Amino acid dipepetide frequency for Simian hemorrhagic fever virus (SHFV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.546AlaAla: 9.546 ± 1.189
3.096AlaCys: 3.096 ± 0.623
3.354AlaAsp: 3.354 ± 0.892
2.838AlaGlu: 2.838 ± 0.974
5.418AlaPhe: 5.418 ± 0.771
4.386AlaGly: 4.386 ± 0.756
2.58AlaHis: 2.58 ± 0.416
5.934AlaIle: 5.934 ± 0.599
3.354AlaLys: 3.354 ± 0.512
9.288AlaLeu: 9.288 ± 0.831
1.032AlaMet: 1.032 ± 0.254
2.451AlaAsn: 2.451 ± 0.46
5.289AlaPro: 5.289 ± 0.78
1.677AlaGln: 1.677 ± 0.492
4.128AlaArg: 4.128 ± 1.099
6.45AlaSer: 6.45 ± 0.98
3.87AlaThr: 3.87 ± 1.064
7.998AlaVal: 7.998 ± 1.398
1.29AlaTrp: 1.29 ± 0.302
2.064AlaTyr: 2.064 ± 0.353
0.0AlaXaa: 0.0 ± 0.0
Cys
3.096CysAla: 3.096 ± 0.727
2.193CysCys: 2.193 ± 0.614
1.419CysAsp: 1.419 ± 0.411
1.935CysGlu: 1.935 ± 0.411
2.451CysPhe: 2.451 ± 0.542
2.322CysGly: 2.322 ± 0.47
1.677CysHis: 1.677 ± 0.317
0.645CysIle: 0.645 ± 0.219
1.806CysLys: 1.806 ± 0.383
4.644CysLeu: 4.644 ± 1.364
0.645CysMet: 0.645 ± 0.371
0.516CysAsn: 0.516 ± 0.159
1.548CysPro: 1.548 ± 0.441
0.258CysGln: 0.258 ± 0.095
1.161CysArg: 1.161 ± 0.366
2.967CysSer: 2.967 ± 0.536
2.58CysThr: 2.58 ± 0.666
1.677CysVal: 1.677 ± 0.342
1.161CysTrp: 1.161 ± 0.368
1.29CysTyr: 1.29 ± 0.441
0.0CysXaa: 0.0 ± 0.0
Asp
2.064AspAla: 2.064 ± 0.718
1.677AspCys: 1.677 ± 0.311
1.935AspAsp: 1.935 ± 0.541
1.677AspGlu: 1.677 ± 0.587
2.838AspPhe: 2.838 ± 0.538
3.096AspGly: 3.096 ± 0.795
1.935AspHis: 1.935 ± 0.406
2.58AspIle: 2.58 ± 0.573
1.677AspLys: 1.677 ± 0.492
3.999AspLeu: 3.999 ± 0.646
0.645AspMet: 0.645 ± 0.214
0.774AspAsn: 0.774 ± 0.54
3.999AspPro: 3.999 ± 0.905
1.419AspGln: 1.419 ± 0.54
2.58AspArg: 2.58 ± 0.643
4.386AspSer: 4.386 ± 0.742
1.677AspThr: 1.677 ± 0.345
3.225AspVal: 3.225 ± 0.342
0.645AspTrp: 0.645 ± 0.214
2.193AspTyr: 2.193 ± 0.65
0.129AspXaa: 0.129 ± 0.27
Glu
3.225GluAla: 3.225 ± 0.539
0.774GluCys: 0.774 ± 0.231
1.677GluAsp: 1.677 ± 0.413
1.161GluGlu: 1.161 ± 0.233
0.903GluPhe: 0.903 ± 0.317
3.096GluGly: 3.096 ± 1.071
1.161GluHis: 1.161 ± 0.3
1.29GluIle: 1.29 ± 0.416
1.677GluLys: 1.677 ± 0.379
2.322GluLeu: 2.322 ± 0.491
0.774GluMet: 0.774 ± 0.263
0.645GluAsn: 0.645 ± 0.193
2.064GluPro: 2.064 ± 0.364
1.419GluGln: 1.419 ± 0.377
1.419GluArg: 1.419 ± 0.537
2.709GluSer: 2.709 ± 0.415
3.612GluThr: 3.612 ± 0.705
1.419GluVal: 1.419 ± 0.462
1.032GluTrp: 1.032 ± 0.254
1.032GluTyr: 1.032 ± 0.285
0.0GluXaa: 0.0 ± 0.0
Phe
3.612PheAla: 3.612 ± 0.95
2.451PheCys: 2.451 ± 0.415
2.709PheAsp: 2.709 ± 0.574
1.548PheGlu: 1.548 ± 0.71
3.225PhePhe: 3.225 ± 0.69
2.967PheGly: 2.967 ± 0.59
0.774PheHis: 0.774 ± 0.554
3.612PheIle: 3.612 ± 0.963
1.161PheLys: 1.161 ± 0.387
5.031PheLeu: 5.031 ± 0.68
0.0PheMet: 0.0 ± 0.0
1.419PheAsn: 1.419 ± 0.614
2.967PhePro: 2.967 ± 0.603
1.29PheGln: 1.29 ± 0.662
2.064PheArg: 2.064 ± 0.557
3.741PheSer: 3.741 ± 0.568
2.322PheThr: 2.322 ± 0.846
3.87PheVal: 3.87 ± 0.563
0.0PheTrp: 0.0 ± 0.0
1.419PheTyr: 1.419 ± 0.251
0.0PheXaa: 0.0 ± 0.0
Gly
3.87GlyAla: 3.87 ± 0.615
3.225GlyCys: 3.225 ± 0.933
5.418GlyAsp: 5.418 ± 1.182
1.161GlyGlu: 1.161 ± 0.375
3.354GlyPhe: 3.354 ± 0.61
4.644GlyGly: 4.644 ± 0.961
2.193GlyHis: 2.193 ± 0.37
3.741GlyIle: 3.741 ± 0.69
3.999GlyLys: 3.999 ± 0.823
5.934GlyLeu: 5.934 ± 0.666
0.645GlyMet: 0.645 ± 0.224
1.935GlyAsn: 1.935 ± 0.527
2.967GlyPro: 2.967 ± 0.412
1.419GlyGln: 1.419 ± 0.363
3.87GlyArg: 3.87 ± 0.745
4.386GlySer: 4.386 ± 0.858
5.289GlyThr: 5.289 ± 0.82
6.063GlyVal: 6.063 ± 1.629
0.774GlyTrp: 0.774 ± 0.206
2.967GlyTyr: 2.967 ± 0.524
0.0GlyXaa: 0.0 ± 0.0
His
3.225HisAla: 3.225 ± 0.56
1.032HisCys: 1.032 ± 0.594
1.677HisAsp: 1.677 ± 0.349
0.903HisGlu: 0.903 ± 0.348
0.516HisPhe: 0.516 ± 0.35
1.419HisGly: 1.419 ± 0.411
0.903HisHis: 0.903 ± 0.306
2.193HisIle: 2.193 ± 0.639
1.419HisLys: 1.419 ± 0.362
2.064HisLeu: 2.064 ± 0.494
0.516HisMet: 0.516 ± 0.199
1.548HisAsn: 1.548 ± 0.417
2.064HisPro: 2.064 ± 0.553
0.387HisGln: 0.387 ± 0.349
1.161HisArg: 1.161 ± 0.475
1.29HisSer: 1.29 ± 1.038
1.677HisThr: 1.677 ± 0.797
3.225HisVal: 3.225 ± 0.503
0.774HisTrp: 0.774 ± 0.189
1.548HisTyr: 1.548 ± 0.345
0.0HisXaa: 0.0 ± 0.0
Ile
4.773IleAla: 4.773 ± 0.726
2.967IleCys: 2.967 ± 0.457
1.935IleAsp: 1.935 ± 0.526
0.645IleGlu: 0.645 ± 0.344
1.548IlePhe: 1.548 ± 0.688
5.031IleGly: 5.031 ± 0.755
1.032IleHis: 1.032 ± 0.287
4.257IleIle: 4.257 ± 0.735
1.419IleLys: 1.419 ± 0.84
5.805IleLeu: 5.805 ± 1.034
0.516IleMet: 0.516 ± 0.19
1.935IleAsn: 1.935 ± 0.766
3.225IlePro: 3.225 ± 0.586
1.161IleGln: 1.161 ± 0.587
2.967IleArg: 2.967 ± 0.548
2.838IleSer: 2.838 ± 1.004
4.386IleThr: 4.386 ± 1.044
4.257IleVal: 4.257 ± 0.621
0.516IleTrp: 0.516 ± 0.556
1.419IleTyr: 1.419 ± 0.641
0.129IleXaa: 0.129 ± 0.27
Lys
3.612LysAla: 3.612 ± 1.051
1.032LysCys: 1.032 ± 0.283
1.161LysAsp: 1.161 ± 0.394
1.935LysGlu: 1.935 ± 0.433
2.838LysPhe: 2.838 ± 0.587
1.935LysGly: 1.935 ± 0.427
0.903LysHis: 0.903 ± 0.484
1.419LysIle: 1.419 ± 0.361
2.322LysLys: 2.322 ± 0.645
4.128LysLeu: 4.128 ± 0.749
0.774LysMet: 0.774 ± 0.394
1.419LysAsn: 1.419 ± 0.385
3.096LysPro: 3.096 ± 0.726
1.29LysGln: 1.29 ± 0.614
1.806LysArg: 1.806 ± 0.496
2.322LysSer: 2.322 ± 0.349
2.967LysThr: 2.967 ± 0.538
4.257LysVal: 4.257 ± 0.906
0.0LysTrp: 0.0 ± 0.0
2.451LysTyr: 2.451 ± 0.339
0.0LysXaa: 0.0 ± 0.0
Leu
11.481LeuAla: 11.481 ± 0.896
3.612LeuCys: 3.612 ± 1.074
3.999LeuAsp: 3.999 ± 0.776
3.741LeuGlu: 3.741 ± 0.68
4.773LeuPhe: 4.773 ± 0.95
6.321LeuGly: 6.321 ± 0.424
2.451LeuHis: 2.451 ± 0.514
3.225LeuIle: 3.225 ± 1.415
3.612LeuLys: 3.612 ± 0.552
13.545LeuLeu: 13.545 ± 3.279
1.032LeuMet: 1.032 ± 0.525
3.612LeuAsn: 3.612 ± 0.491
7.611LeuPro: 7.611 ± 0.896
2.838LeuGln: 2.838 ± 0.426
4.902LeuArg: 4.902 ± 1.917
9.675LeuSer: 9.675 ± 1.581
6.966LeuThr: 6.966 ± 1.709
6.837LeuVal: 6.837 ± 0.842
0.645LeuTrp: 0.645 ± 0.281
2.451LeuTyr: 2.451 ± 0.679
0.129LeuXaa: 0.129 ± 0.19
Met
1.29MetAla: 1.29 ± 0.329
1.29MetCys: 1.29 ± 0.313
0.516MetAsp: 0.516 ± 0.205
0.258MetGlu: 0.258 ± 0.202
0.645MetPhe: 0.645 ± 0.274
0.645MetGly: 0.645 ± 0.262
0.0MetHis: 0.0 ± 0.0
1.161MetIle: 1.161 ± 0.299
0.516MetLys: 0.516 ± 0.199
1.806MetLeu: 1.806 ± 0.618
0.129MetMet: 0.129 ± 0.234
0.258MetAsn: 0.258 ± 0.095
0.387MetPro: 0.387 ± 0.223
0.0MetGln: 0.0 ± 0.0
0.387MetArg: 0.387 ± 0.131
1.806MetSer: 1.806 ± 0.405
0.258MetThr: 0.258 ± 0.338
1.161MetVal: 1.161 ± 0.774
0.258MetTrp: 0.258 ± 0.095
0.387MetTyr: 0.387 ± 0.313
0.0MetXaa: 0.0 ± 0.0
Asn
2.967AsnAla: 2.967 ± 0.453
0.903AsnCys: 0.903 ± 0.313
1.677AsnAsp: 1.677 ± 0.492
1.677AsnGlu: 1.677 ± 0.4
1.677AsnPhe: 1.677 ± 0.528
2.193AsnGly: 2.193 ± 0.568
1.161AsnHis: 1.161 ± 0.597
1.032AsnIle: 1.032 ± 0.942
1.677AsnLys: 1.677 ± 0.461
2.967AsnLeu: 2.967 ± 1.073
0.516AsnMet: 0.516 ± 0.374
2.193AsnAsn: 2.193 ± 0.579
1.935AsnPro: 1.935 ± 0.312
1.419AsnGln: 1.419 ± 0.308
1.935AsnArg: 1.935 ± 0.426
1.419AsnSer: 1.419 ± 0.457
2.58AsnThr: 2.58 ± 0.506
1.29AsnVal: 1.29 ± 0.515
0.387AsnTrp: 0.387 ± 0.184
0.903AsnTyr: 0.903 ± 0.202
0.0AsnXaa: 0.0 ± 0.0
Pro
5.934ProAla: 5.934 ± 0.796
1.935ProCys: 1.935 ± 0.526
2.709ProAsp: 2.709 ± 0.725
3.096ProGlu: 3.096 ± 0.598
1.548ProPhe: 1.548 ± 0.288
4.515ProGly: 4.515 ± 0.636
2.193ProHis: 2.193 ± 0.585
3.612ProIle: 3.612 ± 0.459
1.935ProLys: 1.935 ± 0.403
6.837ProLeu: 6.837 ± 0.957
1.161ProMet: 1.161 ± 0.367
1.806ProAsn: 1.806 ± 0.358
3.999ProPro: 3.999 ± 0.695
2.451ProGln: 2.451 ± 0.586
3.87ProArg: 3.87 ± 0.531
4.902ProSer: 4.902 ± 0.673
3.999ProThr: 3.999 ± 0.674
5.547ProVal: 5.547 ± 0.671
0.774ProTrp: 0.774 ± 0.485
1.935ProTyr: 1.935 ± 0.379
0.0ProXaa: 0.0 ± 0.0
Gln
1.677GlnAla: 1.677 ± 0.261
0.0GlnCys: 0.0 ± 0.0
1.161GlnAsp: 1.161 ± 0.436
0.903GlnGlu: 0.903 ± 0.237
0.645GlnPhe: 0.645 ± 0.397
2.709GlnGly: 2.709 ± 0.634
0.903GlnHis: 0.903 ± 0.828
1.29GlnIle: 1.29 ± 0.695
1.29GlnLys: 1.29 ± 0.277
3.096GlnLeu: 3.096 ± 0.593
0.774GlnMet: 0.774 ± 0.285
0.774GlnAsn: 0.774 ± 0.284
1.548GlnPro: 1.548 ± 0.334
1.419GlnGln: 1.419 ± 0.546
1.677GlnArg: 1.677 ± 0.749
2.193GlnSer: 2.193 ± 0.973
1.548GlnThr: 1.548 ± 0.833
2.322GlnVal: 2.322 ± 0.51
0.0GlnTrp: 0.0 ± 0.0
1.677GlnTyr: 1.677 ± 0.309
0.0GlnXaa: 0.0 ± 0.0
Arg
4.644ArgAla: 4.644 ± 0.566
1.806ArgCys: 1.806 ± 0.416
1.29ArgAsp: 1.29 ± 0.343
1.548ArgGlu: 1.548 ± 0.601
2.838ArgPhe: 2.838 ± 0.582
3.225ArgGly: 3.225 ± 0.609
1.419ArgHis: 1.419 ± 0.305
1.29ArgIle: 1.29 ± 0.487
2.064ArgLys: 2.064 ± 0.423
6.192ArgLeu: 6.192 ± 0.778
0.258ArgMet: 0.258 ± 0.381
1.806ArgAsn: 1.806 ± 0.353
3.999ArgPro: 3.999 ± 0.604
1.161ArgGln: 1.161 ± 0.456
3.354ArgArg: 3.354 ± 0.766
2.064ArgSer: 2.064 ± 0.988
2.967ArgThr: 2.967 ± 0.426
3.483ArgVal: 3.483 ± 0.522
0.516ArgTrp: 0.516 ± 0.475
2.838ArgTyr: 2.838 ± 0.547
0.0ArgXaa: 0.0 ± 0.0
Ser
4.644SerAla: 4.644 ± 0.506
1.29SerCys: 1.29 ± 0.457
3.87SerAsp: 3.87 ± 0.649
3.612SerGlu: 3.612 ± 0.673
3.354SerPhe: 3.354 ± 0.891
5.934SerGly: 5.934 ± 0.657
1.548SerHis: 1.548 ± 0.417
4.128SerIle: 4.128 ± 1.421
4.128SerLys: 4.128 ± 0.865
6.579SerLeu: 6.579 ± 1.233
1.29SerMet: 1.29 ± 0.34
2.451SerAsn: 2.451 ± 0.911
4.902SerPro: 4.902 ± 0.69
1.935SerGln: 1.935 ± 0.44
2.967SerArg: 2.967 ± 0.568
7.869SerSer: 7.869 ± 2.183
6.192SerThr: 6.192 ± 0.753
7.353SerVal: 7.353 ± 0.569
1.032SerTrp: 1.032 ± 0.585
1.677SerTyr: 1.677 ± 0.484
0.0SerXaa: 0.0 ± 0.0
Thr
7.74ThrAla: 7.74 ± 0.731
1.935ThrCys: 1.935 ± 0.727
1.161ThrAsp: 1.161 ± 0.329
1.032ThrGlu: 1.032 ± 0.307
2.838ThrPhe: 2.838 ± 0.428
5.805ThrGly: 5.805 ± 0.875
2.451ThrHis: 2.451 ± 0.897
3.741ThrIle: 3.741 ± 0.936
2.58ThrLys: 2.58 ± 0.795
4.515ThrLeu: 4.515 ± 0.814
0.516ThrMet: 0.516 ± 0.45
2.193ThrAsn: 2.193 ± 0.622
5.547ThrPro: 5.547 ± 0.713
1.935ThrGln: 1.935 ± 0.812
3.354ThrArg: 3.354 ± 0.324
5.16ThrSer: 5.16 ± 1.546
5.16ThrThr: 5.16 ± 1.143
4.257ThrVal: 4.257 ± 0.663
0.258ThrTrp: 0.258 ± 0.357
3.225ThrTyr: 3.225 ± 0.507
0.129ThrXaa: 0.129 ± 0.19
Val
5.805ValAla: 5.805 ± 1.076
2.967ValCys: 2.967 ± 0.424
5.16ValAsp: 5.16 ± 1.051
2.322ValGlu: 2.322 ± 0.469
2.451ValPhe: 2.451 ± 0.445
4.257ValGly: 4.257 ± 0.904
2.58ValHis: 2.58 ± 0.609
3.999ValIle: 3.999 ± 0.716
2.967ValLys: 2.967 ± 0.513
8.385ValLeu: 8.385 ± 0.892
1.29ValMet: 1.29 ± 0.342
3.096ValAsn: 3.096 ± 0.658
5.418ValPro: 5.418 ± 0.86
2.709ValGln: 2.709 ± 0.775
3.483ValArg: 3.483 ± 0.593
6.966ValSer: 6.966 ± 0.656
4.773ValThr: 4.773 ± 0.836
7.611ValVal: 7.611 ± 1.191
0.516ValTrp: 0.516 ± 0.199
3.483ValTyr: 3.483 ± 0.513
0.0ValXaa: 0.0 ± 0.0
Trp
0.774TrpAla: 0.774 ± 0.446
0.258TrpCys: 0.258 ± 0.095
0.258TrpAsp: 0.258 ± 0.167
0.258TrpGlu: 0.258 ± 0.347
1.032TrpPhe: 1.032 ± 0.516
0.516TrpGly: 0.516 ± 0.19
0.387TrpHis: 0.387 ± 0.197
0.387TrpIle: 0.387 ± 0.165
0.516TrpLys: 0.516 ± 0.19
1.935TrpLeu: 1.935 ± 0.484
0.258TrpMet: 0.258 ± 0.294
0.903TrpAsn: 0.903 ± 0.466
0.903TrpPro: 0.903 ± 0.277
0.258TrpGln: 0.258 ± 0.247
0.129TrpArg: 0.129 ± 0.084
0.516TrpSer: 0.516 ± 0.274
0.516TrpThr: 0.516 ± 0.3
1.032TrpVal: 1.032 ± 0.262
0.0TrpTrp: 0.0 ± 0.0
0.516TrpTyr: 0.516 ± 0.19
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.935TyrAla: 1.935 ± 0.405
1.548TyrCys: 1.548 ± 0.337
2.064TyrAsp: 2.064 ± 0.529
1.161TyrGlu: 1.161 ± 0.375
1.29TyrPhe: 1.29 ± 0.338
2.838TyrGly: 2.838 ± 0.651
1.29TyrHis: 1.29 ± 0.532
3.225TyrIle: 3.225 ± 0.713
1.548TyrLys: 1.548 ± 0.491
4.128TyrLeu: 4.128 ± 0.748
0.258TyrMet: 0.258 ± 0.219
0.903TyrAsn: 0.903 ± 0.223
1.29TyrPro: 1.29 ± 0.245
1.161TyrGln: 1.161 ± 0.337
1.548TyrArg: 1.548 ± 0.58
3.096TyrSer: 3.096 ± 0.761
2.193TyrThr: 2.193 ± 0.416
3.225TyrVal: 3.225 ± 0.447
0.774TyrTrp: 0.774 ± 0.213
1.29TyrTyr: 1.29 ± 0.695
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.129XaaAla: 0.129 ± 0.27
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.258XaaLeu: 0.258 ± 0.38
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.129XaaVal: 0.129 ± 0.27
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14 proteins (7753 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski