Amino acid dipepetide frequency for Microterricola viridarii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.517AlaAla: 22.517 ± 0.251	0.638AlaCys: 0.638 ± 0.029	7.734AlaAsp: 7.734 ± 0.099	9.027AlaGlu: 9.027 ± 0.115	3.933AlaPhe: 3.933 ± 0.066	13.091AlaGly: 13.091 ± 0.132	2.41AlaHis: 2.41 ± 0.051	6.282AlaIle: 6.282 ± 0.085	2.839AlaLys: 2.839 ± 0.061	15.376AlaLeu: 15.376 ± 0.164	2.744AlaMet: 2.744 ± 0.052	2.688AlaAsn: 2.688 ± 0.055	6.837AlaPro: 6.837 ± 0.123	4.207AlaGln: 4.207 ± 0.08	8.322AlaArg: 8.322 ± 0.106	7.999AlaSer: 7.999 ± 0.098	7.465AlaThr: 7.465 ± 0.109	11.717AlaVal: 11.717 ± 0.127	1.77AlaTrp: 1.77 ± 0.043	2.16AlaTyr: 2.16 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.677CysAla: 0.677 ± 0.025	0.047CysCys: 0.047 ± 0.007	0.292CysAsp: 0.292 ± 0.017	0.217CysGlu: 0.217 ± 0.013	0.185CysPhe: 0.185 ± 0.014	0.573CysGly: 0.573 ± 0.024	0.114CysHis: 0.114 ± 0.011	0.234CysIle: 0.234 ± 0.017	0.074CysLys: 0.074 ± 0.009	0.414CysLeu: 0.414 ± 0.02	0.096CysMet: 0.096 ± 0.009	0.124CysAsn: 0.124 ± 0.012	0.247CysPro: 0.247 ± 0.018	0.126CysGln: 0.126 ± 0.011	0.262CysArg: 0.262 ± 0.015	0.35CysSer: 0.35 ± 0.02	0.338CysThr: 0.338 ± 0.023	0.395CysVal: 0.395 ± 0.018	0.073CysTrp: 0.073 ± 0.009	0.115CysTyr: 0.115 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.658AspAla: 8.658 ± 0.109	0.25AspCys: 0.25 ± 0.017	3.273AspAsp: 3.273 ± 0.084	3.841AspGlu: 3.841 ± 0.068	1.813AspPhe: 1.813 ± 0.042	5.533AspGly: 5.533 ± 0.083	0.965AspHis: 0.965 ± 0.033	2.439AspIle: 2.439 ± 0.057	1.072AspLys: 1.072 ± 0.037	5.084AspLeu: 5.084 ± 0.068	0.862AspMet: 0.862 ± 0.028	1.116AspAsn: 1.116 ± 0.037	3.549AspPro: 3.549 ± 0.066	1.382AspGln: 1.382 ± 0.036	3.387AspArg: 3.387 ± 0.063	2.914AspSer: 2.914 ± 0.051	2.822AspThr: 2.822 ± 0.059	4.651AspVal: 4.651 ± 0.069	0.927AspTrp: 0.927 ± 0.035	1.357AspTyr: 1.357 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.891GluAla: 6.891 ± 0.09	0.202GluCys: 0.202 ± 0.014	2.202GluAsp: 2.202 ± 0.047	2.806GluGlu: 2.806 ± 0.064	1.847GluPhe: 1.847 ± 0.039	3.594GluGly: 3.594 ± 0.077	1.43GluHis: 1.43 ± 0.044	2.815GluIle: 2.815 ± 0.061	1.393GluLys: 1.393 ± 0.045	7.527GluLeu: 7.527 ± 0.103	1.049GluMet: 1.049 ± 0.03	1.355GluAsn: 1.355 ± 0.042	2.912GluPro: 2.912 ± 0.068	2.588GluGln: 2.588 ± 0.054	4.917GluArg: 4.917 ± 0.088	3.068GluSer: 3.068 ± 0.063	2.942GluThr: 2.942 ± 0.055	4.124GluVal: 4.124 ± 0.064	0.821GluTrp: 0.821 ± 0.028	1.16GluTyr: 1.16 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.532PheAla: 4.532 ± 0.076	0.194PheCys: 0.194 ± 0.015	2.364PheAsp: 2.364 ± 0.054	1.886PheGlu: 1.886 ± 0.041	1.138PhePhe: 1.138 ± 0.036	3.645PheGly: 3.645 ± 0.069	0.552PheHis: 0.552 ± 0.023	1.332PheIle: 1.332 ± 0.04	0.522PheLys: 0.522 ± 0.023	2.882PheLeu: 2.882 ± 0.063	0.516PheMet: 0.516 ± 0.023	0.855PheAsn: 0.855 ± 0.029	1.426PhePro: 1.426 ± 0.037	0.798PheGln: 0.798 ± 0.025	1.699PheArg: 1.699 ± 0.04	2.075PheSer: 2.075 ± 0.046	2.282PheThr: 2.282 ± 0.053	2.825PheVal: 2.825 ± 0.06	0.524PheTrp: 0.524 ± 0.026	0.721PheTyr: 0.721 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	11.384GlyAla: 11.384 ± 0.137	0.616GlyCys: 0.616 ± 0.029	4.615GlyAsp: 4.615 ± 0.067	4.855GlyGlu: 4.855 ± 0.07	3.498GlyPhe: 3.498 ± 0.054	7.874GlyGly: 7.874 ± 0.113	1.907GlyHis: 1.907 ± 0.051	5.135GlyIle: 5.135 ± 0.074	2.318GlyLys: 2.318 ± 0.059	9.151GlyLeu: 9.151 ± 0.116	2.0GlyMet: 2.0 ± 0.048	1.978GlyAsn: 1.978 ± 0.044	3.687GlyPro: 3.687 ± 0.057	2.795GlyGln: 2.795 ± 0.053	5.687GlyArg: 5.687 ± 0.08	5.818GlySer: 5.818 ± 0.09	5.776GlyThr: 5.776 ± 0.099	7.999GlyVal: 7.999 ± 0.093	1.625GlyTrp: 1.625 ± 0.043	2.252GlyTyr: 2.252 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.226HisAla: 2.226 ± 0.051	0.115HisCys: 0.115 ± 0.011	1.236HisAsp: 1.236 ± 0.037	1.15HisGlu: 1.15 ± 0.039	0.602HisPhe: 0.602 ± 0.022	2.039HisGly: 2.039 ± 0.044	0.487HisHis: 0.487 ± 0.025	0.74HisIle: 0.74 ± 0.027	0.302HisLys: 0.302 ± 0.016	1.824HisLeu: 1.824 ± 0.044	0.331HisMet: 0.331 ± 0.018	0.443HisAsn: 0.443 ± 0.02	1.38HisPro: 1.38 ± 0.042	0.508HisGln: 0.508 ± 0.023	1.389HisArg: 1.389 ± 0.037	1.145HisSer: 1.145 ± 0.03	1.046HisThr: 1.046 ± 0.034	1.471HisVal: 1.471 ± 0.036	0.298HisTrp: 0.298 ± 0.017	0.443HisTyr: 0.443 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.397IleAla: 7.397 ± 0.092	0.246IleCys: 0.246 ± 0.016	3.434IleAsp: 3.434 ± 0.06	2.982IleGlu: 2.982 ± 0.061	1.342IlePhe: 1.342 ± 0.042	5.047IleGly: 5.047 ± 0.077	0.708IleHis: 0.708 ± 0.03	2.004IleIle: 2.004 ± 0.052	0.922IleLys: 0.922 ± 0.034	3.792IleLeu: 3.792 ± 0.06	0.705IleMet: 0.705 ± 0.027	1.075IleAsn: 1.075 ± 0.032	2.354IlePro: 2.354 ± 0.05	1.019IleGln: 1.019 ± 0.033	2.509IleArg: 2.509 ± 0.049	2.605IleSer: 2.605 ± 0.051	3.002IleThr: 3.002 ± 0.053	4.809IleVal: 4.809 ± 0.078	0.576IleTrp: 0.576 ± 0.028	0.858IleTyr: 0.858 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	2.645LysAla: 2.645 ± 0.063	0.05LysCys: 0.05 ± 0.007	1.0LysAsp: 1.0 ± 0.041	0.92LysGlu: 0.92 ± 0.033	0.59LysPhe: 0.59 ± 0.026	1.531LysGly: 1.531 ± 0.046	0.519LysHis: 0.519 ± 0.023	0.977LysIle: 0.977 ± 0.036	0.819LysLys: 0.819 ± 0.037	2.28LysLeu: 2.28 ± 0.056	0.462LysMet: 0.462 ± 0.025	0.642LysAsn: 0.642 ± 0.028	1.367LysPro: 1.367 ± 0.038	0.837LysGln: 0.837 ± 0.031	1.571LysArg: 1.571 ± 0.036	1.228LysSer: 1.228 ± 0.036	1.369LysThr: 1.369 ± 0.044	1.675LysVal: 1.675 ± 0.047	0.24LysTrp: 0.24 ± 0.015	0.453LysTyr: 0.453 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	15.664LeuAla: 15.664 ± 0.154	0.581LeuCys: 0.581 ± 0.022	6.517LeuAsp: 6.517 ± 0.073	5.333LeuGlu: 5.333 ± 0.07	3.251LeuPhe: 3.251 ± 0.06	10.071LeuGly: 10.071 ± 0.116	1.892LeuHis: 1.892 ± 0.044	4.787LeuIle: 4.787 ± 0.088	1.946LeuLys: 1.946 ± 0.051	11.112LeuLeu: 11.112 ± 0.159	1.696LeuMet: 1.696 ± 0.04	2.252LeuAsn: 2.252 ± 0.046	5.722LeuPro: 5.722 ± 0.074	2.714LeuGln: 2.714 ± 0.056	6.915LeuArg: 6.915 ± 0.099	6.547LeuSer: 6.547 ± 0.086	6.133LeuThr: 6.133 ± 0.081	9.164LeuVal: 9.164 ± 0.118	1.269LeuTrp: 1.269 ± 0.038	1.67LeuTyr: 1.67 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.327MetAla: 2.327 ± 0.055	0.076MetCys: 0.076 ± 0.008	0.741MetAsp: 0.741 ± 0.024	0.662MetGlu: 0.662 ± 0.026	0.559MetPhe: 0.559 ± 0.026	1.299MetGly: 1.299 ± 0.037	0.378MetHis: 0.378 ± 0.021	0.932MetIle: 0.932 ± 0.029	0.493MetLys: 0.493 ± 0.022	2.208MetLeu: 2.208 ± 0.053	0.346MetMet: 0.346 ± 0.022	0.522MetAsn: 0.522 ± 0.021	1.208MetPro: 1.208 ± 0.035	0.64MetGln: 0.64 ± 0.023	1.292MetArg: 1.292 ± 0.04	1.516MetSer: 1.516 ± 0.042	1.567MetThr: 1.567 ± 0.038	1.428MetVal: 1.428 ± 0.041	0.196MetTrp: 0.196 ± 0.015	0.286MetTyr: 0.286 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.86AsnAla: 2.86 ± 0.058	0.133AsnCys: 0.133 ± 0.011	1.248AsnAsp: 1.248 ± 0.041	1.133AsnGlu: 1.133 ± 0.036	0.814AsnPhe: 0.814 ± 0.032	2.251AsnGly: 2.251 ± 0.052	0.412AsnHis: 0.412 ± 0.021	1.028AsnIle: 1.028 ± 0.032	0.557AsnLys: 0.557 ± 0.025	2.079AsnLeu: 2.079 ± 0.038	0.403AsnMet: 0.403 ± 0.019	0.58AsnAsn: 0.58 ± 0.025	1.767AsnPro: 1.767 ± 0.044	0.63AsnGln: 0.63 ± 0.025	1.377AsnArg: 1.377 ± 0.038	1.202AsnSer: 1.202 ± 0.035	1.406AsnThr: 1.406 ± 0.039	1.84AsnVal: 1.84 ± 0.044	0.356AsnTrp: 0.356 ± 0.019	0.574AsnTyr: 0.574 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.781ProAla: 7.781 ± 0.13	0.174ProCys: 0.174 ± 0.016	3.3ProAsp: 3.3 ± 0.058	3.667ProGlu: 3.667 ± 0.065	1.715ProPhe: 1.715 ± 0.052	5.079ProGly: 5.079 ± 0.076	1.034ProHis: 1.034 ± 0.035	2.226ProIle: 2.226 ± 0.045	1.067ProLys: 1.067 ± 0.037	4.989ProLeu: 4.989 ± 0.072	0.884ProMet: 0.884 ± 0.028	1.202ProAsn: 1.202 ± 0.039	2.044ProPro: 2.044 ± 0.057	1.568ProGln: 1.568 ± 0.045	2.967ProArg: 2.967 ± 0.057	3.113ProSer: 3.113 ± 0.06	3.191ProThr: 3.191 ± 0.062	4.783ProVal: 4.783 ± 0.081	0.83ProTrp: 0.83 ± 0.025	0.983ProTyr: 0.983 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.017GlnAla: 4.017 ± 0.057	0.107GlnCys: 0.107 ± 0.01	1.132GlnAsp: 1.132 ± 0.037	1.198GlnGlu: 1.198 ± 0.036	0.983GlnPhe: 0.983 ± 0.034	2.223GlnGly: 2.223 ± 0.052	0.666GlnHis: 0.666 ± 0.025	1.622GlnIle: 1.622 ± 0.044	0.705GlnLys: 0.705 ± 0.028	3.655GlnLeu: 3.655 ± 0.056	0.625GlnMet: 0.625 ± 0.026	0.805GlnAsn: 0.805 ± 0.026	1.675GlnPro: 1.675 ± 0.048	1.278GlnGln: 1.278 ± 0.041	2.402GlnArg: 2.402 ± 0.049	1.728GlnSer: 1.728 ± 0.047	1.593GlnThr: 1.593 ± 0.037	2.247GlnVal: 2.247 ± 0.055	0.448GlnTrp: 0.448 ± 0.024	0.618GlnTyr: 0.618 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.449ArgAla: 8.449 ± 0.112	0.288ArgCys: 0.288 ± 0.017	3.438ArgAsp: 3.438 ± 0.068	3.796ArgGlu: 3.796 ± 0.071	2.311ArgPhe: 2.311 ± 0.049	5.119ArgGly: 5.119 ± 0.08	1.354ArgHis: 1.354 ± 0.04	3.143ArgIle: 3.143 ± 0.062	1.312ArgLys: 1.312 ± 0.043	6.701ArgLeu: 6.701 ± 0.1	1.587ArgMet: 1.587 ± 0.042	1.349ArgAsn: 1.349 ± 0.037	3.208ArgPro: 3.208 ± 0.067	1.971ArgGln: 1.971 ± 0.049	5.176ArgArg: 5.176 ± 0.082	3.782ArgSer: 3.782 ± 0.064	3.676ArgThr: 3.676 ± 0.062	5.445ArgVal: 5.445 ± 0.079	1.067ArgTrp: 1.067 ± 0.034	1.464ArgTyr: 1.464 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	8.061SerAla: 8.061 ± 0.102	0.321SerCys: 0.321 ± 0.022	3.269SerAsp: 3.269 ± 0.054	2.967SerGlu: 2.967 ± 0.061	2.082SerPhe: 2.082 ± 0.048	6.268SerGly: 6.268 ± 0.09	1.05SerHis: 1.05 ± 0.031	2.786SerIle: 2.786 ± 0.055	1.257SerLys: 1.257 ± 0.043	5.677SerLeu: 5.677 ± 0.084	1.239SerMet: 1.239 ± 0.043	1.345SerAsn: 1.345 ± 0.037	3.041SerPro: 3.041 ± 0.054	1.463SerGln: 1.463 ± 0.04	3.475SerArg: 3.475 ± 0.064	3.609SerSer: 3.609 ± 0.068	3.907SerThr: 3.907 ± 0.063	4.97SerVal: 4.97 ± 0.078	0.951SerTrp: 0.951 ± 0.03	1.417SerTyr: 1.417 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	8.136ThrAla: 8.136 ± 0.119	0.236ThrCys: 0.236 ± 0.014	3.241ThrAsp: 3.241 ± 0.056	3.127ThrGlu: 3.127 ± 0.064	1.816ThrPhe: 1.816 ± 0.046	5.744ThrGly: 5.744 ± 0.084	1.045ThrHis: 1.045 ± 0.035	2.954ThrIle: 2.954 ± 0.056	1.184ThrLys: 1.184 ± 0.039	6.564ThrLeu: 6.564 ± 0.088	0.986ThrMet: 0.986 ± 0.03	1.251ThrAsn: 1.251 ± 0.035	3.984ThrPro: 3.984 ± 0.069	1.516ThrGln: 1.516 ± 0.04	3.394ThrArg: 3.394 ± 0.063	3.272ThrSer: 3.272 ± 0.064	3.587ThrThr: 3.587 ± 0.071	5.972ThrVal: 5.972 ± 0.095	0.669ThrTrp: 0.669 ± 0.029	0.853ThrTyr: 0.853 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	11.482ValAla: 11.482 ± 0.126	0.466ValCys: 0.466 ± 0.022	5.038ValAsp: 5.038 ± 0.084	4.434ValGlu: 4.434 ± 0.071	2.972ValPhe: 2.972 ± 0.063	6.942ValGly: 6.942 ± 0.093	1.62ValHis: 1.62 ± 0.042	4.538ValIle: 4.538 ± 0.074	1.641ValLys: 1.641 ± 0.041	9.862ValLeu: 9.862 ± 0.118	1.533ValMet: 1.533 ± 0.037	2.124ValAsn: 2.124 ± 0.053	4.463ValPro: 4.463 ± 0.063	2.485ValGln: 2.485 ± 0.046	5.389ValArg: 5.389 ± 0.078	5.109ValSer: 5.109 ± 0.078	5.45ValThr: 5.45 ± 0.081	7.986ValVal: 7.986 ± 0.101	1.065ValTrp: 1.065 ± 0.032	1.501ValTyr: 1.501 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.663TrpAla: 1.663 ± 0.04	0.096TrpCys: 0.096 ± 0.01	0.651TrpAsp: 0.651 ± 0.025	0.579TrpGlu: 0.579 ± 0.024	0.564TrpPhe: 0.564 ± 0.023	1.129TrpGly: 1.129 ± 0.033	0.337TrpHis: 0.337 ± 0.019	0.644TrpIle: 0.644 ± 0.031	0.33TrpLys: 0.33 ± 0.019	1.871TrpLeu: 1.871 ± 0.051	0.342TrpMet: 0.342 ± 0.021	0.426TrpAsn: 0.426 ± 0.022	0.726TrpPro: 0.726 ± 0.029	0.612TrpGln: 0.612 ± 0.026	1.031TrpArg: 1.031 ± 0.036	0.88TrpSer: 0.88 ± 0.032	0.767TrpThr: 0.767 ± 0.031	1.13TrpVal: 1.13 ± 0.035	0.317TrpTrp: 0.317 ± 0.019	0.27TrpTyr: 0.27 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.387TyrAla: 2.387 ± 0.049	0.12TyrCys: 0.12 ± 0.01	1.169TyrAsp: 1.169 ± 0.039	1.063TyrGlu: 1.063 ± 0.036	0.756TyrPhe: 0.756 ± 0.025	1.919TyrGly: 1.919 ± 0.044	0.296TyrHis: 0.296 ± 0.016	0.768TyrIle: 0.768 ± 0.031	0.42TyrLys: 0.42 ± 0.02	2.186TyrLeu: 2.186 ± 0.049	0.27TyrMet: 0.27 ± 0.016	0.517TyrAsn: 0.517 ± 0.021	1.004TyrPro: 1.004 ± 0.033	0.588TyrGln: 0.588 ± 0.025	1.472TyrArg: 1.472 ± 0.043	1.196TyrSer: 1.196 ± 0.033	1.212TyrThr: 1.212 ± 0.036	1.467TyrVal: 1.467 ± 0.036	0.343TyrTrp: 0.343 ± 0.018	0.452TyrTyr: 0.452 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3119 proteins (1022284 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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