Amino acid dipepetide frequency for Scytalidium lignicola (Hyphomycete)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.923AlaAla: 7.923 ± 0.043	1.032AlaCys: 1.032 ± 0.014	3.74AlaAsp: 3.74 ± 0.027	4.65AlaGlu: 4.65 ± 0.031	3.067AlaPhe: 3.067 ± 0.025	5.399AlaGly: 5.399 ± 0.038	1.587AlaHis: 1.587 ± 0.018	4.689AlaIle: 4.689 ± 0.028	3.981AlaLys: 3.981 ± 0.028	7.417AlaLeu: 7.417 ± 0.042	1.881AlaMet: 1.881 ± 0.02	2.948AlaAsn: 2.948 ± 0.021	4.045AlaPro: 4.045 ± 0.035	3.088AlaGln: 3.088 ± 0.023	4.219AlaArg: 4.219 ± 0.027	6.654AlaSer: 6.654 ± 0.039	5.096AlaThr: 5.096 ± 0.033	5.082AlaVal: 5.082 ± 0.031	1.122AlaTrp: 1.122 ± 0.014	2.178AlaTyr: 2.178 ± 0.019	0.007AlaXaa: 0.007 ± 0.001
Cys	0.899CysAla: 0.899 ± 0.012	0.238CysCys: 0.238 ± 0.007	0.634CysAsp: 0.634 ± 0.009	0.585CysGlu: 0.585 ± 0.011	0.556CysPhe: 0.556 ± 0.009	0.953CysGly: 0.953 ± 0.015	0.318CysHis: 0.318 ± 0.008	0.808CysIle: 0.808 ± 0.013	0.535CysLys: 0.535 ± 0.009	1.238CysLeu: 1.238 ± 0.015	0.267CysMet: 0.267 ± 0.006	0.475CysAsn: 0.475 ± 0.01	0.623CysPro: 0.623 ± 0.011	0.452CysGln: 0.452 ± 0.009	0.66CysArg: 0.66 ± 0.011	0.96CysSer: 0.96 ± 0.014	0.712CysThr: 0.712 ± 0.009	0.754CysVal: 0.754 ± 0.011	0.208CysTrp: 0.208 ± 0.006	0.394CysTyr: 0.394 ± 0.008	0.002CysXaa: 0.002 ± 0.001
Asp	4.044AspAla: 4.044 ± 0.025	0.623AspCys: 0.623 ± 0.011	3.814AspAsp: 3.814 ± 0.036	4.262AspGlu: 4.262 ± 0.033	2.222AspPhe: 2.222 ± 0.019	3.851AspGly: 3.851 ± 0.025	1.185AspHis: 1.185 ± 0.012	3.584AspIle: 3.584 ± 0.023	2.414AspLys: 2.414 ± 0.021	5.071AspLeu: 5.071 ± 0.031	1.21AspMet: 1.21 ± 0.015	2.048AspAsn: 2.048 ± 0.018	3.199AspPro: 3.199 ± 0.022	1.844AspGln: 1.844 ± 0.017	2.767AspArg: 2.767 ± 0.026	4.11AspSer: 4.11 ± 0.028	2.918AspThr: 2.918 ± 0.024	3.506AspVal: 3.506 ± 0.024	0.863AspTrp: 0.863 ± 0.013	1.646AspTyr: 1.646 ± 0.017	0.004AspXaa: 0.004 ± 0.001
Glu	5.045GluAla: 5.045 ± 0.038	0.624GluCys: 0.624 ± 0.01	4.178GluAsp: 4.178 ± 0.035	5.718GluGlu: 5.718 ± 0.049	2.077GluPhe: 2.077 ± 0.018	3.723GluGly: 3.723 ± 0.027	1.338GluHis: 1.338 ± 0.015	3.573GluIle: 3.573 ± 0.025	3.944GluLys: 3.944 ± 0.032	5.333GluLeu: 5.333 ± 0.032	1.468GluMet: 1.468 ± 0.016	2.601GluAsn: 2.601 ± 0.022	2.542GluPro: 2.542 ± 0.029	2.413GluGln: 2.413 ± 0.024	3.728GluArg: 3.728 ± 0.031	4.386GluSer: 4.386 ± 0.033	3.448GluThr: 3.448 ± 0.024	3.702GluVal: 3.702 ± 0.028	0.882GluTrp: 0.882 ± 0.011	1.765GluTyr: 1.765 ± 0.018	0.009GluXaa: 0.009 ± 0.001
Phe	2.937PheAla: 2.937 ± 0.025	0.588PheCys: 0.588 ± 0.009	2.278PheAsp: 2.278 ± 0.019	2.213PheGlu: 2.213 ± 0.02	1.672PhePhe: 1.672 ± 0.02	2.928PheGly: 2.928 ± 0.026	0.906PheHis: 0.906 ± 0.013	2.102PheIle: 2.102 ± 0.022	1.689PheLys: 1.689 ± 0.018	3.598PheLeu: 3.598 ± 0.027	0.82PheMet: 0.82 ± 0.01	1.611PheAsn: 1.611 ± 0.017	1.957PhePro: 1.957 ± 0.015	1.462PheGln: 1.462 ± 0.015	1.87PheArg: 1.87 ± 0.018	3.125PheSer: 3.125 ± 0.021	2.274PheThr: 2.274 ± 0.022	2.346PheVal: 2.346 ± 0.021	0.672PheTrp: 0.672 ± 0.01	1.2PheTyr: 1.2 ± 0.015	0.01PheXaa: 0.01 ± 0.001
Gly	4.932GlyAla: 4.932 ± 0.033	0.888GlyCys: 0.888 ± 0.013	3.421GlyAsp: 3.421 ± 0.024	3.552GlyGlu: 3.552 ± 0.024	2.917GlyPhe: 2.917 ± 0.023	5.54GlyGly: 5.54 ± 0.046	1.588GlyHis: 1.588 ± 0.018	4.033GlyIle: 4.033 ± 0.027	3.572GlyLys: 3.572 ± 0.028	6.11GlyLeu: 6.11 ± 0.034	1.558GlyMet: 1.558 ± 0.016	2.796GlyAsn: 2.796 ± 0.025	3.12GlyPro: 3.12 ± 0.028	2.369GlyGln: 2.369 ± 0.022	3.784GlyArg: 3.784 ± 0.03	5.657GlySer: 5.657 ± 0.034	3.986GlyThr: 3.986 ± 0.031	4.345GlyVal: 4.345 ± 0.032	1.185GlyTrp: 1.185 ± 0.015	2.213GlyTyr: 2.213 ± 0.02	0.011GlyXaa: 0.011 ± 0.001
His	1.607HisAla: 1.607 ± 0.015	0.316HisCys: 0.316 ± 0.008	1.214HisAsp: 1.214 ± 0.015	1.269HisGlu: 1.269 ± 0.014	0.904HisPhe: 0.904 ± 0.011	1.601HisGly: 1.601 ± 0.015	0.758HisHis: 0.758 ± 0.015	1.366HisIle: 1.366 ± 0.015	0.951HisLys: 0.951 ± 0.013	2.147HisLeu: 2.147 ± 0.015	0.462HisMet: 0.462 ± 0.008	0.927HisAsn: 0.927 ± 0.012	1.547HisPro: 1.547 ± 0.019	0.924HisGln: 0.924 ± 0.015	1.382HisArg: 1.382 ± 0.018	1.821HisSer: 1.821 ± 0.019	1.277HisThr: 1.277 ± 0.014	1.319HisVal: 1.319 ± 0.014	0.339HisTrp: 0.339 ± 0.008	0.701HisTyr: 0.701 ± 0.012	0.002HisXaa: 0.002 ± 0.001
Ile	4.546IleAla: 4.546 ± 0.031	0.855IleCys: 0.855 ± 0.013	3.21IleAsp: 3.21 ± 0.026	3.335IleGlu: 3.335 ± 0.026	2.333IlePhe: 2.333 ± 0.022	3.657IleGly: 3.657 ± 0.029	1.31IleHis: 1.31 ± 0.015	3.257IleIle: 3.257 ± 0.027	2.65IleLys: 2.65 ± 0.021	5.252IleLeu: 5.252 ± 0.033	1.163IleMet: 1.163 ± 0.015	2.277IleAsn: 2.277 ± 0.019	3.452IlePro: 3.452 ± 0.022	2.219IleGln: 2.219 ± 0.022	2.946IleArg: 2.946 ± 0.021	4.703IleSer: 4.703 ± 0.033	3.447IleThr: 3.447 ± 0.023	3.512IleVal: 3.512 ± 0.026	0.839IleTrp: 0.839 ± 0.012	1.694IleTyr: 1.694 ± 0.019	0.006IleXaa: 0.006 ± 0.001
Lys	4.243LysAla: 4.243 ± 0.029	0.519LysCys: 0.519 ± 0.009	2.944LysAsp: 2.944 ± 0.026	3.805LysGlu: 3.805 ± 0.03	1.622LysPhe: 1.622 ± 0.016	3.181LysGly: 3.181 ± 0.024	1.132LysHis: 1.132 ± 0.016	2.694LysIle: 2.694 ± 0.021	3.421LysLys: 3.421 ± 0.036	4.448LysLeu: 4.448 ± 0.026	1.062LysMet: 1.062 ± 0.012	1.941LysAsn: 1.941 ± 0.019	2.653LysPro: 2.653 ± 0.025	1.862LysGln: 1.862 ± 0.018	3.302LysArg: 3.302 ± 0.027	3.77LysSer: 3.77 ± 0.03	2.923LysThr: 2.923 ± 0.021	2.988LysVal: 2.988 ± 0.024	0.718LysTrp: 0.718 ± 0.009	1.574LysTyr: 1.574 ± 0.017	0.019LysXaa: 0.019 ± 0.002
Leu	7.415LeuAla: 7.415 ± 0.037	1.211LeuCys: 1.211 ± 0.014	5.228LeuAsp: 5.228 ± 0.031	5.771LeuGlu: 5.771 ± 0.041	3.416LeuPhe: 3.416 ± 0.027	5.932LeuGly: 5.932 ± 0.037	2.219LeuHis: 2.219 ± 0.019	4.492LeuIle: 4.492 ± 0.032	4.593LeuLys: 4.593 ± 0.031	8.568LeuLeu: 8.568 ± 0.059	1.784LeuMet: 1.784 ± 0.017	3.543LeuAsn: 3.543 ± 0.026	5.363LeuPro: 5.363 ± 0.029	3.998LeuGln: 3.998 ± 0.028	5.329LeuArg: 5.329 ± 0.036	7.458LeuSer: 7.458 ± 0.035	4.886LeuThr: 4.886 ± 0.03	5.31LeuVal: 5.31 ± 0.035	1.241LeuTrp: 1.241 ± 0.016	2.523LeuTyr: 2.523 ± 0.019	0.006LeuXaa: 0.006 ± 0.001
Met	2.105MetAla: 2.105 ± 0.018	0.239MetCys: 0.239 ± 0.006	1.233MetAsp: 1.233 ± 0.013	1.309MetGlu: 1.309 ± 0.015	0.759MetPhe: 0.759 ± 0.012	1.406MetGly: 1.406 ± 0.015	0.464MetHis: 0.464 ± 0.008	1.115MetIle: 1.115 ± 0.013	1.084MetLys: 1.084 ± 0.015	1.856MetLeu: 1.856 ± 0.017	0.544MetMet: 0.544 ± 0.009	0.846MetAsn: 0.846 ± 0.011	1.156MetPro: 1.156 ± 0.012	0.826MetGln: 0.826 ± 0.014	1.166MetArg: 1.166 ± 0.017	1.817MetSer: 1.817 ± 0.017	1.285MetThr: 1.285 ± 0.014	1.296MetVal: 1.296 ± 0.013	0.262MetTrp: 0.262 ± 0.006	0.515MetTyr: 0.515 ± 0.009	0.002MetXaa: 0.002 ± 0.0
Asn	3.12AsnAla: 3.12 ± 0.024	0.495AsnCys: 0.495 ± 0.01	2.094AsnAsp: 2.094 ± 0.019	2.251AsnGlu: 2.251 ± 0.023	1.549AsnPhe: 1.549 ± 0.016	3.268AsnGly: 3.268 ± 0.026	0.904AsnHis: 0.904 ± 0.012	2.588AsnIle: 2.588 ± 0.021	1.74AsnLys: 1.74 ± 0.017	3.63AsnLeu: 3.63 ± 0.024	0.911AsnMet: 0.911 ± 0.011	1.866AsnAsn: 1.866 ± 0.021	2.578AsnPro: 2.578 ± 0.02	1.489AsnGln: 1.489 ± 0.014	1.967AsnArg: 1.967 ± 0.02	3.284AsnSer: 3.284 ± 0.024	2.471AsnThr: 2.471 ± 0.021	2.426AsnVal: 2.426 ± 0.018	0.62AsnTrp: 0.62 ± 0.01	1.222AsnTyr: 1.222 ± 0.015	0.006AsnXaa: 0.006 ± 0.001
Pro	4.416ProAla: 4.416 ± 0.032	0.482ProCys: 0.482 ± 0.009	2.967ProAsp: 2.967 ± 0.021	3.704ProGlu: 3.704 ± 0.025	2.043ProPhe: 2.043 ± 0.022	3.634ProGly: 3.634 ± 0.028	1.189ProHis: 1.189 ± 0.015	2.902ProIle: 2.902 ± 0.024	2.674ProLys: 2.674 ± 0.021	4.728ProLeu: 4.728 ± 0.032	0.973ProMet: 0.973 ± 0.014	2.342ProAsn: 2.342 ± 0.02	4.616ProPro: 4.616 ± 0.058	2.358ProGln: 2.358 ± 0.028	2.967ProArg: 2.967 ± 0.025	5.634ProSer: 5.634 ± 0.041	3.832ProThr: 3.832 ± 0.029	3.358ProVal: 3.358 ± 0.023	0.717ProTrp: 0.717 ± 0.012	1.546ProTyr: 1.546 ± 0.018	0.006ProXaa: 0.006 ± 0.001
Gln	3.156GlnAla: 3.156 ± 0.028	0.452GlnCys: 0.452 ± 0.008	2.071GlnAsp: 2.071 ± 0.019	2.475GlnGlu: 2.475 ± 0.023	1.328GlnPhe: 1.328 ± 0.015	2.307GlnGly: 2.307 ± 0.021	1.039GlnHis: 1.039 ± 0.013	2.127GlnIle: 2.127 ± 0.02	2.09GlnLys: 2.09 ± 0.018	3.54GlnLeu: 3.54 ± 0.022	0.834GlnMet: 0.834 ± 0.012	1.744GlnAsn: 1.744 ± 0.017	2.247GlnPro: 2.247 ± 0.022	2.298GlnGln: 2.298 ± 0.044	2.436GlnArg: 2.436 ± 0.02	3.163GlnSer: 3.163 ± 0.025	2.288GlnThr: 2.288 ± 0.022	2.164GlnVal: 2.164 ± 0.018	0.582GlnTrp: 0.582 ± 0.01	1.22GlnTyr: 1.22 ± 0.015	0.005GlnXaa: 0.005 ± 0.001
Arg	4.062ArgAla: 4.062 ± 0.028	0.647ArgCys: 0.647 ± 0.012	3.062ArgAsp: 3.062 ± 0.026	3.599ArgGlu: 3.599 ± 0.032	2.013ArgPhe: 2.013 ± 0.02	3.415ArgGly: 3.415 ± 0.028	1.382ArgHis: 1.382 ± 0.014	3.025ArgIle: 3.025 ± 0.021	3.419ArgLys: 3.419 ± 0.027	5.062ArgLeu: 5.062 ± 0.027	1.193ArgMet: 1.193 ± 0.015	2.28ArgAsn: 2.28 ± 0.02	3.035ArgPro: 3.035 ± 0.031	2.37ArgGln: 2.37 ± 0.022	4.453ArgArg: 4.453 ± 0.039	4.494ArgSer: 4.494 ± 0.037	2.999ArgThr: 2.999 ± 0.021	3.069ArgVal: 3.069 ± 0.024	0.894ArgTrp: 0.894 ± 0.013	1.654ArgTyr: 1.654 ± 0.017	0.006ArgXaa: 0.006 ± 0.001
Ser	6.076SerAla: 6.076 ± 0.033	0.92SerCys: 0.92 ± 0.013	4.121SerAsp: 4.121 ± 0.028	4.308SerGlu: 4.308 ± 0.034	3.129SerPhe: 3.129 ± 0.023	5.515SerGly: 5.515 ± 0.032	1.863SerHis: 1.863 ± 0.018	4.741SerIle: 4.741 ± 0.027	4.104SerLys: 4.104 ± 0.03	7.278SerLeu: 7.278 ± 0.034	1.701SerMet: 1.701 ± 0.016	3.477SerAsn: 3.477 ± 0.026	5.273SerPro: 5.273 ± 0.04	3.354SerGln: 3.354 ± 0.027	4.695SerArg: 4.695 ± 0.035	9.096SerSer: 9.096 ± 0.065	5.988SerThr: 5.988 ± 0.045	4.574SerVal: 4.574 ± 0.027	1.165SerTrp: 1.165 ± 0.015	2.269SerTyr: 2.269 ± 0.02	0.006SerXaa: 0.006 ± 0.001
Thr	5.069ThrAla: 5.069 ± 0.035	0.736ThrCys: 0.736 ± 0.011	2.79ThrAsp: 2.79 ± 0.021	3.242ThrGlu: 3.242 ± 0.023	2.372ThrPhe: 2.372 ± 0.018	4.155ThrGly: 4.155 ± 0.031	1.211ThrHis: 1.211 ± 0.015	3.618ThrIle: 3.618 ± 0.026	2.813ThrLys: 2.813 ± 0.025	5.288ThrLeu: 5.288 ± 0.033	1.181ThrMet: 1.181 ± 0.014	2.374ThrAsn: 2.374 ± 0.018	4.174ThrPro: 4.174 ± 0.04	2.097ThrGln: 2.097 ± 0.02	2.915ThrArg: 2.915 ± 0.022	5.649ThrSer: 5.649 ± 0.043	4.92ThrThr: 4.92 ± 0.088	3.861ThrVal: 3.861 ± 0.034	0.863ThrTrp: 0.863 ± 0.013	1.719ThrTyr: 1.719 ± 0.017	0.007ThrXaa: 0.007 ± 0.001
Val	4.986ValAla: 4.986 ± 0.033	0.764ValCys: 0.764 ± 0.013	3.594ValAsp: 3.594 ± 0.023	3.946ValGlu: 3.946 ± 0.028	2.392ValPhe: 2.392 ± 0.024	3.961ValGly: 3.961 ± 0.031	1.305ValHis: 1.305 ± 0.015	3.388ValIle: 3.388 ± 0.024	3.02ValLys: 3.02 ± 0.027	5.557ValLeu: 5.557 ± 0.035	1.293ValMet: 1.293 ± 0.013	2.393ValAsn: 2.393 ± 0.019	3.372ValPro: 3.372 ± 0.022	2.36ValGln: 2.36 ± 0.021	3.064ValArg: 3.064 ± 0.025	4.563ValSer: 4.563 ± 0.025	3.61ValThr: 3.61 ± 0.03	4.219ValVal: 4.219 ± 0.027	0.856ValTrp: 0.856 ± 0.011	1.727ValTyr: 1.727 ± 0.019	0.006ValXaa: 0.006 ± 0.001
Trp	1.08TrpAla: 1.08 ± 0.015	0.195TrpCys: 0.195 ± 0.005	0.886TrpAsp: 0.886 ± 0.014	0.858TrpGlu: 0.858 ± 0.012	0.579TrpPhe: 0.579 ± 0.009	0.962TrpGly: 0.962 ± 0.012	0.354TrpHis: 0.354 ± 0.008	0.904TrpIle: 0.904 ± 0.013	0.855TrpLys: 0.855 ± 0.01	1.356TrpLeu: 1.356 ± 0.02	0.36TrpMet: 0.36 ± 0.008	0.679TrpAsn: 0.679 ± 0.011	0.611TrpPro: 0.611 ± 0.01	0.581TrpGln: 0.581 ± 0.009	0.891TrpArg: 0.891 ± 0.012	1.049TrpSer: 1.049 ± 0.013	0.925TrpThr: 0.925 ± 0.014	0.896TrpVal: 0.896 ± 0.012	0.292TrpTrp: 0.292 ± 0.007	0.466TrpTyr: 0.466 ± 0.009	0.001TrpXaa: 0.001 ± 0.0
Tyr	2.135TyrAla: 2.135 ± 0.019	0.442TyrCys: 0.442 ± 0.009	1.703TyrAsp: 1.703 ± 0.015	1.637TyrGlu: 1.637 ± 0.017	1.299TyrPhe: 1.299 ± 0.016	2.182TyrGly: 2.182 ± 0.019	0.779TyrHis: 0.779 ± 0.013	1.655TyrIle: 1.655 ± 0.018	1.256TyrLys: 1.256 ± 0.015	2.799TyrLeu: 2.799 ± 0.021	0.618TyrMet: 0.618 ± 0.01	1.304TyrAsn: 1.304 ± 0.016	1.518TyrPro: 1.518 ± 0.02	1.201TyrGln: 1.201 ± 0.014	1.586TyrArg: 1.586 ± 0.013	2.253TyrSer: 2.253 ± 0.02	1.763TyrThr: 1.763 ± 0.018	1.639TyrVal: 1.639 ± 0.016	0.457TyrTrp: 0.457 ± 0.009	1.028TyrTyr: 1.028 ± 0.015	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.01XaaAla: 0.01 ± 0.001	0.002XaaCys: 0.002 ± 0.0	0.004XaaAsp: 0.004 ± 0.001	0.005XaaGlu: 0.005 ± 0.001	0.01XaaPhe: 0.01 ± 0.001	0.009XaaGly: 0.009 ± 0.001	0.002XaaHis: 0.002 ± 0.001	0.004XaaIle: 0.004 ± 0.001	0.016XaaLys: 0.016 ± 0.002	0.01XaaLeu: 0.01 ± 0.001	0.003XaaMet: 0.003 ± 0.001	0.005XaaAsn: 0.005 ± 0.001	0.009XaaPro: 0.009 ± 0.001	0.004XaaGln: 0.004 ± 0.001	0.006XaaArg: 0.006 ± 0.001	0.008XaaSer: 0.008 ± 0.001	0.008XaaThr: 0.008 ± 0.001	0.008XaaVal: 0.008 ± 0.001	0.002XaaTrp: 0.002 ± 0.001	0.002XaaTyr: 0.002 ± 0.001	0.005XaaXaa: 0.005 ± 0.001

Statistics based on 12794 proteins (6524524 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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