Amino acid dipepetide frequency for Massilia albidiflava

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.959AlaAla: 19.959 ± 0.17	1.275AlaCys: 1.275 ± 0.028	7.002AlaAsp: 7.002 ± 0.07	6.523AlaGlu: 6.523 ± 0.062	4.16AlaPhe: 4.16 ± 0.049	12.366AlaGly: 12.366 ± 0.129	2.578AlaHis: 2.578 ± 0.041	5.689AlaIle: 5.689 ± 0.06	3.518AlaLys: 3.518 ± 0.057	14.533AlaLeu: 14.533 ± 0.136	3.384AlaMet: 3.384 ± 0.045	3.316AlaAsn: 3.316 ± 0.042	6.729AlaPro: 6.729 ± 0.072	5.306AlaGln: 5.306 ± 0.068	9.223AlaArg: 9.223 ± 0.09	6.773AlaSer: 6.773 ± 0.059	6.702AlaThr: 6.702 ± 0.066	8.986AlaVal: 8.986 ± 0.081	1.915AlaTrp: 1.915 ± 0.037	2.677AlaTyr: 2.677 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.183CysAla: 1.183 ± 0.026	0.132CysCys: 0.132 ± 0.008	0.502CysAsp: 0.502 ± 0.013	0.398CysGlu: 0.398 ± 0.014	0.281CysPhe: 0.281 ± 0.011	0.878CysGly: 0.878 ± 0.02	0.232CysHis: 0.232 ± 0.011	0.383CysIle: 0.383 ± 0.013	0.2CysLys: 0.2 ± 0.01	0.779CysLeu: 0.779 ± 0.019	0.18CysMet: 0.18 ± 0.009	0.218CysAsn: 0.218 ± 0.01	0.391CysPro: 0.391 ± 0.014	0.22CysGln: 0.22 ± 0.01	0.576CysArg: 0.576 ± 0.017	0.42CysSer: 0.42 ± 0.016	0.468CysThr: 0.468 ± 0.016	0.652CysVal: 0.652 ± 0.017	0.132CysTrp: 0.132 ± 0.008	0.21CysTyr: 0.21 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.104AspAla: 7.104 ± 0.07	0.446AspCys: 0.446 ± 0.015	3.134AspAsp: 3.134 ± 0.05	3.112AspGlu: 3.112 ± 0.046	2.168AspPhe: 2.168 ± 0.034	5.52AspGly: 5.52 ± 0.07	1.076AspHis: 1.076 ± 0.021	2.659AspIle: 2.659 ± 0.033	1.825AspLys: 1.825 ± 0.035	5.169AspLeu: 5.169 ± 0.052	1.292AspMet: 1.292 ± 0.028	1.546AspAsn: 1.546 ± 0.035	3.042AspPro: 3.042 ± 0.04	1.644AspGln: 1.644 ± 0.03	3.552AspArg: 3.552 ± 0.046	2.564AspSer: 2.564 ± 0.041	3.074AspThr: 3.074 ± 0.064	4.104AspVal: 4.104 ± 0.045	0.938AspTrp: 0.938 ± 0.019	1.583AspTyr: 1.583 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	6.383GluAla: 6.383 ± 0.066	0.349GluCys: 0.349 ± 0.013	2.103GluAsp: 2.103 ± 0.026	2.792GluGlu: 2.792 ± 0.04	1.808GluPhe: 1.808 ± 0.028	3.696GluGly: 3.696 ± 0.044	1.344GluHis: 1.344 ± 0.029	2.488GluIle: 2.488 ± 0.04	1.898GluLys: 1.898 ± 0.035	5.757GluLeu: 5.757 ± 0.059	1.19GluMet: 1.19 ± 0.024	1.447GluAsn: 1.447 ± 0.028	2.433GluPro: 2.433 ± 0.041	2.553GluGln: 2.553 ± 0.041	4.555GluArg: 4.555 ± 0.061	2.226GluSer: 2.226 ± 0.035	2.577GluThr: 2.577 ± 0.037	3.53GluVal: 3.53 ± 0.044	0.732GluTrp: 0.732 ± 0.019	1.194GluTyr: 1.194 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	4.376PheAla: 4.376 ± 0.046	0.342PheCys: 0.342 ± 0.014	2.687PheAsp: 2.687 ± 0.036	1.817PheGlu: 1.817 ± 0.028	1.284PhePhe: 1.284 ± 0.027	3.432PheGly: 3.432 ± 0.043	0.821PheHis: 0.821 ± 0.023	1.511PheIle: 1.511 ± 0.026	1.056PheLys: 1.056 ± 0.022	2.944PheLeu: 2.944 ± 0.041	0.783PheMet: 0.783 ± 0.02	1.26PheAsn: 1.26 ± 0.027	1.492PhePro: 1.492 ± 0.028	1.073PheGln: 1.073 ± 0.023	2.071PheArg: 2.071 ± 0.03	2.136PheSer: 2.136 ± 0.036	2.229PheThr: 2.229 ± 0.039	2.602PheVal: 2.602 ± 0.039	0.486PheTrp: 0.486 ± 0.017	0.966PheTyr: 0.966 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.128GlyAla: 10.128 ± 0.107	0.776GlyCys: 0.776 ± 0.021	4.409GlyAsp: 4.409 ± 0.061	4.32GlyGlu: 4.32 ± 0.053	3.326GlyPhe: 3.326 ± 0.042	7.688GlyGly: 7.688 ± 0.131	1.916GlyHis: 1.916 ± 0.029	4.435GlyIle: 4.435 ± 0.058	3.648GlyLys: 3.648 ± 0.044	8.005GlyLeu: 8.005 ± 0.067	2.411GlyMet: 2.411 ± 0.035	2.85GlyAsn: 2.85 ± 0.068	3.155GlyPro: 3.155 ± 0.045	3.231GlyGln: 3.231 ± 0.047	5.536GlyArg: 5.536 ± 0.061	4.709GlySer: 4.709 ± 0.062	5.506GlyThr: 5.506 ± 0.07	6.222GlyVal: 6.222 ± 0.057	1.488GlyTrp: 1.488 ± 0.029	2.495GlyTyr: 2.495 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	3.0HisAla: 3.0 ± 0.05	0.249HisCys: 0.249 ± 0.011	1.329HisAsp: 1.329 ± 0.025	1.171HisGlu: 1.171 ± 0.025	0.896HisPhe: 0.896 ± 0.018	2.313HisGly: 2.313 ± 0.034	0.612HisHis: 0.612 ± 0.019	0.886HisIle: 0.886 ± 0.021	0.549HisLys: 0.549 ± 0.017	2.141HisLeu: 2.141 ± 0.033	0.482HisMet: 0.482 ± 0.014	0.517HisAsn: 0.517 ± 0.016	1.326HisPro: 1.326 ± 0.026	0.676HisGln: 0.676 ± 0.019	1.467HisArg: 1.467 ± 0.029	0.968HisSer: 0.968 ± 0.019	1.028HisThr: 1.028 ± 0.024	1.67HisVal: 1.67 ± 0.028	0.377HisTrp: 0.377 ± 0.014	0.69HisTyr: 0.69 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.386IleAla: 6.386 ± 0.064	0.363IleCys: 0.363 ± 0.013	3.334IleAsp: 3.334 ± 0.042	2.816IleGlu: 2.816 ± 0.04	1.232IlePhe: 1.232 ± 0.027	4.335IleGly: 4.335 ± 0.049	0.869IleHis: 0.869 ± 0.018	1.548IleIle: 1.548 ± 0.033	1.274IleLys: 1.274 ± 0.025	3.399IleLeu: 3.399 ± 0.046	0.77IleMet: 0.77 ± 0.021	1.339IleAsn: 1.339 ± 0.027	2.038IlePro: 2.038 ± 0.035	1.042IleGln: 1.042 ± 0.019	2.678IleArg: 2.678 ± 0.04	2.29IleSer: 2.29 ± 0.036	2.478IleThr: 2.478 ± 0.036	3.765IleVal: 3.765 ± 0.045	0.451IleTrp: 0.451 ± 0.016	0.934IleTyr: 0.934 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.798LysAla: 3.798 ± 0.058	0.141LysCys: 0.141 ± 0.009	1.659LysAsp: 1.659 ± 0.033	1.638LysGlu: 1.638 ± 0.034	0.991LysPhe: 0.991 ± 0.021	2.386LysGly: 2.386 ± 0.035	0.648LysHis: 0.648 ± 0.018	1.467LysIle: 1.467 ± 0.03	1.377LysLys: 1.377 ± 0.035	3.483LysLeu: 3.483 ± 0.045	0.836LysMet: 0.836 ± 0.021	1.078LysAsn: 1.078 ± 0.029	2.009LysPro: 2.009 ± 0.035	1.177LysGln: 1.177 ± 0.03	2.065LysArg: 2.065 ± 0.033	1.664LysSer: 1.664 ± 0.032	1.812LysThr: 1.812 ± 0.033	2.434LysVal: 2.434 ± 0.039	0.394LysTrp: 0.394 ± 0.016	0.768LysTyr: 0.768 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	15.623LeuAla: 15.623 ± 0.13	0.957LeuCys: 0.957 ± 0.021	6.119LeuAsp: 6.119 ± 0.057	5.022LeuGlu: 5.022 ± 0.059	3.474LeuPhe: 3.474 ± 0.045	7.913LeuGly: 7.913 ± 0.069	2.327LeuHis: 2.327 ± 0.036	3.482LeuIle: 3.482 ± 0.045	3.383LeuLys: 3.383 ± 0.043	10.826LeuLeu: 10.826 ± 0.11	2.154LeuMet: 2.154 ± 0.032	2.73LeuAsn: 2.73 ± 0.042	6.058LeuPro: 6.058 ± 0.06	3.666LeuGln: 3.666 ± 0.043	7.57LeuArg: 7.57 ± 0.072	5.704LeuSer: 5.704 ± 0.057	5.119LeuThr: 5.119 ± 0.074	7.466LeuVal: 7.466 ± 0.068	1.145LeuTrp: 1.145 ± 0.027	2.336LeuTyr: 2.336 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.015MetAla: 3.015 ± 0.039	0.168MetCys: 0.168 ± 0.009	1.071MetAsp: 1.071 ± 0.021	1.061MetGlu: 1.061 ± 0.021	0.732MetPhe: 0.732 ± 0.021	1.613MetGly: 1.613 ± 0.034	0.526MetHis: 0.526 ± 0.017	0.952MetIle: 0.952 ± 0.022	1.033MetLys: 1.033 ± 0.024	2.679MetLeu: 2.679 ± 0.036	0.589MetMet: 0.589 ± 0.018	0.905MetAsn: 0.905 ± 0.02	1.478MetPro: 1.478 ± 0.022	0.971MetGln: 0.971 ± 0.022	1.695MetArg: 1.695 ± 0.026	1.453MetSer: 1.453 ± 0.023	1.537MetThr: 1.537 ± 0.033	1.59MetVal: 1.59 ± 0.029	0.218MetTrp: 0.218 ± 0.012	0.443MetTyr: 0.443 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.595AsnAla: 3.595 ± 0.051	0.233AsnCys: 0.233 ± 0.011	1.642AsnAsp: 1.642 ± 0.043	1.34AsnGlu: 1.34 ± 0.024	1.031AsnPhe: 1.031 ± 0.025	2.863AsnGly: 2.863 ± 0.045	0.565AsnHis: 0.565 ± 0.017	1.33AsnIle: 1.33 ± 0.03	0.832AsnLys: 0.832 ± 0.024	2.856AsnLeu: 2.856 ± 0.042	0.615AsnMet: 0.615 ± 0.017	0.93AsnAsn: 0.93 ± 0.024	1.825AsnPro: 1.825 ± 0.034	0.917AsnGln: 0.917 ± 0.022	1.84AsnArg: 1.84 ± 0.028	1.364AsnSer: 1.364 ± 0.028	1.596AsnThr: 1.596 ± 0.032	2.284AsnVal: 2.284 ± 0.039	0.455AsnTrp: 0.455 ± 0.015	0.82AsnTyr: 0.82 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	8.188ProAla: 8.188 ± 0.076	0.383ProCys: 0.383 ± 0.014	3.283ProAsp: 3.283 ± 0.04	3.14ProGlu: 3.14 ± 0.043	1.801ProPhe: 1.801 ± 0.029	4.929ProGly: 4.929 ± 0.05	1.153ProHis: 1.153 ± 0.024	1.742ProIle: 1.742 ± 0.034	1.438ProLys: 1.438 ± 0.029	5.064ProLeu: 5.064 ± 0.052	1.163ProMet: 1.163 ± 0.025	1.356ProAsn: 1.356 ± 0.028	2.776ProPro: 2.776 ± 0.05	1.87ProGln: 1.87 ± 0.032	3.007ProArg: 3.007 ± 0.04	2.497ProSer: 2.497 ± 0.04	2.157ProThr: 2.157 ± 0.034	4.433ProVal: 4.433 ± 0.049	0.686ProTrp: 0.686 ± 0.017	1.207ProTyr: 1.207 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	5.212GlnAla: 5.212 ± 0.065	0.279GlnCys: 0.279 ± 0.012	1.582GlnAsp: 1.582 ± 0.027	1.611GlnGlu: 1.611 ± 0.033	1.3GlnPhe: 1.3 ± 0.026	2.859GlnGly: 2.859 ± 0.037	0.9GlnHis: 0.9 ± 0.02	1.458GlnIle: 1.458 ± 0.033	1.119GlnLys: 1.119 ± 0.025	3.998GlnLeu: 3.998 ± 0.063	0.933GlnMet: 0.933 ± 0.024	0.922GlnAsn: 0.922 ± 0.022	2.243GlnPro: 2.243 ± 0.039	1.819GlnGln: 1.819 ± 0.037	2.972GlnArg: 2.972 ± 0.042	1.73GlnSer: 1.73 ± 0.029	1.551GlnThr: 1.551 ± 0.031	2.975GlnVal: 2.975 ± 0.038	0.568GlnTrp: 0.568 ± 0.015	0.955GlnTyr: 0.955 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	7.887ArgAla: 7.887 ± 0.088	0.536ArgCys: 0.536 ± 0.018	3.992ArgAsp: 3.992 ± 0.042	3.905ArgGlu: 3.905 ± 0.054	2.777ArgPhe: 2.777 ± 0.039	4.759ArgGly: 4.759 ± 0.047	2.044ArgHis: 2.044 ± 0.035	3.501ArgIle: 3.501 ± 0.039	2.162ArgLys: 2.162 ± 0.034	7.546ArgLeu: 7.546 ± 0.08	1.915ArgMet: 1.915 ± 0.028	2.054ArgAsn: 2.054 ± 0.029	3.23ArgPro: 3.23 ± 0.047	2.995ArgGln: 2.995 ± 0.044	5.167ArgArg: 5.167 ± 0.067	3.236ArgSer: 3.236 ± 0.041	3.551ArgThr: 3.551 ± 0.043	4.634ArgVal: 4.634 ± 0.052	1.089ArgTrp: 1.089 ± 0.024	2.14ArgTyr: 2.14 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.505SerAla: 6.505 ± 0.068	0.398SerCys: 0.398 ± 0.015	2.601SerAsp: 2.601 ± 0.039	2.285SerGlu: 2.285 ± 0.036	1.984SerPhe: 1.984 ± 0.028	5.208SerGly: 5.208 ± 0.059	1.183SerHis: 1.183 ± 0.023	2.366SerIle: 2.366 ± 0.039	1.54SerLys: 1.54 ± 0.03	5.253SerLeu: 5.253 ± 0.047	1.276SerMet: 1.276 ± 0.023	1.505SerAsn: 1.505 ± 0.033	2.63SerPro: 2.63 ± 0.039	1.685SerGln: 1.685 ± 0.031	3.369SerArg: 3.369 ± 0.042	2.898SerSer: 2.898 ± 0.045	3.004SerThr: 3.004 ± 0.044	3.784SerVal: 3.784 ± 0.038	0.743SerTrp: 0.743 ± 0.02	1.457SerTyr: 1.457 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	6.589ThrAla: 6.589 ± 0.076	0.397ThrCys: 0.397 ± 0.015	2.75ThrAsp: 2.75 ± 0.039	2.35ThrGlu: 2.35 ± 0.035	1.963ThrPhe: 1.963 ± 0.03	5.265ThrGly: 5.265 ± 0.07	1.04ThrHis: 1.04 ± 0.023	2.601ThrIle: 2.601 ± 0.037	1.309ThrLys: 1.309 ± 0.03	6.268ThrLeu: 6.268 ± 0.06	1.209ThrMet: 1.209 ± 0.024	1.408ThrAsn: 1.408 ± 0.028	3.363ThrPro: 3.363 ± 0.042	1.711ThrGln: 1.711 ± 0.042	3.274ThrArg: 3.274 ± 0.048	2.894ThrSer: 2.894 ± 0.065	2.982ThrThr: 2.982 ± 0.064	4.708ThrVal: 4.708 ± 0.062	0.808ThrTrp: 0.808 ± 0.022	1.362ThrTyr: 1.362 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.701ValAla: 9.701 ± 0.08	0.62ValCys: 0.62 ± 0.02	4.238ValAsp: 4.238 ± 0.043	3.926ValGlu: 3.926 ± 0.055	2.563ValPhe: 2.563 ± 0.031	5.08ValGly: 5.08 ± 0.055	1.536ValHis: 1.536 ± 0.028	3.359ValIle: 3.359 ± 0.045	2.437ValLys: 2.437 ± 0.038	7.914ValLeu: 7.914 ± 0.072	1.662ValMet: 1.662 ± 0.027	2.298ValAsn: 2.298 ± 0.035	4.142ValPro: 4.142 ± 0.047	2.67ValGln: 2.67 ± 0.035	5.18ValArg: 5.18 ± 0.053	3.948ValSer: 3.948 ± 0.042	4.651ValThr: 4.651 ± 0.058	5.551ValVal: 5.551 ± 0.05	0.83ValTrp: 0.83 ± 0.021	1.667ValTyr: 1.667 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.162TrpAla: 1.162 ± 0.025	0.144TrpCys: 0.144 ± 0.008	0.659TrpAsp: 0.659 ± 0.02	0.613TrpGlu: 0.613 ± 0.019	0.553TrpPhe: 0.553 ± 0.017	0.907TrpGly: 0.907 ± 0.025	0.424TrpHis: 0.424 ± 0.014	0.624TrpIle: 0.624 ± 0.02	0.49TrpLys: 0.49 ± 0.018	1.833TrpLeu: 1.833 ± 0.033	0.403TrpMet: 0.403 ± 0.014	0.523TrpAsn: 0.523 ± 0.018	0.658TrpPro: 0.658 ± 0.019	0.791TrpGln: 0.791 ± 0.018	1.248TrpArg: 1.248 ± 0.026	0.824TrpSer: 0.824 ± 0.021	0.777TrpThr: 0.777 ± 0.024	0.83TrpVal: 0.83 ± 0.022	0.255TrpTrp: 0.255 ± 0.011	0.387TrpTyr: 0.387 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.82TyrAla: 2.82 ± 0.039	0.247TyrCys: 0.247 ± 0.011	1.458TyrAsp: 1.458 ± 0.027	1.214TyrGlu: 1.214 ± 0.029	1.044TyrPhe: 1.044 ± 0.02	2.243TyrGly: 2.243 ± 0.04	0.551TyrHis: 0.551 ± 0.015	0.858TyrIle: 0.858 ± 0.02	0.739TyrLys: 0.739 ± 0.021	2.63TyrLeu: 2.63 ± 0.042	0.481TyrMet: 0.481 ± 0.015	0.736TyrAsn: 0.736 ± 0.021	1.256TyrPro: 1.256 ± 0.024	0.967TyrGln: 0.967 ± 0.022	2.072TyrArg: 2.072 ± 0.032	1.373TyrSer: 1.373 ± 0.031	1.453TyrThr: 1.453 ± 0.029	1.754TyrVal: 1.754 ± 0.029	0.396TyrTrp: 0.396 ± 0.013	0.79TyrTyr: 0.79 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5987 proteins (2173394 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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