Amino acid dipepetide frequency for Pseudoroseicyclus aestuarii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.374AlaAla: 20.374 ± 0.245	1.084AlaCys: 1.084 ± 0.036	6.735AlaAsp: 6.735 ± 0.1	9.948AlaGlu: 9.948 ± 0.137	4.115AlaPhe: 4.115 ± 0.071	12.336AlaGly: 12.336 ± 0.139	2.151AlaHis: 2.151 ± 0.055	5.418AlaIle: 5.418 ± 0.072	2.65AlaLys: 2.65 ± 0.063	16.912AlaLeu: 16.912 ± 0.192	4.033AlaMet: 4.033 ± 0.069	2.108AlaAsn: 2.108 ± 0.047	7.696AlaPro: 7.696 ± 0.117	5.534AlaGln: 5.534 ± 0.082	10.698AlaArg: 10.698 ± 0.13	5.859AlaSer: 5.859 ± 0.081	5.74AlaThr: 5.74 ± 0.081	9.176AlaVal: 9.176 ± 0.113	1.723AlaTrp: 1.723 ± 0.045	2.345AlaTyr: 2.345 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.069CysAla: 1.069 ± 0.033	0.099CysCys: 0.099 ± 0.01	0.53CysAsp: 0.53 ± 0.022	0.376CysGlu: 0.376 ± 0.02	0.274CysPhe: 0.274 ± 0.016	0.898CysGly: 0.898 ± 0.033	0.233CysHis: 0.233 ± 0.015	0.354CysIle: 0.354 ± 0.021	0.117CysLys: 0.117 ± 0.01	0.808CysLeu: 0.808 ± 0.031	0.146CysMet: 0.146 ± 0.013	0.156CysAsn: 0.156 ± 0.013	0.437CysPro: 0.437 ± 0.022	0.168CysGln: 0.168 ± 0.014	0.588CysArg: 0.588 ± 0.026	0.366CysSer: 0.366 ± 0.019	0.368CysThr: 0.368 ± 0.019	0.546CysVal: 0.546 ± 0.021	0.115CysTrp: 0.115 ± 0.01	0.163CysTyr: 0.163 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.28AspAla: 7.28 ± 0.107	0.46AspCys: 0.46 ± 0.023	2.935AspAsp: 2.935 ± 0.072	3.708AspGlu: 3.708 ± 0.063	2.051AspPhe: 2.051 ± 0.05	5.406AspGly: 5.406 ± 0.095	1.247AspHis: 1.247 ± 0.04	2.56AspIle: 2.56 ± 0.054	1.126AspLys: 1.126 ± 0.037	6.631AspLeu: 6.631 ± 0.095	1.463AspMet: 1.463 ± 0.038	0.965AspAsn: 0.965 ± 0.034	4.115AspPro: 4.115 ± 0.069	1.676AspGln: 1.676 ± 0.043	4.721AspArg: 4.721 ± 0.079	2.194AspSer: 2.194 ± 0.05	2.611AspThr: 2.611 ± 0.056	3.663AspVal: 3.663 ± 0.067	1.358AspTrp: 1.358 ± 0.041	1.528AspTyr: 1.528 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	11.437GluAla: 11.437 ± 0.155	0.257GluCys: 0.257 ± 0.014	3.641GluAsp: 3.641 ± 0.073	4.37GluGlu: 4.37 ± 0.084	1.397GluPhe: 1.397 ± 0.034	6.645GluGly: 6.645 ± 0.099	1.068GluHis: 1.068 ± 0.035	3.358GluIle: 3.358 ± 0.051	1.418GluLys: 1.418 ± 0.044	4.542GluLeu: 4.542 ± 0.072	1.843GluMet: 1.843 ± 0.046	1.275GluAsn: 1.275 ± 0.037	2.873GluPro: 2.873 ± 0.064	1.946GluGln: 1.946 ± 0.057	4.752GluArg: 4.752 ± 0.081	2.133GluSer: 2.133 ± 0.053	3.985GluThr: 3.985 ± 0.068	4.958GluVal: 4.958 ± 0.069	0.58GluTrp: 0.58 ± 0.024	0.843GluTyr: 0.843 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.356PheAla: 4.356 ± 0.07	0.339PheCys: 0.339 ± 0.019	2.675PheAsp: 2.675 ± 0.059	2.034PheGlu: 2.034 ± 0.046	1.209PhePhe: 1.209 ± 0.037	3.477PheGly: 3.477 ± 0.068	0.613PheHis: 0.613 ± 0.026	1.246PheIle: 1.246 ± 0.042	0.563PheLys: 0.563 ± 0.023	3.026PheLeu: 3.026 ± 0.067	0.654PheMet: 0.654 ± 0.027	0.79PheAsn: 0.79 ± 0.033	1.405PhePro: 1.405 ± 0.035	0.847PheGln: 0.847 ± 0.028	2.062PheArg: 2.062 ± 0.048	1.831PheSer: 1.831 ± 0.042	1.922PheThr: 1.922 ± 0.048	2.426PheVal: 2.426 ± 0.052	0.564PheTrp: 0.564 ± 0.024	0.853PheTyr: 0.853 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	11.799GlyAla: 11.799 ± 0.138	0.868GlyCys: 0.868 ± 0.033	4.783GlyAsp: 4.783 ± 0.079	5.395GlyGlu: 5.395 ± 0.078	3.628GlyPhe: 3.628 ± 0.058	8.61GlyGly: 8.61 ± 0.144	1.834GlyHis: 1.834 ± 0.044	4.186GlyIle: 4.186 ± 0.075	2.263GlyLys: 2.263 ± 0.062	10.34GlyLeu: 10.34 ± 0.113	2.618GlyMet: 2.618 ± 0.052	1.803GlyAsn: 1.803 ± 0.056	4.483GlyPro: 4.483 ± 0.074	3.412GlyGln: 3.412 ± 0.06	7.127GlyArg: 7.127 ± 0.097	4.552GlySer: 4.552 ± 0.079	5.302GlyThr: 5.302 ± 0.085	6.17GlyVal: 6.17 ± 0.085	1.752GlyTrp: 1.752 ± 0.049	2.18GlyTyr: 2.18 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.256HisAla: 2.256 ± 0.049	0.178HisCys: 0.178 ± 0.014	1.269HisAsp: 1.269 ± 0.039	1.064HisGlu: 1.064 ± 0.032	0.686HisPhe: 0.686 ± 0.026	1.834HisGly: 1.834 ± 0.042	0.546HisHis: 0.546 ± 0.025	0.725HisIle: 0.725 ± 0.028	0.35HisLys: 0.35 ± 0.02	2.007HisLeu: 2.007 ± 0.046	0.455HisMet: 0.455 ± 0.023	0.336HisAsn: 0.336 ± 0.019	1.398HisPro: 1.398 ± 0.041	0.495HisGln: 0.495 ± 0.021	1.484HisArg: 1.484 ± 0.039	0.781HisSer: 0.781 ± 0.029	0.622HisThr: 0.622 ± 0.025	1.413HisVal: 1.413 ± 0.043	0.351HisTrp: 0.351 ± 0.02	0.517HisTyr: 0.517 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.98IleAla: 6.98 ± 0.086	0.477IleCys: 0.477 ± 0.023	3.285IleAsp: 3.285 ± 0.055	3.52IleGlu: 3.52 ± 0.057	1.432IlePhe: 1.432 ± 0.036	4.711IleGly: 4.711 ± 0.07	0.766IleHis: 0.766 ± 0.032	1.539IleIle: 1.539 ± 0.046	0.884IleLys: 0.884 ± 0.027	4.439IleLeu: 4.439 ± 0.068	0.839IleMet: 0.839 ± 0.031	0.96IleAsn: 0.96 ± 0.032	2.086IlePro: 2.086 ± 0.046	0.958IleGln: 0.958 ± 0.037	3.069IleArg: 3.069 ± 0.054	2.238IleSer: 2.238 ± 0.048	2.423IleThr: 2.423 ± 0.052	3.297IleVal: 3.297 ± 0.064	0.632IleTrp: 0.632 ± 0.023	0.975IleTyr: 0.975 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	2.879LysAla: 2.879 ± 0.055	0.095LysCys: 0.095 ± 0.01	1.207LysAsp: 1.207 ± 0.045	1.063LysGlu: 1.063 ± 0.038	0.515LysPhe: 0.515 ± 0.022	2.032LysGly: 2.032 ± 0.053	0.402LysHis: 0.402 ± 0.019	1.057LysIle: 1.057 ± 0.034	0.731LysLys: 0.731 ± 0.036	2.003LysLeu: 2.003 ± 0.051	0.608LysMet: 0.608 ± 0.032	0.448LysAsn: 0.448 ± 0.021	1.256LysPro: 1.256 ± 0.038	0.613LysGln: 0.613 ± 0.027	1.597LysArg: 1.597 ± 0.046	1.132LysSer: 1.132 ± 0.04	1.347LysThr: 1.347 ± 0.041	1.582LysVal: 1.582 ± 0.047	0.221LysTrp: 0.221 ± 0.016	0.369LysTyr: 0.369 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.961LeuAla: 14.961 ± 0.163	1.006LeuCys: 1.006 ± 0.032	6.158LeuAsp: 6.158 ± 0.095	5.764LeuGlu: 5.764 ± 0.083	3.297LeuPhe: 3.297 ± 0.064	9.355LeuGly: 9.355 ± 0.102	1.917LeuHis: 1.917 ± 0.045	4.918LeuIle: 4.918 ± 0.066	2.393LeuLys: 2.393 ± 0.05	10.272LeuLeu: 10.272 ± 0.156	2.557LeuMet: 2.557 ± 0.05	2.222LeuAsn: 2.222 ± 0.044	6.51LeuPro: 6.51 ± 0.097	3.008LeuGln: 3.008 ± 0.059	8.573LeuArg: 8.573 ± 0.112	6.787LeuSer: 6.787 ± 0.094	6.239LeuThr: 6.239 ± 0.082	7.249LeuVal: 7.249 ± 0.104	1.506LeuTrp: 1.506 ± 0.048	2.114LeuTyr: 2.114 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.468MetAla: 3.468 ± 0.062	0.139MetCys: 0.139 ± 0.011	1.244MetAsp: 1.244 ± 0.03	1.294MetGlu: 1.294 ± 0.037	0.641MetPhe: 0.641 ± 0.023	2.029MetGly: 2.029 ± 0.044	0.443MetHis: 0.443 ± 0.021	1.425MetIle: 1.425 ± 0.04	0.719MetLys: 0.719 ± 0.028	2.627MetLeu: 2.627 ± 0.054	0.686MetMet: 0.686 ± 0.028	0.63MetAsn: 0.63 ± 0.023	1.638MetPro: 1.638 ± 0.039	0.982MetGln: 0.982 ± 0.034	2.062MetArg: 2.062 ± 0.053	1.501MetSer: 1.501 ± 0.039	2.214MetThr: 2.214 ± 0.043	1.726MetVal: 1.726 ± 0.045	0.203MetTrp: 0.203 ± 0.014	0.302MetTyr: 0.302 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.525AsnAla: 2.525 ± 0.048	0.163AsnCys: 0.163 ± 0.013	1.147AsnAsp: 1.147 ± 0.042	1.004AsnGlu: 1.004 ± 0.036	0.752AsnPhe: 0.752 ± 0.029	1.851AsnGly: 1.851 ± 0.044	0.401AsnHis: 0.401 ± 0.019	0.984AsnIle: 0.984 ± 0.036	0.394AsnLys: 0.394 ± 0.02	2.033AsnLeu: 2.033 ± 0.047	0.496AsnMet: 0.496 ± 0.023	0.462AsnAsn: 0.462 ± 0.023	1.493AsnPro: 1.493 ± 0.043	0.535AsnGln: 0.535 ± 0.026	1.469AsnArg: 1.469 ± 0.038	0.872AsnSer: 0.872 ± 0.031	0.982AsnThr: 0.982 ± 0.028	1.352AsnVal: 1.352 ± 0.04	0.321AsnTrp: 0.321 ± 0.019	0.486AsnTyr: 0.486 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	7.486ProAla: 7.486 ± 0.124	0.354ProCys: 0.354 ± 0.019	3.747ProAsp: 3.747 ± 0.067	5.228ProGlu: 5.228 ± 0.088	1.873ProPhe: 1.873 ± 0.038	5.44ProGly: 5.44 ± 0.084	1.063ProHis: 1.063 ± 0.031	1.997ProIle: 1.997 ± 0.044	1.181ProLys: 1.181 ± 0.037	5.75ProLeu: 5.75 ± 0.084	1.33ProMet: 1.33 ± 0.033	1.0ProAsn: 1.0 ± 0.032	2.848ProPro: 2.848 ± 0.064	2.242ProGln: 2.242 ± 0.044	3.558ProArg: 3.558 ± 0.067	2.53ProSer: 2.53 ± 0.048	2.181ProThr: 2.181 ± 0.043	4.283ProVal: 4.283 ± 0.068	0.787ProTrp: 0.787 ± 0.034	1.116ProTyr: 1.116 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.725GlnAla: 4.725 ± 0.075	0.149GlnCys: 0.149 ± 0.013	1.919GlnAsp: 1.919 ± 0.045	1.993GlnGlu: 1.993 ± 0.045	0.924GlnPhe: 0.924 ± 0.028	3.034GlnGly: 3.034 ± 0.058	0.575GlnHis: 0.575 ± 0.023	1.799GlnIle: 1.799 ± 0.041	0.69GlnLys: 0.69 ± 0.03	2.945GlnLeu: 2.945 ± 0.057	1.026GlnMet: 1.026 ± 0.03	0.675GlnAsn: 0.675 ± 0.023	1.968GlnPro: 1.968 ± 0.045	1.279GlnGln: 1.279 ± 0.045	2.598GlnArg: 2.598 ± 0.058	1.61GlnSer: 1.61 ± 0.04	1.67GlnThr: 1.67 ± 0.044	2.499GlnVal: 2.499 ± 0.054	0.39GlnTrp: 0.39 ± 0.021	0.575GlnTyr: 0.575 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	9.775ArgAla: 9.775 ± 0.115	0.488ArgCys: 0.488 ± 0.022	4.437ArgAsp: 4.437 ± 0.063	4.264ArgGlu: 4.264 ± 0.06	2.594ArgPhe: 2.594 ± 0.05	5.85ArgGly: 5.85 ± 0.081	1.702ArgHis: 1.702 ± 0.044	4.04ArgIle: 4.04 ± 0.068	1.542ArgLys: 1.542 ± 0.05	8.908ArgLeu: 8.908 ± 0.115	2.122ArgMet: 2.122 ± 0.047	1.393ArgAsn: 1.393 ± 0.039	4.238ArgPro: 4.238 ± 0.078	2.731ArgGln: 2.731 ± 0.054	6.602ArgArg: 6.602 ± 0.103	3.583ArgSer: 3.583 ± 0.059	3.064ArgThr: 3.064 ± 0.06	5.027ArgVal: 5.027 ± 0.065	1.098ArgTrp: 1.098 ± 0.032	1.616ArgTyr: 1.616 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.865SerAla: 5.865 ± 0.092	0.375SerCys: 0.375 ± 0.019	2.929SerAsp: 2.929 ± 0.055	2.598SerGlu: 2.598 ± 0.05	2.033SerPhe: 2.033 ± 0.042	5.665SerGly: 5.665 ± 0.09	0.891SerHis: 0.891 ± 0.035	2.188SerIle: 2.188 ± 0.053	0.999SerLys: 0.999 ± 0.035	5.137SerLeu: 5.137 ± 0.076	1.183SerMet: 1.183 ± 0.032	0.984SerAsn: 0.984 ± 0.032	2.424SerPro: 2.424 ± 0.045	1.48SerGln: 1.48 ± 0.035	3.418SerArg: 3.418 ± 0.073	2.356SerSer: 2.356 ± 0.055	2.449SerThr: 2.449 ± 0.053	3.498SerVal: 3.498 ± 0.063	0.731SerTrp: 0.731 ± 0.024	1.256SerTyr: 1.256 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.619ThrAla: 6.619 ± 0.091	0.423ThrCys: 0.423 ± 0.023	3.077ThrAsp: 3.077 ± 0.061	3.136ThrGlu: 3.136 ± 0.06	1.646ThrPhe: 1.646 ± 0.046	5.686ThrGly: 5.686 ± 0.083	0.97ThrHis: 0.97 ± 0.034	2.336ThrIle: 2.336 ± 0.048	0.979ThrLys: 0.979 ± 0.03	6.138ThrLeu: 6.138 ± 0.089	1.15ThrMet: 1.15 ± 0.034	1.025ThrAsn: 1.025 ± 0.035	3.367ThrPro: 3.367 ± 0.054	1.541ThrGln: 1.541 ± 0.04	3.713ThrArg: 3.713 ± 0.061	2.481ThrSer: 2.481 ± 0.052	2.554ThrThr: 2.554 ± 0.06	4.105ThrVal: 4.105 ± 0.069	0.647ThrTrp: 0.647 ± 0.027	1.094ThrTyr: 1.094 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	8.783ValAla: 8.783 ± 0.108	0.518ValCys: 0.518 ± 0.023	3.645ValAsp: 3.645 ± 0.055	4.676ValGlu: 4.676 ± 0.064	2.566ValPhe: 2.566 ± 0.056	5.046ValGly: 5.046 ± 0.071	1.161ValHis: 1.161 ± 0.036	3.811ValIle: 3.811 ± 0.067	1.444ValLys: 1.444 ± 0.048	8.431ValLeu: 8.431 ± 0.098	1.971ValMet: 1.971 ± 0.048	1.6ValAsn: 1.6 ± 0.042	3.878ValPro: 3.878 ± 0.061	2.319ValGln: 2.319 ± 0.053	4.163ValArg: 4.163 ± 0.062	3.789ValSer: 3.789 ± 0.065	5.111ValThr: 5.111 ± 0.08	5.201ValVal: 5.201 ± 0.089	0.947ValTrp: 0.947 ± 0.028	1.31ValTyr: 1.31 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.519TrpAla: 1.519 ± 0.042	0.154TrpCys: 0.154 ± 0.013	0.806TrpAsp: 0.806 ± 0.031	0.639TrpGlu: 0.639 ± 0.028	0.509TrpPhe: 0.509 ± 0.024	1.114TrpGly: 1.114 ± 0.038	0.345TrpHis: 0.345 ± 0.02	0.796TrpIle: 0.796 ± 0.028	0.309TrpLys: 0.309 ± 0.015	1.779TrpLeu: 1.779 ± 0.047	0.411TrpMet: 0.411 ± 0.02	0.37TrpAsn: 0.37 ± 0.02	0.815TrpPro: 0.815 ± 0.028	0.661TrpGln: 0.661 ± 0.021	1.24TrpArg: 1.24 ± 0.037	0.829TrpSer: 0.829 ± 0.029	0.863TrpThr: 0.863 ± 0.027	0.832TrpVal: 0.832 ± 0.028	0.246TrpTrp: 0.246 ± 0.015	0.285TrpTyr: 0.285 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.481TyrAla: 2.481 ± 0.05	0.185TyrCys: 0.185 ± 0.014	1.528TyrAsp: 1.528 ± 0.046	1.247TyrGlu: 1.247 ± 0.04	0.747TyrPhe: 0.747 ± 0.03	2.088TyrGly: 2.088 ± 0.049	0.439TyrHis: 0.439 ± 0.02	0.777TyrIle: 0.777 ± 0.032	0.405TyrLys: 0.405 ± 0.022	2.075TyrLeu: 2.075 ± 0.044	0.384TyrMet: 0.384 ± 0.019	0.518TyrAsn: 0.518 ± 0.023	1.064TyrPro: 1.064 ± 0.036	0.615TyrGln: 0.615 ± 0.026	1.578TyrArg: 1.578 ± 0.04	1.036TyrSer: 1.036 ± 0.031	1.042TyrThr: 1.042 ± 0.036	1.366TyrVal: 1.366 ± 0.04	0.35TyrTrp: 0.35 ± 0.022	0.522TyrTyr: 0.522 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3295 proteins (1035711 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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