Amino acid dipepetide frequency for Mycobacterium phage Saal

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.102AlaAla: 14.102 ± 1.477
1.093AlaCys: 1.093 ± 0.243
7.324AlaAsp: 7.324 ± 0.579
6.778AlaGlu: 6.778 ± 0.622
2.952AlaPhe: 2.952 ± 0.407
9.675AlaGly: 9.675 ± 1.352
2.624AlaHis: 2.624 ± 0.38
4.646AlaIle: 4.646 ± 0.604
4.099AlaLys: 4.099 ± 0.4
7.871AlaLeu: 7.871 ± 0.753
1.968AlaMet: 1.968 ± 0.308
3.116AlaAsn: 3.116 ± 0.459
4.755AlaPro: 4.755 ± 0.534
3.061AlaGln: 3.061 ± 0.296
7.762AlaArg: 7.762 ± 0.706
5.521AlaSer: 5.521 ± 0.524
5.794AlaThr: 5.794 ± 0.555
6.286AlaVal: 6.286 ± 0.474
2.35AlaTrp: 2.35 ± 0.396
2.296AlaTyr: 2.296 ± 0.433
0.0AlaXaa: 0.0 ± 0.0
Cys
0.984CysAla: 0.984 ± 0.259
0.055CysCys: 0.055 ± 0.059
1.257CysAsp: 1.257 ± 0.342
0.711CysGlu: 0.711 ± 0.192
0.328CysPhe: 0.328 ± 0.122
1.476CysGly: 1.476 ± 0.332
0.273CysHis: 0.273 ± 0.111
0.055CysIle: 0.055 ± 0.053
0.492CysLys: 0.492 ± 0.176
0.656CysLeu: 0.656 ± 0.213
0.109CysMet: 0.109 ± 0.082
0.383CysAsn: 0.383 ± 0.137
1.203CysPro: 1.203 ± 0.233
0.164CysGln: 0.164 ± 0.093
0.601CysArg: 0.601 ± 0.198
0.711CysSer: 0.711 ± 0.206
0.547CysThr: 0.547 ± 0.162
0.875CysVal: 0.875 ± 0.191
0.328CysTrp: 0.328 ± 0.123
0.164CysTyr: 0.164 ± 0.094
0.0CysXaa: 0.0 ± 0.0
Asp
7.051AspAla: 7.051 ± 0.682
0.82AspCys: 0.82 ± 0.187
4.919AspAsp: 4.919 ± 0.567
3.936AspGlu: 3.936 ± 0.583
1.694AspPhe: 1.694 ± 0.239
6.668AspGly: 6.668 ± 0.714
1.366AspHis: 1.366 ± 0.276
2.405AspIle: 2.405 ± 0.335
1.913AspLys: 1.913 ± 0.316
5.958AspLeu: 5.958 ± 0.448
1.366AspMet: 1.366 ± 0.271
1.694AspAsn: 1.694 ± 0.293
4.974AspPro: 4.974 ± 0.59
2.35AspGln: 2.35 ± 0.365
5.193AspArg: 5.193 ± 0.629
3.498AspSer: 3.498 ± 0.512
4.427AspThr: 4.427 ± 0.471
3.717AspVal: 3.717 ± 0.547
1.694AspTrp: 1.694 ± 0.292
1.804AspTyr: 1.804 ± 0.305
0.0AspXaa: 0.0 ± 0.0
Glu
6.395GluAla: 6.395 ± 0.742
0.711GluCys: 0.711 ± 0.244
3.444GluAsp: 3.444 ± 0.395
3.498GluGlu: 3.498 ± 0.534
2.569GluPhe: 2.569 ± 0.367
3.116GluGly: 3.116 ± 0.404
1.694GluHis: 1.694 ± 0.374
1.749GluIle: 1.749 ± 0.322
2.241GluLys: 2.241 ± 0.304
5.794GluLeu: 5.794 ± 0.852
1.749GluMet: 1.749 ± 0.288
1.968GluAsn: 1.968 ± 0.268
3.006GluPro: 3.006 ± 0.492
3.225GluGln: 3.225 ± 0.377
5.083GluArg: 5.083 ± 0.615
2.788GluSer: 2.788 ± 0.491
4.209GluThr: 4.209 ± 0.564
4.045GluVal: 4.045 ± 0.481
1.093GluTrp: 1.093 ± 0.216
1.804GluTyr: 1.804 ± 0.339
0.0GluXaa: 0.0 ± 0.0
Phe
3.116PheAla: 3.116 ± 0.382
0.164PheCys: 0.164 ± 0.085
2.624PheAsp: 2.624 ± 0.524
1.585PheGlu: 1.585 ± 0.277
0.82PhePhe: 0.82 ± 0.292
3.116PheGly: 3.116 ± 0.678
0.547PheHis: 0.547 ± 0.182
1.366PheIle: 1.366 ± 0.325
1.093PheLys: 1.093 ± 0.209
1.968PheLeu: 1.968 ± 0.288
0.875PheMet: 0.875 ± 0.224
1.148PheAsn: 1.148 ± 0.316
1.476PhePro: 1.476 ± 0.307
1.148PheGln: 1.148 ± 0.331
1.749PheArg: 1.749 ± 0.284
1.858PheSer: 1.858 ± 0.362
2.405PheThr: 2.405 ± 0.325
2.405PheVal: 2.405 ± 0.261
0.711PheTrp: 0.711 ± 0.213
0.984PheTyr: 0.984 ± 0.273
0.0PheXaa: 0.0 ± 0.0
Gly
8.308GlyAla: 8.308 ± 1.259
1.093GlyCys: 1.093 ± 0.252
5.794GlyAsp: 5.794 ± 0.657
4.537GlyGlu: 4.537 ± 0.504
2.46GlyPhe: 2.46 ± 0.413
10.44GlyGly: 10.44 ± 2.231
2.022GlyHis: 2.022 ± 0.306
4.209GlyIle: 4.209 ± 0.624
2.46GlyLys: 2.46 ± 0.334
6.177GlyLeu: 6.177 ± 0.576
2.733GlyMet: 2.733 ± 0.493
2.897GlyAsn: 2.897 ± 0.413
4.373GlyPro: 4.373 ± 0.605
2.077GlyGln: 2.077 ± 0.509
5.083GlyArg: 5.083 ± 0.628
5.958GlySer: 5.958 ± 0.868
6.122GlyThr: 6.122 ± 0.908
5.302GlyVal: 5.302 ± 0.516
2.46GlyTrp: 2.46 ± 0.328
2.46GlyTyr: 2.46 ± 0.439
0.0GlyXaa: 0.0 ± 0.0
His
2.077HisAla: 2.077 ± 0.366
0.273HisCys: 0.273 ± 0.152
1.257HisAsp: 1.257 ± 0.237
1.421HisGlu: 1.421 ± 0.263
0.601HisPhe: 0.601 ± 0.158
1.53HisGly: 1.53 ± 0.262
0.875HisHis: 0.875 ± 0.25
1.694HisIle: 1.694 ± 0.298
1.039HisLys: 1.039 ± 0.276
1.257HisLeu: 1.257 ± 0.28
0.547HisMet: 0.547 ± 0.167
0.984HisAsn: 0.984 ± 0.25
1.421HisPro: 1.421 ± 0.253
0.929HisGln: 0.929 ± 0.243
1.804HisArg: 1.804 ± 0.322
0.929HisSer: 0.929 ± 0.197
1.312HisThr: 1.312 ± 0.237
1.257HisVal: 1.257 ± 0.372
0.328HisTrp: 0.328 ± 0.12
0.984HisTyr: 0.984 ± 0.173
0.0HisXaa: 0.0 ± 0.0
Ile
5.247IleAla: 5.247 ± 0.62
0.656IleCys: 0.656 ± 0.228
3.772IleAsp: 3.772 ± 0.469
4.045IleGlu: 4.045 ± 0.432
0.711IlePhe: 0.711 ± 0.198
3.444IleGly: 3.444 ± 0.494
1.421IleHis: 1.421 ± 0.28
1.366IleIle: 1.366 ± 0.273
1.093IleLys: 1.093 ± 0.199
2.022IleLeu: 2.022 ± 0.374
0.328IleMet: 0.328 ± 0.128
1.694IleAsn: 1.694 ± 0.288
2.788IlePro: 2.788 ± 0.326
1.585IleGln: 1.585 ± 0.271
2.296IleArg: 2.296 ± 0.362
2.624IleSer: 2.624 ± 0.474
3.936IleThr: 3.936 ± 0.439
3.28IleVal: 3.28 ± 0.394
0.875IleTrp: 0.875 ± 0.184
0.656IleTyr: 0.656 ± 0.179
0.0IleXaa: 0.0 ± 0.0
Lys
4.099LysAla: 4.099 ± 0.527
0.328LysCys: 0.328 ± 0.126
2.077LysAsp: 2.077 ± 0.31
1.039LysGlu: 1.039 ± 0.209
1.421LysPhe: 1.421 ± 0.229
2.569LysGly: 2.569 ± 0.399
1.039LysHis: 1.039 ± 0.274
0.82LysIle: 0.82 ± 0.188
1.257LysLys: 1.257 ± 0.344
2.678LysLeu: 2.678 ± 0.473
0.601LysMet: 0.601 ± 0.156
0.984LysAsn: 0.984 ± 0.232
2.733LysPro: 2.733 ± 0.431
1.749LysGln: 1.749 ± 0.265
2.241LysArg: 2.241 ± 0.384
1.804LysSer: 1.804 ± 0.252
2.077LysThr: 2.077 ± 0.335
2.514LysVal: 2.514 ± 0.398
0.875LysTrp: 0.875 ± 0.241
0.984LysTyr: 0.984 ± 0.255
0.0LysXaa: 0.0 ± 0.0
Leu
7.652LeuAla: 7.652 ± 0.685
0.82LeuCys: 0.82 ± 0.213
4.701LeuAsp: 4.701 ± 0.582
4.263LeuGlu: 4.263 ± 0.472
2.405LeuPhe: 2.405 ± 0.351
5.411LeuGly: 5.411 ± 0.536
0.82LeuHis: 0.82 ± 0.205
3.389LeuIle: 3.389 ± 0.504
2.022LeuLys: 2.022 ± 0.314
4.755LeuLeu: 4.755 ± 0.502
1.694LeuMet: 1.694 ± 0.333
2.678LeuAsn: 2.678 ± 0.397
4.755LeuPro: 4.755 ± 0.691
3.006LeuGln: 3.006 ± 0.429
4.865LeuArg: 4.865 ± 0.592
5.794LeuSer: 5.794 ± 0.591
5.466LeuThr: 5.466 ± 0.466
5.083LeuVal: 5.083 ± 0.546
1.093LeuTrp: 1.093 ± 0.237
2.296LeuTyr: 2.296 ± 0.376
0.0LeuXaa: 0.0 ± 0.0
Met
2.405MetAla: 2.405 ± 0.345
0.219MetCys: 0.219 ± 0.145
1.64MetAsp: 1.64 ± 0.324
0.929MetGlu: 0.929 ± 0.2
0.765MetPhe: 0.765 ± 0.229
1.64MetGly: 1.64 ± 0.262
0.328MetHis: 0.328 ± 0.118
0.929MetIle: 0.929 ± 0.198
0.984MetLys: 0.984 ± 0.237
2.077MetLeu: 2.077 ± 0.259
0.601MetMet: 0.601 ± 0.229
0.875MetAsn: 0.875 ± 0.22
1.366MetPro: 1.366 ± 0.237
0.383MetGln: 0.383 ± 0.141
1.476MetArg: 1.476 ± 0.301
2.842MetSer: 2.842 ± 0.342
2.132MetThr: 2.132 ± 0.253
1.421MetVal: 1.421 ± 0.292
0.328MetTrp: 0.328 ± 0.132
0.273MetTyr: 0.273 ± 0.131
0.0MetXaa: 0.0 ± 0.0
Asn
3.608AsnAla: 3.608 ± 0.378
0.273AsnCys: 0.273 ± 0.113
1.64AsnAsp: 1.64 ± 0.275
1.585AsnGlu: 1.585 ± 0.308
0.82AsnPhe: 0.82 ± 0.285
3.826AsnGly: 3.826 ± 0.595
0.984AsnHis: 0.984 ± 0.191
1.476AsnIle: 1.476 ± 0.475
1.093AsnLys: 1.093 ± 0.242
2.405AsnLeu: 2.405 ± 0.348
0.82AsnMet: 0.82 ± 0.183
1.858AsnAsn: 1.858 ± 0.385
2.624AsnPro: 2.624 ± 0.306
1.148AsnGln: 1.148 ± 0.318
2.132AsnArg: 2.132 ± 0.395
1.913AsnSer: 1.913 ± 0.267
2.405AsnThr: 2.405 ± 0.286
2.186AsnVal: 2.186 ± 0.313
0.656AsnTrp: 0.656 ± 0.182
0.711AsnTyr: 0.711 ± 0.18
0.0AsnXaa: 0.0 ± 0.0
Pro
5.357ProAla: 5.357 ± 0.618
0.82ProCys: 0.82 ± 0.205
3.826ProAsp: 3.826 ± 0.47
4.427ProGlu: 4.427 ± 0.463
1.804ProPhe: 1.804 ± 0.339
6.286ProGly: 6.286 ± 0.696
1.694ProHis: 1.694 ± 0.315
1.749ProIle: 1.749 ± 0.311
2.405ProLys: 2.405 ± 0.384
4.482ProLeu: 4.482 ± 0.53
1.64ProMet: 1.64 ± 0.368
2.405ProAsn: 2.405 ± 0.303
4.154ProPro: 4.154 ± 0.509
2.296ProGln: 2.296 ± 0.43
3.225ProArg: 3.225 ± 0.533
3.116ProSer: 3.116 ± 0.414
3.444ProThr: 3.444 ± 0.42
4.591ProVal: 4.591 ± 0.521
1.148ProTrp: 1.148 ± 0.259
1.257ProTyr: 1.257 ± 0.246
0.0ProXaa: 0.0 ± 0.0
Gln
4.591GlnAla: 4.591 ± 0.59
0.273GlnCys: 0.273 ± 0.127
1.421GlnAsp: 1.421 ± 0.226
1.53GlnGlu: 1.53 ± 0.282
1.257GlnPhe: 1.257 ± 0.228
2.35GlnGly: 2.35 ± 0.458
0.984GlnHis: 0.984 ± 0.212
1.968GlnIle: 1.968 ± 0.317
1.203GlnLys: 1.203 ± 0.218
2.897GlnLeu: 2.897 ± 0.34
0.601GlnMet: 0.601 ± 0.211
0.765GlnAsn: 0.765 ± 0.242
2.405GlnPro: 2.405 ± 0.377
0.984GlnGln: 0.984 ± 0.259
2.514GlnArg: 2.514 ± 0.413
2.077GlnSer: 2.077 ± 0.372
1.858GlnThr: 1.858 ± 0.347
2.733GlnVal: 2.733 ± 0.386
0.601GlnTrp: 0.601 ± 0.156
0.984GlnTyr: 0.984 ± 0.241
0.0GlnXaa: 0.0 ± 0.0
Arg
6.341ArgAla: 6.341 ± 0.666
0.929ArgCys: 0.929 ± 0.278
4.974ArgAsp: 4.974 ± 0.612
4.865ArgGlu: 4.865 ± 0.559
2.788ArgPhe: 2.788 ± 0.466
4.154ArgGly: 4.154 ± 0.399
1.093ArgHis: 1.093 ± 0.293
4.318ArgIle: 4.318 ± 0.618
2.35ArgLys: 2.35 ± 0.39
4.755ArgLeu: 4.755 ± 0.556
2.405ArgMet: 2.405 ± 0.318
2.405ArgAsn: 2.405 ± 0.395
3.444ArgPro: 3.444 ± 0.498
1.64ArgGln: 1.64 ± 0.314
5.794ArgArg: 5.794 ± 0.727
3.772ArgSer: 3.772 ± 0.472
3.225ArgThr: 3.225 ± 0.503
4.919ArgVal: 4.919 ± 0.698
1.749ArgTrp: 1.749 ± 0.31
2.077ArgTyr: 2.077 ± 0.284
0.0ArgXaa: 0.0 ± 0.0
Ser
5.411SerAla: 5.411 ± 0.808
0.547SerCys: 0.547 ± 0.2
3.99SerAsp: 3.99 ± 0.574
3.116SerGlu: 3.116 ± 0.503
2.241SerPhe: 2.241 ± 0.386
6.614SerGly: 6.614 ± 1.08
1.148SerHis: 1.148 ± 0.233
2.952SerIle: 2.952 ± 0.352
2.405SerLys: 2.405 ± 0.32
4.318SerLeu: 4.318 ± 0.465
1.53SerMet: 1.53 ± 0.258
2.514SerAsn: 2.514 ± 0.346
3.444SerPro: 3.444 ± 0.382
1.312SerGln: 1.312 ± 0.237
3.225SerArg: 3.225 ± 0.418
3.772SerSer: 3.772 ± 0.703
3.662SerThr: 3.662 ± 0.512
5.138SerVal: 5.138 ± 0.766
1.148SerTrp: 1.148 ± 0.217
1.421SerTyr: 1.421 ± 0.233
0.0SerXaa: 0.0 ± 0.0
Thr
6.013ThrAla: 6.013 ± 0.604
0.492ThrCys: 0.492 ± 0.151
4.537ThrAsp: 4.537 ± 0.547
4.099ThrGlu: 4.099 ± 0.446
1.53ThrPhe: 1.53 ± 0.336
6.122ThrGly: 6.122 ± 0.589
1.53ThrHis: 1.53 ± 0.259
3.772ThrIle: 3.772 ± 0.511
2.022ThrLys: 2.022 ± 0.384
3.936ThrLeu: 3.936 ± 0.437
1.366ThrMet: 1.366 ± 0.256
1.968ThrAsn: 1.968 ± 0.336
4.865ThrPro: 4.865 ± 0.595
2.132ThrGln: 2.132 ± 0.353
3.99ThrArg: 3.99 ± 0.394
3.826ThrSer: 3.826 ± 0.47
4.209ThrThr: 4.209 ± 0.574
6.231ThrVal: 6.231 ± 0.589
1.148ThrTrp: 1.148 ± 0.302
2.022ThrTyr: 2.022 ± 0.353
0.0ThrXaa: 0.0 ± 0.0
Val
6.832ValAla: 6.832 ± 0.57
0.984ValCys: 0.984 ± 0.232
4.919ValAsp: 4.919 ± 0.489
4.755ValGlu: 4.755 ± 0.514
2.296ValPhe: 2.296 ± 0.425
5.575ValGly: 5.575 ± 0.689
1.203ValHis: 1.203 ± 0.235
2.842ValIle: 2.842 ± 0.406
2.514ValLys: 2.514 ± 0.37
5.302ValLeu: 5.302 ± 0.643
1.585ValMet: 1.585 ± 0.253
2.514ValAsn: 2.514 ± 0.295
3.936ValPro: 3.936 ± 0.461
3.116ValGln: 3.116 ± 0.291
4.591ValArg: 4.591 ± 0.586
4.81ValSer: 4.81 ± 0.628
5.357ValThr: 5.357 ± 0.594
6.231ValVal: 6.231 ± 0.705
1.421ValTrp: 1.421 ± 0.351
1.749ValTyr: 1.749 ± 0.323
0.0ValXaa: 0.0 ± 0.0
Trp
1.749TrpAla: 1.749 ± 0.3
0.437TrpCys: 0.437 ± 0.152
1.366TrpAsp: 1.366 ± 0.27
1.203TrpGlu: 1.203 ± 0.305
0.765TrpPhe: 0.765 ± 0.223
0.984TrpGly: 0.984 ± 0.227
0.601TrpHis: 0.601 ± 0.193
1.093TrpIle: 1.093 ± 0.19
0.711TrpLys: 0.711 ± 0.184
1.804TrpLeu: 1.804 ± 0.337
0.82TrpMet: 0.82 ± 0.217
0.601TrpAsn: 0.601 ± 0.214
0.711TrpPro: 0.711 ± 0.211
0.984TrpGln: 0.984 ± 0.22
2.241TrpArg: 2.241 ± 0.421
1.203TrpSer: 1.203 ± 0.246
1.312TrpThr: 1.312 ± 0.242
1.53TrpVal: 1.53 ± 0.406
1.039TrpTrp: 1.039 ± 0.226
0.437TrpTyr: 0.437 ± 0.144
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.733TyrAla: 2.733 ± 0.406
0.383TyrCys: 0.383 ± 0.178
1.968TyrAsp: 1.968 ± 0.412
1.858TyrGlu: 1.858 ± 0.337
0.929TyrPhe: 0.929 ± 0.235
1.968TyrGly: 1.968 ± 0.429
0.273TyrHis: 0.273 ± 0.112
1.039TyrIle: 1.039 ± 0.2
0.492TyrLys: 0.492 ± 0.158
1.858TyrLeu: 1.858 ± 0.31
0.219TyrMet: 0.219 ± 0.094
0.765TyrAsn: 0.765 ± 0.185
1.694TyrPro: 1.694 ± 0.271
0.711TyrGln: 0.711 ± 0.184
2.132TyrArg: 2.132 ± 0.378
1.093TyrSer: 1.093 ± 0.249
1.913TyrThr: 1.913 ± 0.336
2.788TyrVal: 2.788 ± 0.344
0.547TyrTrp: 0.547 ± 0.159
0.492TyrTyr: 0.492 ± 0.154
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 101 proteins (18296 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski