: 1.813 ± 0.029	0.304TrpMet: 0.304 ± 0.011	0.376TrpAsn: 0.376 ± 0.013	0.808TrpPro: 0.808 ± 0.017	0.692TrpGln: 0.692 ± 0.016	1.33TrpArg: 1.33 ± 0.024	0.995TrpSer: 0.995 ± 0.019	0.973TrpThr: 0.973 ± 0.021	1.055TrpVal: 1.055 ± 0.02	0.348TrpTrp: 0.348 ± 0.013	0.317TrpTyr: 0.317 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.5TyrAla: 2.5 ± 0.033	0.213TyrCys: 0.213 ± 0.009	1.304TyrAsp: 1.304 ± 0.025	1.045TyrGlu: 1.045 ± 0.022	0.734TyrPhe: 0.734 ± 0.017	2.019TyrGly: 2.019 ± 0.029	0.466TyrHis: 0.466 ± 0.013	0.596TyrIle: 0.596 ± 0.013	0.303TyrLys: 0.303 ± 0.01	2.509TyrLeu: 2.509 ± 0.03	0.256TyrMet: 0.256 ± 0.01	0.429TyrAsn: 0.429 ± 0.013	1.274TyrPro: 1.274 ± 0.024	0.715TyrGln: 0.715 ± 0.017	2.069TyrArg: 2.069 ± 0.027	1.096TyrSer: 1.096 ± 0.02	1.238TyrThr: 1.238 ± 0.022	1.565TyrVal: 1.565 ± 0.031	0.399TyrTrp: 0.399 ± 0.013	0.488TyrTyr: 0.488 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8414 proteins (2750564 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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