Amino acid dipepetide frequency for Eubacterium sp. CAG:603

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.729AlaAla: 4.729 ± 0.12
0.758AlaCys: 0.758 ± 0.034
4.061AlaAsp: 4.061 ± 0.08
3.99AlaGlu: 3.99 ± 0.083
2.514AlaPhe: 2.514 ± 0.062
4.597AlaGly: 4.597 ± 0.094
0.858AlaHis: 0.858 ± 0.038
5.676AlaIle: 5.676 ± 0.091
5.204AlaLys: 5.204 ± 0.101
5.441AlaLeu: 5.441 ± 0.097
1.874AlaMet: 1.874 ± 0.059
3.035AlaAsn: 3.035 ± 0.067
1.338AlaPro: 1.338 ± 0.048
1.39AlaGln: 1.39 ± 0.055
2.245AlaArg: 2.245 ± 0.059
3.538AlaSer: 3.538 ± 0.078
3.265AlaThr: 3.265 ± 0.088
4.569AlaVal: 4.569 ± 0.091
0.392AlaTrp: 0.392 ± 0.022
2.588AlaTyr: 2.588 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.748CysAla: 0.748 ± 0.035
0.218CysCys: 0.218 ± 0.018
0.858CysAsp: 0.858 ± 0.038
0.925CysGlu: 0.925 ± 0.036
0.557CysPhe: 0.557 ± 0.03
1.261CysGly: 1.261 ± 0.051
0.237CysHis: 0.237 ± 0.02
1.249CysIle: 1.249 ± 0.044
0.969CysLys: 0.969 ± 0.039
0.953CysLeu: 0.953 ± 0.038
0.458CysMet: 0.458 ± 0.024
0.765CysAsn: 0.765 ± 0.034
0.457CysPro: 0.457 ± 0.024
0.26CysGln: 0.26 ± 0.018
0.491CysArg: 0.491 ± 0.028
0.857CysSer: 0.857 ± 0.038
0.686CysThr: 0.686 ± 0.032
0.889CysVal: 0.889 ± 0.035
0.071CysTrp: 0.071 ± 0.009
0.561CysTyr: 0.561 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
3.475AspAla: 3.475 ± 0.079
0.725AspCys: 0.725 ± 0.03
3.959AspAsp: 3.959 ± 0.078
5.62AspGlu: 5.62 ± 0.094
2.527AspPhe: 2.527 ± 0.063
4.4AspGly: 4.4 ± 0.106
0.549AspHis: 0.549 ± 0.023
6.355AspIle: 6.355 ± 0.098
5.977AspLys: 5.977 ± 0.107
4.248AspLeu: 4.248 ± 0.07
2.004AspMet: 2.004 ± 0.057
4.361AspAsn: 4.361 ± 0.095
1.035AspPro: 1.035 ± 0.039
0.655AspGln: 0.655 ± 0.034
2.205AspArg: 2.205 ± 0.056
3.672AspSer: 3.672 ± 0.082
3.54AspThr: 3.54 ± 0.101
4.053AspVal: 4.053 ± 0.067
0.408AspTrp: 0.408 ± 0.027
3.429AspTyr: 3.429 ± 0.081
0.0AspXaa: 0.0 ± 0.0
Glu
4.58GluAla: 4.58 ± 0.103
0.921GluCys: 0.921 ± 0.035
4.488GluAsp: 4.488 ± 0.085
6.518GluGlu: 6.518 ± 0.114
3.045GluPhe: 3.045 ± 0.07
3.405GluGly: 3.405 ± 0.064
1.108GluHis: 1.108 ± 0.034
6.884GluIle: 6.884 ± 0.11
6.856GluLys: 6.856 ± 0.111
6.712GluLeu: 6.712 ± 0.114
2.308GluMet: 2.308 ± 0.057
5.307GluAsn: 5.307 ± 0.098
1.574GluPro: 1.574 ± 0.052
2.084GluGln: 2.084 ± 0.058
2.789GluArg: 2.789 ± 0.066
3.505GluSer: 3.505 ± 0.064
3.501GluThr: 3.501 ± 0.077
4.727GluVal: 4.727 ± 0.077
0.555GluTrp: 0.555 ± 0.029
3.806GluTyr: 3.806 ± 0.08
0.0GluXaa: 0.0 ± 0.0
Phe
2.605PheAla: 2.605 ± 0.063
0.58PheCys: 0.58 ± 0.029
2.648PheAsp: 2.648 ± 0.054
2.793PheGlu: 2.793 ± 0.063
1.492PhePhe: 1.492 ± 0.051
2.712PheGly: 2.712 ± 0.06
0.496PheHis: 0.496 ± 0.03
3.736PheIle: 3.736 ± 0.095
2.826PheLys: 2.826 ± 0.06
2.968PheLeu: 2.968 ± 0.069
1.268PheMet: 1.268 ± 0.054
2.47PheAsn: 2.47 ± 0.052
1.007PhePro: 1.007 ± 0.039
0.833PheGln: 0.833 ± 0.035
1.403PheArg: 1.403 ± 0.043
2.742PheSer: 2.742 ± 0.074
2.294PheThr: 2.294 ± 0.06
2.771PheVal: 2.771 ± 0.058
0.319PheTrp: 0.319 ± 0.022
1.746PheTyr: 1.746 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
3.829GlyAla: 3.829 ± 0.088
0.969GlyCys: 0.969 ± 0.044
3.38GlyAsp: 3.38 ± 0.083
4.058GlyGlu: 4.058 ± 0.078
2.69GlyPhe: 2.69 ± 0.063
3.963GlyGly: 3.963 ± 0.099
1.074GlyHis: 1.074 ± 0.034
6.838GlyIle: 6.838 ± 0.106
5.597GlyLys: 5.597 ± 0.089
5.03GlyLeu: 5.03 ± 0.096
2.072GlyMet: 2.072 ± 0.052
3.863GlyAsn: 3.863 ± 0.091
0.967GlyPro: 0.967 ± 0.044
1.529GlyGln: 1.529 ± 0.05
2.523GlyArg: 2.523 ± 0.072
3.683GlySer: 3.683 ± 0.073
3.749GlyThr: 3.749 ± 0.083
4.386GlyVal: 4.386 ± 0.08
0.481GlyTrp: 0.481 ± 0.038
3.242GlyTyr: 3.242 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
0.664HisAla: 0.664 ± 0.027
0.217HisCys: 0.217 ± 0.018
0.721HisAsp: 0.721 ± 0.029
0.698HisGlu: 0.698 ± 0.033
0.685HisPhe: 0.685 ± 0.033
0.857HisGly: 0.857 ± 0.036
0.282HisHis: 0.282 ± 0.034
1.437HisIle: 1.437 ± 0.047
1.068HisLys: 1.068 ± 0.036
1.094HisLeu: 1.094 ± 0.043
0.426HisMet: 0.426 ± 0.026
0.941HisAsn: 0.941 ± 0.035
0.485HisPro: 0.485 ± 0.03
0.346HisGln: 0.346 ± 0.019
0.555HisArg: 0.555 ± 0.029
0.9HisSer: 0.9 ± 0.035
0.781HisThr: 0.781 ± 0.032
0.677HisVal: 0.677 ± 0.031
0.092HisTrp: 0.092 ± 0.01
0.594HisTyr: 0.594 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.028IleAla: 6.028 ± 0.096
1.559IleCys: 1.559 ± 0.046
5.847IleAsp: 5.847 ± 0.098
6.462IleGlu: 6.462 ± 0.11
3.59IlePhe: 3.59 ± 0.088
5.57IleGly: 5.57 ± 0.107
1.169IleHis: 1.169 ± 0.04
8.474IleIle: 8.474 ± 0.142
7.053IleLys: 7.053 ± 0.112
7.335IleLeu: 7.335 ± 0.126
2.597IleMet: 2.597 ± 0.069
5.673IleAsn: 5.673 ± 0.109
2.908IlePro: 2.908 ± 0.062
2.001IleGln: 2.001 ± 0.048
3.306IleArg: 3.306 ± 0.069
6.735IleSer: 6.735 ± 0.114
5.106IleThr: 5.106 ± 0.083
5.954IleVal: 5.954 ± 0.1
0.561IleTrp: 0.561 ± 0.03
3.835IleTyr: 3.835 ± 0.09
0.0IleXaa: 0.0 ± 0.0
Lys
5.144LysAla: 5.144 ± 0.098
1.016LysCys: 1.016 ± 0.039
5.25LysAsp: 5.25 ± 0.09
7.405LysGlu: 7.405 ± 0.104
2.698LysPhe: 2.698 ± 0.057
4.396LysGly: 4.396 ± 0.076
1.064LysHis: 1.064 ± 0.033
6.956LysIle: 6.956 ± 0.092
7.342LysLys: 7.342 ± 0.111
6.582LysLeu: 6.582 ± 0.1
2.622LysMet: 2.622 ± 0.062
5.453LysAsn: 5.453 ± 0.095
1.928LysPro: 1.928 ± 0.055
2.245LysGln: 2.245 ± 0.047
3.07LysArg: 3.07 ± 0.074
4.656LysSer: 4.656 ± 0.09
4.191LysThr: 4.191 ± 0.086
5.287LysVal: 5.287 ± 0.07
0.727LysTrp: 0.727 ± 0.052
4.399LysTyr: 4.399 ± 0.086
0.0LysXaa: 0.0 ± 0.0
Leu
5.218LeuAla: 5.218 ± 0.093
1.222LeuCys: 1.222 ± 0.044
5.11LeuAsp: 5.11 ± 0.091
5.881LeuGlu: 5.881 ± 0.092
3.296LeuPhe: 3.296 ± 0.082
4.994LeuGly: 4.994 ± 0.08
1.1LeuHis: 1.1 ± 0.035
6.717LeuIle: 6.717 ± 0.114
6.515LeuLys: 6.515 ± 0.107
6.801LeuLeu: 6.801 ± 0.116
2.317LeuMet: 2.317 ± 0.063
4.709LeuAsn: 4.709 ± 0.097
2.575LeuPro: 2.575 ± 0.069
1.959LeuGln: 1.959 ± 0.057
3.056LeuArg: 3.056 ± 0.073
5.939LeuSer: 5.939 ± 0.091
4.507LeuThr: 4.507 ± 0.08
5.105LeuVal: 5.105 ± 0.099
0.537LeuTrp: 0.537 ± 0.026
3.317LeuTyr: 3.317 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
2.146MetAla: 2.146 ± 0.062
0.423MetCys: 0.423 ± 0.027
1.704MetAsp: 1.704 ± 0.047
2.11MetGlu: 2.11 ± 0.055
1.182MetPhe: 1.182 ± 0.061
1.801MetGly: 1.801 ± 0.057
0.386MetHis: 0.386 ± 0.025
2.533MetIle: 2.533 ± 0.054
2.598MetLys: 2.598 ± 0.06
2.635MetLeu: 2.635 ± 0.065
0.847MetMet: 0.847 ± 0.038
1.867MetAsn: 1.867 ± 0.057
1.052MetPro: 1.052 ± 0.044
0.918MetGln: 0.918 ± 0.04
1.044MetArg: 1.044 ± 0.038
2.1MetSer: 2.1 ± 0.061
1.52MetThr: 1.52 ± 0.052
1.882MetVal: 1.882 ± 0.051
0.176MetTrp: 0.176 ± 0.015
1.056MetTyr: 1.056 ± 0.049
0.0MetXaa: 0.0 ± 0.0
Asn
3.604AsnAla: 3.604 ± 0.076
0.759AsnCys: 0.759 ± 0.035
3.7AsnAsp: 3.7 ± 0.076
4.506AsnGlu: 4.506 ± 0.082
1.915AsnPhe: 1.915 ± 0.059
4.487AsnGly: 4.487 ± 0.101
0.746AsnHis: 0.746 ± 0.034
6.248AsnIle: 6.248 ± 0.117
5.06AsnLys: 5.06 ± 0.085
4.39AsnLeu: 4.39 ± 0.086
2.009AsnMet: 2.009 ± 0.055
4.483AsnAsn: 4.483 ± 0.116
1.961AsnPro: 1.961 ± 0.054
1.422AsnGln: 1.422 ± 0.045
2.216AsnArg: 2.216 ± 0.055
3.833AsnSer: 3.833 ± 0.1
3.266AsnThr: 3.266 ± 0.08
4.256AsnVal: 4.256 ± 0.074
0.38AsnTrp: 0.38 ± 0.028
2.682AsnTyr: 2.682 ± 0.073
0.0AsnXaa: 0.0 ± 0.0
Pro
1.611ProAla: 1.611 ± 0.049
0.312ProCys: 0.312 ± 0.024
2.037ProAsp: 2.037 ± 0.047
2.419ProGlu: 2.419 ± 0.06
1.235ProPhe: 1.235 ± 0.043
1.652ProGly: 1.652 ± 0.05
0.416ProHis: 0.416 ± 0.024
2.039ProIle: 2.039 ± 0.053
1.761ProLys: 1.761 ± 0.05
1.999ProLeu: 1.999 ± 0.056
0.702ProMet: 0.702 ± 0.033
1.155ProAsn: 1.155 ± 0.039
0.499ProPro: 0.499 ± 0.028
0.69ProGln: 0.69 ± 0.038
0.729ProArg: 0.729 ± 0.028
1.418ProSer: 1.418 ± 0.047
1.337ProThr: 1.337 ± 0.042
2.309ProVal: 2.309 ± 0.056
0.228ProTrp: 0.228 ± 0.021
1.273ProTyr: 1.273 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
1.596GlnAla: 1.596 ± 0.051
0.262GlnCys: 0.262 ± 0.02
1.148GlnAsp: 1.148 ± 0.04
1.43GlnGlu: 1.43 ± 0.044
0.991GlnPhe: 0.991 ± 0.039
1.376GlnGly: 1.376 ± 0.047
0.287GlnHis: 0.287 ± 0.019
2.22GlnIle: 2.22 ± 0.065
1.985GlnLys: 1.985 ± 0.049
2.144GlnLeu: 2.144 ± 0.056
0.824GlnMet: 0.824 ± 0.035
1.498GlnAsn: 1.498 ± 0.046
0.593GlnPro: 0.593 ± 0.027
0.682GlnGln: 0.682 ± 0.034
0.879GlnArg: 0.879 ± 0.034
1.375GlnSer: 1.375 ± 0.048
1.399GlnThr: 1.399 ± 0.051
1.493GlnVal: 1.493 ± 0.054
0.179GlnTrp: 0.179 ± 0.017
1.15GlnTyr: 1.15 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
1.92ArgAla: 1.92 ± 0.053
0.488ArgCys: 0.488 ± 0.027
2.087ArgAsp: 2.087 ± 0.052
2.96ArgGlu: 2.96 ± 0.071
1.547ArgPhe: 1.547 ± 0.05
1.923ArgGly: 1.923 ± 0.053
0.551ArgHis: 0.551 ± 0.024
3.569ArgIle: 3.569 ± 0.066
3.326ArgLys: 3.326 ± 0.07
3.185ArgLeu: 3.185 ± 0.073
1.172ArgMet: 1.172 ± 0.04
2.46ArgAsn: 2.46 ± 0.061
0.938ArgPro: 0.938 ± 0.035
1.007ArgGln: 1.007 ± 0.039
1.634ArgArg: 1.634 ± 0.051
1.658ArgSer: 1.658 ± 0.05
1.756ArgThr: 1.756 ± 0.05
2.18ArgVal: 2.18 ± 0.057
0.216ArgTrp: 0.216 ± 0.017
1.769ArgTyr: 1.769 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
3.571SerAla: 3.571 ± 0.071
0.649SerCys: 0.649 ± 0.035
4.561SerAsp: 4.561 ± 0.102
4.731SerGlu: 4.731 ± 0.09
2.527SerPhe: 2.527 ± 0.062
4.87SerGly: 4.87 ± 0.096
0.808SerHis: 0.808 ± 0.037
5.075SerIle: 5.075 ± 0.098
5.133SerLys: 5.133 ± 0.092
4.804SerLeu: 4.804 ± 0.09
1.756SerMet: 1.756 ± 0.055
3.599SerAsn: 3.599 ± 0.08
1.5SerPro: 1.5 ± 0.047
1.524SerGln: 1.524 ± 0.052
2.193SerArg: 2.193 ± 0.058
3.966SerSer: 3.966 ± 0.088
3.239SerThr: 3.239 ± 0.084
4.416SerVal: 4.416 ± 0.084
0.366SerTrp: 0.366 ± 0.024
2.725SerTyr: 2.725 ± 0.074
0.0SerXaa: 0.0 ± 0.0
Thr
3.288ThrAla: 3.288 ± 0.084
0.602ThrCys: 0.602 ± 0.032
3.867ThrAsp: 3.867 ± 0.097
3.776ThrGlu: 3.776 ± 0.081
2.346ThrPhe: 2.346 ± 0.056
4.316ThrGly: 4.316 ± 0.087
0.773ThrHis: 0.773 ± 0.033
4.766ThrIle: 4.766 ± 0.09
3.883ThrLys: 3.883 ± 0.076
4.475ThrLeu: 4.475 ± 0.101
1.356ThrMet: 1.356 ± 0.049
2.828ThrAsn: 2.828 ± 0.073
1.765ThrPro: 1.765 ± 0.053
1.233ThrGln: 1.233 ± 0.041
1.604ThrArg: 1.604 ± 0.047
3.407ThrSer: 3.407 ± 0.079
3.12ThrThr: 3.12 ± 0.088
4.104ThrVal: 4.104 ± 0.099
0.309ThrTrp: 0.309 ± 0.023
2.384ThrTyr: 2.384 ± 0.064
0.0ThrXaa: 0.0 ± 0.0
Val
4.357ValAla: 4.357 ± 0.086
1.062ValCys: 1.062 ± 0.037
4.085ValAsp: 4.085 ± 0.083
4.515ValGlu: 4.515 ± 0.08
2.655ValPhe: 2.655 ± 0.069
3.885ValGly: 3.885 ± 0.074
0.858ValHis: 0.858 ± 0.033
6.249ValIle: 6.249 ± 0.097
5.395ValLys: 5.395 ± 0.091
5.795ValLeu: 5.795 ± 0.1
1.936ValMet: 1.936 ± 0.059
4.057ValAsn: 4.057 ± 0.092
1.913ValPro: 1.913 ± 0.055
1.409ValGln: 1.409 ± 0.042
2.396ValArg: 2.396 ± 0.065
4.664ValSer: 4.664 ± 0.074
4.049ValThr: 4.049 ± 0.108
4.997ValVal: 4.997 ± 0.092
0.418ValTrp: 0.418 ± 0.024
2.833ValTyr: 2.833 ± 0.071
0.0ValXaa: 0.0 ± 0.0
Trp
0.392TrpAla: 0.392 ± 0.024
0.106TrpCys: 0.106 ± 0.014
0.381TrpAsp: 0.381 ± 0.023
0.408TrpGlu: 0.408 ± 0.022
0.304TrpPhe: 0.304 ± 0.02
0.454TrpGly: 0.454 ± 0.026
0.108TrpHis: 0.108 ± 0.013
0.618TrpIle: 0.618 ± 0.033
0.541TrpLys: 0.541 ± 0.029
0.62TrpLeu: 0.62 ± 0.03
0.141TrpMet: 0.141 ± 0.016
0.454TrpAsn: 0.454 ± 0.029
0.132TrpPro: 0.132 ± 0.015
0.264TrpGln: 0.264 ± 0.02
0.243TrpArg: 0.243 ± 0.017
0.367TrpSer: 0.367 ± 0.021
0.334TrpThr: 0.334 ± 0.023
0.407TrpVal: 0.407 ± 0.026
0.076TrpTrp: 0.076 ± 0.01
0.42TrpTyr: 0.42 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.556TyrAla: 2.556 ± 0.058
0.624TyrCys: 0.624 ± 0.033
3.303TyrAsp: 3.303 ± 0.081
3.466TyrGlu: 3.466 ± 0.081
1.912TyrPhe: 1.912 ± 0.053
3.009TyrGly: 3.009 ± 0.069
0.649TyrHis: 0.649 ± 0.029
4.126TyrIle: 4.126 ± 0.083
3.34TyrLys: 3.34 ± 0.074
3.664TyrLeu: 3.664 ± 0.076
1.291TyrMet: 1.291 ± 0.044
2.945TyrAsn: 2.945 ± 0.07
1.195TyrPro: 1.195 ± 0.041
1.059TyrGln: 1.059 ± 0.04
1.765TyrArg: 1.765 ± 0.055
2.999TyrSer: 2.999 ± 0.077
2.561TyrThr: 2.561 ± 0.082
3.064TyrVal: 3.064 ± 0.078
0.281TyrTrp: 0.281 ± 0.017
2.46TyrTyr: 2.46 ± 0.086
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2287 proteins (737511 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski