Amino acid dipepetide frequency for Tolypothrix sp. NIES-4075

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.264AlaAla: 7.264 ± 0.079
0.829AlaCys: 0.829 ± 0.02
3.924AlaAsp: 3.924 ± 0.042
5.074AlaGlu: 5.074 ± 0.051
3.121AlaPhe: 3.121 ± 0.039
5.244AlaGly: 5.244 ± 0.071
1.198AlaHis: 1.198 ± 0.026
6.986AlaIle: 6.986 ± 0.069
4.225AlaLys: 4.225 ± 0.049
8.724AlaLeu: 8.724 ± 0.07
1.671AlaMet: 1.671 ± 0.029
3.54AlaAsn: 3.54 ± 0.054
2.77AlaPro: 2.77 ± 0.036
3.988AlaGln: 3.988 ± 0.043
3.477AlaArg: 3.477 ± 0.038
5.224AlaSer: 5.224 ± 0.06
4.723AlaThr: 4.723 ± 0.054
5.562AlaVal: 5.562 ± 0.061
0.983AlaTrp: 0.983 ± 0.022
2.395AlaTyr: 2.395 ± 0.037
0.0AlaXaa: 0.0 ± 0.0
Cys
0.656CysAla: 0.656 ± 0.019
0.187CysCys: 0.187 ± 0.01
0.597CysAsp: 0.597 ± 0.016
0.552CysGlu: 0.552 ± 0.017
0.429CysPhe: 0.429 ± 0.013
0.839CysGly: 0.839 ± 0.022
0.251CysHis: 0.251 ± 0.012
0.62CysIle: 0.62 ± 0.017
0.406CysLys: 0.406 ± 0.015
1.121CysLeu: 1.121 ± 0.024
0.17CysMet: 0.17 ± 0.009
0.4CysAsn: 0.4 ± 0.014
0.571CysPro: 0.571 ± 0.017
0.586CysGln: 0.586 ± 0.018
0.547CysArg: 0.547 ± 0.017
0.633CysSer: 0.633 ± 0.017
0.501CysThr: 0.501 ± 0.014
0.667CysVal: 0.667 ± 0.017
0.149CysTrp: 0.149 ± 0.008
0.371CysTyr: 0.371 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.828AspAla: 3.828 ± 0.041
0.51AspCys: 0.51 ± 0.016
2.231AspAsp: 2.231 ± 0.035
3.022AspGlu: 3.022 ± 0.044
2.342AspPhe: 2.342 ± 0.034
3.173AspGly: 3.173 ± 0.05
0.562AspHis: 0.562 ± 0.017
3.404AspIle: 3.404 ± 0.043
2.758AspLys: 2.758 ± 0.046
5.324AspLeu: 5.324 ± 0.059
0.816AspMet: 0.816 ± 0.022
2.317AspAsn: 2.317 ± 0.037
2.162AspPro: 2.162 ± 0.031
1.466AspGln: 1.466 ± 0.027
3.216AspArg: 3.216 ± 0.038
2.91AspSer: 2.91 ± 0.037
2.458AspThr: 2.458 ± 0.032
3.045AspVal: 3.045 ± 0.041
0.854AspTrp: 0.854 ± 0.022
1.833AspTyr: 1.833 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
5.283GluAla: 5.283 ± 0.061
0.531GluCys: 0.531 ± 0.016
2.721GluAsp: 2.721 ± 0.047
4.066GluGlu: 4.066 ± 0.056
2.426GluPhe: 2.426 ± 0.032
3.004GluGly: 3.004 ± 0.042
1.047GluHis: 1.047 ± 0.026
4.814GluIle: 4.814 ± 0.051
3.844GluLys: 3.844 ± 0.046
6.87GluLeu: 6.87 ± 0.069
1.345GluMet: 1.345 ± 0.027
2.942GluAsn: 2.942 ± 0.039
2.281GluPro: 2.281 ± 0.034
3.442GluGln: 3.442 ± 0.051
3.31GluArg: 3.31 ± 0.044
3.48GluSer: 3.48 ± 0.044
3.372GluThr: 3.372 ± 0.052
4.28GluVal: 4.28 ± 0.053
0.828GluTrp: 0.828 ± 0.022
1.968GluTyr: 1.968 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
3.232PheAla: 3.232 ± 0.041
0.578PheCys: 0.578 ± 0.02
2.223PheAsp: 2.223 ± 0.031
2.223PheGlu: 2.223 ± 0.037
1.732PhePhe: 1.732 ± 0.031
2.982PheGly: 2.982 ± 0.037
0.767PheHis: 0.767 ± 0.019
2.512PheIle: 2.512 ± 0.037
1.743PheLys: 1.743 ± 0.032
4.075PheLeu: 4.075 ± 0.045
0.687PheMet: 0.687 ± 0.015
1.818PheAsn: 1.818 ± 0.031
1.813PhePro: 1.813 ± 0.031
1.753PheGln: 1.753 ± 0.029
1.757PheArg: 1.757 ± 0.029
3.025PheSer: 3.025 ± 0.045
2.338PheThr: 2.338 ± 0.032
2.536PheVal: 2.536 ± 0.038
0.689PheTrp: 0.689 ± 0.02
1.404PheTyr: 1.404 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
4.633GlyAla: 4.633 ± 0.061
0.783GlyCys: 0.783 ± 0.019
3.299GlyAsp: 3.299 ± 0.045
4.101GlyGlu: 4.101 ± 0.043
2.872GlyPhe: 2.872 ± 0.04
4.71GlyGly: 4.71 ± 0.08
1.223GlyHis: 1.223 ± 0.03
4.882GlyIle: 4.882 ± 0.055
4.262GlyLys: 4.262 ± 0.055
6.449GlyLeu: 6.449 ± 0.062
1.485GlyMet: 1.485 ± 0.026
3.263GlyAsn: 3.263 ± 0.068
1.12GlyPro: 1.12 ± 0.025
2.822GlyGln: 2.822 ± 0.038
3.196GlyArg: 3.196 ± 0.04
4.104GlySer: 4.104 ± 0.06
3.765GlyThr: 3.765 ± 0.058
4.733GlyVal: 4.733 ± 0.054
1.065GlyTrp: 1.065 ± 0.025
2.296GlyTyr: 2.296 ± 0.035
0.0GlyXaa: 0.0 ± 0.0
His
1.085HisAla: 1.085 ± 0.025
0.255HisCys: 0.255 ± 0.01
0.746HisAsp: 0.746 ± 0.018
0.939HisGlu: 0.939 ± 0.022
0.798HisPhe: 0.798 ± 0.019
1.055HisGly: 1.055 ± 0.023
0.558HisHis: 0.558 ± 0.02
1.117HisIle: 1.117 ± 0.024
0.833HisLys: 0.833 ± 0.019
2.163HisLeu: 2.163 ± 0.037
0.27HisMet: 0.27 ± 0.011
0.785HisAsn: 0.785 ± 0.02
1.296HisPro: 1.296 ± 0.027
1.062HisGln: 1.062 ± 0.024
1.047HisArg: 1.047 ± 0.022
1.251HisSer: 1.251 ± 0.024
0.932HisThr: 0.932 ± 0.025
0.879HisVal: 0.879 ± 0.021
0.323HisTrp: 0.323 ± 0.013
0.661HisTyr: 0.661 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
7.272IleAla: 7.272 ± 0.067
0.806IleCys: 0.806 ± 0.022
3.609IleAsp: 3.609 ± 0.039
4.292IleGlu: 4.292 ± 0.051
2.637IlePhe: 2.637 ± 0.04
4.43IleGly: 4.43 ± 0.054
1.218IleHis: 1.218 ± 0.025
4.007IleIle: 4.007 ± 0.051
3.391IleLys: 3.391 ± 0.043
6.633IleLeu: 6.633 ± 0.055
0.865IleMet: 0.865 ± 0.019
3.267IleAsn: 3.267 ± 0.052
3.604IlePro: 3.604 ± 0.043
2.946IleGln: 2.946 ± 0.043
3.109IleArg: 3.109 ± 0.041
4.584IleSer: 4.584 ± 0.054
3.748IleThr: 3.748 ± 0.049
4.358IleVal: 4.358 ± 0.05
0.892IleTrp: 0.892 ± 0.023
2.03IleTyr: 2.03 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
4.331LysAla: 4.331 ± 0.051
0.384LysCys: 0.384 ± 0.016
2.369LysAsp: 2.369 ± 0.035
3.183LysGlu: 3.183 ± 0.045
1.868LysPhe: 1.868 ± 0.031
2.889LysGly: 2.889 ± 0.037
0.932LysHis: 0.932 ± 0.023
3.733LysIle: 3.733 ± 0.051
2.742LysLys: 2.742 ± 0.047
5.895LysLeu: 5.895 ± 0.066
1.032LysMet: 1.032 ± 0.024
2.353LysAsn: 2.353 ± 0.035
2.609LysPro: 2.609 ± 0.034
2.99LysGln: 2.99 ± 0.034
2.662LysArg: 2.662 ± 0.033
3.385LysSer: 3.385 ± 0.044
3.101LysThr: 3.101 ± 0.039
3.465LysVal: 3.465 ± 0.045
0.555LysTrp: 0.555 ± 0.016
1.579LysTyr: 1.579 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
9.242LeuAla: 9.242 ± 0.076
1.073LeuCys: 1.073 ± 0.025
5.107LeuAsp: 5.107 ± 0.055
7.075LeuGlu: 7.075 ± 0.074
3.86LeuPhe: 3.86 ± 0.049
7.285LeuGly: 7.285 ± 0.065
1.953LeuHis: 1.953 ± 0.031
6.848LeuIle: 6.848 ± 0.068
5.774LeuLys: 5.774 ± 0.06
11.383LeuLeu: 11.383 ± 0.098
2.055LeuMet: 2.055 ± 0.031
4.739LeuAsn: 4.739 ± 0.052
5.789LeuPro: 5.789 ± 0.065
5.776LeuGln: 5.776 ± 0.063
5.555LeuArg: 5.555 ± 0.061
7.68LeuSer: 7.68 ± 0.067
6.434LeuThr: 6.434 ± 0.065
7.025LeuVal: 7.025 ± 0.067
1.392LeuTrp: 1.392 ± 0.032
2.77LeuTyr: 2.77 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
1.587MetAla: 1.587 ± 0.027
0.135MetCys: 0.135 ± 0.008
0.68MetAsp: 0.68 ± 0.017
0.927MetGlu: 0.927 ± 0.022
0.609MetPhe: 0.609 ± 0.017
1.306MetGly: 1.306 ± 0.026
0.357MetHis: 0.357 ± 0.016
1.076MetIle: 1.076 ± 0.022
1.028MetLys: 1.028 ± 0.021
2.035MetLeu: 2.035 ± 0.028
0.462MetMet: 0.462 ± 0.014
0.866MetAsn: 0.866 ± 0.025
1.005MetPro: 1.005 ± 0.025
1.04MetGln: 1.04 ± 0.02
1.018MetArg: 1.018 ± 0.021
1.398MetSer: 1.398 ± 0.023
1.27MetThr: 1.27 ± 0.026
1.192MetVal: 1.192 ± 0.025
0.188MetTrp: 0.188 ± 0.01
0.386MetTyr: 0.386 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
3.32AsnAla: 3.32 ± 0.059
0.495AsnCys: 0.495 ± 0.018
1.788AsnAsp: 1.788 ± 0.033
2.031AsnGlu: 2.031 ± 0.032
2.015AsnPhe: 2.015 ± 0.029
2.838AsnGly: 2.838 ± 0.052
0.839AsnHis: 0.839 ± 0.019
3.056AsnIle: 3.056 ± 0.046
2.082AsnLys: 2.082 ± 0.033
5.621AsnLeu: 5.621 ± 0.062
0.673AsnMet: 0.673 ± 0.018
2.389AsnAsn: 2.389 ± 0.046
2.848AsnPro: 2.848 ± 0.041
2.693AsnGln: 2.693 ± 0.04
2.452AsnArg: 2.452 ± 0.036
3.316AsnSer: 3.316 ± 0.043
2.471AsnThr: 2.471 ± 0.041
2.432AsnVal: 2.432 ± 0.039
0.748AsnTrp: 0.748 ± 0.018
1.625AsnTyr: 1.625 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
3.118ProAla: 3.118 ± 0.045
0.349ProCys: 0.349 ± 0.013
2.862ProAsp: 2.862 ± 0.041
3.67ProGlu: 3.67 ± 0.048
1.755ProPhe: 1.755 ± 0.03
2.851ProGly: 2.851 ± 0.046
0.918ProHis: 0.918 ± 0.022
3.084ProIle: 3.084 ± 0.043
2.381ProLys: 2.381 ± 0.034
4.634ProLeu: 4.634 ± 0.05
0.776ProMet: 0.776 ± 0.022
2.341ProAsn: 2.341 ± 0.039
2.321ProPro: 2.321 ± 0.054
2.566ProGln: 2.566 ± 0.038
1.688ProArg: 1.688 ± 0.031
3.014ProSer: 3.014 ± 0.036
2.886ProThr: 2.886 ± 0.041
3.058ProVal: 3.058 ± 0.043
0.561ProTrp: 0.561 ± 0.016
1.257ProTyr: 1.257 ± 0.025
0.0ProXaa: 0.0 ± 0.0
Gln
4.563GlnAla: 4.563 ± 0.057
0.37GlnCys: 0.37 ± 0.012
2.027GlnAsp: 2.027 ± 0.031
3.37GlnGlu: 3.37 ± 0.046
1.768GlnPhe: 1.768 ± 0.03
3.124GlnGly: 3.124 ± 0.043
0.897GlnHis: 0.897 ± 0.021
3.668GlnIle: 3.668 ± 0.042
2.915GlnLys: 2.915 ± 0.039
6.068GlnLeu: 6.068 ± 0.071
1.064GlnMet: 1.064 ± 0.024
2.126GlnAsn: 2.126 ± 0.035
2.505GlnPro: 2.505 ± 0.042
3.833GlnGln: 3.833 ± 0.062
2.927GlnArg: 2.927 ± 0.037
2.99GlnSer: 2.99 ± 0.038
2.935GlnThr: 2.935 ± 0.035
3.674GlnVal: 3.674 ± 0.043
0.601GlnTrp: 0.601 ± 0.017
1.235GlnTyr: 1.235 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
3.214ArgAla: 3.214 ± 0.039
0.501ArgCys: 0.501 ± 0.014
2.481ArgAsp: 2.481 ± 0.038
3.251ArgGlu: 3.251 ± 0.041
2.225ArgPhe: 2.225 ± 0.032
2.986ArgGly: 2.986 ± 0.04
1.019ArgHis: 1.019 ± 0.024
3.299ArgIle: 3.299 ± 0.041
2.41ArgLys: 2.41 ± 0.038
5.967ArgLeu: 5.967 ± 0.059
1.024ArgMet: 1.024 ± 0.02
2.183ArgAsn: 2.183 ± 0.032
1.946ArgPro: 1.946 ± 0.033
3.114ArgGln: 3.114 ± 0.039
3.032ArgArg: 3.032 ± 0.047
3.429ArgSer: 3.429 ± 0.042
2.596ArgThr: 2.596 ± 0.036
3.364ArgVal: 3.364 ± 0.041
0.763ArgTrp: 0.763 ± 0.023
1.921ArgTyr: 1.921 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
4.819SerAla: 4.819 ± 0.049
0.686SerCys: 0.686 ± 0.019
3.437SerAsp: 3.437 ± 0.046
3.889SerGlu: 3.889 ± 0.045
2.709SerPhe: 2.709 ± 0.041
4.783SerGly: 4.783 ± 0.06
1.277SerHis: 1.277 ± 0.023
3.898SerIle: 3.898 ± 0.046
3.02SerLys: 3.02 ± 0.036
7.545SerLeu: 7.545 ± 0.072
1.193SerMet: 1.193 ± 0.024
2.926SerAsn: 2.926 ± 0.043
3.484SerPro: 3.484 ± 0.051
3.735SerGln: 3.735 ± 0.042
3.201SerArg: 3.201 ± 0.042
4.679SerSer: 4.679 ± 0.071
3.634SerThr: 3.634 ± 0.042
4.327SerVal: 4.327 ± 0.046
0.968SerTrp: 0.968 ± 0.025
1.869SerTyr: 1.869 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
4.791ThrAla: 4.791 ± 0.059
0.497ThrCys: 0.497 ± 0.015
2.632ThrAsp: 2.632 ± 0.033
3.188ThrGlu: 3.188 ± 0.046
2.185ThrPhe: 2.185 ± 0.034
4.163ThrGly: 4.163 ± 0.061
1.026ThrHis: 1.026 ± 0.021
3.748ThrIle: 3.748 ± 0.049
2.572ThrLys: 2.572 ± 0.035
6.273ThrLeu: 6.273 ± 0.053
0.777ThrMet: 0.777 ± 0.021
2.484ThrAsn: 2.484 ± 0.037
3.468ThrPro: 3.468 ± 0.053
2.918ThrGln: 2.918 ± 0.04
2.477ThrArg: 2.477 ± 0.037
3.667ThrSer: 3.667 ± 0.047
3.543ThrThr: 3.543 ± 0.054
3.978ThrVal: 3.978 ± 0.041
0.706ThrTrp: 0.706 ± 0.02
1.631ThrTyr: 1.631 ± 0.027
0.0ThrXaa: 0.0 ± 0.0
Val
5.651ValAla: 5.651 ± 0.06
0.708ValCys: 0.708 ± 0.018
3.388ValAsp: 3.388 ± 0.039
4.436ValGlu: 4.436 ± 0.047
2.615ValPhe: 2.615 ± 0.038
4.51ValGly: 4.51 ± 0.057
1.017ValHis: 1.017 ± 0.025
4.322ValIle: 4.322 ± 0.045
3.556ValLys: 3.556 ± 0.043
6.613ValLeu: 6.613 ± 0.065
1.406ValMet: 1.406 ± 0.027
3.002ValAsn: 3.002 ± 0.04
2.817ValPro: 2.817 ± 0.043
2.815ValGln: 2.815 ± 0.037
3.265ValArg: 3.265 ± 0.038
4.407ValSer: 4.407 ± 0.044
3.823ValThr: 3.823 ± 0.048
4.853ValVal: 4.853 ± 0.053
0.877ValTrp: 0.877 ± 0.022
1.898ValTyr: 1.898 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
0.864TrpAla: 0.864 ± 0.022
0.159TrpCys: 0.159 ± 0.008
0.662TrpAsp: 0.662 ± 0.022
0.87TrpGlu: 0.87 ± 0.023
0.58TrpPhe: 0.58 ± 0.019
0.96TrpGly: 0.96 ± 0.023
0.338TrpHis: 0.338 ± 0.013
0.811TrpIle: 0.811 ± 0.02
0.655TrpLys: 0.655 ± 0.016
1.851TrpLeu: 1.851 ± 0.037
0.31TrpMet: 0.31 ± 0.011
0.666TrpAsn: 0.666 ± 0.02
0.123TrpPro: 0.123 ± 0.008
1.126TrpGln: 1.126 ± 0.028
0.853TrpArg: 0.853 ± 0.023
0.888TrpSer: 0.888 ± 0.023
0.621TrpThr: 0.621 ± 0.017
0.931TrpVal: 0.931 ± 0.024
0.215TrpTrp: 0.215 ± 0.011
0.429TrpTyr: 0.429 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.169TyrAla: 2.169 ± 0.033
0.417TyrCys: 0.417 ± 0.013
1.447TyrAsp: 1.447 ± 0.029
1.693TyrGlu: 1.693 ± 0.027
1.344TyrPhe: 1.344 ± 0.026
1.931TyrGly: 1.931 ± 0.03
0.66TyrHis: 0.66 ± 0.018
1.813TyrIle: 1.813 ± 0.029
1.46TyrLys: 1.46 ± 0.026
3.572TyrLeu: 3.572 ± 0.041
0.482TyrMet: 0.482 ± 0.016
1.326TyrAsn: 1.326 ± 0.029
1.556TyrPro: 1.556 ± 0.029
1.989TyrGln: 1.989 ± 0.03
1.935TyrArg: 1.935 ± 0.032
2.014TyrSer: 2.014 ± 0.031
1.573TyrThr: 1.573 ± 0.025
1.622TyrVal: 1.622 ± 0.026
0.556TyrTrp: 0.556 ± 0.016
1.124TyrTyr: 1.124 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7285 proteins (2192051 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski