Amino acid dipepetide frequency for Shinella zoogloeoides (Crabtreella saccharophila)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.628AlaAla: 17.628 ± 0.204	0.985AlaCys: 0.985 ± 0.027	7.108AlaAsp: 7.108 ± 0.084	8.27AlaGlu: 8.27 ± 0.102	4.845AlaPhe: 4.845 ± 0.067	11.433AlaGly: 11.433 ± 0.14	2.256AlaHis: 2.256 ± 0.041	6.821AlaIle: 6.821 ± 0.073	4.262AlaLys: 4.262 ± 0.069	13.487AlaLeu: 13.487 ± 0.167	3.607AlaMet: 3.607 ± 0.06	2.988AlaAsn: 2.988 ± 0.047	4.966AlaPro: 4.966 ± 0.07	3.444AlaGln: 3.444 ± 0.065	8.653AlaArg: 8.653 ± 0.112	6.396AlaSer: 6.396 ± 0.071	5.996AlaThr: 5.996 ± 0.062	9.018AlaVal: 9.018 ± 0.079	1.363AlaTrp: 1.363 ± 0.032	2.613AlaTyr: 2.613 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.84CysAla: 0.84 ± 0.026	0.103CysCys: 0.103 ± 0.009	0.493CysAsp: 0.493 ± 0.02	0.447CysGlu: 0.447 ± 0.019	0.299CysPhe: 0.299 ± 0.014	0.839CysGly: 0.839 ± 0.03	0.211CysHis: 0.211 ± 0.013	0.411CysIle: 0.411 ± 0.018	0.197CysLys: 0.197 ± 0.012	0.767CysLeu: 0.767 ± 0.026	0.15CysMet: 0.15 ± 0.011	0.18CysAsn: 0.18 ± 0.011	0.404CysPro: 0.404 ± 0.02	0.206CysGln: 0.206 ± 0.012	0.591CysArg: 0.591 ± 0.024	0.402CysSer: 0.402 ± 0.018	0.403CysThr: 0.403 ± 0.016	0.534CysVal: 0.534 ± 0.018	0.103CysTrp: 0.103 ± 0.009	0.2CysTyr: 0.2 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.906AspAla: 6.906 ± 0.082	0.476AspCys: 0.476 ± 0.019	3.094AspAsp: 3.094 ± 0.065	3.571AspGlu: 3.571 ± 0.057	2.332AspPhe: 2.332 ± 0.044	5.306AspGly: 5.306 ± 0.07	1.264AspHis: 1.264 ± 0.033	3.414AspIle: 3.414 ± 0.054	1.824AspLys: 1.824 ± 0.051	5.813AspLeu: 5.813 ± 0.073	1.494AspMet: 1.494 ± 0.036	1.365AspAsn: 1.365 ± 0.033	3.229AspPro: 3.229 ± 0.046	1.527AspGln: 1.527 ± 0.035	4.328AspArg: 4.328 ± 0.067	1.954AspSer: 1.954 ± 0.038	2.676AspThr: 2.676 ± 0.055	4.108AspVal: 4.108 ± 0.061	0.929AspTrp: 0.929 ± 0.027	1.556AspTyr: 1.556 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	8.265GluAla: 8.265 ± 0.104	0.356GluCys: 0.356 ± 0.016	3.071GluAsp: 3.071 ± 0.054	3.781GluGlu: 3.781 ± 0.069	1.806GluPhe: 1.806 ± 0.036	4.765GluGly: 4.765 ± 0.062	1.189GluHis: 1.189 ± 0.031	3.794GluIle: 3.794 ± 0.054	2.894GluLys: 2.894 ± 0.055	5.033GluLeu: 5.033 ± 0.069	1.567GluMet: 1.567 ± 0.032	1.874GluAsn: 1.874 ± 0.034	2.691GluPro: 2.691 ± 0.051	1.972GluGln: 1.972 ± 0.045	5.093GluArg: 5.093 ± 0.066	2.316GluSer: 2.316 ± 0.045	4.05GluThr: 4.05 ± 0.058	3.702GluVal: 3.702 ± 0.057	0.698GluTrp: 0.698 ± 0.024	1.002GluTyr: 1.002 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.641PheAla: 4.641 ± 0.064	0.412PheCys: 0.412 ± 0.018	2.679PheAsp: 2.679 ± 0.04	2.194PheGlu: 2.194 ± 0.037	1.491PhePhe: 1.491 ± 0.033	3.667PheGly: 3.667 ± 0.057	0.731PheHis: 0.731 ± 0.023	1.763PheIle: 1.763 ± 0.04	1.083PheLys: 1.083 ± 0.028	3.684PheLeu: 3.684 ± 0.061	0.884PheMet: 0.884 ± 0.026	1.085PheAsn: 1.085 ± 0.03	1.576PhePro: 1.576 ± 0.033	1.054PheGln: 1.054 ± 0.028	2.374PheArg: 2.374 ± 0.046	2.435PheSer: 2.435 ± 0.049	2.06PheThr: 2.06 ± 0.046	2.94PheVal: 2.94 ± 0.049	0.524PheTrp: 0.524 ± 0.022	0.925PheTyr: 0.925 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.308GlyAla: 9.308 ± 0.117	0.766GlyCys: 0.766 ± 0.025	4.526GlyAsp: 4.526 ± 0.068	5.294GlyGlu: 5.294 ± 0.062	3.696GlyPhe: 3.696 ± 0.057	7.448GlyGly: 7.448 ± 0.124	1.81GlyHis: 1.81 ± 0.043	5.012GlyIle: 5.012 ± 0.071	3.766GlyLys: 3.766 ± 0.066	8.955GlyLeu: 8.955 ± 0.092	2.367GlyMet: 2.367 ± 0.042	2.391GlyAsn: 2.391 ± 0.062	3.175GlyPro: 3.175 ± 0.046	2.555GlyGln: 2.555 ± 0.041	6.263GlyArg: 6.263 ± 0.079	4.39GlySer: 4.39 ± 0.071	4.679GlyThr: 4.679 ± 0.084	6.067GlyVal: 6.067 ± 0.069	1.307GlyTrp: 1.307 ± 0.036	2.299GlyTyr: 2.299 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.415HisAla: 2.415 ± 0.047	0.224HisCys: 0.224 ± 0.014	1.229HisAsp: 1.229 ± 0.034	1.085HisGlu: 1.085 ± 0.029	0.866HisPhe: 0.866 ± 0.024	1.886HisGly: 1.886 ± 0.039	0.523HisHis: 0.523 ± 0.025	0.991HisIle: 0.991 ± 0.026	0.513HisLys: 0.513 ± 0.023	1.941HisLeu: 1.941 ± 0.042	0.507HisMet: 0.507 ± 0.018	0.471HisAsn: 0.471 ± 0.019	1.222HisPro: 1.222 ± 0.03	0.535HisGln: 0.535 ± 0.018	1.435HisArg: 1.435 ± 0.036	0.915HisSer: 0.915 ± 0.023	0.775HisThr: 0.775 ± 0.026	1.54HisVal: 1.54 ± 0.036	0.282HisTrp: 0.282 ± 0.015	0.545HisTyr: 0.545 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.933IleAla: 7.933 ± 0.091	0.489IleCys: 0.489 ± 0.019	3.819IleAsp: 3.819 ± 0.05	3.703IleGlu: 3.703 ± 0.062	1.806IlePhe: 1.806 ± 0.037	5.138IleGly: 5.138 ± 0.07	0.938IleHis: 0.938 ± 0.028	2.258IleIle: 2.258 ± 0.04	1.502IleLys: 1.502 ± 0.037	4.769IleLeu: 4.769 ± 0.069	1.009IleMet: 1.009 ± 0.031	1.49IleAsn: 1.49 ± 0.036	2.334IlePro: 2.334 ± 0.041	1.16IleGln: 1.16 ± 0.029	3.587IleArg: 3.587 ± 0.053	2.92IleSer: 2.92 ± 0.05	2.678IleThr: 2.678 ± 0.042	4.609IleVal: 4.609 ± 0.066	0.59IleTrp: 0.59 ± 0.025	1.151IleTyr: 1.151 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	5.032LysAla: 5.032 ± 0.08	0.15LysCys: 0.15 ± 0.01	2.016LysAsp: 2.016 ± 0.043	1.905LysGlu: 1.905 ± 0.043	0.92LysPhe: 0.92 ± 0.029	2.969LysGly: 2.969 ± 0.048	0.639LysHis: 0.639 ± 0.021	1.896LysIle: 1.896 ± 0.044	1.526LysLys: 1.526 ± 0.042	3.437LysLeu: 3.437 ± 0.052	0.827LysMet: 0.827 ± 0.026	0.982LysAsn: 0.982 ± 0.027	2.177LysPro: 2.177 ± 0.04	1.084LysGln: 1.084 ± 0.032	2.493LysArg: 2.493 ± 0.046	1.982LysSer: 1.982 ± 0.038	2.258LysThr: 2.258 ± 0.042	2.667LysVal: 2.667 ± 0.048	0.361LysTrp: 0.361 ± 0.02	0.658LysTyr: 0.658 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.544LeuAla: 13.544 ± 0.122	0.846LeuCys: 0.846 ± 0.025	5.986LeuAsp: 5.986 ± 0.068	5.363LeuGlu: 5.363 ± 0.065	3.799LeuPhe: 3.799 ± 0.064	8.016LeuGly: 8.016 ± 0.089	1.784LeuHis: 1.784 ± 0.041	4.836LeuIle: 4.836 ± 0.072	4.093LeuLys: 4.093 ± 0.062	9.302LeuLeu: 9.302 ± 0.112	2.355LeuMet: 2.355 ± 0.041	2.539LeuAsn: 2.539 ± 0.045	5.271LeuPro: 5.271 ± 0.072	2.547LeuGln: 2.547 ± 0.046	6.309LeuArg: 6.309 ± 0.07	6.78LeuSer: 6.78 ± 0.113	5.613LeuThr: 5.613 ± 0.09	7.528LeuVal: 7.528 ± 0.085	1.068LeuTrp: 1.068 ± 0.031	2.139LeuTyr: 2.139 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.26MetAla: 3.26 ± 0.051	0.141MetCys: 0.141 ± 0.011	1.166MetAsp: 1.166 ± 0.027	1.255MetGlu: 1.255 ± 0.028	0.683MetPhe: 0.683 ± 0.023	1.822MetGly: 1.822 ± 0.041	0.435MetHis: 0.435 ± 0.018	1.411MetIle: 1.411 ± 0.033	1.133MetLys: 1.133 ± 0.031	2.521MetLeu: 2.521 ± 0.041	0.668MetMet: 0.668 ± 0.024	0.829MetAsn: 0.829 ± 0.025	1.475MetPro: 1.475 ± 0.03	0.821MetGln: 0.821 ± 0.025	1.846MetArg: 1.846 ± 0.037	1.644MetSer: 1.644 ± 0.038	1.944MetThr: 1.944 ± 0.033	1.694MetVal: 1.694 ± 0.038	0.191MetTrp: 0.191 ± 0.013	0.286MetTyr: 0.286 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.318AsnAla: 3.318 ± 0.053	0.231AsnCys: 0.231 ± 0.013	1.483AsnAsp: 1.483 ± 0.036	1.354AsnGlu: 1.354 ± 0.036	0.953AsnPhe: 0.953 ± 0.029	2.666AsnGly: 2.666 ± 0.064	0.518AsnHis: 0.518 ± 0.019	1.43AsnIle: 1.43 ± 0.032	0.728AsnLys: 0.728 ± 0.024	2.573AsnLeu: 2.573 ± 0.046	0.65AsnMet: 0.65 ± 0.02	0.716AsnAsn: 0.716 ± 0.026	1.841AsnPro: 1.841 ± 0.04	0.729AsnGln: 0.729 ± 0.023	1.944AsnArg: 1.944 ± 0.044	1.195AsnSer: 1.195 ± 0.035	1.302AsnThr: 1.302 ± 0.031	2.007AsnVal: 2.007 ± 0.044	0.438AsnTrp: 0.438 ± 0.018	0.644AsnTyr: 0.644 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.177ProAla: 6.177 ± 0.085	0.289ProCys: 0.289 ± 0.014	3.368ProAsp: 3.368 ± 0.053	3.71ProGlu: 3.71 ± 0.055	2.018ProPhe: 2.018 ± 0.038	4.153ProGly: 4.153 ± 0.052	1.01ProHis: 1.01 ± 0.035	2.142ProIle: 2.142 ± 0.043	1.723ProLys: 1.723 ± 0.034	4.485ProLeu: 4.485 ± 0.053	1.129ProMet: 1.129 ± 0.032	1.243ProAsn: 1.243 ± 0.027	2.032ProPro: 2.032 ± 0.042	1.505ProGln: 1.505 ± 0.032	2.532ProArg: 2.532 ± 0.05	2.472ProSer: 2.472 ± 0.042	2.26ProThr: 2.26 ± 0.042	4.328ProVal: 4.328 ± 0.076	0.596ProTrp: 0.596 ± 0.021	1.152ProTyr: 1.152 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.711GlnAla: 3.711 ± 0.054	0.169GlnCys: 0.169 ± 0.011	1.29GlnAsp: 1.29 ± 0.029	1.539GlnGlu: 1.539 ± 0.035	1.002GlnPhe: 1.002 ± 0.028	2.062GlnGly: 2.062 ± 0.039	0.585GlnHis: 0.585 ± 0.021	1.81GlnIle: 1.81 ± 0.068	1.192GlnLys: 1.192 ± 0.03	2.631GlnLeu: 2.631 ± 0.047	0.829GlnMet: 0.829 ± 0.025	0.819GlnAsn: 0.819 ± 0.023	1.578GlnPro: 1.578 ± 0.035	1.113GlnGln: 1.113 ± 0.04	2.144GlnArg: 2.144 ± 0.044	1.649GlnSer: 1.649 ± 0.038	1.671GlnThr: 1.671 ± 0.04	2.064GlnVal: 2.064 ± 0.05	0.361GlnTrp: 0.361 ± 0.014	0.53GlnTyr: 0.53 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.7ArgAla: 7.7 ± 0.094	0.424ArgCys: 0.424 ± 0.016	4.007ArgAsp: 4.007 ± 0.058	4.267ArgGlu: 4.267 ± 0.065	2.974ArgPhe: 2.974 ± 0.057	4.632ArgGly: 4.632 ± 0.061	1.759ArgHis: 1.759 ± 0.038	4.208ArgIle: 4.208 ± 0.061	2.642ArgLys: 2.642 ± 0.046	7.727ArgLeu: 7.727 ± 0.09	1.905ArgMet: 1.905 ± 0.034	1.954ArgAsn: 1.954 ± 0.036	3.388ArgPro: 3.388 ± 0.054	2.558ArgGln: 2.558 ± 0.047	5.639ArgArg: 5.639 ± 0.084	3.609ArgSer: 3.609 ± 0.057	3.399ArgThr: 3.399 ± 0.052	4.453ArgVal: 4.453 ± 0.062	0.899ArgTrp: 0.899 ± 0.024	1.723ArgTyr: 1.723 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.19SerAla: 6.19 ± 0.079	0.376SerCys: 0.376 ± 0.017	2.91SerAsp: 2.91 ± 0.042	2.869SerGlu: 2.869 ± 0.045	2.271SerPhe: 2.271 ± 0.044	5.676SerGly: 5.676 ± 0.081	1.118SerHis: 1.118 ± 0.029	2.956SerIle: 2.956 ± 0.047	1.634SerLys: 1.634 ± 0.042	5.407SerLeu: 5.407 ± 0.065	1.313SerMet: 1.313 ± 0.031	1.385SerAsn: 1.385 ± 0.032	2.55SerPro: 2.55 ± 0.048	1.488SerGln: 1.488 ± 0.034	3.65SerArg: 3.65 ± 0.052	2.86SerSer: 2.86 ± 0.055	2.737SerThr: 2.737 ± 0.053	3.955SerVal: 3.955 ± 0.054	0.668SerTrp: 0.668 ± 0.024	1.273SerTyr: 1.273 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.442ThrAla: 6.442 ± 0.08	0.387ThrCys: 0.387 ± 0.018	2.904ThrAsp: 2.904 ± 0.051	2.731ThrGlu: 2.731 ± 0.049	2.159ThrPhe: 2.159 ± 0.044	5.294ThrGly: 5.294 ± 0.076	0.996ThrHis: 0.996 ± 0.03	3.112ThrIle: 3.112 ± 0.058	1.535ThrLys: 1.535 ± 0.039	5.842ThrLeu: 5.842 ± 0.064	1.3ThrMet: 1.3 ± 0.03	1.325ThrAsn: 1.325 ± 0.036	3.054ThrPro: 3.054 ± 0.056	1.325ThrGln: 1.325 ± 0.037	3.287ThrArg: 3.287 ± 0.054	2.698ThrSer: 2.698 ± 0.055	2.945ThrThr: 2.945 ± 0.06	4.803ThrVal: 4.803 ± 0.066	0.592ThrTrp: 0.592 ± 0.023	1.262ThrTyr: 1.262 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.305ValAla: 9.305 ± 0.1	0.583ValCys: 0.583 ± 0.019	4.018ValAsp: 4.018 ± 0.059	4.778ValGlu: 4.778 ± 0.072	2.848ValPhe: 2.848 ± 0.047	5.386ValGly: 5.386 ± 0.076	1.39ValHis: 1.39 ± 0.036	4.0ValIle: 4.0 ± 0.061	2.593ValLys: 2.593 ± 0.045	7.502ValLeu: 7.502 ± 0.077	1.839ValMet: 1.839 ± 0.036	2.03ValAsn: 2.03 ± 0.035	3.638ValPro: 3.638 ± 0.053	1.865ValGln: 1.865 ± 0.04	4.857ValArg: 4.857 ± 0.062	4.664ValSer: 4.664 ± 0.064	4.735ValThr: 4.735 ± 0.062	5.925ValVal: 5.925 ± 0.073	0.877ValTrp: 0.877 ± 0.027	1.511ValTyr: 1.511 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.134TrpAla: 1.134 ± 0.027	0.135TrpCys: 0.135 ± 0.01	0.562TrpAsp: 0.562 ± 0.021	0.54TrpGlu: 0.54 ± 0.023	0.512TrpPhe: 0.512 ± 0.021	0.782TrpGly: 0.782 ± 0.026	0.293TrpHis: 0.293 ± 0.014	0.628TrpIle: 0.628 ± 0.022	0.502TrpLys: 0.502 ± 0.018	1.544TrpLeu: 1.544 ± 0.041	0.347TrpMet: 0.347 ± 0.017	0.441TrpAsn: 0.441 ± 0.019	0.63TrpPro: 0.63 ± 0.022	0.563TrpGln: 0.563 ± 0.019	1.016TrpArg: 1.016 ± 0.029	0.77TrpSer: 0.77 ± 0.025	0.723TrpThr: 0.723 ± 0.026	0.757TrpVal: 0.757 ± 0.023	0.21TrpTrp: 0.21 ± 0.012	0.295TrpTyr: 0.295 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.392TyrAla: 2.392 ± 0.047	0.239TyrCys: 0.239 ± 0.013	1.435TyrAsp: 1.435 ± 0.036	1.262TyrGlu: 1.262 ± 0.031	0.92TyrPhe: 0.92 ± 0.029	2.133TyrGly: 2.133 ± 0.042	0.452TyrHis: 0.452 ± 0.018	0.99TyrIle: 0.99 ± 0.028	0.638TyrLys: 0.638 ± 0.025	2.296TyrLeu: 2.296 ± 0.039	0.477TyrMet: 0.477 ± 0.021	0.617TyrAsn: 0.617 ± 0.02	1.093TyrPro: 1.093 ± 0.03	0.696TyrGln: 0.696 ± 0.018	1.824TyrArg: 1.824 ± 0.038	1.237TyrSer: 1.237 ± 0.037	1.091TyrThr: 1.091 ± 0.031	1.644TyrVal: 1.644 ± 0.036	0.326TyrTrp: 0.326 ± 0.014	0.585TyrTyr: 0.585 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4498 proteins (1397387 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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