Amino acid dipepetide frequency for Limisphaera ngatamarikiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.884AlaAla: 12.884 ± 0.168	1.256AlaCys: 1.256 ± 0.042	4.787AlaAsp: 4.787 ± 0.071	6.658AlaGlu: 6.658 ± 0.099	3.363AlaPhe: 3.363 ± 0.063	10.236AlaGly: 10.236 ± 0.12	2.097AlaHis: 2.097 ± 0.05	3.627AlaIle: 3.627 ± 0.065	1.659AlaLys: 1.659 ± 0.051	11.793AlaLeu: 11.793 ± 0.137	2.106AlaMet: 2.106 ± 0.054	2.386AlaAsn: 2.386 ± 0.049	5.582AlaPro: 5.582 ± 0.107	3.525AlaGln: 3.525 ± 0.062	10.365AlaArg: 10.365 ± 0.124	4.242AlaSer: 4.242 ± 0.071	5.182AlaThr: 5.182 ± 0.09	8.621AlaVal: 8.621 ± 0.116	2.325AlaTrp: 2.325 ± 0.061	2.079AlaTyr: 2.079 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.084CysAla: 1.084 ± 0.036	0.199CysCys: 0.199 ± 0.015	0.505CysAsp: 0.505 ± 0.023	0.684CysGlu: 0.684 ± 0.023	0.36CysPhe: 0.36 ± 0.022	1.174CysGly: 1.174 ± 0.038	0.353CysHis: 0.353 ± 0.029	0.466CysIle: 0.466 ± 0.021	0.244CysLys: 0.244 ± 0.015	1.235CysLeu: 1.235 ± 0.039	0.194CysMet: 0.194 ± 0.014	0.257CysAsn: 0.257 ± 0.019	0.693CysPro: 0.693 ± 0.028	0.33CysGln: 0.33 ± 0.019	1.002CysArg: 1.002 ± 0.034	0.515CysSer: 0.515 ± 0.024	0.524CysThr: 0.524 ± 0.024	0.843CysVal: 0.843 ± 0.03	0.238CysTrp: 0.238 ± 0.014	0.313CysTyr: 0.313 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.648AspAla: 4.648 ± 0.073	0.518AspCys: 0.518 ± 0.026	2.047AspAsp: 2.047 ± 0.061	2.791AspGlu: 2.791 ± 0.061	1.889AspPhe: 1.889 ± 0.046	4.639AspGly: 4.639 ± 0.116	1.059AspHis: 1.059 ± 0.034	1.706AspIle: 1.706 ± 0.047	0.854AspLys: 0.854 ± 0.034	5.748AspLeu: 5.748 ± 0.083	0.694AspMet: 0.694 ± 0.028	1.086AspAsn: 1.086 ± 0.039	4.445AspPro: 4.445 ± 0.081	1.569AspGln: 1.569 ± 0.051	4.254AspArg: 4.254 ± 0.07	1.718AspSer: 1.718 ± 0.046	2.199AspThr: 2.199 ± 0.055	3.269AspVal: 3.269 ± 0.063	1.157AspTrp: 1.157 ± 0.033	1.381AspTyr: 1.381 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.872GluAla: 6.872 ± 0.098	0.563GluCys: 0.563 ± 0.026	2.484GluAsp: 2.484 ± 0.06	4.013GluGlu: 4.013 ± 0.081	2.13GluPhe: 2.13 ± 0.048	4.619GluGly: 4.619 ± 0.08	1.265GluHis: 1.265 ± 0.037	2.919GluIle: 2.919 ± 0.064	1.858GluLys: 1.858 ± 0.058	6.864GluLeu: 6.864 ± 0.091	1.133GluMet: 1.133 ± 0.03	1.455GluAsn: 1.455 ± 0.041	3.846GluPro: 3.846 ± 0.068	2.586GluGln: 2.586 ± 0.061	5.302GluArg: 5.302 ± 0.107	2.649GluSer: 2.649 ± 0.047	3.373GluThr: 3.373 ± 0.061	5.276GluVal: 5.276 ± 0.079	1.138GluTrp: 1.138 ± 0.035	1.364GluTyr: 1.364 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.141PheAla: 3.141 ± 0.056	0.462PheCys: 0.462 ± 0.021	2.155PheAsp: 2.155 ± 0.044	2.302PheGlu: 2.302 ± 0.046	1.283PhePhe: 1.283 ± 0.043	2.994PheGly: 2.994 ± 0.059	0.898PheHis: 0.898 ± 0.028	1.213PheIle: 1.213 ± 0.037	0.78PheLys: 0.78 ± 0.028	3.75PheLeu: 3.75 ± 0.069	0.535PheMet: 0.535 ± 0.021	0.99PheAsn: 0.99 ± 0.035	1.804PhePro: 1.804 ± 0.041	1.323PheGln: 1.323 ± 0.037	2.868PheArg: 2.868 ± 0.058	1.667PheSer: 1.667 ± 0.04	1.952PheThr: 1.952 ± 0.043	2.697PheVal: 2.697 ± 0.056	0.795PheTrp: 0.795 ± 0.029	1.182PheTyr: 1.182 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	7.813GlyAla: 7.813 ± 0.113	1.121GlyCys: 1.121 ± 0.039	3.969GlyAsp: 3.969 ± 0.099	4.476GlyGlu: 4.476 ± 0.069	3.208GlyPhe: 3.208 ± 0.058	7.407GlyGly: 7.407 ± 0.151	1.804GlyHis: 1.804 ± 0.035	3.448GlyIle: 3.448 ± 0.06	1.91GlyLys: 1.91 ± 0.048	9.502GlyLeu: 9.502 ± 0.116	1.809GlyMet: 1.809 ± 0.045	2.203GlyAsn: 2.203 ± 0.077	5.186GlyPro: 5.186 ± 0.09	3.156GlyGln: 3.156 ± 0.066	8.262GlyArg: 8.262 ± 0.11	4.744GlySer: 4.744 ± 0.083	5.245GlyThr: 5.245 ± 0.119	6.491GlyVal: 6.491 ± 0.091	2.463GlyTrp: 2.463 ± 0.063	2.29GlyTyr: 2.29 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.143HisAla: 2.143 ± 0.048	0.308HisCys: 0.308 ± 0.017	1.072HisAsp: 1.072 ± 0.031	1.181HisGlu: 1.181 ± 0.035	0.863HisPhe: 0.863 ± 0.029	2.005HisGly: 2.005 ± 0.05	0.647HisHis: 0.647 ± 0.028	0.81HisIle: 0.81 ± 0.029	0.43HisLys: 0.43 ± 0.022	2.399HisLeu: 2.399 ± 0.052	0.35HisMet: 0.35 ± 0.02	0.542HisAsn: 0.542 ± 0.02	2.033HisPro: 2.033 ± 0.045	0.844HisGln: 0.844 ± 0.031	1.906HisArg: 1.906 ± 0.054	0.848HisSer: 0.848 ± 0.031	1.008HisThr: 1.008 ± 0.029	1.625HisVal: 1.625 ± 0.039	0.589HisTrp: 0.589 ± 0.025	0.621HisTyr: 0.621 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	3.798IleAla: 3.798 ± 0.069	0.501IleCys: 0.501 ± 0.025	1.471IleAsp: 1.471 ± 0.043	2.854IleGlu: 2.854 ± 0.062	1.132IlePhe: 1.132 ± 0.034	3.121IleGly: 3.121 ± 0.063	1.017IleHis: 1.017 ± 0.029	1.388IleIle: 1.388 ± 0.048	0.892IleLys: 0.892 ± 0.038	4.325IleLeu: 4.325 ± 0.077	0.543IleMet: 0.543 ± 0.024	1.16IleAsn: 1.16 ± 0.037	2.503IlePro: 2.503 ± 0.044	1.48IleGln: 1.48 ± 0.04	3.954IleArg: 3.954 ± 0.062	1.797IleSer: 1.797 ± 0.045	2.304IleThr: 2.304 ± 0.06	3.016IleVal: 3.016 ± 0.067	0.567IleTrp: 0.567 ± 0.025	0.98IleTyr: 0.98 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	2.332LysAla: 2.332 ± 0.059	0.202LysCys: 0.202 ± 0.015	0.997LysAsp: 0.997 ± 0.036	1.287LysGlu: 1.287 ± 0.047	0.662LysPhe: 0.662 ± 0.026	1.606LysGly: 1.606 ± 0.044	0.485LysHis: 0.485 ± 0.023	1.02LysIle: 1.02 ± 0.039	0.793LysLys: 0.793 ± 0.033	2.416LysLeu: 2.416 ± 0.057	0.412LysMet: 0.412 ± 0.022	0.594LysAsn: 0.594 ± 0.026	1.781LysPro: 1.781 ± 0.048	0.829LysGln: 0.829 ± 0.031	1.71LysArg: 1.71 ± 0.057	0.976LysSer: 0.976 ± 0.034	1.335LysThr: 1.335 ± 0.041	1.862LysVal: 1.862 ± 0.049	0.321LysTrp: 0.321 ± 0.019	0.596LysTyr: 0.596 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.334LeuAla: 12.334 ± 0.15	1.277LeuCys: 1.277 ± 0.037	5.395LeuAsp: 5.395 ± 0.086	7.311LeuGlu: 7.311 ± 0.101	3.351LeuPhe: 3.351 ± 0.065	8.995LeuGly: 8.995 ± 0.106	2.379LeuHis: 2.379 ± 0.049	3.883LeuIle: 3.883 ± 0.068	2.751LeuLys: 2.751 ± 0.057	11.06LeuLeu: 11.06 ± 0.165	1.934LeuMet: 1.934 ± 0.044	2.807LeuAsn: 2.807 ± 0.059	6.662LeuPro: 6.662 ± 0.091	4.471LeuGln: 4.471 ± 0.074	10.019LeuArg: 10.019 ± 0.116	4.872LeuSer: 4.872 ± 0.07	6.138LeuThr: 6.138 ± 0.078	8.643LeuVal: 8.643 ± 0.105	2.263LeuTrp: 2.263 ± 0.063	2.505LeuTyr: 2.505 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.01MetAla: 2.01 ± 0.045	0.142MetCys: 0.142 ± 0.012	0.936MetAsp: 0.936 ± 0.032	1.126MetGlu: 1.126 ± 0.032	0.538MetPhe: 0.538 ± 0.026	1.435MetGly: 1.435 ± 0.034	0.349MetHis: 0.349 ± 0.021	0.755MetIle: 0.755 ± 0.028	0.818MetLys: 0.818 ± 0.034	1.706MetLeu: 1.706 ± 0.046	0.302MetMet: 0.302 ± 0.016	0.735MetAsn: 0.735 ± 0.024	1.048MetPro: 1.048 ± 0.03	0.628MetGln: 0.628 ± 0.026	1.393MetArg: 1.393 ± 0.038	0.937MetSer: 0.937 ± 0.034	1.021MetThr: 1.021 ± 0.032	1.429MetVal: 1.429 ± 0.034	0.208MetTrp: 0.208 ± 0.014	0.284MetTyr: 0.284 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.647AsnAla: 2.647 ± 0.058	0.289AsnCys: 0.289 ± 0.019	1.15AsnAsp: 1.15 ± 0.047	1.253AsnGlu: 1.253 ± 0.036	0.926AsnPhe: 0.926 ± 0.027	2.522AsnGly: 2.522 ± 0.079	0.628AsnHis: 0.628 ± 0.025	1.031AsnIle: 1.031 ± 0.035	0.489AsnLys: 0.489 ± 0.023	3.143AsnLeu: 3.143 ± 0.064	0.353AsnMet: 0.353 ± 0.017	0.847AsnAsn: 0.847 ± 0.036	2.405AsnPro: 2.405 ± 0.057	0.968AsnGln: 0.968 ± 0.037	2.293AsnArg: 2.293 ± 0.057	1.089AsnSer: 1.089 ± 0.035	1.344AsnThr: 1.344 ± 0.049	2.035AsnVal: 2.035 ± 0.056	0.569AsnTrp: 0.569 ± 0.027	0.735AsnTyr: 0.735 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	7.762ProAla: 7.762 ± 0.119	0.533ProCys: 0.533 ± 0.021	4.438ProAsp: 4.438 ± 0.076	5.114ProGlu: 5.114 ± 0.076	1.952ProPhe: 1.952 ± 0.044	7.051ProGly: 7.051 ± 0.108	1.323ProHis: 1.323 ± 0.039	2.001ProIle: 2.001 ± 0.046	1.129ProLys: 1.129 ± 0.034	5.641ProLeu: 5.641 ± 0.084	1.253ProMet: 1.253 ± 0.035	1.624ProAsn: 1.624 ± 0.046	4.846ProPro: 4.846 ± 0.103	1.891ProGln: 1.891 ± 0.042	4.565ProArg: 4.565 ± 0.07	2.688ProSer: 2.688 ± 0.049	3.186ProThr: 3.186 ± 0.069	5.743ProVal: 5.743 ± 0.082	1.485ProTrp: 1.485 ± 0.041	1.288ProTyr: 1.288 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	3.849GlnAla: 3.849 ± 0.066	0.34GlnCys: 0.34 ± 0.017	1.286GlnAsp: 1.286 ± 0.034	1.896GlnGlu: 1.896 ± 0.052	1.187GlnPhe: 1.187 ± 0.031	2.73GlnGly: 2.73 ± 0.058	0.754GlnHis: 0.754 ± 0.025	1.69GlnIle: 1.69 ± 0.045	1.043GlnLys: 1.043 ± 0.038	3.79GlnLeu: 3.79 ± 0.056	0.746GlnMet: 0.746 ± 0.029	0.927GlnAsn: 0.927 ± 0.034	2.855GlnPro: 2.855 ± 0.057	1.739GlnGln: 1.739 ± 0.047	3.213GlnArg: 3.213 ± 0.061	1.546GlnSer: 1.546 ± 0.037	2.206GlnThr: 2.206 ± 0.051	2.992GlnVal: 2.992 ± 0.054	0.904GlnTrp: 0.904 ± 0.028	0.794GlnTyr: 0.794 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	8.938ArgAla: 8.938 ± 0.103	0.937ArgCys: 0.937 ± 0.031	3.879ArgAsp: 3.879 ± 0.067	5.532ArgGlu: 5.532 ± 0.102	3.712ArgPhe: 3.712 ± 0.058	5.748ArgGly: 5.748 ± 0.084	2.13ArgHis: 2.13 ± 0.051	4.136ArgIle: 4.136 ± 0.07	2.22ArgLys: 2.22 ± 0.061	10.489ArgLeu: 10.489 ± 0.139	1.709ArgMet: 1.709 ± 0.047	2.105ArgAsn: 2.105 ± 0.047	5.492ArgPro: 5.492 ± 0.084	3.585ArgGln: 3.585 ± 0.065	7.902ArgArg: 7.902 ± 0.137	3.95ArgSer: 3.95 ± 0.069	4.263ArgThr: 4.263 ± 0.062	7.08ArgVal: 7.08 ± 0.091	2.234ArgTrp: 2.234 ± 0.053	2.384ArgTyr: 2.384 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	4.492SerAla: 4.492 ± 0.062	0.474SerCys: 0.474 ± 0.022	2.243SerAsp: 2.243 ± 0.044	2.348SerGlu: 2.348 ± 0.053	1.689SerPhe: 1.689 ± 0.045	4.939SerGly: 4.939 ± 0.101	0.933SerHis: 0.933 ± 0.029	1.612SerIle: 1.612 ± 0.04	0.854SerLys: 0.854 ± 0.031	4.718SerLeu: 4.718 ± 0.067	0.821SerMet: 0.821 ± 0.028	1.269SerAsn: 1.269 ± 0.053	3.22SerPro: 3.22 ± 0.063	1.308SerGln: 1.308 ± 0.033	3.486SerArg: 3.486 ± 0.057	2.142SerSer: 2.142 ± 0.048	2.466SerThr: 2.466 ± 0.059	3.525SerVal: 3.525 ± 0.063	0.996SerTrp: 0.996 ± 0.031	1.072SerTyr: 1.072 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.627ThrAla: 5.627 ± 0.082	0.531ThrCys: 0.531 ± 0.021	2.574ThrAsp: 2.574 ± 0.062	2.75ThrGlu: 2.75 ± 0.062	2.014ThrPhe: 2.014 ± 0.051	5.564ThrGly: 5.564 ± 0.089	1.108ThrHis: 1.108 ± 0.033	2.021ThrIle: 2.021 ± 0.051	0.854ThrLys: 0.854 ± 0.031	6.387ThrLeu: 6.387 ± 0.105	0.732ThrMet: 0.732 ± 0.024	2.328ThrAsn: 2.328 ± 0.1	3.779ThrPro: 3.779 ± 0.069	1.463ThrGln: 1.463 ± 0.041	4.167ThrArg: 4.167 ± 0.07	2.33ThrSer: 2.33 ± 0.052	2.817ThrThr: 2.817 ± 0.059	4.76ThrVal: 4.76 ± 0.085	1.055ThrTrp: 1.055 ± 0.038	1.234ThrTyr: 1.234 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	8.218ValAla: 8.218 ± 0.105	0.983ValCys: 0.983 ± 0.038	3.859ValAsp: 3.859 ± 0.069	5.234ValGlu: 5.234 ± 0.08	2.793ValPhe: 2.793 ± 0.057	6.155ValGly: 6.155 ± 0.095	1.833ValHis: 1.833 ± 0.04	3.207ValIle: 3.207 ± 0.063	1.63ValLys: 1.63 ± 0.043	8.81ValLeu: 8.81 ± 0.114	1.406ValMet: 1.406 ± 0.041	2.052ValAsn: 2.052 ± 0.054	4.843ValPro: 4.843 ± 0.085	2.793ValGln: 2.793 ± 0.06	7.469ValArg: 7.469 ± 0.099	3.695ValSer: 3.695 ± 0.07	4.891ValThr: 4.891 ± 0.088	7.405ValVal: 7.405 ± 0.115	1.745ValTrp: 1.745 ± 0.051	1.904ValTyr: 1.904 ± 0.046	0.001ValXaa: 0.001 ± 0.001
Trp	1.859TrpAla: 1.859 ± 0.047	0.281TrpCys: 0.281 ± 0.015	1.068TrpAsp: 1.068 ± 0.035	1.241TrpGlu: 1.241 ± 0.034	0.821TrpPhe: 0.821 ± 0.032	1.417TrpGly: 1.417 ± 0.043	0.532TrpHis: 0.532 ± 0.023	1.04TrpIle: 1.04 ± 0.034	0.506TrpLys: 0.506 ± 0.022	2.73TrpLeu: 2.73 ± 0.068	0.459TrpMet: 0.459 ± 0.019	0.648TrpAsn: 0.648 ± 0.028	1.226TrpPro: 1.226 ± 0.038	1.046TrpGln: 1.046 ± 0.029	1.916TrpArg: 1.916 ± 0.053	1.132TrpSer: 1.132 ± 0.03	1.34TrpThr: 1.34 ± 0.046	1.769TrpVal: 1.769 ± 0.04	0.65TrpTrp: 0.65 ± 0.031	0.518TrpTyr: 0.518 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.321TyrAla: 2.321 ± 0.051	0.297TyrCys: 0.297 ± 0.019	1.358TyrAsp: 1.358 ± 0.037	1.658TyrGlu: 1.658 ± 0.042	0.921TyrPhe: 0.921 ± 0.032	2.152TyrGly: 2.152 ± 0.05	0.626TyrHis: 0.626 ± 0.022	0.83TyrIle: 0.83 ± 0.028	0.504TyrLys: 0.504 ± 0.02	2.543TyrLeu: 2.543 ± 0.05	0.309TyrMet: 0.309 ± 0.014	0.702TyrAsn: 0.702 ± 0.031	1.263TyrPro: 1.263 ± 0.037	0.952TyrGln: 0.952 ± 0.031	2.378TyrArg: 2.378 ± 0.052	1.069TyrSer: 1.069 ± 0.035	1.301TyrThr: 1.301 ± 0.04	1.845TyrVal: 1.845 ± 0.044	0.496TyrTrp: 0.496 ± 0.024	0.752TyrTyr: 0.752 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 2810 proteins (1068520 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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