Amino acid dipepetide frequency for Proteobacteria bacterium CAG:495

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.84AlaAla: 8.84 ± 0.199
1.047AlaCys: 1.047 ± 0.061
4.992AlaAsp: 4.992 ± 0.122
6.474AlaGlu: 6.474 ± 0.147
3.365AlaPhe: 3.365 ± 0.084
5.888AlaGly: 5.888 ± 0.129
1.238AlaHis: 1.238 ± 0.046
4.553AlaIle: 4.553 ± 0.094
5.849AlaLys: 5.849 ± 0.123
8.28AlaLeu: 8.28 ± 0.136
2.163AlaMet: 2.163 ± 0.073
3.308AlaAsn: 3.308 ± 0.082
3.061AlaPro: 3.061 ± 0.084
3.244AlaGln: 3.244 ± 0.099
3.788AlaArg: 3.788 ± 0.088
4.514AlaSer: 4.514 ± 0.107
3.151AlaThr: 3.151 ± 0.093
6.697AlaVal: 6.697 ± 0.134
0.723AlaTrp: 0.723 ± 0.04
2.914AlaTyr: 2.914 ± 0.081
0.0AlaXaa: 0.0 ± 0.0
Cys
0.936CysAla: 0.936 ± 0.047
0.286CysCys: 0.286 ± 0.025
0.658CysAsp: 0.658 ± 0.047
0.731CysGlu: 0.731 ± 0.043
0.662CysPhe: 0.662 ± 0.038
1.267CysGly: 1.267 ± 0.064
0.226CysHis: 0.226 ± 0.022
0.763CysIle: 0.763 ± 0.043
0.761CysLys: 0.761 ± 0.053
1.238CysLeu: 1.238 ± 0.06
0.268CysMet: 0.268 ± 0.025
0.588CysAsn: 0.588 ± 0.043
0.707CysPro: 0.707 ± 0.055
0.362CysGln: 0.362 ± 0.034
0.834CysArg: 0.834 ± 0.051
0.975CysSer: 0.975 ± 0.08
0.62CysThr: 0.62 ± 0.059
0.747CysVal: 0.747 ± 0.042
0.153CysTrp: 0.153 ± 0.018
0.477CysTyr: 0.477 ± 0.04
0.0CysXaa: 0.0 ± 0.0
Asp
4.426AspAla: 4.426 ± 0.103
0.761AspCys: 0.761 ± 0.045
3.443AspAsp: 3.443 ± 0.106
4.218AspGlu: 4.218 ± 0.103
3.175AspPhe: 3.175 ± 0.093
4.08AspGly: 4.08 ± 0.136
0.63AspHis: 0.63 ± 0.038
4.436AspIle: 4.436 ± 0.095
4.321AspLys: 4.321 ± 0.102
4.474AspLeu: 4.474 ± 0.101
1.599AspMet: 1.599 ± 0.056
3.187AspAsn: 3.187 ± 0.082
1.432AspPro: 1.432 ± 0.051
0.999AspGln: 0.999 ± 0.042
2.348AspArg: 2.348 ± 0.073
2.859AspSer: 2.859 ± 0.088
2.356AspThr: 2.356 ± 0.067
4.011AspVal: 4.011 ± 0.096
0.662AspTrp: 0.662 ± 0.038
2.36AspTyr: 2.36 ± 0.085
0.0AspXaa: 0.0 ± 0.0
Glu
5.727GluAla: 5.727 ± 0.132
0.671GluCys: 0.671 ± 0.047
3.608GluAsp: 3.608 ± 0.093
5.455GluGlu: 5.455 ± 0.167
2.65GluPhe: 2.65 ± 0.067
3.508GluGly: 3.508 ± 0.091
1.216GluHis: 1.216 ± 0.055
5.135GluIle: 5.135 ± 0.119
5.781GluLys: 5.781 ± 0.126
6.393GluLeu: 6.393 ± 0.151
1.844GluMet: 1.844 ± 0.064
4.204GluAsn: 4.204 ± 0.1
2.108GluPro: 2.108 ± 0.079
2.962GluGln: 2.962 ± 0.079
3.385GluArg: 3.385 ± 0.115
2.726GluSer: 2.726 ± 0.082
3.528GluThr: 3.528 ± 0.089
4.694GluVal: 4.694 ± 0.11
0.608GluTrp: 0.608 ± 0.038
2.211GluTyr: 2.211 ± 0.069
0.0GluXaa: 0.0 ± 0.0
Phe
3.743PheAla: 3.743 ± 0.096
0.711PheCys: 0.711 ± 0.038
2.879PheAsp: 2.879 ± 0.09
2.71PheGlu: 2.71 ± 0.079
2.138PhePhe: 2.138 ± 0.08
3.065PheGly: 3.065 ± 0.078
0.594PheHis: 0.594 ± 0.029
3.034PheIle: 3.034 ± 0.085
2.565PheLys: 2.565 ± 0.066
3.949PheLeu: 3.949 ± 0.107
1.331PheMet: 1.331 ± 0.055
2.318PheAsn: 2.318 ± 0.076
1.458PhePro: 1.458 ± 0.058
1.085PheGln: 1.085 ± 0.043
1.842PheArg: 1.842 ± 0.064
3.19PheSer: 3.19 ± 0.074
1.991PheThr: 1.991 ± 0.066
3.129PheVal: 3.129 ± 0.076
0.536PheTrp: 0.536 ± 0.034
1.802PheTyr: 1.802 ± 0.063
0.0PheXaa: 0.0 ± 0.0
Gly
4.859GlyAla: 4.859 ± 0.12
1.17GlyCys: 1.17 ± 0.059
3.447GlyAsp: 3.447 ± 0.085
4.231GlyGlu: 4.231 ± 0.105
3.083GlyPhe: 3.083 ± 0.083
4.436GlyGly: 4.436 ± 0.119
1.18GlyHis: 1.18 ± 0.052
4.907GlyIle: 4.907 ± 0.092
4.992GlyLys: 4.992 ± 0.11
6.178GlyLeu: 6.178 ± 0.118
1.943GlyMet: 1.943 ± 0.068
3.123GlyAsn: 3.123 ± 0.103
1.307GlyPro: 1.307 ± 0.055
2.144GlyGln: 2.144 ± 0.069
3.206GlyArg: 3.206 ± 0.089
3.987GlySer: 3.987 ± 0.109
3.544GlyThr: 3.544 ± 0.112
4.452GlyVal: 4.452 ± 0.098
0.765GlyTrp: 0.765 ± 0.04
2.763GlyTyr: 2.763 ± 0.085
0.0GlyXaa: 0.0 ± 0.0
His
1.067HisAla: 1.067 ± 0.048
0.254HisCys: 0.254 ± 0.023
0.791HisAsp: 0.791 ± 0.04
0.874HisGlu: 0.874 ± 0.041
0.773HisPhe: 0.773 ± 0.038
1.142HisGly: 1.142 ± 0.048
0.348HisHis: 0.348 ± 0.033
1.202HisIle: 1.202 ± 0.056
1.035HisLys: 1.035 ± 0.05
1.585HisLeu: 1.585 ± 0.059
0.397HisMet: 0.397 ± 0.03
0.904HisAsn: 0.904 ± 0.045
0.934HisPro: 0.934 ± 0.046
0.574HisGln: 0.574 ± 0.031
0.894HisArg: 0.894 ± 0.042
0.838HisSer: 0.838 ± 0.042
0.707HisThr: 0.707 ± 0.04
0.777HisVal: 0.777 ± 0.042
0.169HisTrp: 0.169 ± 0.02
0.658HisTyr: 0.658 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
5.904IleAla: 5.904 ± 0.118
0.973IleCys: 0.973 ± 0.046
3.945IleAsp: 3.945 ± 0.094
4.518IleGlu: 4.518 ± 0.106
2.889IlePhe: 2.889 ± 0.088
4.585IleGly: 4.585 ± 0.119
0.92IleHis: 0.92 ± 0.043
4.788IleIle: 4.788 ± 0.112
4.927IleLys: 4.927 ± 0.109
5.779IleLeu: 5.779 ± 0.104
1.649IleMet: 1.649 ± 0.065
3.651IleAsn: 3.651 ± 0.085
2.885IlePro: 2.885 ± 0.083
1.643IleGln: 1.643 ± 0.059
3.204IleArg: 3.204 ± 0.085
4.776IleSer: 4.776 ± 0.112
3.341IleThr: 3.341 ± 0.092
4.77IleVal: 4.77 ± 0.094
0.604IleTrp: 0.604 ± 0.038
2.183IleTyr: 2.183 ± 0.077
0.0IleXaa: 0.0 ± 0.0
Lys
5.857LysAla: 5.857 ± 0.128
0.719LysCys: 0.719 ± 0.051
4.041LysAsp: 4.041 ± 0.09
5.06LysGlu: 5.06 ± 0.108
2.579LysPhe: 2.579 ± 0.073
3.842LysGly: 3.842 ± 0.102
1.061LysHis: 1.061 ± 0.042
5.783LysIle: 5.783 ± 0.121
5.93LysLys: 5.93 ± 0.136
6.528LysLeu: 6.528 ± 0.128
2.116LysMet: 2.116 ± 0.057
4.051LysAsn: 4.051 ± 0.101
2.426LysPro: 2.426 ± 0.06
2.529LysGln: 2.529 ± 0.08
3.065LysArg: 3.065 ± 0.08
3.862LysSer: 3.862 ± 0.089
3.91LysThr: 3.91 ± 0.087
4.671LysVal: 4.671 ± 0.113
0.588LysTrp: 0.588 ± 0.034
2.39LysTyr: 2.39 ± 0.073
0.0LysXaa: 0.0 ± 0.0
Leu
8.161LeuAla: 8.161 ± 0.132
1.13LeuCys: 1.13 ± 0.05
5.056LeuAsp: 5.056 ± 0.114
6.049LeuGlu: 6.049 ± 0.119
3.943LeuPhe: 3.943 ± 0.103
6.244LeuGly: 6.244 ± 0.128
1.353LeuHis: 1.353 ± 0.051
5.87LeuIle: 5.87 ± 0.12
6.854LeuLys: 6.854 ± 0.132
8.975LeuLeu: 8.975 ± 0.185
2.398LeuMet: 2.398 ± 0.065
4.712LeuAsn: 4.712 ± 0.104
4.317LeuPro: 4.317 ± 0.095
3.27LeuGln: 3.27 ± 0.091
4.704LeuArg: 4.704 ± 0.114
6.882LeuSer: 6.882 ± 0.136
4.887LeuThr: 4.887 ± 0.094
5.632LeuVal: 5.632 ± 0.132
0.993LeuTrp: 0.993 ± 0.053
2.99LeuTyr: 2.99 ± 0.081
0.0LeuXaa: 0.0 ± 0.0
Met
2.241MetAla: 2.241 ± 0.078
0.24MetCys: 0.24 ± 0.024
1.271MetAsp: 1.271 ± 0.052
1.655MetGlu: 1.655 ± 0.062
1.049MetPhe: 1.049 ± 0.048
1.508MetGly: 1.508 ± 0.063
0.481MetHis: 0.481 ± 0.034
1.73MetIle: 1.73 ± 0.061
1.895MetLys: 1.895 ± 0.062
2.775MetLeu: 2.775 ± 0.083
0.777MetMet: 0.777 ± 0.049
1.208MetAsn: 1.208 ± 0.051
1.307MetPro: 1.307 ± 0.052
1.027MetGln: 1.027 ± 0.041
1.26MetArg: 1.26 ± 0.053
1.794MetSer: 1.794 ± 0.063
1.448MetThr: 1.448 ± 0.061
1.633MetVal: 1.633 ± 0.055
0.175MetTrp: 0.175 ± 0.019
0.664MetTyr: 0.664 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
3.937AsnAla: 3.937 ± 0.1
0.628AsnCys: 0.628 ± 0.041
2.531AsnAsp: 2.531 ± 0.079
2.889AsnGlu: 2.889 ± 0.089
2.275AsnPhe: 2.275 ± 0.072
3.441AsnGly: 3.441 ± 0.099
0.826AsnHis: 0.826 ± 0.038
3.661AsnIle: 3.661 ± 0.106
3.359AsnLys: 3.359 ± 0.094
4.941AsnLeu: 4.941 ± 0.124
1.353AsnMet: 1.353 ± 0.051
2.64AsnAsn: 2.64 ± 0.091
2.541AsnPro: 2.541 ± 0.074
1.691AsnGln: 1.691 ± 0.069
2.755AsnArg: 2.755 ± 0.075
2.781AsnSer: 2.781 ± 0.086
2.235AsnThr: 2.235 ± 0.076
3.314AsnVal: 3.314 ± 0.1
0.584AsnTrp: 0.584 ± 0.033
1.913AsnTyr: 1.913 ± 0.065
0.0AsnXaa: 0.0 ± 0.0
Pro
3.475ProAla: 3.475 ± 0.101
0.473ProCys: 0.473 ± 0.038
2.465ProAsp: 2.465 ± 0.071
3.695ProGlu: 3.695 ± 0.094
1.701ProPhe: 1.701 ± 0.07
2.082ProGly: 2.082 ± 0.064
0.745ProHis: 0.745 ± 0.033
1.842ProIle: 1.842 ± 0.068
2.187ProLys: 2.187 ± 0.071
3.538ProLeu: 3.538 ± 0.087
0.83ProMet: 0.83 ± 0.042
1.585ProAsn: 1.585 ± 0.06
0.999ProPro: 0.999 ± 0.053
1.818ProGln: 1.818 ± 0.078
1.589ProArg: 1.589 ± 0.056
2.251ProSer: 2.251 ± 0.076
1.548ProThr: 1.548 ± 0.059
2.964ProVal: 2.964 ± 0.069
0.411ProTrp: 0.411 ± 0.03
1.48ProTyr: 1.48 ± 0.06
0.004ProXaa: 0.004 ± 0.003
Gln
2.994GlnAla: 2.994 ± 0.083
0.362GlnCys: 0.362 ± 0.034
1.708GlnAsp: 1.708 ± 0.059
2.422GlnGlu: 2.422 ± 0.076
1.111GlnPhe: 1.111 ± 0.044
2.008GlnGly: 2.008 ± 0.067
0.497GlnHis: 0.497 ± 0.033
2.487GlnIle: 2.487 ± 0.076
2.851GlnLys: 2.851 ± 0.075
2.978GlnLeu: 2.978 ± 0.078
1.051GlnMet: 1.051 ± 0.045
2.13GlnAsn: 2.13 ± 0.082
1.331GlnPro: 1.331 ± 0.053
1.452GlnGln: 1.452 ± 0.084
1.683GlnArg: 1.683 ± 0.064
1.822GlnSer: 1.822 ± 0.062
2.006GlnThr: 2.006 ± 0.071
1.969GlnVal: 1.969 ± 0.063
0.282GlnTrp: 0.282 ± 0.027
1.111GlnTyr: 1.111 ± 0.048
0.002GlnXaa: 0.002 ± 0.002
Arg
3.272ArgAla: 3.272 ± 0.08
0.622ArgCys: 0.622 ± 0.038
2.459ArgAsp: 2.459 ± 0.082
3.568ArgGlu: 3.568 ± 0.107
2.215ArgPhe: 2.215 ± 0.075
2.785ArgGly: 2.785 ± 0.078
1.033ArgHis: 1.033 ± 0.047
3.496ArgIle: 3.496 ± 0.094
3.421ArgLys: 3.421 ± 0.09
5.145ArgLeu: 5.145 ± 0.114
1.291ArgMet: 1.291 ± 0.05
2.257ArgAsn: 2.257 ± 0.068
1.794ArgPro: 1.794 ± 0.066
2.297ArgGln: 2.297 ± 0.084
3.165ArgArg: 3.165 ± 0.1
2.533ArgSer: 2.533 ± 0.075
2.084ArgThr: 2.084 ± 0.059
2.736ArgVal: 2.736 ± 0.096
0.439ArgTrp: 0.439 ± 0.03
1.929ArgTyr: 1.929 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
5.187SerAla: 5.187 ± 0.117
0.991SerCys: 0.991 ± 0.096
3.27SerAsp: 3.27 ± 0.097
3.822SerGlu: 3.822 ± 0.091
3.02SerPhe: 3.02 ± 0.082
4.943SerGly: 4.943 ± 0.114
0.981SerHis: 0.981 ± 0.048
3.548SerIle: 3.548 ± 0.094
3.743SerLys: 3.743 ± 0.078
5.996SerLeu: 5.996 ± 0.12
1.271SerMet: 1.271 ± 0.056
2.565SerAsn: 2.565 ± 0.09
2.215SerPro: 2.215 ± 0.07
2.054SerGln: 2.054 ± 0.059
3.224SerArg: 3.224 ± 0.085
4.158SerSer: 4.158 ± 0.116
2.503SerThr: 2.503 ± 0.077
4.138SerVal: 4.138 ± 0.098
0.693SerTrp: 0.693 ± 0.039
2.175SerTyr: 2.175 ± 0.07
0.002SerXaa: 0.002 ± 0.002
Thr
4.643ThrAla: 4.643 ± 0.115
0.582ThrCys: 0.582 ± 0.058
2.569ThrAsp: 2.569 ± 0.064
2.773ThrGlu: 2.773 ± 0.079
2.167ThrPhe: 2.167 ± 0.067
3.677ThrGly: 3.677 ± 0.092
0.765ThrHis: 0.765 ± 0.034
2.986ThrIle: 2.986 ± 0.087
2.638ThrLys: 2.638 ± 0.093
4.684ThrLeu: 4.684 ± 0.1
1.043ThrMet: 1.043 ± 0.045
2.02ThrAsn: 2.02 ± 0.066
2.666ThrPro: 2.666 ± 0.077
1.464ThrGln: 1.464 ± 0.06
1.929ThrArg: 1.929 ± 0.068
3.077ThrSer: 3.077 ± 0.078
2.577ThrThr: 2.577 ± 0.073
3.58ThrVal: 3.58 ± 0.105
0.377ThrTrp: 0.377 ± 0.028
1.681ThrTyr: 1.681 ± 0.064
0.0ThrXaa: 0.0 ± 0.0
Val
5.32ValAla: 5.32 ± 0.111
0.997ValCys: 0.997 ± 0.055
3.842ValAsp: 3.842 ± 0.093
4.49ValGlu: 4.49 ± 0.106
3.077ValPhe: 3.077 ± 0.087
4.168ValGly: 4.168 ± 0.102
0.924ValHis: 0.924 ± 0.043
4.97ValIle: 4.97 ± 0.107
4.855ValLys: 4.855 ± 0.124
6.359ValLeu: 6.359 ± 0.127
1.693ValMet: 1.693 ± 0.064
3.268ValAsn: 3.268 ± 0.078
2.525ValPro: 2.525 ± 0.076
1.76ValGln: 1.76 ± 0.061
3.121ValArg: 3.121 ± 0.084
4.82ValSer: 4.82 ± 0.107
3.405ValThr: 3.405 ± 0.088
5.169ValVal: 5.169 ± 0.121
0.739ValTrp: 0.739 ± 0.041
2.459ValTyr: 2.459 ± 0.078
0.0ValXaa: 0.0 ± 0.0
Trp
0.646TrpAla: 0.646 ± 0.036
0.135TrpCys: 0.135 ± 0.015
0.501TrpAsp: 0.501 ± 0.032
0.622TrpGlu: 0.622 ± 0.037
0.487TrpPhe: 0.487 ± 0.034
0.705TrpGly: 0.705 ± 0.04
0.217TrpHis: 0.217 ± 0.024
0.568TrpIle: 0.568 ± 0.033
0.675TrpLys: 0.675 ± 0.04
1.196TrpLeu: 1.196 ± 0.053
0.328TrpMet: 0.328 ± 0.024
0.546TrpAsn: 0.546 ± 0.036
0.304TrpPro: 0.304 ± 0.03
0.491TrpGln: 0.491 ± 0.029
0.56TrpArg: 0.56 ± 0.032
0.58TrpSer: 0.58 ± 0.038
0.411TrpThr: 0.411 ± 0.03
0.564TrpVal: 0.564 ± 0.037
0.181TrpTrp: 0.181 ± 0.019
0.373TrpTyr: 0.373 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.851TyrAla: 2.851 ± 0.071
0.509TyrCys: 0.509 ± 0.036
2.302TyrAsp: 2.302 ± 0.076
2.157TyrGlu: 2.157 ± 0.068
1.71TyrPhe: 1.71 ± 0.06
2.344TyrGly: 2.344 ± 0.073
0.687TyrHis: 0.687 ± 0.036
2.177TyrIle: 2.177 ± 0.079
2.372TyrLys: 2.372 ± 0.075
3.429TyrLeu: 3.429 ± 0.084
0.791TyrMet: 0.791 ± 0.041
2.03TyrAsn: 2.03 ± 0.074
1.365TyrPro: 1.365 ± 0.059
1.391TyrGln: 1.391 ± 0.055
1.983TyrArg: 1.983 ± 0.071
2.07TyrSer: 2.07 ± 0.071
1.645TyrThr: 1.645 ± 0.069
2.312TyrVal: 2.312 ± 0.081
0.409TyrTrp: 0.409 ± 0.03
1.482TyrTyr: 1.482 ± 0.071
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.002XaaGly: 0.002 ± 0.002
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.004XaaArg: 0.004 ± 0.003
0.002XaaSer: 0.002 ± 0.002
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.006XaaXaa: 0.006 ± 0.004
Statistics based on 1693 proteins (496630 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski