Amino acid dipepetide frequency for Paludisphaera borealis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.98AlaAla: 14.98 ± 0.125	1.113AlaCys: 1.113 ± 0.025	6.89AlaAsp: 6.89 ± 0.076	7.13AlaGlu: 7.13 ± 0.084	3.932AlaPhe: 3.932 ± 0.054	9.543AlaGly: 9.543 ± 0.089	1.948AlaHis: 1.948 ± 0.032	4.999AlaIle: 4.999 ± 0.047	4.086AlaLys: 4.086 ± 0.062	11.266AlaLeu: 11.266 ± 0.101	2.399AlaMet: 2.399 ± 0.042	2.605AlaAsn: 2.605 ± 0.045	6.126AlaPro: 6.126 ± 0.073	3.189AlaGln: 3.189 ± 0.047	8.574AlaArg: 8.574 ± 0.095	7.043AlaSer: 7.043 ± 0.067	6.03AlaThr: 6.03 ± 0.07	9.129AlaVal: 9.129 ± 0.078	1.803AlaTrp: 1.803 ± 0.037	2.37AlaTyr: 2.37 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	0.752CysAla: 0.752 ± 0.02	0.144CysCys: 0.144 ± 0.009	0.581CysAsp: 0.581 ± 0.018	0.477CysGlu: 0.477 ± 0.016	0.329CysPhe: 0.329 ± 0.012	0.893CysGly: 0.893 ± 0.029	0.329CysHis: 0.329 ± 0.016	0.319CysIle: 0.319 ± 0.013	0.226CysLys: 0.226 ± 0.011	0.975CysLeu: 0.975 ± 0.023	0.147CysMet: 0.147 ± 0.009	0.248CysAsn: 0.248 ± 0.012	0.566CysPro: 0.566 ± 0.019	0.288CysGln: 0.288 ± 0.01	0.765CysArg: 0.765 ± 0.02	0.485CysSer: 0.485 ± 0.017	0.402CysThr: 0.402 ± 0.015	0.657CysVal: 0.657 ± 0.017	0.152CysTrp: 0.152 ± 0.009	0.254CysTyr: 0.254 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.061AspAla: 7.061 ± 0.074	0.428AspCys: 0.428 ± 0.016	4.158AspAsp: 4.158 ± 0.058	3.803AspGlu: 3.803 ± 0.049	2.086AspPhe: 2.086 ± 0.036	5.647AspGly: 5.647 ± 0.07	1.463AspHis: 1.463 ± 0.028	1.476AspIle: 1.476 ± 0.032	1.692AspLys: 1.692 ± 0.034	6.446AspLeu: 6.446 ± 0.058	0.854AspMet: 0.854 ± 0.024	1.053AspAsn: 1.053 ± 0.024	4.463AspPro: 4.463 ± 0.054	2.144AspGln: 2.144 ± 0.032	5.278AspArg: 5.278 ± 0.064	2.79AspSer: 2.79 ± 0.035	1.79AspThr: 1.79 ± 0.029	4.874AspVal: 4.874 ± 0.054	1.067AspTrp: 1.067 ± 0.022	1.442AspTyr: 1.442 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	7.194GluAla: 7.194 ± 0.078	0.368GluCys: 0.368 ± 0.015	2.456GluAsp: 2.456 ± 0.04	2.875GluGlu: 2.875 ± 0.047	1.892GluPhe: 1.892 ± 0.034	4.21GluGly: 4.21 ± 0.054	1.246GluHis: 1.246 ± 0.026	2.946GluIle: 2.946 ± 0.041	2.162GluLys: 2.162 ± 0.044	5.623GluLeu: 5.623 ± 0.074	1.13GluMet: 1.13 ± 0.024	1.426GluAsn: 1.426 ± 0.029	3.684GluPro: 3.684 ± 0.046	2.04GluGln: 2.04 ± 0.04	4.71GluArg: 4.71 ± 0.06	3.454GluSer: 3.454 ± 0.042	3.214GluThr: 3.214 ± 0.046	4.163GluVal: 4.163 ± 0.051	0.756GluTrp: 0.756 ± 0.02	1.152GluTyr: 1.152 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.747PheAla: 3.747 ± 0.047	0.339PheCys: 0.339 ± 0.013	2.579PheAsp: 2.579 ± 0.038	2.067PheGlu: 2.067 ± 0.034	1.259PhePhe: 1.259 ± 0.029	3.275PheGly: 3.275 ± 0.044	0.88PheHis: 0.88 ± 0.021	1.212PheIle: 1.212 ± 0.026	0.952PheLys: 0.952 ± 0.022	3.664PheLeu: 3.664 ± 0.048	0.565PheMet: 0.565 ± 0.016	1.101PheAsn: 1.101 ± 0.027	1.792PhePro: 1.792 ± 0.032	1.29PheGln: 1.29 ± 0.022	2.538PheArg: 2.538 ± 0.036	2.061PheSer: 2.061 ± 0.037	1.855PheThr: 1.855 ± 0.033	2.631PheVal: 2.631 ± 0.035	0.606PheTrp: 0.606 ± 0.018	0.891PheTyr: 0.891 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	8.188GlyAla: 8.188 ± 0.091	0.945GlyCys: 0.945 ± 0.025	4.877GlyAsp: 4.877 ± 0.059	4.525GlyGlu: 4.525 ± 0.049	3.322GlyPhe: 3.322 ± 0.043	7.967GlyGly: 7.967 ± 0.252	1.655GlyHis: 1.655 ± 0.031	3.03GlyIle: 3.03 ± 0.047	3.427GlyLys: 3.427 ± 0.054	8.891GlyLeu: 8.891 ± 0.072	1.958GlyMet: 1.958 ± 0.035	2.056GlyAsn: 2.056 ± 0.069	4.527GlyPro: 4.527 ± 0.057	2.627GlyGln: 2.627 ± 0.047	7.216GlyArg: 7.216 ± 0.081	5.195GlySer: 5.195 ± 0.099	4.248GlyThr: 4.248 ± 0.061	6.82GlyVal: 6.82 ± 0.067	1.586GlyTrp: 1.586 ± 0.033	2.169GlyTyr: 2.169 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.119HisAla: 2.119 ± 0.037	0.233HisCys: 0.233 ± 0.011	1.425HisAsp: 1.425 ± 0.028	1.216HisGlu: 1.216 ± 0.025	0.746HisPhe: 0.746 ± 0.019	1.903HisGly: 1.903 ± 0.031	0.609HisHis: 0.609 ± 0.02	0.697HisIle: 0.697 ± 0.02	0.568HisLys: 0.568 ± 0.017	2.036HisLeu: 2.036 ± 0.034	0.329HisMet: 0.329 ± 0.011	0.536HisAsn: 0.536 ± 0.019	1.531HisPro: 1.531 ± 0.027	0.641HisGln: 0.641 ± 0.016	1.618HisArg: 1.618 ± 0.03	0.968HisSer: 0.968 ± 0.023	0.806HisThr: 0.806 ± 0.022	1.509HisVal: 1.509 ± 0.025	0.356HisTrp: 0.356 ± 0.014	0.549HisTyr: 0.549 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	5.354IleAla: 5.354 ± 0.051	0.404IleCys: 0.404 ± 0.013	3.401IleAsp: 3.401 ± 0.048	3.179IleGlu: 3.179 ± 0.04	1.252IlePhe: 1.252 ± 0.03	3.837IleGly: 3.837 ± 0.051	0.986IleHis: 0.986 ± 0.02	1.425IleIle: 1.425 ± 0.029	1.364IleLys: 1.364 ± 0.027	4.131IleLeu: 4.131 ± 0.045	0.58IleMet: 0.58 ± 0.016	1.205IleAsn: 1.205 ± 0.029	2.452IlePro: 2.452 ± 0.034	1.413IleGln: 1.413 ± 0.03	3.181IleArg: 3.181 ± 0.042	2.099IleSer: 2.099 ± 0.032	2.135IleThr: 2.135 ± 0.042	3.669IleVal: 3.669 ± 0.05	0.533IleTrp: 0.533 ± 0.018	1.006IleTyr: 1.006 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	4.153LysAla: 4.153 ± 0.055	0.197LysCys: 0.197 ± 0.01	1.831LysAsp: 1.831 ± 0.04	1.728LysGlu: 1.728 ± 0.033	0.983LysPhe: 0.983 ± 0.023	2.557LysGly: 2.557 ± 0.036	0.642LysHis: 0.642 ± 0.018	1.745LysIle: 1.745 ± 0.032	1.466LysLys: 1.466 ± 0.036	3.477LysLeu: 3.477 ± 0.05	0.652LysMet: 0.652 ± 0.017	0.999LysAsn: 0.999 ± 0.024	2.75LysPro: 2.75 ± 0.041	1.183LysGln: 1.183 ± 0.036	2.307LysArg: 2.307 ± 0.035	2.018LysSer: 2.018 ± 0.031	2.202LysThr: 2.202 ± 0.035	2.36LysVal: 2.36 ± 0.038	0.377LysTrp: 0.377 ± 0.013	0.729LysTyr: 0.729 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	13.452LeuAla: 13.452 ± 0.118	0.967LeuCys: 0.967 ± 0.021	6.64LeuAsp: 6.64 ± 0.062	5.544LeuGlu: 5.544 ± 0.06	3.281LeuPhe: 3.281 ± 0.045	8.797LeuGly: 8.797 ± 0.071	1.86LeuHis: 1.86 ± 0.032	4.807LeuIle: 4.807 ± 0.056	3.768LeuLys: 3.768 ± 0.047	9.476LeuLeu: 9.476 ± 0.084	1.768LeuMet: 1.768 ± 0.03	2.629LeuAsn: 2.629 ± 0.039	5.495LeuPro: 5.495 ± 0.052	2.625LeuGln: 2.625 ± 0.04	7.157LeuArg: 7.157 ± 0.073	5.786LeuSer: 5.786 ± 0.056	5.611LeuThr: 5.611 ± 0.051	7.465LeuVal: 7.465 ± 0.061	1.285LeuTrp: 1.285 ± 0.028	2.115LeuTyr: 2.115 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.136MetAla: 2.136 ± 0.034	0.133MetCys: 0.133 ± 0.009	0.847MetAsp: 0.847 ± 0.021	0.884MetGlu: 0.884 ± 0.023	0.601MetPhe: 0.601 ± 0.019	1.526MetGly: 1.526 ± 0.035	0.355MetHis: 0.355 ± 0.014	1.131MetIle: 1.131 ± 0.023	0.781MetLys: 0.781 ± 0.018	1.905MetLeu: 1.905 ± 0.03	0.479MetMet: 0.479 ± 0.019	0.682MetAsn: 0.682 ± 0.016	1.157MetPro: 1.157 ± 0.024	0.52MetGln: 0.52 ± 0.016	1.315MetArg: 1.315 ± 0.025	1.388MetSer: 1.388 ± 0.025	1.387MetThr: 1.387 ± 0.026	1.337MetVal: 1.337 ± 0.026	0.165MetTrp: 0.165 ± 0.01	0.319MetTyr: 0.319 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.735AsnAla: 2.735 ± 0.043	0.239AsnCys: 0.239 ± 0.01	1.5AsnAsp: 1.5 ± 0.031	1.19AsnGlu: 1.19 ± 0.024	0.953AsnPhe: 0.953 ± 0.026	2.372AsnGly: 2.372 ± 0.066	0.586AsnHis: 0.586 ± 0.017	1.031AsnIle: 1.031 ± 0.024	0.656AsnLys: 0.656 ± 0.018	2.797AsnLeu: 2.797 ± 0.043	0.444AsnMet: 0.444 ± 0.016	0.813AsnAsn: 0.813 ± 0.033	2.085AsnPro: 2.085 ± 0.039	0.988AsnGln: 0.988 ± 0.027	1.992AsnArg: 1.992 ± 0.038	1.404AsnSer: 1.404 ± 0.035	1.323AsnThr: 1.323 ± 0.038	1.965AsnVal: 1.965 ± 0.04	0.422AsnTrp: 0.422 ± 0.015	0.735AsnTyr: 0.735 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.204ProAla: 7.204 ± 0.084	0.425ProCys: 0.425 ± 0.016	4.093ProAsp: 4.093 ± 0.047	4.179ProGlu: 4.179 ± 0.049	1.981ProPhe: 1.981 ± 0.03	5.436ProGly: 5.436 ± 0.061	1.079ProHis: 1.079 ± 0.024	2.858ProIle: 2.858 ± 0.034	2.25ProLys: 2.25 ± 0.042	5.106ProLeu: 5.106 ± 0.051	1.153ProMet: 1.153 ± 0.023	1.734ProAsn: 1.734 ± 0.032	3.986ProPro: 3.986 ± 0.067	1.526ProGln: 1.526 ± 0.031	3.927ProArg: 3.927 ± 0.051	4.118ProSer: 4.118 ± 0.049	3.53ProThr: 3.53 ± 0.044	4.25ProVal: 4.25 ± 0.051	0.889ProTrp: 0.889 ± 0.02	1.236ProTyr: 1.236 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	4.043GlnAla: 4.043 ± 0.058	0.266GlnCys: 0.266 ± 0.011	1.307GlnAsp: 1.307 ± 0.022	1.409GlnGlu: 1.409 ± 0.028	1.117GlnPhe: 1.117 ± 0.023	2.639GlnGly: 2.639 ± 0.047	0.575GlnHis: 0.575 ± 0.015	1.655GlnIle: 1.655 ± 0.028	1.044GlnLys: 1.044 ± 0.026	2.809GlnLeu: 2.809 ± 0.041	0.573GlnMet: 0.573 ± 0.016	0.851GlnAsn: 0.851 ± 0.025	1.922GlnPro: 1.922 ± 0.034	1.082GlnGln: 1.082 ± 0.033	2.077GlnArg: 2.077 ± 0.034	1.853GlnSer: 1.853 ± 0.034	1.851GlnThr: 1.851 ± 0.036	2.437GlnVal: 2.437 ± 0.042	0.433GlnTrp: 0.433 ± 0.015	0.756GlnTyr: 0.756 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	7.362ArgAla: 7.362 ± 0.081	0.672ArgCys: 0.672 ± 0.02	4.413ArgAsp: 4.413 ± 0.05	4.411ArgGlu: 4.411 ± 0.053	3.117ArgPhe: 3.117 ± 0.039	5.358ArgGly: 5.358 ± 0.056	1.565ArgHis: 1.565 ± 0.031	3.907ArgIle: 3.907 ± 0.05	2.605ArgLys: 2.605 ± 0.04	8.649ArgLeu: 8.649 ± 0.083	1.593ArgMet: 1.593 ± 0.029	1.898ArgAsn: 1.898 ± 0.034	4.787ArgPro: 4.787 ± 0.053	2.31ArgGln: 2.31 ± 0.036	7.209ArgArg: 7.209 ± 0.075	4.557ArgSer: 4.557 ± 0.052	3.698ArgThr: 3.698 ± 0.04	5.102ArgVal: 5.102 ± 0.051	1.358ArgTrp: 1.358 ± 0.026	1.84ArgTyr: 1.84 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.214SerAla: 6.214 ± 0.067	0.518SerCys: 0.518 ± 0.018	3.115SerAsp: 3.115 ± 0.04	2.848SerGlu: 2.848 ± 0.038	2.124SerPhe: 2.124 ± 0.034	5.391SerGly: 5.391 ± 0.08	1.179SerHis: 1.179 ± 0.025	2.704SerIle: 2.704 ± 0.039	1.955SerLys: 1.955 ± 0.052	5.94SerLeu: 5.94 ± 0.045	1.263SerMet: 1.263 ± 0.025	1.63SerAsn: 1.63 ± 0.039	3.961SerPro: 3.961 ± 0.046	1.913SerGln: 1.913 ± 0.035	4.447SerArg: 4.447 ± 0.048	3.743SerSer: 3.743 ± 0.058	3.385SerThr: 3.385 ± 0.049	3.947SerVal: 3.947 ± 0.048	1.011SerTrp: 1.011 ± 0.021	1.425SerTyr: 1.425 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	5.984ThrAla: 5.984 ± 0.063	0.417ThrCys: 0.417 ± 0.015	2.757ThrAsp: 2.757 ± 0.04	2.345ThrGlu: 2.345 ± 0.036	2.012ThrPhe: 2.012 ± 0.029	4.63ThrGly: 4.63 ± 0.062	1.021ThrHis: 1.021 ± 0.023	2.944ThrIle: 2.944 ± 0.039	1.507ThrLys: 1.507 ± 0.029	5.542ThrLeu: 5.542 ± 0.059	0.949ThrMet: 0.949 ± 0.021	1.403ThrAsn: 1.403 ± 0.036	3.842ThrPro: 3.842 ± 0.05	1.325ThrGln: 1.325 ± 0.026	3.292ThrArg: 3.292 ± 0.037	3.279ThrSer: 3.279 ± 0.049	3.368ThrThr: 3.368 ± 0.066	4.105ThrVal: 4.105 ± 0.056	0.777ThrTrp: 0.777 ± 0.02	1.234ThrTyr: 1.234 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	8.939ValAla: 8.939 ± 0.069	0.776ValCys: 0.776 ± 0.02	4.808ValAsp: 4.808 ± 0.051	4.87ValGlu: 4.87 ± 0.055	2.791ValPhe: 2.791 ± 0.042	6.194ValGly: 6.194 ± 0.062	1.524ValHis: 1.524 ± 0.029	3.117ValIle: 3.117 ± 0.036	2.548ValLys: 2.548 ± 0.043	7.547ValLeu: 7.547 ± 0.069	1.428ValMet: 1.428 ± 0.029	2.045ValAsn: 2.045 ± 0.038	3.837ValPro: 3.837 ± 0.049	2.214ValGln: 2.214 ± 0.033	5.566ValArg: 5.566 ± 0.058	4.12ValSer: 4.12 ± 0.047	3.784ValThr: 3.784 ± 0.06	7.386ValVal: 7.386 ± 0.078	1.138ValTrp: 1.138 ± 0.026	1.774ValTyr: 1.774 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.371TrpAla: 1.371 ± 0.025	0.162TrpCys: 0.162 ± 0.009	0.84TrpAsp: 0.84 ± 0.023	0.687TrpGlu: 0.687 ± 0.019	0.589TrpPhe: 0.589 ± 0.017	1.063TrpGly: 1.063 ± 0.026	0.301TrpHis: 0.301 ± 0.013	0.832TrpIle: 0.832 ± 0.018	0.612TrpLys: 0.612 ± 0.019	1.811TrpLeu: 1.811 ± 0.035	0.36TrpMet: 0.36 ± 0.013	0.554TrpAsn: 0.554 ± 0.019	0.783TrpPro: 0.783 ± 0.022	0.444TrpGln: 0.444 ± 0.015	1.264TrpArg: 1.264 ± 0.026	1.078TrpSer: 1.078 ± 0.024	1.004TrpThr: 1.004 ± 0.022	1.009TrpVal: 1.009 ± 0.021	0.293TrpTrp: 0.293 ± 0.013	0.35TrpTyr: 0.35 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.167TyrAla: 2.167 ± 0.034	0.242TyrCys: 0.242 ± 0.011	1.494TyrAsp: 1.494 ± 0.025	1.336TyrGlu: 1.336 ± 0.028	0.935TyrPhe: 0.935 ± 0.021	1.992TyrGly: 1.992 ± 0.031	0.589TyrHis: 0.589 ± 0.015	0.774TyrIle: 0.774 ± 0.021	0.689TyrLys: 0.689 ± 0.019	2.438TyrLeu: 2.438 ± 0.039	0.423TyrMet: 0.423 ± 0.015	0.762TyrAsn: 0.762 ± 0.02	1.212TyrPro: 1.212 ± 0.026	0.936TyrGln: 0.936 ± 0.019	1.979TyrArg: 1.979 ± 0.031	1.273TyrSer: 1.273 ± 0.031	1.11TyrThr: 1.11 ± 0.029	1.593TyrVal: 1.593 ± 0.027	0.401TyrTrp: 0.401 ± 0.013	0.763TyrTyr: 0.763 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5693 proteins (2148798 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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