Amino acid dipepetide frequency for Varunaivibrio sulfuroxidans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.157AlaAla: 14.157 ± 0.199
1.296AlaCys: 1.296 ± 0.034
6.161AlaAsp: 6.161 ± 0.09
5.757AlaGlu: 5.757 ± 0.101
4.323AlaPhe: 4.323 ± 0.073
9.059AlaGly: 9.059 ± 0.121
2.8AlaHis: 2.8 ± 0.062
6.35AlaIle: 6.35 ± 0.09
4.47AlaLys: 4.47 ± 0.085
13.616AlaLeu: 13.616 ± 0.159
3.657AlaMet: 3.657 ± 0.065
2.869AlaAsn: 2.869 ± 0.054
6.014AlaPro: 6.014 ± 0.108
4.358AlaGln: 4.358 ± 0.069
9.478AlaArg: 9.478 ± 0.135
5.226AlaSer: 5.226 ± 0.073
5.2AlaThr: 5.2 ± 0.073
8.769AlaVal: 8.769 ± 0.118
1.344AlaTrp: 1.344 ± 0.035
2.772AlaTyr: 2.772 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
1.433CysAla: 1.433 ± 0.041
0.121CysCys: 0.121 ± 0.013
0.685CysAsp: 0.685 ± 0.03
0.507CysGlu: 0.507 ± 0.023
0.322CysPhe: 0.322 ± 0.017
0.932CysGly: 0.932 ± 0.036
0.29CysHis: 0.29 ± 0.023
0.425CysIle: 0.425 ± 0.022
0.256CysLys: 0.256 ± 0.018
0.799CysLeu: 0.799 ± 0.03
0.197CysMet: 0.197 ± 0.015
0.241CysAsn: 0.241 ± 0.018
0.587CysPro: 0.587 ± 0.031
0.251CysGln: 0.251 ± 0.016
0.715CysArg: 0.715 ± 0.031
0.434CysSer: 0.434 ± 0.024
0.469CysThr: 0.469 ± 0.026
0.777CysVal: 0.777 ± 0.037
0.113CysTrp: 0.113 ± 0.013
0.227CysTyr: 0.227 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
7.286AspAla: 7.286 ± 0.104
0.478AspCys: 0.478 ± 0.024
4.019AspAsp: 4.019 ± 0.081
3.429AspGlu: 3.429 ± 0.067
2.309AspPhe: 2.309 ± 0.056
5.632AspGly: 5.632 ± 0.118
1.367AspHis: 1.367 ± 0.043
3.987AspIle: 3.987 ± 0.078
2.197AspLys: 2.197 ± 0.056
5.807AspLeu: 5.807 ± 0.076
1.58AspMet: 1.58 ± 0.045
1.486AspAsn: 1.486 ± 0.04
3.288AspPro: 3.288 ± 0.06
1.478AspGln: 1.478 ± 0.04
3.687AspArg: 3.687 ± 0.066
2.231AspSer: 2.231 ± 0.05
2.958AspThr: 2.958 ± 0.073
4.865AspVal: 4.865 ± 0.087
0.839AspTrp: 0.839 ± 0.034
1.435AspTyr: 1.435 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
5.956GluAla: 5.956 ± 0.09
0.362GluCys: 0.362 ± 0.023
3.207GluAsp: 3.207 ± 0.072
3.016GluGlu: 3.016 ± 0.078
1.529GluPhe: 1.529 ± 0.039
4.21GluGly: 4.21 ± 0.061
1.264GluHis: 1.264 ± 0.04
3.659GluIle: 3.659 ± 0.071
3.011GluLys: 3.011 ± 0.06
4.301GluLeu: 4.301 ± 0.08
1.653GluMet: 1.653 ± 0.043
2.161GluAsn: 2.161 ± 0.054
1.854GluPro: 1.854 ± 0.055
1.761GluGln: 1.761 ± 0.046
4.596GluArg: 4.596 ± 0.088
2.262GluSer: 2.262 ± 0.054
3.518GluThr: 3.518 ± 0.071
3.501GluVal: 3.501 ± 0.063
0.496GluTrp: 0.496 ± 0.022
1.017GluTyr: 1.017 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
4.3PheAla: 4.3 ± 0.067
0.443PheCys: 0.443 ± 0.024
2.693PheAsp: 2.693 ± 0.056
2.046PheGlu: 2.046 ± 0.046
1.729PhePhe: 1.729 ± 0.057
3.194PheGly: 3.194 ± 0.067
0.765PheHis: 0.765 ± 0.028
1.974PheIle: 1.974 ± 0.047
1.313PheLys: 1.313 ± 0.037
3.607PheLeu: 3.607 ± 0.083
0.896PheMet: 0.896 ± 0.035
1.18PheAsn: 1.18 ± 0.038
1.621PhePro: 1.621 ± 0.042
1.001PheGln: 1.001 ± 0.037
1.94PheArg: 1.94 ± 0.044
2.612PheSer: 2.612 ± 0.054
2.166PheThr: 2.166 ± 0.055
2.782PheVal: 2.782 ± 0.061
0.531PheTrp: 0.531 ± 0.023
0.997PheTyr: 0.997 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
10.761GlyAla: 10.761 ± 0.13
0.974GlyCys: 0.974 ± 0.036
5.295GlyAsp: 5.295 ± 0.115
5.031GlyGlu: 5.031 ± 0.078
3.274GlyPhe: 3.274 ± 0.06
8.106GlyGly: 8.106 ± 0.141
1.893GlyHis: 1.893 ± 0.052
4.248GlyIle: 4.248 ± 0.077
3.692GlyLys: 3.692 ± 0.075
8.061GlyLeu: 8.061 ± 0.103
2.301GlyMet: 2.301 ± 0.053
2.045GlyAsn: 2.045 ± 0.082
3.072GlyPro: 3.072 ± 0.064
2.392GlyGln: 2.392 ± 0.05
6.004GlyArg: 6.004 ± 0.077
3.772GlySer: 3.772 ± 0.07
3.709GlyThr: 3.709 ± 0.075
7.491GlyVal: 7.491 ± 0.1
1.11GlyTrp: 1.11 ± 0.035
2.265GlyTyr: 2.265 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.345HisAla: 2.345 ± 0.049
0.271HisCys: 0.271 ± 0.019
1.458HisAsp: 1.458 ± 0.042
1.131HisGlu: 1.131 ± 0.037
0.947HisPhe: 0.947 ± 0.036
2.14HisGly: 2.14 ± 0.05
0.626HisHis: 0.626 ± 0.03
1.265HisIle: 1.265 ± 0.041
0.761HisLys: 0.761 ± 0.026
2.211HisLeu: 2.211 ± 0.046
0.547HisMet: 0.547 ± 0.025
0.639HisAsn: 0.639 ± 0.032
1.499HisPro: 1.499 ± 0.045
0.606HisGln: 0.606 ± 0.028
1.534HisArg: 1.534 ± 0.046
0.88HisSer: 0.88 ± 0.033
1.034HisThr: 1.034 ± 0.037
1.56HisVal: 1.56 ± 0.043
0.311HisTrp: 0.311 ± 0.02
0.626HisTyr: 0.626 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
7.667IleAla: 7.667 ± 0.104
0.512IleCys: 0.512 ± 0.025
4.154IleAsp: 4.154 ± 0.077
3.465IleGlu: 3.465 ± 0.071
2.074IlePhe: 2.074 ± 0.056
5.048IleGly: 5.048 ± 0.085
1.042IleHis: 1.042 ± 0.036
2.574IleIle: 2.574 ± 0.065
2.026IleLys: 2.026 ± 0.052
5.065IleLeu: 5.065 ± 0.08
1.123IleMet: 1.123 ± 0.041
1.632IleAsn: 1.632 ± 0.049
2.614IlePro: 2.614 ± 0.057
1.329IleGln: 1.329 ± 0.042
2.958IleArg: 2.958 ± 0.058
3.275IleSer: 3.275 ± 0.06
2.907IleThr: 2.907 ± 0.059
4.514IleVal: 4.514 ± 0.085
0.529IleTrp: 0.529 ± 0.026
1.206IleTyr: 1.206 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
4.489LysAla: 4.489 ± 0.084
0.274LysCys: 0.274 ± 0.018
2.372LysAsp: 2.372 ± 0.062
1.994LysGlu: 1.994 ± 0.053
1.07LysPhe: 1.07 ± 0.036
3.354LysGly: 3.354 ± 0.067
0.77LysHis: 0.77 ± 0.03
2.761LysIle: 2.761 ± 0.061
2.491LysLys: 2.491 ± 0.066
3.186LysLeu: 3.186 ± 0.066
1.172LysMet: 1.172 ± 0.039
1.688LysAsn: 1.688 ± 0.048
2.007LysPro: 2.007 ± 0.062
1.024LysGln: 1.024 ± 0.035
2.726LysArg: 2.726 ± 0.055
2.281LysSer: 2.281 ± 0.055
2.869LysThr: 2.869 ± 0.055
2.835LysVal: 2.835 ± 0.062
0.44LysTrp: 0.44 ± 0.021
0.839LysTyr: 0.839 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
11.47LeuAla: 11.47 ± 0.141
1.053LeuCys: 1.053 ± 0.033
6.244LeuAsp: 6.244 ± 0.105
5.227LeuGlu: 5.227 ± 0.082
3.749LeuPhe: 3.749 ± 0.084
8.791LeuGly: 8.791 ± 0.1
1.902LeuHis: 1.902 ± 0.049
5.387LeuIle: 5.387 ± 0.083
4.562LeuLys: 4.562 ± 0.07
8.687LeuLeu: 8.687 ± 0.122
2.402LeuMet: 2.402 ± 0.057
3.165LeuAsn: 3.165 ± 0.065
4.709LeuPro: 4.709 ± 0.078
2.303LeuGln: 2.303 ± 0.052
6.483LeuArg: 6.483 ± 0.097
6.995LeuSer: 6.995 ± 0.095
5.189LeuThr: 5.189 ± 0.08
6.413LeuVal: 6.413 ± 0.1
1.072LeuTrp: 1.072 ± 0.04
2.18LeuTyr: 2.18 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
3.303MetAla: 3.303 ± 0.063
0.194MetCys: 0.194 ± 0.015
1.444MetAsp: 1.444 ± 0.045
1.169MetGlu: 1.169 ± 0.037
0.857MetPhe: 0.857 ± 0.035
2.136MetGly: 2.136 ± 0.049
0.541MetHis: 0.541 ± 0.024
1.595MetIle: 1.595 ± 0.048
1.136MetLys: 1.136 ± 0.041
2.283MetLeu: 2.283 ± 0.056
0.774MetMet: 0.774 ± 0.034
0.971MetAsn: 0.971 ± 0.037
1.267MetPro: 1.267 ± 0.038
0.679MetGln: 0.679 ± 0.025
1.728MetArg: 1.728 ± 0.044
1.748MetSer: 1.748 ± 0.042
1.956MetThr: 1.956 ± 0.047
1.99MetVal: 1.99 ± 0.052
0.241MetTrp: 0.241 ± 0.018
0.415MetTyr: 0.415 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.695AsnAla: 3.695 ± 0.065
0.287AsnCys: 0.287 ± 0.019
1.673AsnAsp: 1.673 ± 0.077
1.322AsnGlu: 1.322 ± 0.049
1.131AsnPhe: 1.131 ± 0.04
2.311AsnGly: 2.311 ± 0.057
0.617AsnHis: 0.617 ± 0.028
1.831AsnIle: 1.831 ± 0.041
1.02AsnLys: 1.02 ± 0.037
2.901AsnLeu: 2.901 ± 0.066
0.725AsnMet: 0.725 ± 0.03
0.761AsnAsn: 0.761 ± 0.035
1.889AsnPro: 1.889 ± 0.045
0.693AsnGln: 0.693 ± 0.027
1.845AsnArg: 1.845 ± 0.045
1.145AsnSer: 1.145 ± 0.038
1.608AsnThr: 1.608 ± 0.041
2.194AsnVal: 2.194 ± 0.044
0.366AsnTrp: 0.366 ± 0.019
0.659AsnTyr: 0.659 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
5.021ProAla: 5.021 ± 0.084
0.422ProCys: 0.422 ± 0.023
3.4ProAsp: 3.4 ± 0.062
3.331ProGlu: 3.331 ± 0.057
2.008ProPhe: 2.008 ± 0.048
4.266ProGly: 4.266 ± 0.074
1.146ProHis: 1.146 ± 0.037
2.334ProIle: 2.334 ± 0.056
2.012ProLys: 2.012 ± 0.062
4.7ProLeu: 4.7 ± 0.073
1.224ProMet: 1.224 ± 0.037
1.276ProAsn: 1.276 ± 0.038
2.892ProPro: 2.892 ± 0.084
1.582ProGln: 1.582 ± 0.041
2.915ProArg: 2.915 ± 0.059
2.921ProSer: 2.921 ± 0.065
2.637ProThr: 2.637 ± 0.057
3.602ProVal: 3.602 ± 0.065
0.658ProTrp: 0.658 ± 0.026
1.267ProTyr: 1.267 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
3.395GlnAla: 3.395 ± 0.075
0.275GlnCys: 0.275 ± 0.018
1.588GlnAsp: 1.588 ± 0.037
1.397GlnGlu: 1.397 ± 0.041
0.906GlnPhe: 0.906 ± 0.035
2.576GlnGly: 2.576 ± 0.069
0.566GlnHis: 0.566 ± 0.027
1.799GlnIle: 1.799 ± 0.043
1.411GlnLys: 1.411 ± 0.044
2.265GlnLeu: 2.265 ± 0.053
0.832GlnMet: 0.832 ± 0.03
1.053GlnAsn: 1.053 ± 0.035
1.247GlnPro: 1.247 ± 0.041
0.867GlnGln: 0.867 ± 0.035
2.002GlnArg: 2.002 ± 0.049
1.795GlnSer: 1.795 ± 0.046
1.783GlnThr: 1.783 ± 0.047
2.056GlnVal: 2.056 ± 0.045
0.392GlnTrp: 0.392 ± 0.02
0.602GlnTyr: 0.602 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
8.536ArgAla: 8.536 ± 0.131
0.547ArgCys: 0.547 ± 0.027
4.253ArgAsp: 4.253 ± 0.068
4.081ArgGlu: 4.081 ± 0.068
2.724ArgPhe: 2.724 ± 0.06
4.947ArgGly: 4.947 ± 0.085
1.99ArgHis: 1.99 ± 0.049
3.897ArgIle: 3.897 ± 0.056
2.684ArgLys: 2.684 ± 0.061
7.423ArgLeu: 7.423 ± 0.097
1.792ArgMet: 1.792 ± 0.043
1.721ArgAsn: 1.721 ± 0.049
3.294ArgPro: 3.294 ± 0.069
2.285ArgGln: 2.285 ± 0.053
5.862ArgArg: 5.862 ± 0.093
2.917ArgSer: 2.917 ± 0.051
3.465ArgThr: 3.465 ± 0.064
4.883ArgVal: 4.883 ± 0.076
0.805ArgTrp: 0.805 ± 0.027
1.666ArgTyr: 1.666 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
6.235SerAla: 6.235 ± 0.096
0.565SerCys: 0.565 ± 0.026
2.922SerAsp: 2.922 ± 0.066
2.697SerGlu: 2.697 ± 0.057
1.976SerPhe: 1.976 ± 0.047
5.422SerGly: 5.422 ± 0.092
1.177SerHis: 1.177 ± 0.037
2.532SerIle: 2.532 ± 0.053
1.859SerLys: 1.859 ± 0.047
4.989SerLeu: 4.989 ± 0.078
1.358SerMet: 1.358 ± 0.047
1.31SerAsn: 1.31 ± 0.041
2.883SerPro: 2.883 ± 0.068
1.548SerGln: 1.548 ± 0.041
3.464SerArg: 3.464 ± 0.075
2.907SerSer: 2.907 ± 0.071
2.531SerThr: 2.531 ± 0.059
3.827SerVal: 3.827 ± 0.064
0.721SerTrp: 0.721 ± 0.026
1.203SerTyr: 1.203 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
5.682ThrAla: 5.682 ± 0.085
0.482ThrCys: 0.482 ± 0.024
2.501ThrAsp: 2.501 ± 0.06
2.188ThrGlu: 2.188 ± 0.058
2.203ThrPhe: 2.203 ± 0.059
4.386ThrGly: 4.386 ± 0.074
1.186ThrHis: 1.186 ± 0.036
2.851ThrIle: 2.851 ± 0.053
1.743ThrLys: 1.743 ± 0.044
6.325ThrLeu: 6.325 ± 0.09
1.246ThrMet: 1.246 ± 0.038
1.263ThrAsn: 1.263 ± 0.041
3.922ThrPro: 3.922 ± 0.07
1.68ThrGln: 1.68 ± 0.04
3.193ThrArg: 3.193 ± 0.053
2.63ThrSer: 2.63 ± 0.059
2.877ThrThr: 2.877 ± 0.069
4.486ThrVal: 4.486 ± 0.066
0.618ThrTrp: 0.618 ± 0.028
1.257ThrTyr: 1.257 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
8.332ValAla: 8.332 ± 0.099
0.814ValCys: 0.814 ± 0.03
4.226ValAsp: 4.226 ± 0.072
4.033ValGlu: 4.033 ± 0.073
3.197ValPhe: 3.197 ± 0.067
5.919ValGly: 5.919 ± 0.085
1.683ValHis: 1.683 ± 0.049
4.475ValIle: 4.475 ± 0.074
2.766ValLys: 2.766 ± 0.059
7.927ValLeu: 7.927 ± 0.102
2.01ValMet: 2.01 ± 0.047
2.17ValAsn: 2.17 ± 0.055
3.235ValPro: 3.235 ± 0.054
1.938ValGln: 1.938 ± 0.05
5.534ValArg: 5.534 ± 0.096
4.357ValSer: 4.357 ± 0.071
4.046ValThr: 4.046 ± 0.074
6.333ValVal: 6.333 ± 0.11
0.87ValTrp: 0.87 ± 0.034
1.622ValTyr: 1.622 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
1.134TrpAla: 1.134 ± 0.037
0.142TrpCys: 0.142 ± 0.012
0.654TrpAsp: 0.654 ± 0.031
0.475TrpGlu: 0.475 ± 0.024
0.454TrpPhe: 0.454 ± 0.024
0.875TrpGly: 0.875 ± 0.031
0.205TrpHis: 0.205 ± 0.017
0.662TrpIle: 0.662 ± 0.029
0.464TrpLys: 0.464 ± 0.026
1.361TrpLeu: 1.361 ± 0.04
0.353TrpMet: 0.353 ± 0.018
0.391TrpAsn: 0.391 ± 0.021
0.603TrpPro: 0.603 ± 0.025
0.355TrpGln: 0.355 ± 0.021
1.243TrpArg: 1.243 ± 0.034
0.643TrpSer: 0.643 ± 0.025
0.647TrpThr: 0.647 ± 0.029
0.849TrpVal: 0.849 ± 0.034
0.179TrpTrp: 0.179 ± 0.014
0.289TrpTyr: 0.289 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.481TyrAla: 2.481 ± 0.053
0.271TyrCys: 0.271 ± 0.019
1.409TyrAsp: 1.409 ± 0.039
1.037TyrGlu: 1.037 ± 0.04
1.009TyrPhe: 1.009 ± 0.036
2.191TyrGly: 2.191 ± 0.047
0.56TyrHis: 0.56 ± 0.025
1.108TyrIle: 1.108 ± 0.035
0.764TyrLys: 0.764 ± 0.027
2.472TyrLeu: 2.472 ± 0.056
0.583TyrMet: 0.583 ± 0.024
0.652TyrAsn: 0.652 ± 0.028
1.115TyrPro: 1.115 ± 0.036
0.679TyrGln: 0.679 ± 0.029
1.865TyrArg: 1.865 ± 0.047
1.095TyrSer: 1.095 ± 0.034
1.149TyrThr: 1.149 ± 0.04
1.762TyrVal: 1.762 ± 0.047
0.342TyrTrp: 0.342 ± 0.02
0.688TyrTyr: 0.688 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2811 proteins (887076 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski