Amino acid dipepetide frequency for Enterobacteria phage C-1 INW-2012

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.333AlaAla: 5.333 ± 2.826
0.889AlaCys: 0.889 ± 0.586
3.556AlaAsp: 3.556 ± 1.768
0.889AlaGlu: 0.889 ± 0.729
0.0AlaPhe: 0.0 ± 0.0
3.556AlaGly: 3.556 ± 0.911
0.889AlaHis: 0.889 ± 0.586
2.667AlaIle: 2.667 ± 1.246
2.667AlaLys: 2.667 ± 1.065
9.778AlaLeu: 9.778 ± 2.665
0.0AlaMet: 0.0 ± 0.0
1.778AlaAsn: 1.778 ± 1.458
2.667AlaPro: 2.667 ± 1.561
1.778AlaGln: 1.778 ± 1.172
4.444AlaArg: 4.444 ± 1.467
3.556AlaSer: 3.556 ± 0.911
5.333AlaThr: 5.333 ± 2.538
4.444AlaVal: 4.444 ± 1.735
0.889AlaTrp: 0.889 ± 0.729
4.444AlaTyr: 4.444 ± 0.609
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.889CysAsp: 0.889 ± 0.586
0.889CysGlu: 0.889 ± 0.586
0.0CysPhe: 0.0 ± 0.0
0.889CysGly: 0.889 ± 0.586
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
2.667CysLys: 2.667 ± 1.065
0.0CysLeu: 0.0 ± 0.0
0.889CysMet: 0.889 ± 0.586
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.889CysGln: 0.889 ± 0.729
0.889CysArg: 0.889 ± 0.586
0.889CysSer: 0.889 ± 0.586
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.889CysTyr: 0.889 ± 0.586
0.0CysXaa: 0.0 ± 0.0
Asp
2.667AspAla: 2.667 ± 2.025
0.889AspCys: 0.889 ± 0.586
0.889AspAsp: 0.889 ± 0.586
1.778AspGlu: 1.778 ± 1.172
1.778AspPhe: 1.778 ± 1.458
3.556AspGly: 3.556 ± 1.273
0.0AspHis: 0.0 ± 0.0
7.111AspIle: 7.111 ± 2.434
2.667AspLys: 2.667 ± 0.755
4.444AspLeu: 4.444 ± 1.357
0.889AspMet: 0.889 ± 0.729
0.889AspAsn: 0.889 ± 0.586
4.444AspPro: 4.444 ± 1.134
1.778AspGln: 1.778 ± 0.456
3.556AspArg: 3.556 ± 2.272
4.444AspSer: 4.444 ± 2.299
2.667AspThr: 2.667 ± 0.755
5.333AspVal: 5.333 ± 0.606
0.889AspTrp: 0.889 ± 0.729
0.889AspTyr: 0.889 ± 0.729
0.0AspXaa: 0.0 ± 0.0
Glu
5.333GluAla: 5.333 ± 3.208
0.0GluCys: 0.0 ± 0.0
1.778GluAsp: 1.778 ± 1.172
3.556GluGlu: 3.556 ± 2.344
1.778GluPhe: 1.778 ± 1.458
5.333GluGly: 5.333 ± 2.255
0.0GluHis: 0.0 ± 0.0
1.778GluIle: 1.778 ± 1.172
2.667GluLys: 2.667 ± 0.803
6.222GluLeu: 6.222 ± 2.981
0.0GluMet: 0.0 ± 0.0
1.778GluAsn: 1.778 ± 1.136
3.556GluPro: 3.556 ± 2.344
0.889GluGln: 0.889 ± 1.154
4.444GluArg: 4.444 ± 1.134
5.333GluSer: 5.333 ± 1.624
1.778GluThr: 1.778 ± 0.456
0.889GluVal: 0.889 ± 0.586
1.778GluTrp: 1.778 ± 1.172
1.778GluTyr: 1.778 ± 0.456
0.0GluXaa: 0.0 ± 0.0
Phe
2.667PheAla: 2.667 ± 0.803
0.0PheCys: 0.0 ± 0.0
5.333PheAsp: 5.333 ± 1.326
0.889PheGlu: 0.889 ± 0.586
0.889PhePhe: 0.889 ± 0.586
3.556PheGly: 3.556 ± 0.911
0.0PheHis: 0.0 ± 0.0
2.667PheIle: 2.667 ± 1.246
0.0PheLys: 0.0 ± 0.0
2.667PheLeu: 2.667 ± 0.755
0.0PheMet: 0.0 ± 0.0
3.556PheAsn: 3.556 ± 0.911
2.667PhePro: 2.667 ± 1.065
0.889PheGln: 0.889 ± 1.154
5.333PheArg: 5.333 ± 0.606
5.333PheSer: 5.333 ± 2.13
4.444PheThr: 4.444 ± 1.134
3.556PheVal: 3.556 ± 1.273
0.0PheTrp: 0.0 ± 0.0
1.778PheTyr: 1.778 ± 1.172
0.0PheXaa: 0.0 ± 0.0
Gly
3.556GlyAla: 3.556 ± 1.807
0.0GlyCys: 0.0 ± 0.0
3.556GlyAsp: 3.556 ± 0.911
4.444GlyGlu: 4.444 ± 0.609
2.667GlyPhe: 2.667 ± 0.755
3.556GlyGly: 3.556 ± 0.788
0.0GlyHis: 0.0 ± 0.0
4.444GlyIle: 4.444 ± 2.299
3.556GlyLys: 3.556 ± 2.225
8.0GlyLeu: 8.0 ± 1.506
0.889GlyMet: 0.889 ± 1.973
1.778GlyAsn: 1.778 ± 1.172
2.667GlyPro: 2.667 ± 1.758
0.889GlyGln: 0.889 ± 0.729
4.444GlyArg: 4.444 ± 1.134
4.444GlySer: 4.444 ± 1.101
7.111GlyThr: 7.111 ± 4.66
5.333GlyVal: 5.333 ± 2.15
3.556GlyTrp: 3.556 ± 0.911
1.778GlyTyr: 1.778 ± 1.562
0.0GlyXaa: 0.0 ± 0.0
His
0.889HisAla: 0.889 ± 0.729
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
1.778HisGlu: 1.778 ± 1.172
0.889HisPhe: 0.889 ± 0.586
1.778HisGly: 1.778 ± 1.458
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
1.778HisLys: 1.778 ± 1.388
0.889HisLeu: 0.889 ± 0.729
0.889HisMet: 0.889 ± 0.586
0.889HisAsn: 0.889 ± 0.586
0.889HisPro: 0.889 ± 0.729
0.889HisGln: 0.889 ± 0.729
3.556HisArg: 3.556 ± 0.911
0.0HisSer: 0.0 ± 0.0
0.889HisThr: 0.889 ± 1.154
0.889HisVal: 0.889 ± 0.586
0.889HisTrp: 0.889 ± 0.586
0.889HisTyr: 0.889 ± 0.586
0.0HisXaa: 0.0 ± 0.0
Ile
0.889IleAla: 0.889 ± 0.729
0.889IleCys: 0.889 ± 0.586
5.333IleAsp: 5.333 ± 3.516
0.889IleGlu: 0.889 ± 0.586
1.778IlePhe: 1.778 ± 1.172
3.556IleGly: 3.556 ± 1.164
1.778IleHis: 1.778 ± 1.388
3.556IleIle: 3.556 ± 1.807
3.556IleLys: 3.556 ± 1.768
2.667IleLeu: 2.667 ± 1.547
0.0IleMet: 0.0 ± 0.0
5.333IleAsn: 5.333 ± 2.782
1.778IlePro: 1.778 ± 1.172
0.0IleGln: 0.0 ± 0.0
4.444IleArg: 4.444 ± 2.485
1.778IleSer: 1.778 ± 1.136
5.333IleThr: 5.333 ± 1.532
3.556IleVal: 3.556 ± 2.272
0.889IleTrp: 0.889 ± 0.586
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
4.444LysAla: 4.444 ± 1.594
0.0LysCys: 0.0 ± 0.0
4.444LysAsp: 4.444 ± 1.911
3.556LysGlu: 3.556 ± 0.911
4.444LysPhe: 4.444 ± 1.101
4.444LysGly: 4.444 ± 1.173
0.0LysHis: 0.0 ± 0.0
1.778LysIle: 1.778 ± 0.456
3.556LysLys: 3.556 ± 1.273
1.778LysLeu: 1.778 ± 1.388
0.889LysMet: 0.889 ± 0.729
1.778LysAsn: 1.778 ± 1.172
2.667LysPro: 2.667 ± 1.065
0.889LysGln: 0.889 ± 1.464
1.778LysArg: 1.778 ± 1.458
1.778LysSer: 1.778 ± 0.456
4.444LysThr: 4.444 ± 0.609
4.444LysVal: 4.444 ± 0.609
1.778LysTrp: 1.778 ± 1.172
2.667LysTyr: 2.667 ± 0.755
0.0LysXaa: 0.0 ± 0.0
Leu
8.0LeuAla: 8.0 ± 2.331
1.778LeuCys: 1.778 ± 0.456
1.778LeuAsp: 1.778 ± 1.136
7.111LeuGlu: 7.111 ± 0.727
2.667LeuPhe: 2.667 ± 1.758
4.444LeuGly: 4.444 ± 1.467
1.778LeuHis: 1.778 ± 1.172
7.111LeuIle: 7.111 ± 2.148
4.444LeuLys: 4.444 ± 1.134
7.111LeuLeu: 7.111 ± 1.76
1.778LeuMet: 1.778 ± 0.585
6.222LeuAsn: 6.222 ± 1.507
3.556LeuPro: 3.556 ± 1.498
2.667LeuGln: 2.667 ± 0.803
9.778LeuArg: 9.778 ± 3.671
8.889LeuSer: 8.889 ± 3.871
9.778LeuThr: 9.778 ± 2.192
8.889LeuVal: 8.889 ± 1.218
2.667LeuTrp: 2.667 ± 2.793
1.778LeuTyr: 1.778 ± 1.458
0.0LeuXaa: 0.0 ± 0.0
Met
2.667MetAla: 2.667 ± 0.803
0.0MetCys: 0.0 ± 0.0
0.889MetAsp: 0.889 ± 0.729
0.0MetGlu: 0.0 ± 0.0
1.778MetPhe: 1.778 ± 1.136
0.889MetGly: 0.889 ± 0.586
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.889MetLys: 0.889 ± 0.729
1.778MetLeu: 1.778 ± 0.456
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
2.667MetPro: 2.667 ± 2.025
0.0MetGln: 0.0 ± 0.0
0.889MetArg: 0.889 ± 0.729
0.889MetSer: 0.889 ± 0.586
0.0MetThr: 0.0 ± 0.0
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
1.778MetTyr: 1.778 ± 0.456
0.0MetXaa: 0.0 ± 0.0
Asn
1.778AsnAla: 1.778 ± 1.172
0.889AsnCys: 0.889 ± 0.586
2.667AsnAsp: 2.667 ± 1.758
1.778AsnGlu: 1.778 ± 1.458
0.0AsnPhe: 0.0 ± 0.0
7.111AsnGly: 7.111 ± 1.35
3.556AsnHis: 3.556 ± 1.807
0.889AsnIle: 0.889 ± 0.586
0.889AsnLys: 0.889 ± 0.586
6.222AsnLeu: 6.222 ± 2.775
0.889AsnMet: 0.889 ± 0.586
1.778AsnAsn: 1.778 ± 1.164
2.667AsnPro: 2.667 ± 0.803
2.667AsnGln: 2.667 ± 0.803
3.556AsnArg: 3.556 ± 1.768
0.0AsnSer: 0.0 ± 0.0
3.556AsnThr: 3.556 ± 0.911
2.667AsnVal: 2.667 ± 1.561
0.0AsnTrp: 0.0 ± 0.0
1.778AsnTyr: 1.778 ± 1.458
0.0AsnXaa: 0.0 ± 0.0
Pro
0.889ProAla: 0.889 ± 0.729
0.0ProCys: 0.0 ± 0.0
2.667ProAsp: 2.667 ± 1.547
2.667ProGlu: 2.667 ± 1.391
5.333ProPhe: 5.333 ± 2.13
1.778ProGly: 1.778 ± 1.172
0.0ProHis: 0.0 ± 0.0
3.556ProIle: 3.556 ± 1.807
1.778ProLys: 1.778 ± 1.172
5.333ProLeu: 5.333 ± 2.13
0.889ProMet: 0.889 ± 0.729
0.0ProAsn: 0.0 ± 0.0
2.667ProPro: 2.667 ± 1.065
1.778ProGln: 1.778 ± 1.136
2.667ProArg: 2.667 ± 1.391
5.333ProSer: 5.333 ± 1.532
2.667ProThr: 2.667 ± 0.803
7.111ProVal: 7.111 ± 2.06
0.0ProTrp: 0.0 ± 0.0
0.889ProTyr: 0.889 ± 0.586
0.0ProXaa: 0.0 ± 0.0
Gln
0.0GlnAla: 0.0 ± 0.0
0.0GlnCys: 0.0 ± 0.0
1.778GlnAsp: 1.778 ± 2.309
3.556GlnGlu: 3.556 ± 1.807
0.889GlnPhe: 0.889 ± 0.729
0.0GlnGly: 0.0 ± 0.0
0.0GlnHis: 0.0 ± 0.0
0.0GlnIle: 0.0 ± 0.0
1.778GlnLys: 1.778 ± 1.172
2.667GlnLeu: 2.667 ± 2.214
0.0GlnMet: 0.0 ± 0.0
1.778GlnAsn: 1.778 ± 1.164
1.778GlnPro: 1.778 ± 0.456
0.889GlnGln: 0.889 ± 0.729
1.778GlnArg: 1.778 ± 1.458
1.778GlnSer: 1.778 ± 0.456
2.667GlnThr: 2.667 ± 2.214
4.444GlnVal: 4.444 ± 3.114
1.778GlnTrp: 1.778 ± 0.456
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
5.333ArgAla: 5.333 ± 0.606
1.778ArgCys: 1.778 ± 0.456
4.444ArgAsp: 4.444 ± 1.499
4.444ArgGlu: 4.444 ± 1.832
8.0ArgPhe: 8.0 ± 2.116
2.667ArgGly: 2.667 ± 1.758
1.778ArgHis: 1.778 ± 1.458
3.556ArgIle: 3.556 ± 1.273
3.556ArgLys: 3.556 ± 2.225
8.0ArgLeu: 8.0 ± 3.265
1.778ArgMet: 1.778 ± 1.183
3.556ArgAsn: 3.556 ± 1.768
0.889ArgPro: 0.889 ± 0.586
2.667ArgGln: 2.667 ± 0.803
5.333ArgArg: 5.333 ± 2.404
6.222ArgSer: 6.222 ± 2.826
8.889ArgThr: 8.889 ± 1.218
7.111ArgVal: 7.111 ± 3.15
0.889ArgTrp: 0.889 ± 0.729
0.889ArgTyr: 0.889 ± 0.586
0.0ArgXaa: 0.0 ± 0.0
Ser
4.444SerAla: 4.444 ± 1.467
0.889SerCys: 0.889 ± 0.586
2.667SerAsp: 2.667 ± 1.758
3.556SerGlu: 3.556 ± 0.911
3.556SerPhe: 3.556 ± 0.911
7.111SerGly: 7.111 ± 2.512
1.778SerHis: 1.778 ± 0.456
1.778SerIle: 1.778 ± 0.456
5.333SerLys: 5.333 ± 0.606
8.889SerLeu: 8.889 ± 0.835
0.889SerMet: 0.889 ± 0.586
4.444SerAsn: 4.444 ± 1.101
3.556SerPro: 3.556 ± 0.911
2.667SerGln: 2.667 ± 0.755
5.333SerArg: 5.333 ± 2.404
7.111SerSer: 7.111 ± 1.049
5.333SerThr: 5.333 ± 1.326
5.333SerVal: 5.333 ± 1.326
0.0SerTrp: 0.0 ± 0.0
0.889SerTyr: 0.889 ± 0.729
0.0SerXaa: 0.0 ± 0.0
Thr
2.667ThrAla: 2.667 ± 0.803
0.0ThrCys: 0.0 ± 0.0
1.778ThrAsp: 1.778 ± 0.456
3.556ThrGlu: 3.556 ± 0.788
6.222ThrPhe: 6.222 ± 3.541
5.333ThrGly: 5.333 ± 2.13
0.889ThrHis: 0.889 ± 0.729
4.444ThrIle: 4.444 ± 0.609
4.444ThrLys: 4.444 ± 1.467
9.778ThrLeu: 9.778 ± 3.907
0.889ThrMet: 0.889 ± 0.729
4.444ThrAsn: 4.444 ± 3.051
2.667ThrPro: 2.667 ± 2.214
0.889ThrGln: 0.889 ± 0.729
5.333ThrArg: 5.333 ± 1.088
7.111ThrSer: 7.111 ± 0.727
2.667ThrThr: 2.667 ± 0.755
8.889ThrVal: 8.889 ± 4.225
0.889ThrTrp: 0.889 ± 0.586
1.778ThrTyr: 1.778 ± 1.164
0.0ThrXaa: 0.0 ± 0.0
Val
7.111ValAla: 7.111 ± 3.921
0.0ValCys: 0.0 ± 0.0
4.444ValAsp: 4.444 ± 0.609
5.333ValGlu: 5.333 ± 1.088
0.0ValPhe: 0.0 ± 0.0
5.333ValGly: 5.333 ± 4.237
1.778ValHis: 1.778 ± 0.456
2.667ValIle: 2.667 ± 0.755
4.444ValLys: 4.444 ± 1.467
4.444ValLeu: 4.444 ± 2.792
0.889ValMet: 0.889 ± 0.586
3.556ValAsn: 3.556 ± 2.327
4.444ValPro: 4.444 ± 1.827
3.556ValGln: 3.556 ± 1.936
9.778ValArg: 9.778 ± 1.235
9.778ValSer: 9.778 ± 2.258
4.444ValThr: 4.444 ± 1.735
5.333ValVal: 5.333 ± 1.088
1.778ValTrp: 1.778 ± 1.562
1.778ValTyr: 1.778 ± 1.136
0.0ValXaa: 0.0 ± 0.0
Trp
0.889TrpAla: 0.889 ± 0.729
0.889TrpCys: 0.889 ± 0.586
1.778TrpAsp: 1.778 ± 1.172
0.0TrpGlu: 0.0 ± 0.0
1.778TrpPhe: 1.778 ± 1.388
0.0TrpGly: 0.0 ± 0.0
1.778TrpHis: 1.778 ± 0.456
0.0TrpIle: 0.0 ± 0.0
0.889TrpLys: 0.889 ± 0.586
4.444TrpLeu: 4.444 ± 2.535
0.889TrpMet: 0.889 ± 0.729
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.778TrpArg: 1.778 ± 0.456
0.889TrpSer: 0.889 ± 0.586
0.889TrpThr: 0.889 ± 0.729
0.889TrpVal: 0.889 ± 0.729
0.0TrpTrp: 0.0 ± 0.0
0.889TrpTyr: 0.889 ± 0.586
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
0.889TyrCys: 0.889 ± 0.729
0.889TyrAsp: 0.889 ± 0.729
0.0TyrGlu: 0.0 ± 0.0
1.778TyrPhe: 1.778 ± 0.456
2.667TyrGly: 2.667 ± 0.755
2.667TyrHis: 2.667 ± 1.065
0.0TyrIle: 0.0 ± 0.0
0.0TyrLys: 0.0 ± 0.0
7.111TyrLeu: 7.111 ± 1.703
0.889TyrMet: 0.889 ± 0.867
1.778TyrAsn: 1.778 ± 0.456
1.778TyrPro: 1.778 ± 1.172
0.889TyrGln: 0.889 ± 0.729
2.667TyrArg: 2.667 ± 0.755
0.0TyrSer: 0.0 ± 0.0
1.778TyrThr: 1.778 ± 1.164
1.778TyrVal: 1.778 ± 1.164
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1126 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski