Amino acid dipepetide frequency for Enterobacteria phage RB51 (Bacteriophage RB51)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.615AlaAla: 4.615 ± 0.333
0.511AlaCys: 0.511 ± 0.099
3.385AlaAsp: 3.385 ± 0.303
5.012AlaGlu: 5.012 ± 0.344
2.345AlaPhe: 2.345 ± 0.201
4.142AlaGly: 4.142 ± 0.35
1.173AlaHis: 1.173 ± 0.156
4.596AlaIle: 4.596 ± 0.302
4.842AlaLys: 4.842 ± 0.363
5.352AlaLeu: 5.352 ± 0.356
1.21AlaMet: 1.21 ± 0.158
3.177AlaAsn: 3.177 ± 0.255
2.27AlaPro: 2.27 ± 0.19
2.667AlaGln: 2.667 ± 0.193
2.742AlaArg: 2.742 ± 0.246
4.028AlaSer: 4.028 ± 0.28
3.177AlaThr: 3.177 ± 0.39
4.482AlaVal: 4.482 ± 0.332
0.87AlaTrp: 0.87 ± 0.14
2.326AlaTyr: 2.326 ± 0.259
0.0AlaXaa: 0.0 ± 0.0
Cys
0.624CysAla: 0.624 ± 0.117
0.151CysCys: 0.151 ± 0.057
0.775CysAsp: 0.775 ± 0.122
0.87CysGlu: 0.87 ± 0.108
0.359CysPhe: 0.359 ± 0.081
0.832CysGly: 0.832 ± 0.142
0.303CysHis: 0.303 ± 0.073
0.624CysIle: 0.624 ± 0.1
0.757CysLys: 0.757 ± 0.123
0.738CysLeu: 0.738 ± 0.119
0.246CysMet: 0.246 ± 0.065
0.473CysAsn: 0.473 ± 0.102
0.567CysPro: 0.567 ± 0.095
0.378CysGln: 0.378 ± 0.081
0.586CysArg: 0.586 ± 0.115
0.813CysSer: 0.813 ± 0.112
0.492CysThr: 0.492 ± 0.096
0.775CysVal: 0.775 ± 0.14
0.132CysTrp: 0.132 ± 0.05
0.435CysTyr: 0.435 ± 0.095
0.0CysXaa: 0.0 ± 0.0
Asp
3.65AspAla: 3.65 ± 0.252
0.7AspCys: 0.7 ± 0.104
4.085AspAsp: 4.085 ± 0.292
4.709AspGlu: 4.709 ± 0.345
3.556AspPhe: 3.556 ± 0.282
4.407AspGly: 4.407 ± 0.292
0.889AspHis: 0.889 ± 0.109
5.031AspIle: 5.031 ± 0.301
4.728AspLys: 4.728 ± 0.312
4.69AspLeu: 4.69 ± 0.357
1.929AspMet: 1.929 ± 0.229
2.837AspAsn: 2.837 ± 0.256
2.118AspPro: 2.118 ± 0.236
1.343AspGln: 1.343 ± 0.149
2.137AspArg: 2.137 ± 0.212
3.764AspSer: 3.764 ± 0.243
3.139AspThr: 3.139 ± 0.233
4.35AspVal: 4.35 ± 0.35
1.267AspTrp: 1.267 ± 0.159
3.385AspTyr: 3.385 ± 0.235
0.0AspXaa: 0.0 ± 0.0
Glu
4.879GluAla: 4.879 ± 0.305
0.908GluCys: 0.908 ± 0.147
4.066GluAsp: 4.066 ± 0.306
5.163GluGlu: 5.163 ± 0.317
3.139GluPhe: 3.139 ± 0.258
3.801GluGly: 3.801 ± 0.31
1.154GluHis: 1.154 ± 0.132
6.26GluIle: 6.26 ± 0.36
5.485GluLys: 5.485 ± 0.356
6.695GluLeu: 6.695 ± 0.388
2.099GluMet: 2.099 ± 0.231
3.896GluAsn: 3.896 ± 0.282
1.589GluPro: 1.589 ± 0.194
2.478GluGln: 2.478 ± 0.243
2.723GluArg: 2.723 ± 0.245
4.558GluSer: 4.558 ± 0.316
4.293GluThr: 4.293 ± 0.328
4.823GluVal: 4.823 ± 0.256
1.116GluTrp: 1.116 ± 0.156
3.461GluTyr: 3.461 ± 0.267
0.0GluXaa: 0.0 ± 0.0
Phe
2.534PheAla: 2.534 ± 0.206
0.567PheCys: 0.567 ± 0.097
3.234PheAsp: 3.234 ± 0.257
3.518PheGlu: 3.518 ± 0.244
1.475PhePhe: 1.475 ± 0.18
3.007PheGly: 3.007 ± 0.219
0.719PheHis: 0.719 ± 0.136
3.329PheIle: 3.329 ± 0.299
3.915PheLys: 3.915 ± 0.296
2.402PheLeu: 2.402 ± 0.182
1.437PheMet: 1.437 ± 0.146
2.969PheAsn: 2.969 ± 0.195
1.135PhePro: 1.135 ± 0.139
1.475PheGln: 1.475 ± 0.192
1.759PheArg: 1.759 ± 0.171
3.234PheSer: 3.234 ± 0.249
2.856PheThr: 2.856 ± 0.266
2.629PheVal: 2.629 ± 0.226
0.567PheTrp: 0.567 ± 0.091
1.948PheTyr: 1.948 ± 0.19
0.0PheXaa: 0.0 ± 0.0
Gly
2.856GlyAla: 2.856 ± 0.255
0.624GlyCys: 0.624 ± 0.112
4.028GlyAsp: 4.028 ± 0.319
3.877GlyGlu: 3.877 ± 0.262
2.723GlyPhe: 2.723 ± 0.219
3.707GlyGly: 3.707 ± 0.625
0.927GlyHis: 0.927 ± 0.143
4.652GlyIle: 4.652 ± 0.272
4.671GlyLys: 4.671 ± 0.306
4.728GlyLeu: 4.728 ± 0.32
1.986GlyMet: 1.986 ± 0.217
3.31GlyAsn: 3.31 ± 0.451
1.721GlyPro: 1.721 ± 0.164
2.288GlyGln: 2.288 ± 0.26
2.326GlyArg: 2.326 ± 0.196
3.991GlySer: 3.991 ± 0.253
3.953GlyThr: 3.953 ± 0.386
3.972GlyVal: 3.972 ± 0.277
0.946GlyTrp: 0.946 ± 0.15
3.007GlyTyr: 3.007 ± 0.229
0.0GlyXaa: 0.0 ± 0.0
His
0.889HisAla: 0.889 ± 0.107
0.265HisCys: 0.265 ± 0.078
0.946HisAsp: 0.946 ± 0.114
1.173HisGlu: 1.173 ± 0.137
0.927HisPhe: 0.927 ± 0.129
0.851HisGly: 0.851 ± 0.137
0.416HisHis: 0.416 ± 0.118
1.456HisIle: 1.456 ± 0.197
1.475HisLys: 1.475 ± 0.182
1.456HisLeu: 1.456 ± 0.166
0.435HisMet: 0.435 ± 0.084
0.7HisAsn: 0.7 ± 0.099
0.794HisPro: 0.794 ± 0.114
0.548HisGln: 0.548 ± 0.119
0.813HisArg: 0.813 ± 0.131
1.21HisSer: 1.21 ± 0.153
0.965HisThr: 0.965 ± 0.119
0.889HisVal: 0.889 ± 0.126
0.322HisTrp: 0.322 ± 0.09
0.624HisTyr: 0.624 ± 0.09
0.0HisXaa: 0.0 ± 0.0
Ile
5.163IleAla: 5.163 ± 0.302
0.643IleCys: 0.643 ± 0.115
5.466IleAsp: 5.466 ± 0.304
5.806IleGlu: 5.806 ± 0.386
2.799IlePhe: 2.799 ± 0.232
3.839IleGly: 3.839 ± 0.242
1.418IleHis: 1.418 ± 0.198
5.825IleIle: 5.825 ± 0.332
6.941IleLys: 6.941 ± 0.482
4.861IleLeu: 4.861 ± 0.284
1.986IleMet: 1.986 ± 0.186
5.239IleAsn: 5.239 ± 0.285
2.818IlePro: 2.818 ± 0.256
2.704IleGln: 2.704 ± 0.233
3.442IleArg: 3.442 ± 0.23
4.955IleSer: 4.955 ± 0.312
4.634IleThr: 4.634 ± 0.307
4.236IleVal: 4.236 ± 0.334
0.7IleTrp: 0.7 ± 0.122
2.913IleTyr: 2.913 ± 0.233
0.0IleXaa: 0.0 ± 0.0
Lys
5.674LysAla: 5.674 ± 0.363
0.87LysCys: 0.87 ± 0.15
5.277LysAsp: 5.277 ± 0.384
5.806LysGlu: 5.806 ± 0.363
4.047LysPhe: 4.047 ± 0.27
4.066LysGly: 4.066 ± 0.232
1.778LysHis: 1.778 ± 0.197
6.147LysIle: 6.147 ± 0.332
5.031LysLys: 5.031 ± 0.391
6.355LysLeu: 6.355 ± 0.322
2.515LysMet: 2.515 ± 0.227
4.539LysAsn: 4.539 ± 0.311
2.364LysPro: 2.364 ± 0.215
2.326LysGln: 2.326 ± 0.208
3.31LysArg: 3.31 ± 0.283
5.05LysSer: 5.05 ± 0.329
4.236LysThr: 4.236 ± 0.31
5.031LysVal: 5.031 ± 0.361
1.191LysTrp: 1.191 ± 0.136
3.461LysTyr: 3.461 ± 0.303
0.0LysXaa: 0.0 ± 0.0
Leu
4.652LeuAla: 4.652 ± 0.321
0.946LeuCys: 0.946 ± 0.131
4.993LeuAsp: 4.993 ± 0.333
5.352LeuGlu: 5.352 ± 0.34
3.442LeuPhe: 3.442 ± 0.24
3.953LeuGly: 3.953 ± 0.223
1.116LeuHis: 1.116 ± 0.15
5.352LeuIle: 5.352 ± 0.343
6.241LeuLys: 6.241 ± 0.355
4.993LeuLeu: 4.993 ± 0.351
2.099LeuMet: 2.099 ± 0.172
4.634LeuAsn: 4.634 ± 0.27
2.818LeuPro: 2.818 ± 0.234
2.421LeuGln: 2.421 ± 0.219
3.158LeuArg: 3.158 ± 0.226
5.371LeuSer: 5.371 ± 0.337
4.255LeuThr: 4.255 ± 0.279
4.463LeuVal: 4.463 ± 0.307
0.889LeuTrp: 0.889 ± 0.141
2.742LeuTyr: 2.742 ± 0.239
0.0LeuXaa: 0.0 ± 0.0
Met
2.307MetAla: 2.307 ± 0.221
0.303MetCys: 0.303 ± 0.078
1.305MetAsp: 1.305 ± 0.158
1.816MetGlu: 1.816 ± 0.23
1.248MetPhe: 1.248 ± 0.14
1.437MetGly: 1.437 ± 0.187
0.435MetHis: 0.435 ± 0.091
2.251MetIle: 2.251 ± 0.229
3.045MetLys: 3.045 ± 0.297
1.778MetLeu: 1.778 ± 0.197
0.965MetMet: 0.965 ± 0.143
1.74MetAsn: 1.74 ± 0.183
0.643MetPro: 0.643 ± 0.104
0.87MetGln: 0.87 ± 0.118
1.135MetArg: 1.135 ± 0.151
1.759MetSer: 1.759 ± 0.156
1.778MetThr: 1.778 ± 0.16
1.248MetVal: 1.248 ± 0.147
0.17MetTrp: 0.17 ± 0.056
1.04MetTyr: 1.04 ± 0.141
0.0MetXaa: 0.0 ± 0.0
Asn
3.669AsnAla: 3.669 ± 0.269
0.567AsnCys: 0.567 ± 0.11
3.423AsnAsp: 3.423 ± 0.242
3.896AsnGlu: 3.896 ± 0.249
2.553AsnPhe: 2.553 ± 0.193
4.199AsnGly: 4.199 ± 0.468
0.794AsnHis: 0.794 ± 0.112
4.634AsnIle: 4.634 ± 0.261
4.577AsnLys: 4.577 ± 0.269
4.161AsnLeu: 4.161 ± 0.276
1.702AsnMet: 1.702 ± 0.197
3.385AsnAsn: 3.385 ± 0.27
2.421AsnPro: 2.421 ± 0.206
1.778AsnGln: 1.778 ± 0.197
2.44AsnArg: 2.44 ± 0.192
3.726AsnSer: 3.726 ± 0.329
2.742AsnThr: 2.742 ± 0.23
3.196AsnVal: 3.196 ± 0.27
0.757AsnTrp: 0.757 ± 0.127
2.515AsnTyr: 2.515 ± 0.204
0.0AsnXaa: 0.0 ± 0.0
Pro
1.797ProAla: 1.797 ± 0.179
0.416ProCys: 0.416 ± 0.091
2.496ProAsp: 2.496 ± 0.249
3.026ProGlu: 3.026 ± 0.293
1.57ProPhe: 1.57 ± 0.181
2.383ProGly: 2.383 ± 0.245
0.624ProHis: 0.624 ± 0.097
2.232ProIle: 2.232 ± 0.222
2.345ProLys: 2.345 ± 0.246
2.156ProLeu: 2.156 ± 0.189
0.851ProMet: 0.851 ± 0.147
1.967ProAsn: 1.967 ± 0.19
1.059ProPro: 1.059 ± 0.152
1.059ProGln: 1.059 ± 0.129
1.097ProArg: 1.097 ± 0.141
2.194ProSer: 2.194 ± 0.184
2.175ProThr: 2.175 ± 0.221
2.364ProVal: 2.364 ± 0.2
0.643ProTrp: 0.643 ± 0.11
1.437ProTyr: 1.437 ± 0.172
0.0ProXaa: 0.0 ± 0.0
Gln
2.213GlnAla: 2.213 ± 0.218
0.284GlnCys: 0.284 ± 0.075
1.626GlnAsp: 1.626 ± 0.206
2.496GlnGlu: 2.496 ± 0.254
1.74GlnPhe: 1.74 ± 0.204
1.929GlnGly: 1.929 ± 0.239
0.511GlnHis: 0.511 ± 0.103
2.78GlnIle: 2.78 ± 0.215
2.553GlnLys: 2.553 ± 0.216
2.742GlnLeu: 2.742 ± 0.215
0.832GlnMet: 0.832 ± 0.126
1.608GlnAsn: 1.608 ± 0.189
1.191GlnPro: 1.191 ± 0.167
1.021GlnGln: 1.021 ± 0.165
1.872GlnArg: 1.872 ± 0.185
2.043GlnSer: 2.043 ± 0.194
1.948GlnThr: 1.948 ± 0.188
2.194GlnVal: 2.194 ± 0.208
0.53GlnTrp: 0.53 ± 0.111
1.778GlnTyr: 1.778 ± 0.158
0.0GlnXaa: 0.0 ± 0.0
Arg
2.515ArgAla: 2.515 ± 0.258
0.567ArgCys: 0.567 ± 0.108
2.572ArgAsp: 2.572 ± 0.196
3.253ArgGlu: 3.253 ± 0.214
1.778ArgPhe: 1.778 ± 0.157
2.818ArgGly: 2.818 ± 0.252
0.681ArgHis: 0.681 ± 0.103
3.102ArgIle: 3.102 ± 0.236
3.215ArgLys: 3.215 ± 0.27
3.366ArgLeu: 3.366 ± 0.23
0.927ArgMet: 0.927 ± 0.118
2.156ArgAsn: 2.156 ± 0.176
1.229ArgPro: 1.229 ± 0.144
1.608ArgGln: 1.608 ± 0.178
2.043ArgArg: 2.043 ± 0.185
2.515ArgSer: 2.515 ± 0.222
2.118ArgThr: 2.118 ± 0.185
2.818ArgVal: 2.818 ± 0.245
0.775ArgTrp: 0.775 ± 0.134
1.608ArgTyr: 1.608 ± 0.191
0.0ArgXaa: 0.0 ± 0.0
Ser
3.631SerAla: 3.631 ± 0.232
0.757SerCys: 0.757 ± 0.146
3.801SerAsp: 3.801 ± 0.267
4.142SerGlu: 4.142 ± 0.246
2.837SerPhe: 2.837 ± 0.235
4.52SerGly: 4.52 ± 0.31
1.173SerHis: 1.173 ± 0.146
5.277SerIle: 5.277 ± 0.339
5.39SerLys: 5.39 ± 0.371
4.974SerLeu: 4.974 ± 0.323
1.551SerMet: 1.551 ± 0.198
3.631SerAsn: 3.631 ± 0.329
2.364SerPro: 2.364 ± 0.191
2.251SerGln: 2.251 ± 0.238
2.667SerArg: 2.667 ± 0.236
5.579SerSer: 5.579 ± 0.451
4.104SerThr: 4.104 ± 0.288
4.009SerVal: 4.009 ± 0.27
0.927SerTrp: 0.927 ± 0.129
2.913SerTyr: 2.913 ± 0.282
0.0SerXaa: 0.0 ± 0.0
Thr
4.047ThrAla: 4.047 ± 0.394
0.416ThrCys: 0.416 ± 0.101
3.348ThrAsp: 3.348 ± 0.256
4.047ThrGlu: 4.047 ± 0.296
2.648ThrPhe: 2.648 ± 0.252
4.085ThrGly: 4.085 ± 0.338
1.021ThrHis: 1.021 ± 0.14
4.142ThrIle: 4.142 ± 0.252
3.593ThrLys: 3.593 ± 0.249
4.047ThrLeu: 4.047 ± 0.263
1.154ThrMet: 1.154 ± 0.154
3.102ThrAsn: 3.102 ± 0.302
2.704ThrPro: 2.704 ± 0.275
2.061ThrGln: 2.061 ± 0.237
2.44ThrArg: 2.44 ± 0.276
3.329ThrSer: 3.329 ± 0.288
3.121ThrThr: 3.121 ± 0.327
4.539ThrVal: 4.539 ± 0.358
0.794ThrTrp: 0.794 ± 0.135
2.496ThrTyr: 2.496 ± 0.22
0.0ThrXaa: 0.0 ± 0.0
Val
3.499ValAla: 3.499 ± 0.251
0.889ValCys: 0.889 ± 0.121
3.745ValAsp: 3.745 ± 0.279
5.201ValGlu: 5.201 ± 0.346
2.629ValPhe: 2.629 ± 0.255
3.366ValGly: 3.366 ± 0.277
1.078ValHis: 1.078 ± 0.149
4.558ValIle: 4.558 ± 0.304
5.749ValLys: 5.749 ± 0.32
4.539ValLeu: 4.539 ± 0.245
1.721ValMet: 1.721 ± 0.17
4.217ValAsn: 4.217 ± 0.257
1.986ValPro: 1.986 ± 0.196
2.251ValGln: 2.251 ± 0.257
2.667ValArg: 2.667 ± 0.205
4.501ValSer: 4.501 ± 0.234
4.047ValThr: 4.047 ± 0.324
4.539ValVal: 4.539 ± 0.272
0.719ValTrp: 0.719 ± 0.11
2.496ValTyr: 2.496 ± 0.214
0.0ValXaa: 0.0 ± 0.0
Trp
0.794TrpAla: 0.794 ± 0.118
0.132TrpCys: 0.132 ± 0.053
0.927TrpAsp: 0.927 ± 0.134
0.813TrpGlu: 0.813 ± 0.107
0.851TrpPhe: 0.851 ± 0.156
0.586TrpGly: 0.586 ± 0.106
0.189TrpHis: 0.189 ± 0.055
0.908TrpIle: 0.908 ± 0.131
1.437TrpLys: 1.437 ± 0.178
1.04TrpLeu: 1.04 ± 0.142
0.511TrpMet: 0.511 ± 0.097
1.021TrpAsn: 1.021 ± 0.147
0.435TrpPro: 0.435 ± 0.085
0.624TrpGln: 0.624 ± 0.104
0.454TrpArg: 0.454 ± 0.096
0.965TrpSer: 0.965 ± 0.138
0.719TrpThr: 0.719 ± 0.113
0.775TrpVal: 0.775 ± 0.121
0.189TrpTrp: 0.189 ± 0.056
0.832TrpTyr: 0.832 ± 0.135
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.913TyrAla: 2.913 ± 0.237
0.416TyrCys: 0.416 ± 0.086
3.215TyrAsp: 3.215 ± 0.267
2.61TyrGlu: 2.61 ± 0.277
2.061TyrPhe: 2.061 ± 0.211
2.364TyrGly: 2.364 ± 0.214
0.757TyrHis: 0.757 ± 0.14
3.234TyrIle: 3.234 ± 0.25
3.083TyrLys: 3.083 ± 0.257
2.818TyrLeu: 2.818 ± 0.232
1.097TyrMet: 1.097 ± 0.161
2.534TyrAsn: 2.534 ± 0.225
1.664TyrPro: 1.664 ± 0.158
1.74TyrGln: 1.74 ± 0.187
1.853TyrArg: 1.853 ± 0.182
2.913TyrSer: 2.913 ± 0.265
2.383TyrThr: 2.383 ± 0.198
3.064TyrVal: 3.064 ± 0.268
0.7TyrTrp: 0.7 ± 0.116
1.835TyrTyr: 1.835 ± 0.233
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 273 proteins (52876 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski