Amino acid dipepetide frequency for Desulfobotulus alkaliphilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.407AlaAla: 9.407 ± 0.118	1.334AlaCys: 1.334 ± 0.04	4.596AlaAsp: 4.596 ± 0.069	6.175AlaGlu: 6.175 ± 0.08	4.373AlaPhe: 4.373 ± 0.073	7.962AlaGly: 7.962 ± 0.097	1.755AlaHis: 1.755 ± 0.049	5.076AlaIle: 5.076 ± 0.071	3.458AlaLys: 3.458 ± 0.058	10.204AlaLeu: 10.204 ± 0.119	3.51AlaMet: 3.51 ± 0.053	1.956AlaAsn: 1.956 ± 0.047	3.157AlaPro: 3.157 ± 0.061	2.196AlaGln: 2.196 ± 0.043	5.432AlaArg: 5.432 ± 0.08	5.678AlaSer: 5.678 ± 0.079	3.569AlaThr: 3.569 ± 0.07	5.971AlaVal: 5.971 ± 0.087	0.937AlaTrp: 0.937 ± 0.031	2.173AlaTyr: 2.173 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.842CysAla: 0.842 ± 0.032	0.235CysCys: 0.235 ± 0.014	0.581CysAsp: 0.581 ± 0.023	0.587CysGlu: 0.587 ± 0.021	0.566CysPhe: 0.566 ± 0.024	1.251CysGly: 1.251 ± 0.038	0.411CysHis: 0.411 ± 0.025	0.774CysIle: 0.774 ± 0.028	0.427CysLys: 0.427 ± 0.019	1.299CysLeu: 1.299 ± 0.035	0.361CysMet: 0.361 ± 0.019	0.32CysAsn: 0.32 ± 0.018	0.734CysPro: 0.734 ± 0.031	0.32CysGln: 0.32 ± 0.017	0.932CysArg: 0.932 ± 0.033	0.72CysSer: 0.72 ± 0.032	0.589CysThr: 0.589 ± 0.022	0.728CysVal: 0.728 ± 0.029	0.135CysTrp: 0.135 ± 0.013	0.267CysTyr: 0.267 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.215AspAla: 5.215 ± 0.072	0.56AspCys: 0.56 ± 0.023	2.209AspAsp: 2.209 ± 0.052	3.196AspGlu: 3.196 ± 0.059	2.933AspPhe: 2.933 ± 0.054	3.866AspGly: 3.866 ± 0.082	1.159AspHis: 1.159 ± 0.026	3.968AspIle: 3.968 ± 0.066	2.349AspLys: 2.349 ± 0.051	6.058AspLeu: 6.058 ± 0.087	1.804AspMet: 1.804 ± 0.04	1.405AspAsn: 1.405 ± 0.035	2.788AspPro: 2.788 ± 0.054	1.551AspGln: 1.551 ± 0.037	3.503AspArg: 3.503 ± 0.06	2.699AspSer: 2.699 ± 0.048	3.017AspThr: 3.017 ± 0.053	3.267AspVal: 3.267 ± 0.066	0.723AspTrp: 0.723 ± 0.028	1.706AspTyr: 1.706 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	6.945GluAla: 6.945 ± 0.094	0.45GluCys: 0.45 ± 0.022	4.126GluAsp: 4.126 ± 0.064	5.755GluGlu: 5.755 ± 0.097	1.901GluPhe: 1.901 ± 0.04	5.296GluGly: 5.296 ± 0.072	1.094GluHis: 1.094 ± 0.029	4.88GluIle: 4.88 ± 0.076	6.799GluLys: 6.799 ± 0.091	5.796GluLeu: 5.796 ± 0.069	2.151GluMet: 2.151 ± 0.045	3.381GluAsn: 3.381 ± 0.064	2.13GluPro: 2.13 ± 0.051	1.993GluGln: 1.993 ± 0.052	4.218GluArg: 4.218 ± 0.063	3.838GluSer: 3.838 ± 0.061	3.868GluThr: 3.868 ± 0.059	4.199GluVal: 4.199 ± 0.067	0.641GluTrp: 0.641 ± 0.026	1.46GluTyr: 1.46 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.183PheAla: 3.183 ± 0.06	0.713PheCys: 0.713 ± 0.026	2.456PheAsp: 2.456 ± 0.043	2.504PheGlu: 2.504 ± 0.047	2.817PhePhe: 2.817 ± 0.064	3.026PheGly: 3.026 ± 0.048	1.139PheHis: 1.139 ± 0.032	2.631PheIle: 2.631 ± 0.052	1.665PheLys: 1.665 ± 0.043	4.83PheLeu: 4.83 ± 0.072	1.362PheMet: 1.362 ± 0.036	1.286PheAsn: 1.286 ± 0.032	2.058PhePro: 2.058 ± 0.043	1.486PheGln: 1.486 ± 0.039	2.792PheArg: 2.792 ± 0.05	3.778PheSer: 3.778 ± 0.069	2.504PheThr: 2.504 ± 0.051	2.651PheVal: 2.651 ± 0.052	0.588PheTrp: 0.588 ± 0.023	1.399PheTyr: 1.399 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.537GlyAla: 5.537 ± 0.082	1.094GlyCys: 1.094 ± 0.036	3.783GlyAsp: 3.783 ± 0.068	5.225GlyGlu: 5.225 ± 0.077	3.745GlyPhe: 3.745 ± 0.057	5.711GlyGly: 5.711 ± 0.097	1.732GlyHis: 1.732 ± 0.047	5.431GlyIle: 5.431 ± 0.079	4.593GlyLys: 4.593 ± 0.068	8.34GlyLeu: 8.34 ± 0.104	2.796GlyMet: 2.796 ± 0.051	2.432GlyAsn: 2.432 ± 0.053	2.561GlyPro: 2.561 ± 0.054	2.386GlyGln: 2.386 ± 0.057	4.988GlyArg: 4.988 ± 0.081	4.69GlySer: 4.69 ± 0.083	3.667GlyThr: 3.667 ± 0.067	4.907GlyVal: 4.907 ± 0.077	0.953GlyTrp: 0.953 ± 0.031	2.32GlyTyr: 2.32 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.877HisAla: 1.877 ± 0.044	0.324HisCys: 0.324 ± 0.018	0.979HisAsp: 0.979 ± 0.028	1.345HisGlu: 1.345 ± 0.03	1.105HisPhe: 1.105 ± 0.032	1.99HisGly: 1.99 ± 0.046	0.581HisHis: 0.581 ± 0.023	1.414HisIle: 1.414 ± 0.035	0.912HisLys: 0.912 ± 0.028	2.488HisLeu: 2.488 ± 0.057	0.701HisMet: 0.701 ± 0.028	0.595HisAsn: 0.595 ± 0.022	1.547HisPro: 1.547 ± 0.037	0.661HisGln: 0.661 ± 0.027	1.501HisArg: 1.501 ± 0.039	1.14HisSer: 1.14 ± 0.03	1.219HisThr: 1.219 ± 0.035	1.282HisVal: 1.282 ± 0.038	0.246HisTrp: 0.246 ± 0.016	0.709HisTyr: 0.709 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.034IleAla: 5.034 ± 0.088	0.842IleCys: 0.842 ± 0.026	2.634IleAsp: 2.634 ± 0.051	3.557IleGlu: 3.557 ± 0.064	2.904IlePhe: 2.904 ± 0.054	3.906IleGly: 3.906 ± 0.079	1.757IleHis: 1.757 ± 0.036	3.203IleIle: 3.203 ± 0.067	2.518IleLys: 2.518 ± 0.053	7.353IleLeu: 7.353 ± 0.098	1.449IleMet: 1.449 ± 0.039	1.832IleAsn: 1.832 ± 0.043	3.548IlePro: 3.548 ± 0.063	2.232IleGln: 2.232 ± 0.043	5.315IleArg: 5.315 ± 0.069	4.039IleSer: 4.039 ± 0.055	3.121IleThr: 3.121 ± 0.061	3.299IleVal: 3.299 ± 0.054	0.626IleTrp: 0.626 ± 0.024	1.52IleTyr: 1.52 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	5.011LysAla: 5.011 ± 0.08	0.376LysCys: 0.376 ± 0.019	3.392LysAsp: 3.392 ± 0.051	4.358LysGlu: 4.358 ± 0.077	1.194LysPhe: 1.194 ± 0.036	4.152LysGly: 4.152 ± 0.061	0.797LysHis: 0.797 ± 0.027	3.437LysIle: 3.437 ± 0.061	4.625LysLys: 4.625 ± 0.085	3.697LysLeu: 3.697 ± 0.061	1.409LysMet: 1.409 ± 0.036	2.745LysAsn: 2.745 ± 0.056	2.25LysPro: 2.25 ± 0.05	1.4LysGln: 1.4 ± 0.037	2.737LysArg: 2.737 ± 0.047	2.731LysSer: 2.731 ± 0.052	3.119LysThr: 3.119 ± 0.052	2.738LysVal: 2.738 ± 0.061	0.427LysTrp: 0.427 ± 0.021	1.108LysTyr: 1.108 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	9.788LeuAla: 9.788 ± 0.103	1.468LeuCys: 1.468 ± 0.04	5.704LeuAsp: 5.704 ± 0.076	7.489LeuGlu: 7.489 ± 0.096	5.0LeuPhe: 5.0 ± 0.083	7.087LeuGly: 7.087 ± 0.099	2.402LeuHis: 2.402 ± 0.047	5.598LeuIle: 5.598 ± 0.085	5.763LeuLys: 5.763 ± 0.082	10.737LeuLeu: 10.737 ± 0.132	3.145LeuMet: 3.145 ± 0.059	3.171LeuAsn: 3.171 ± 0.05	5.525LeuPro: 5.525 ± 0.08	3.377LeuGln: 3.377 ± 0.065	6.239LeuArg: 6.239 ± 0.098	7.491LeuSer: 7.491 ± 0.092	4.865LeuThr: 4.865 ± 0.064	6.723LeuVal: 6.723 ± 0.081	1.099LeuTrp: 1.099 ± 0.037	2.62LeuTyr: 2.62 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.765MetAla: 3.765 ± 0.063	0.173MetCys: 0.173 ± 0.013	2.49MetAsp: 2.49 ± 0.048	2.987MetGlu: 2.987 ± 0.052	0.727MetPhe: 0.727 ± 0.029	2.927MetGly: 2.927 ± 0.057	0.589MetHis: 0.589 ± 0.023	1.518MetIle: 1.518 ± 0.041	1.776MetLys: 1.776 ± 0.039	2.707MetLeu: 2.707 ± 0.05	0.795MetMet: 0.795 ± 0.03	1.113MetAsn: 1.113 ± 0.034	1.45MetPro: 1.45 ± 0.032	1.219MetGln: 1.219 ± 0.034	1.553MetArg: 1.553 ± 0.036	1.334MetSer: 1.334 ± 0.037	1.554MetThr: 1.554 ± 0.032	2.165MetVal: 2.165 ± 0.05	0.157MetTrp: 0.157 ± 0.013	0.462MetTyr: 0.462 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.776AsnAla: 2.776 ± 0.054	0.354AsnCys: 0.354 ± 0.019	1.347AsnAsp: 1.347 ± 0.035	1.678AsnGlu: 1.678 ± 0.043	1.325AsnPhe: 1.325 ± 0.036	2.135AsnGly: 2.135 ± 0.045	0.822AsnHis: 0.822 ± 0.028	2.236AsnIle: 2.236 ± 0.045	1.269AsnLys: 1.269 ± 0.035	3.56AsnLeu: 3.56 ± 0.061	0.902AsnMet: 0.902 ± 0.027	1.024AsnAsn: 1.024 ± 0.033	2.251AsnPro: 2.251 ± 0.048	1.126AsnGln: 1.126 ± 0.031	2.29AsnArg: 2.29 ± 0.048	1.492AsnSer: 1.492 ± 0.037	1.761AsnThr: 1.761 ± 0.049	1.687AsnVal: 1.687 ± 0.045	0.376AsnTrp: 0.376 ± 0.02	0.878AsnTyr: 0.878 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	4.05ProAla: 4.05 ± 0.076	0.522ProCys: 0.522 ± 0.024	3.55ProAsp: 3.55 ± 0.058	5.34ProGlu: 5.34 ± 0.071	2.246ProPhe: 2.246 ± 0.047	3.83ProGly: 3.83 ± 0.071	1.07ProHis: 1.07 ± 0.033	1.792ProIle: 1.792 ± 0.042	1.613ProLys: 1.613 ± 0.046	4.864ProLeu: 4.864 ± 0.078	1.496ProMet: 1.496 ± 0.035	0.907ProAsn: 0.907 ± 0.029	2.16ProPro: 2.16 ± 0.05	1.209ProGln: 1.209 ± 0.034	1.974ProArg: 1.974 ± 0.041	2.561ProSer: 2.561 ± 0.048	1.4ProThr: 1.4 ± 0.04	4.107ProVal: 4.107 ± 0.068	0.645ProTrp: 0.645 ± 0.023	1.125ProTyr: 1.125 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.19GlnAla: 3.19 ± 0.061	0.261GlnCys: 0.261 ± 0.015	1.763GlnAsp: 1.763 ± 0.041	2.326GlnGlu: 2.326 ± 0.04	0.862GlnPhe: 0.862 ± 0.027	2.347GlnGly: 2.347 ± 0.042	0.649GlnHis: 0.649 ± 0.026	1.936GlnIle: 1.936 ± 0.047	2.209GlnLys: 2.209 ± 0.05	2.532GlnLeu: 2.532 ± 0.045	0.981GlnMet: 0.981 ± 0.033	1.265GlnAsn: 1.265 ± 0.032	1.378GlnPro: 1.378 ± 0.037	1.283GlnGln: 1.283 ± 0.037	2.095GlnArg: 2.095 ± 0.052	1.772GlnSer: 1.772 ± 0.04	1.701GlnThr: 1.701 ± 0.046	2.03GlnVal: 2.03 ± 0.044	0.409GlnTrp: 0.409 ± 0.019	0.683GlnTyr: 0.683 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	4.426ArgAla: 4.426 ± 0.077	0.7ArgCys: 0.7 ± 0.031	3.177ArgAsp: 3.177 ± 0.057	4.904ArgGlu: 4.904 ± 0.071	3.001ArgPhe: 3.001 ± 0.049	3.488ArgGly: 3.488 ± 0.057	1.594ArgHis: 1.594 ± 0.041	5.095ArgIle: 5.095 ± 0.07	3.655ArgLys: 3.655 ± 0.066	6.671ArgLeu: 6.671 ± 0.079	2.495ArgMet: 2.495 ± 0.042	2.137ArgAsn: 2.137 ± 0.044	2.562ArgPro: 2.562 ± 0.053	2.493ArgGln: 2.493 ± 0.055	3.842ArgArg: 3.842 ± 0.066	3.642ArgSer: 3.642 ± 0.055	2.735ArgThr: 2.735 ± 0.045	4.009ArgVal: 4.009 ± 0.065	0.742ArgTrp: 0.742 ± 0.031	1.879ArgTyr: 1.879 ± 0.041	0.001ArgXaa: 0.001 ± 0.001
Ser	4.836SerAla: 4.836 ± 0.066	0.73SerCys: 0.73 ± 0.029	3.16SerAsp: 3.16 ± 0.055	3.93SerGlu: 3.93 ± 0.067	2.986SerPhe: 2.986 ± 0.052	5.843SerGly: 5.843 ± 0.092	1.513SerHis: 1.513 ± 0.037	3.433SerIle: 3.433 ± 0.059	1.962SerLys: 1.962 ± 0.042	7.227SerLeu: 7.227 ± 0.084	1.967SerMet: 1.967 ± 0.043	1.291SerAsn: 1.291 ± 0.034	3.128SerPro: 3.128 ± 0.064	1.806SerGln: 1.806 ± 0.042	4.045SerArg: 4.045 ± 0.063	3.674SerSer: 3.674 ± 0.072	2.531SerThr: 2.531 ± 0.054	3.689SerVal: 3.689 ± 0.058	0.773SerTrp: 0.773 ± 0.029	1.514SerTyr: 1.514 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.64ThrAla: 4.64 ± 0.076	0.605ThrCys: 0.605 ± 0.024	2.623ThrAsp: 2.623 ± 0.044	3.143ThrGlu: 3.143 ± 0.056	2.041ThrPhe: 2.041 ± 0.044	5.334ThrGly: 5.334 ± 0.089	1.119ThrHis: 1.119 ± 0.029	2.684ThrIle: 2.684 ± 0.053	1.6ThrLys: 1.6 ± 0.037	5.955ThrLeu: 5.955 ± 0.074	1.224ThrMet: 1.224 ± 0.032	1.087ThrAsn: 1.087 ± 0.036	2.778ThrPro: 2.778 ± 0.052	1.345ThrGln: 1.345 ± 0.04	3.019ThrArg: 3.019 ± 0.05	2.494ThrSer: 2.494 ± 0.058	2.107ThrThr: 2.107 ± 0.052	3.028ThrVal: 3.028 ± 0.065	0.456ThrTrp: 0.456 ± 0.022	1.088ThrTyr: 1.088 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	5.387ValAla: 5.387 ± 0.092	0.915ValCys: 0.915 ± 0.03	3.4ValAsp: 3.4 ± 0.056	3.984ValGlu: 3.984 ± 0.069	3.369ValPhe: 3.369 ± 0.057	3.773ValGly: 3.773 ± 0.081	1.494ValHis: 1.494 ± 0.038	3.54ValIle: 3.54 ± 0.052	2.898ValLys: 2.898 ± 0.055	7.103ValLeu: 7.103 ± 0.083	1.904ValMet: 1.904 ± 0.042	2.106ValAsn: 2.106 ± 0.044	2.627ValPro: 2.627 ± 0.047	2.101ValGln: 2.101 ± 0.042	4.172ValArg: 4.172 ± 0.067	4.316ValSer: 4.316 ± 0.065	3.159ValThr: 3.159 ± 0.072	4.17ValVal: 4.17 ± 0.076	0.712ValTrp: 0.712 ± 0.028	1.603ValTyr: 1.603 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.719TrpAla: 0.719 ± 0.029	0.122TrpCys: 0.122 ± 0.011	0.615TrpAsp: 0.615 ± 0.026	0.86TrpGlu: 0.86 ± 0.029	0.509TrpPhe: 0.509 ± 0.022	0.731TrpGly: 0.731 ± 0.026	0.267TrpHis: 0.267 ± 0.017	0.698TrpIle: 0.698 ± 0.03	0.613TrpLys: 0.613 ± 0.027	1.224TrpLeu: 1.224 ± 0.038	0.413TrpMet: 0.413 ± 0.017	0.405TrpAsn: 0.405 ± 0.019	0.497TrpPro: 0.497 ± 0.023	0.582TrpGln: 0.582 ± 0.02	0.607TrpArg: 0.607 ± 0.024	0.579TrpSer: 0.579 ± 0.025	0.509TrpThr: 0.509 ± 0.023	0.684TrpVal: 0.684 ± 0.024	0.131TrpTrp: 0.131 ± 0.013	0.322TrpTyr: 0.322 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.293TyrAla: 2.293 ± 0.051	0.3TyrCys: 0.3 ± 0.016	1.39TyrAsp: 1.39 ± 0.039	1.579TyrGlu: 1.579 ± 0.041	1.262TyrPhe: 1.262 ± 0.034	2.238TyrGly: 2.238 ± 0.047	0.671TyrHis: 0.671 ± 0.028	1.347TyrIle: 1.347 ± 0.032	0.999TyrLys: 0.999 ± 0.034	2.649TyrLeu: 2.649 ± 0.052	0.598TyrMet: 0.598 ± 0.023	0.831TyrAsn: 0.831 ± 0.029	1.334TyrPro: 1.334 ± 0.032	0.905TyrGln: 0.905 ± 0.028	1.993TyrArg: 1.993 ± 0.044	1.367TyrSer: 1.367 ± 0.034	1.372TyrThr: 1.372 ± 0.046	1.4TyrVal: 1.4 ± 0.039	0.308TyrTrp: 0.308 ± 0.018	0.848TyrTyr: 0.848 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 3369 proteins (1138264 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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