Amino acid dipepetide frequency for Clostridium sp. CAG:354

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.706AlaAla: 2.706 ± 0.108
0.533AlaCys: 0.533 ± 0.039
2.968AlaAsp: 2.968 ± 0.07
3.979AlaGlu: 3.979 ± 0.1
2.018AlaPhe: 2.018 ± 0.067
3.205AlaGly: 3.205 ± 0.099
0.717AlaHis: 0.717 ± 0.04
5.722AlaIle: 5.722 ± 0.117
5.51AlaLys: 5.51 ± 0.121
4.256AlaLeu: 4.256 ± 0.104
1.355AlaMet: 1.355 ± 0.062
3.205AlaAsn: 3.205 ± 0.095
1.248AlaPro: 1.248 ± 0.057
1.321AlaGln: 1.321 ± 0.062
1.93AlaArg: 1.93 ± 0.067
2.796AlaSer: 2.796 ± 0.084
3.004AlaThr: 3.004 ± 0.1
3.329AlaVal: 3.329 ± 0.097
0.327AlaTrp: 0.327 ± 0.03
1.995AlaTyr: 1.995 ± 0.061
0.002AlaXaa: 0.002 ± 0.002
Cys
0.489CysAla: 0.489 ± 0.035
0.13CysCys: 0.13 ± 0.02
0.587CysAsp: 0.587 ± 0.037
0.663CysGlu: 0.663 ± 0.04
0.472CysPhe: 0.472 ± 0.034
0.847CysGly: 0.847 ± 0.048
0.174CysHis: 0.174 ± 0.02
1.078CysIle: 1.078 ± 0.052
1.0CysLys: 1.0 ± 0.045
0.866CysLeu: 0.866 ± 0.047
0.3CysMet: 0.3 ± 0.026
0.709CysAsn: 0.709 ± 0.04
0.371CysPro: 0.371 ± 0.033
0.212CysGln: 0.212 ± 0.023
0.371CysArg: 0.371 ± 0.027
0.612CysSer: 0.612 ± 0.038
0.552CysThr: 0.552 ± 0.036
0.589CysVal: 0.589 ± 0.036
0.061CysTrp: 0.061 ± 0.013
0.468CysTyr: 0.468 ± 0.034
0.0CysXaa: 0.0 ± 0.0
Asp
2.374AspAla: 2.374 ± 0.068
0.615AspCys: 0.615 ± 0.039
3.031AspAsp: 3.031 ± 0.103
5.252AspGlu: 5.252 ± 0.13
2.674AspPhe: 2.674 ± 0.079
3.266AspGly: 3.266 ± 0.093
0.499AspHis: 0.499 ± 0.033
6.328AspIle: 6.328 ± 0.122
5.632AspLys: 5.632 ± 0.109
4.933AspLeu: 4.933 ± 0.098
1.544AspMet: 1.544 ± 0.054
3.912AspAsn: 3.912 ± 0.103
1.166AspPro: 1.166 ± 0.05
0.919AspGln: 0.919 ± 0.047
1.77AspArg: 1.77 ± 0.059
3.111AspSer: 3.111 ± 0.086
3.136AspThr: 3.136 ± 0.094
3.475AspVal: 3.475 ± 0.083
0.436AspTrp: 0.436 ± 0.032
2.865AspTyr: 2.865 ± 0.086
0.0AspXaa: 0.0 ± 0.0
Glu
4.258GluAla: 4.258 ± 0.097
0.705GluCys: 0.705 ± 0.036
4.797GluAsp: 4.797 ± 0.129
8.847GluGlu: 8.847 ± 0.191
3.207GluPhe: 3.207 ± 0.085
3.744GluGly: 3.744 ± 0.097
1.074GluHis: 1.074 ± 0.045
8.251GluIle: 8.251 ± 0.156
9.468GluLys: 9.468 ± 0.172
7.511GluLeu: 7.511 ± 0.147
2.045GluMet: 2.045 ± 0.075
7.066GluAsn: 7.066 ± 0.136
1.609GluPro: 1.609 ± 0.066
2.513GluGln: 2.513 ± 0.078
2.836GluArg: 2.836 ± 0.078
3.157GluSer: 3.157 ± 0.081
3.826GluThr: 3.826 ± 0.103
4.673GluVal: 4.673 ± 0.107
0.493GluTrp: 0.493 ± 0.035
3.947GluTyr: 3.947 ± 0.1
0.0GluXaa: 0.0 ± 0.0
Phe
2.24PheAla: 2.24 ± 0.069
0.539PheCys: 0.539 ± 0.034
2.439PheAsp: 2.439 ± 0.079
3.01PheGlu: 3.01 ± 0.075
1.8PhePhe: 1.8 ± 0.073
2.429PheGly: 2.429 ± 0.072
0.403PheHis: 0.403 ± 0.03
4.134PheIle: 4.134 ± 0.111
3.654PheLys: 3.654 ± 0.095
3.379PheLeu: 3.379 ± 0.101
0.961PheMet: 0.961 ± 0.049
2.769PheAsn: 2.769 ± 0.09
1.061PhePro: 1.061 ± 0.05
0.787PheGln: 0.787 ± 0.043
1.162PheArg: 1.162 ± 0.05
2.611PheSer: 2.611 ± 0.08
2.003PheThr: 2.003 ± 0.064
2.446PheVal: 2.446 ± 0.072
0.375PheTrp: 0.375 ± 0.028
1.808PheTyr: 1.808 ± 0.062
0.0PheXaa: 0.0 ± 0.0
Gly
2.869GlyAla: 2.869 ± 0.09
0.596GlyCys: 0.596 ± 0.036
2.737GlyAsp: 2.737 ± 0.075
3.914GlyGlu: 3.914 ± 0.089
2.414GlyPhe: 2.414 ± 0.079
3.226GlyGly: 3.226 ± 0.121
0.887GlyHis: 0.887 ± 0.049
6.297GlyIle: 6.297 ± 0.134
5.829GlyLys: 5.829 ± 0.115
4.382GlyLeu: 4.382 ± 0.096
1.508GlyMet: 1.508 ± 0.064
3.484GlyAsn: 3.484 ± 0.094
0.912GlyPro: 0.912 ± 0.046
1.42GlyGln: 1.42 ± 0.062
2.083GlyArg: 2.083 ± 0.071
2.897GlySer: 2.897 ± 0.097
3.635GlyThr: 3.635 ± 0.106
3.375GlyVal: 3.375 ± 0.099
0.39GlyTrp: 0.39 ± 0.034
2.949GlyTyr: 2.949 ± 0.083
0.002GlyXaa: 0.002 ± 0.002
His
0.552HisAla: 0.552 ± 0.036
0.162HisCys: 0.162 ± 0.019
0.596HisAsp: 0.596 ± 0.037
0.799HisGlu: 0.799 ± 0.042
0.608HisPhe: 0.608 ± 0.037
0.82HisGly: 0.82 ± 0.044
0.231HisHis: 0.231 ± 0.028
1.223HisIle: 1.223 ± 0.058
1.042HisLys: 1.042 ± 0.051
1.086HisLeu: 1.086 ± 0.049
0.304HisMet: 0.304 ± 0.023
0.789HisAsn: 0.789 ± 0.041
0.51HisPro: 0.51 ± 0.033
0.298HisGln: 0.298 ± 0.028
0.445HisArg: 0.445 ± 0.033
0.803HisSer: 0.803 ± 0.043
0.673HisThr: 0.673 ± 0.041
0.631HisVal: 0.631 ± 0.039
0.09HisTrp: 0.09 ± 0.015
0.482HisTyr: 0.482 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
5.837IleAla: 5.837 ± 0.118
1.221IleCys: 1.221 ± 0.053
6.177IleAsp: 6.177 ± 0.116
7.979IleGlu: 7.979 ± 0.161
3.989IlePhe: 3.989 ± 0.123
5.439IleGly: 5.439 ± 0.13
1.156IleHis: 1.156 ± 0.051
10.103IleIle: 10.103 ± 0.208
9.34IleLys: 9.34 ± 0.153
9.374IleLeu: 9.374 ± 0.191
2.194IleMet: 2.194 ± 0.07
7.006IleAsn: 7.006 ± 0.128
3.245IlePro: 3.245 ± 0.086
2.565IleGln: 2.565 ± 0.068
3.108IleArg: 3.108 ± 0.081
6.502IleSer: 6.502 ± 0.138
5.472IleThr: 5.472 ± 0.117
6.118IleVal: 6.118 ± 0.138
0.558IleTrp: 0.558 ± 0.04
4.184IleTyr: 4.184 ± 0.103
0.0IleXaa: 0.0 ± 0.0
Lys
4.977LysAla: 4.977 ± 0.118
0.91LysCys: 0.91 ± 0.047
6.2LysAsp: 6.2 ± 0.127
10.607LysGlu: 10.607 ± 0.195
3.402LysPhe: 3.402 ± 0.086
4.413LysGly: 4.413 ± 0.107
1.105LysHis: 1.105 ± 0.048
9.957LysIle: 9.957 ± 0.163
9.537LysLys: 9.537 ± 0.178
8.564LysLeu: 8.564 ± 0.164
2.622LysMet: 2.622 ± 0.074
7.379LysAsn: 7.379 ± 0.16
2.114LysPro: 2.114 ± 0.086
3.18LysGln: 3.18 ± 0.091
3.536LysArg: 3.536 ± 0.098
4.187LysSer: 4.187 ± 0.104
5.095LysThr: 5.095 ± 0.111
5.776LysVal: 5.776 ± 0.109
0.608LysTrp: 0.608 ± 0.039
5.053LysTyr: 5.053 ± 0.132
0.0LysXaa: 0.0 ± 0.0
Leu
4.973LeuAla: 4.973 ± 0.098
0.925LeuCys: 0.925 ± 0.049
4.963LeuAsp: 4.963 ± 0.1
7.276LeuGlu: 7.276 ± 0.151
3.322LeuPhe: 3.322 ± 0.112
4.874LeuGly: 4.874 ± 0.108
1.089LeuHis: 1.089 ± 0.053
7.874LeuIle: 7.874 ± 0.155
8.822LeuLys: 8.822 ± 0.158
7.133LeuLeu: 7.133 ± 0.167
1.827LeuMet: 1.827 ± 0.06
6.137LeuAsn: 6.137 ± 0.133
2.561LeuPro: 2.561 ± 0.078
2.538LeuGln: 2.538 ± 0.072
2.869LeuArg: 2.869 ± 0.088
5.135LeuSer: 5.135 ± 0.117
4.306LeuThr: 4.306 ± 0.098
4.973LeuVal: 4.973 ± 0.102
0.489LeuTrp: 0.489 ± 0.033
3.513LeuTyr: 3.513 ± 0.096
0.0LeuXaa: 0.0 ± 0.0
Met
1.521MetAla: 1.521 ± 0.057
0.275MetCys: 0.275 ± 0.022
1.361MetAsp: 1.361 ± 0.053
1.888MetGlu: 1.888 ± 0.062
0.841MetPhe: 0.841 ± 0.042
1.296MetGly: 1.296 ± 0.055
0.254MetHis: 0.254 ± 0.025
1.949MetIle: 1.949 ± 0.072
2.538MetLys: 2.538 ± 0.078
2.169MetLeu: 2.169 ± 0.069
0.564MetMet: 0.564 ± 0.036
1.684MetAsn: 1.684 ± 0.059
0.919MetPro: 0.919 ± 0.041
1.003MetGln: 1.003 ± 0.041
0.688MetArg: 0.688 ± 0.039
1.407MetSer: 1.407 ± 0.048
1.11MetThr: 1.11 ± 0.054
1.317MetVal: 1.317 ± 0.059
0.149MetTrp: 0.149 ± 0.018
1.049MetTyr: 1.049 ± 0.053
0.0MetXaa: 0.0 ± 0.0
Asn
3.19AsnAla: 3.19 ± 0.087
0.745AsnCys: 0.745 ± 0.044
3.383AsnAsp: 3.383 ± 0.091
5.403AsnGlu: 5.403 ± 0.112
2.836AsnPhe: 2.836 ± 0.078
4.109AsnGly: 4.109 ± 0.122
0.707AsnHis: 0.707 ± 0.041
7.956AsnIle: 7.956 ± 0.158
7.427AsnLys: 7.427 ± 0.166
6.429AsnLeu: 6.429 ± 0.126
1.823AsnMet: 1.823 ± 0.062
5.527AsnAsn: 5.527 ± 0.169
2.005AsnPro: 2.005 ± 0.07
1.854AsnGln: 1.854 ± 0.072
2.047AsnArg: 2.047 ± 0.06
4.195AsnSer: 4.195 ± 0.134
4.071AsnThr: 4.071 ± 0.108
3.96AsnVal: 3.96 ± 0.089
0.468AsnTrp: 0.468 ± 0.034
3.308AsnTyr: 3.308 ± 0.108
0.0AsnXaa: 0.0 ± 0.0
Pro
1.338ProAla: 1.338 ± 0.055
0.327ProCys: 0.327 ± 0.027
1.561ProAsp: 1.561 ± 0.062
2.448ProGlu: 2.448 ± 0.074
1.172ProPhe: 1.172 ± 0.044
1.441ProGly: 1.441 ± 0.064
0.373ProHis: 0.373 ± 0.03
2.561ProIle: 2.561 ± 0.075
2.313ProLys: 2.313 ± 0.075
1.842ProLeu: 1.842 ± 0.07
0.55ProMet: 0.55 ± 0.035
1.751ProAsn: 1.751 ± 0.065
0.497ProPro: 0.497 ± 0.037
0.722ProGln: 0.722 ± 0.042
0.68ProArg: 0.68 ± 0.037
1.378ProSer: 1.378 ± 0.055
1.544ProThr: 1.544 ± 0.061
1.772ProVal: 1.772 ± 0.066
0.185ProTrp: 0.185 ± 0.022
1.095ProTyr: 1.095 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
1.561GlnAla: 1.561 ± 0.064
0.18GlnCys: 0.18 ± 0.02
1.632GlnAsp: 1.632 ± 0.063
2.67GlnGlu: 2.67 ± 0.08
0.862GlnPhe: 0.862 ± 0.045
1.443GlnGly: 1.443 ± 0.061
0.214GlnHis: 0.214 ± 0.022
2.936GlnIle: 2.936 ± 0.077
2.871GlnLys: 2.871 ± 0.086
2.056GlnLeu: 2.056 ± 0.066
0.719GlnMet: 0.719 ± 0.039
2.15GlnAsn: 2.15 ± 0.067
0.468GlnPro: 0.468 ± 0.031
0.64GlnGln: 0.64 ± 0.041
1.009GlnArg: 1.009 ± 0.052
1.189GlnSer: 1.189 ± 0.055
1.586GlnThr: 1.586 ± 0.065
1.556GlnVal: 1.556 ± 0.057
0.149GlnTrp: 0.149 ± 0.019
1.242GlnTyr: 1.242 ± 0.063
0.002GlnXaa: 0.002 ± 0.002
Arg
1.613ArgAla: 1.613 ± 0.062
0.344ArgCys: 0.344 ± 0.03
1.724ArgAsp: 1.724 ± 0.074
2.601ArgGlu: 2.601 ± 0.085
1.437ArgPhe: 1.437 ± 0.055
1.577ArgGly: 1.577 ± 0.066
0.497ArgHis: 0.497 ± 0.034
3.259ArgIle: 3.259 ± 0.078
3.532ArgLys: 3.532 ± 0.103
2.716ArgLeu: 2.716 ± 0.072
0.919ArgMet: 0.919 ± 0.043
2.366ArgAsn: 2.366 ± 0.068
0.891ArgPro: 0.891 ± 0.047
0.975ArgGln: 0.975 ± 0.045
1.401ArgArg: 1.401 ± 0.059
1.336ArgSer: 1.336 ± 0.05
1.867ArgThr: 1.867 ± 0.074
1.961ArgVal: 1.961 ± 0.065
0.258ArgTrp: 0.258 ± 0.022
1.55ArgTyr: 1.55 ± 0.058
0.002ArgXaa: 0.002 ± 0.002
Ser
2.536SerAla: 2.536 ± 0.086
0.489SerCys: 0.489 ± 0.032
2.951SerAsp: 2.951 ± 0.09
4.065SerGlu: 4.065 ± 0.089
2.412SerPhe: 2.412 ± 0.074
3.484SerGly: 3.484 ± 0.123
0.717SerHis: 0.717 ± 0.04
5.521SerIle: 5.521 ± 0.131
5.474SerLys: 5.474 ± 0.098
4.56SerLeu: 4.56 ± 0.113
1.221SerMet: 1.221 ± 0.048
4.304SerAsn: 4.304 ± 0.122
1.212SerPro: 1.212 ± 0.047
1.498SerGln: 1.498 ± 0.063
1.743SerArg: 1.743 ± 0.055
3.945SerSer: 3.945 ± 0.119
3.108SerThr: 3.108 ± 0.094
2.993SerVal: 2.993 ± 0.081
0.363SerTrp: 0.363 ± 0.026
2.477SerTyr: 2.477 ± 0.066
0.0SerXaa: 0.0 ± 0.0
Thr
3.066ThrAla: 3.066 ± 0.092
0.478ThrCys: 0.478 ± 0.035
3.318ThrAsp: 3.318 ± 0.099
4.075ThrGlu: 4.075 ± 0.103
2.074ThrPhe: 2.074 ± 0.061
3.773ThrGly: 3.773 ± 0.108
0.713ThrHis: 0.713 ± 0.04
5.351ThrIle: 5.351 ± 0.124
4.797ThrLys: 4.797 ± 0.115
4.491ThrLeu: 4.491 ± 0.095
1.149ThrMet: 1.149 ± 0.048
3.721ThrAsn: 3.721 ± 0.12
1.705ThrPro: 1.705 ± 0.068
1.493ThrGln: 1.493 ± 0.06
1.663ThrArg: 1.663 ± 0.055
3.232ThrSer: 3.232 ± 0.084
3.369ThrThr: 3.369 ± 0.112
3.564ThrVal: 3.564 ± 0.096
0.329ThrTrp: 0.329 ± 0.029
2.395ThrTyr: 2.395 ± 0.079
0.0ThrXaa: 0.0 ± 0.0
Val
3.486ValAla: 3.486 ± 0.093
0.728ValCys: 0.728 ± 0.043
3.419ValAsp: 3.419 ± 0.081
4.686ValGlu: 4.686 ± 0.114
2.227ValPhe: 2.227 ± 0.074
3.593ValGly: 3.593 ± 0.097
0.703ValHis: 0.703 ± 0.043
5.799ValIle: 5.799 ± 0.102
5.418ValLys: 5.418 ± 0.105
5.39ValLeu: 5.39 ± 0.125
1.252ValMet: 1.252 ± 0.05
3.578ValAsn: 3.578 ± 0.104
1.722ValPro: 1.722 ± 0.064
1.816ValGln: 1.816 ± 0.064
1.808ValArg: 1.808 ± 0.062
3.459ValSer: 3.459 ± 0.093
3.513ValThr: 3.513 ± 0.101
4.006ValVal: 4.006 ± 0.107
0.336ValTrp: 0.336 ± 0.027
2.481ValTyr: 2.481 ± 0.081
0.0ValXaa: 0.0 ± 0.0
Trp
0.319TrpAla: 0.319 ± 0.026
0.094TrpCys: 0.094 ± 0.015
0.325TrpAsp: 0.325 ± 0.028
0.43TrpGlu: 0.43 ± 0.03
0.285TrpPhe: 0.285 ± 0.026
0.38TrpGly: 0.38 ± 0.034
0.13TrpHis: 0.13 ± 0.017
0.579TrpIle: 0.579 ± 0.038
0.587TrpLys: 0.587 ± 0.037
0.604TrpLeu: 0.604 ± 0.035
0.134TrpMet: 0.134 ± 0.016
0.522TrpAsn: 0.522 ± 0.041
0.141TrpPro: 0.141 ± 0.018
0.252TrpGln: 0.252 ± 0.02
0.216TrpArg: 0.216 ± 0.023
0.394TrpSer: 0.394 ± 0.033
0.3TrpThr: 0.3 ± 0.024
0.306TrpVal: 0.306 ± 0.026
0.09TrpTrp: 0.09 ± 0.014
0.38TrpTyr: 0.38 ± 0.029
0.002TrpXaa: 0.002 ± 0.002
Tyr
2.217TyrAla: 2.217 ± 0.074
0.556TyrCys: 0.556 ± 0.033
2.771TyrAsp: 2.771 ± 0.079
3.436TyrGlu: 3.436 ± 0.088
1.955TyrPhe: 1.955 ± 0.078
2.446TyrGly: 2.446 ± 0.069
0.501TyrHis: 0.501 ± 0.031
4.69TyrIle: 4.69 ± 0.102
4.43TyrLys: 4.43 ± 0.098
3.859TyrLeu: 3.859 ± 0.092
0.988TyrMet: 0.988 ± 0.046
3.383TyrAsn: 3.383 ± 0.088
1.191TyrPro: 1.191 ± 0.06
1.128TyrGln: 1.128 ± 0.054
1.462TyrArg: 1.462 ± 0.056
2.727TyrSer: 2.727 ± 0.074
2.59TyrThr: 2.59 ± 0.072
2.595TyrVal: 2.595 ± 0.076
0.317TyrTrp: 0.317 ± 0.024
2.089TyrTyr: 2.089 ± 0.086
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.002XaaAla: 0.002 ± 0.002
0.002XaaCys: 0.002 ± 0.002
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.002XaaGln: 0.002 ± 0.002
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.004XaaVal: 0.004 ± 0.003
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.017XaaXaa: 0.017 ± 0.01
Statistics based on 1707 proteins (476769 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski