Amino acid dipepetide frequency for Prevotella sp. CAG:1058

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.846AlaAla: 6.846 ± 0.13	1.251AlaCys: 1.251 ± 0.046	5.363AlaAsp: 5.363 ± 0.095	4.849AlaGlu: 4.849 ± 0.103	3.129AlaPhe: 3.129 ± 0.072	5.991AlaGly: 5.991 ± 0.097	1.238AlaHis: 1.238 ± 0.045	4.755AlaIle: 4.755 ± 0.086	4.525AlaLys: 4.525 ± 0.088	6.756AlaLeu: 6.756 ± 0.113	2.262AlaMet: 2.262 ± 0.058	3.339AlaAsn: 3.339 ± 0.059	2.314AlaPro: 2.314 ± 0.057	2.649AlaGln: 2.649 ± 0.058	3.505AlaArg: 3.505 ± 0.086	4.399AlaSer: 4.399 ± 0.077	4.091AlaThr: 4.091 ± 0.088	5.977AlaVal: 5.977 ± 0.116	0.785AlaTrp: 0.785 ± 0.029	3.098AlaTyr: 3.098 ± 0.076	0.004AlaXaa: 0.004 ± 0.002
Cys	1.034CysAla: 1.034 ± 0.036	0.235CysCys: 0.235 ± 0.022	0.845CysAsp: 0.845 ± 0.036	0.73CysGlu: 0.73 ± 0.033	0.55CysPhe: 0.55 ± 0.029	1.318CysGly: 1.318 ± 0.044	0.354CysHis: 0.354 ± 0.026	0.911CysIle: 0.911 ± 0.035	0.837CysLys: 0.837 ± 0.03	1.227CysLeu: 1.227 ± 0.038	0.435CysMet: 0.435 ± 0.024	0.641CysAsn: 0.641 ± 0.029	0.624CysPro: 0.624 ± 0.031	0.331CysGln: 0.331 ± 0.023	0.784CysArg: 0.784 ± 0.037	0.865CysSer: 0.865 ± 0.029	0.699CysThr: 0.699 ± 0.03	1.005CysVal: 1.005 ± 0.039	0.173CysTrp: 0.173 ± 0.016	0.643CysTyr: 0.643 ± 0.031	0.0CysXaa: 0.0 ± 0.0
Asp	4.481AspAla: 4.481 ± 0.084	0.829AspCys: 0.829 ± 0.035	3.634AspAsp: 3.634 ± 0.072	4.366AspGlu: 4.366 ± 0.08	2.976AspPhe: 2.976 ± 0.065	5.271AspGly: 5.271 ± 0.116	0.83AspHis: 0.83 ± 0.036	4.476AspIle: 4.476 ± 0.077	4.307AspLys: 4.307 ± 0.069	4.255AspLeu: 4.255 ± 0.078	2.011AspMet: 2.011 ± 0.049	3.451AspAsn: 3.451 ± 0.069	1.847AspPro: 1.847 ± 0.057	1.076AspGln: 1.076 ± 0.04	2.541AspArg: 2.541 ± 0.059	3.33AspSer: 3.33 ± 0.075	3.107AspThr: 3.107 ± 0.075	4.223AspVal: 4.223 ± 0.087	0.804AspTrp: 0.804 ± 0.035	2.924AspTyr: 2.924 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	4.82GluAla: 4.82 ± 0.096	0.752GluCys: 0.752 ± 0.036	3.151GluAsp: 3.151 ± 0.076	3.981GluGlu: 3.981 ± 0.079	2.216GluPhe: 2.216 ± 0.049	4.093GluGly: 4.093 ± 0.086	1.223GluHis: 1.223 ± 0.041	4.102GluIle: 4.102 ± 0.083	4.279GluLys: 4.279 ± 0.083	5.396GluLeu: 5.396 ± 0.088	2.005GluMet: 2.005 ± 0.055	3.193GluAsn: 3.193 ± 0.067	1.797GluPro: 1.797 ± 0.049	2.187GluGln: 2.187 ± 0.058	3.315GluArg: 3.315 ± 0.073	2.891GluSer: 2.891 ± 0.061	3.204GluThr: 3.204 ± 0.074	3.773GluVal: 3.773 ± 0.074	0.797GluTrp: 0.797 ± 0.038	2.779GluTyr: 2.779 ± 0.066	0.0GluXaa: 0.0 ± 0.0
Phe	3.201PheAla: 3.201 ± 0.069	0.754PheCys: 0.754 ± 0.032	2.83PheAsp: 2.83 ± 0.058	2.184PheGlu: 2.184 ± 0.063	1.912PhePhe: 1.912 ± 0.055	3.32PheGly: 3.32 ± 0.076	0.788PheHis: 0.788 ± 0.035	3.056PheIle: 3.056 ± 0.074	2.47PheLys: 2.47 ± 0.065	3.204PheLeu: 3.204 ± 0.069	1.399PheMet: 1.399 ± 0.046	2.473PheAsn: 2.473 ± 0.056	1.439PhePro: 1.439 ± 0.042	0.891PheGln: 0.891 ± 0.034	1.977PheArg: 1.977 ± 0.051	3.07PheSer: 3.07 ± 0.081	2.934PheThr: 2.934 ± 0.068	3.023PheVal: 3.023 ± 0.066	0.467PheTrp: 0.467 ± 0.029	1.781PheTyr: 1.781 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.821GlyAla: 4.821 ± 0.093	1.183GlyCys: 1.183 ± 0.044	4.144GlyAsp: 4.144 ± 0.076	4.074GlyGlu: 4.074 ± 0.073	3.267GlyPhe: 3.267 ± 0.073	5.587GlyGly: 5.587 ± 0.11	1.449GlyHis: 1.449 ± 0.043	5.271GlyIle: 5.271 ± 0.093	5.117GlyLys: 5.117 ± 0.094	6.034GlyLeu: 6.034 ± 0.099	2.396GlyMet: 2.396 ± 0.058	3.824GlyAsn: 3.824 ± 0.078	1.379GlyPro: 1.379 ± 0.045	2.145GlyGln: 2.145 ± 0.051	3.825GlyArg: 3.825 ± 0.069	4.202GlySer: 4.202 ± 0.082	4.487GlyThr: 4.487 ± 0.089	5.451GlyVal: 5.451 ± 0.087	0.968GlyTrp: 0.968 ± 0.041	3.277GlyTyr: 3.277 ± 0.074	0.001GlyXaa: 0.001 ± 0.001
His	1.292HisAla: 1.292 ± 0.049	0.313HisCys: 0.313 ± 0.022	1.12HisAsp: 1.12 ± 0.036	1.107HisGlu: 1.107 ± 0.042	0.915HisPhe: 0.915 ± 0.039	1.384HisGly: 1.384 ± 0.044	0.479HisHis: 0.479 ± 0.03	1.277HisIle: 1.277 ± 0.038	1.12HisLys: 1.12 ± 0.038	1.431HisLeu: 1.431 ± 0.047	0.373HisMet: 0.373 ± 0.022	0.92HisAsn: 0.92 ± 0.034	0.93HisPro: 0.93 ± 0.037	0.442HisGln: 0.442 ± 0.026	0.873HisArg: 0.873 ± 0.038	1.026HisSer: 1.026 ± 0.037	0.947HisThr: 0.947 ± 0.032	1.295HisVal: 1.295 ± 0.046	0.231HisTrp: 0.231 ± 0.02	0.825HisTyr: 0.825 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	5.096IleAla: 5.096 ± 0.09	0.972IleCys: 0.972 ± 0.036	4.51IleAsp: 4.51 ± 0.081	4.256IleGlu: 4.256 ± 0.084	2.535IlePhe: 2.535 ± 0.069	4.67IleGly: 4.67 ± 0.086	1.133IleHis: 1.133 ± 0.04	4.804IleIle: 4.804 ± 0.098	4.27IleLys: 4.27 ± 0.078	5.166IleLeu: 5.166 ± 0.102	1.867IleMet: 1.867 ± 0.055	3.685IleAsn: 3.685 ± 0.079	2.768IlePro: 2.768 ± 0.068	1.699IleGln: 1.699 ± 0.051	3.319IleArg: 3.319 ± 0.06	4.46IleSer: 4.46 ± 0.084	4.108IleThr: 4.108 ± 0.084	4.595IleVal: 4.595 ± 0.089	0.551IleTrp: 0.551 ± 0.026	2.534IleTyr: 2.534 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	5.279LysAla: 5.279 ± 0.087	0.624LysCys: 0.624 ± 0.029	4.03LysAsp: 4.03 ± 0.071	4.464LysGlu: 4.464 ± 0.094	2.256LysPhe: 2.256 ± 0.058	4.256LysGly: 4.256 ± 0.076	1.179LysHis: 1.179 ± 0.043	4.173LysIle: 4.173 ± 0.073	4.608LysLys: 4.608 ± 0.091	5.28LysLeu: 5.28 ± 0.084	2.196LysMet: 2.196 ± 0.06	3.364LysAsn: 3.364 ± 0.078	2.199LysPro: 2.199 ± 0.055	2.182LysGln: 2.182 ± 0.052	3.2LysArg: 3.2 ± 0.069	3.426LysSer: 3.426 ± 0.071	3.63LysThr: 3.63 ± 0.077	4.155LysVal: 4.155 ± 0.084	0.74LysTrp: 0.74 ± 0.034	2.959LysTyr: 2.959 ± 0.063	0.0LysXaa: 0.0 ± 0.0
Leu	6.839LeuAla: 6.839 ± 0.116	1.399LeuCys: 1.399 ± 0.044	4.998LeuAsp: 4.998 ± 0.1	4.46LeuGlu: 4.46 ± 0.077	3.923LeuPhe: 3.923 ± 0.09	5.866LeuGly: 5.866 ± 0.11	1.698LeuHis: 1.698 ± 0.053	4.858LeuIle: 4.858 ± 0.092	5.759LeuLys: 5.759 ± 0.083	7.61LeuLeu: 7.61 ± 0.152	2.541LeuMet: 2.541 ± 0.063	4.184LeuAsn: 4.184 ± 0.079	3.724LeuPro: 3.724 ± 0.073	2.638LeuGln: 2.638 ± 0.066	4.383LeuArg: 4.383 ± 0.088	5.934LeuSer: 5.934 ± 0.102	5.086LeuThr: 5.086 ± 0.089	5.515LeuVal: 5.515 ± 0.108	0.887LeuTrp: 0.887 ± 0.039	3.501LeuTyr: 3.501 ± 0.071	0.001LeuXaa: 0.001 ± 0.001
Met	2.666MetAla: 2.666 ± 0.068	0.374MetCys: 0.374 ± 0.025	1.56MetAsp: 1.56 ± 0.048	1.687MetGlu: 1.687 ± 0.047	1.291MetPhe: 1.291 ± 0.042	1.907MetGly: 1.907 ± 0.05	0.532MetHis: 0.532 ± 0.029	1.583MetIle: 1.583 ± 0.049	2.5MetLys: 2.5 ± 0.057	3.003MetLeu: 3.003 ± 0.082	0.92MetMet: 0.92 ± 0.037	1.556MetAsn: 1.556 ± 0.053	1.509MetPro: 1.509 ± 0.049	1.099MetGln: 1.099 ± 0.037	1.65MetArg: 1.65 ± 0.047	1.921MetSer: 1.921 ± 0.056	1.76MetThr: 1.76 ± 0.049	1.745MetVal: 1.745 ± 0.048	0.263MetTrp: 0.263 ± 0.02	0.928MetTyr: 0.928 ± 0.037	0.0MetXaa: 0.0 ± 0.0
Asn	3.795AsnAla: 3.795 ± 0.078	0.636AsnCys: 0.636 ± 0.031	2.88AsnAsp: 2.88 ± 0.069	2.905AsnGlu: 2.905 ± 0.057	2.038AsnPhe: 2.038 ± 0.054	4.079AsnGly: 4.079 ± 0.087	0.796AsnHis: 0.796 ± 0.033	4.049AsnIle: 4.049 ± 0.08	3.129AsnLys: 3.129 ± 0.07	3.954AsnLeu: 3.954 ± 0.067	1.485AsnMet: 1.485 ± 0.05	2.85AsnAsn: 2.85 ± 0.074	2.268AsnPro: 2.268 ± 0.053	1.337AsnGln: 1.337 ± 0.049	2.276AsnArg: 2.276 ± 0.059	2.816AsnSer: 2.816 ± 0.071	2.868AsnThr: 2.868 ± 0.054	3.648AsnVal: 3.648 ± 0.075	0.547AsnTrp: 0.547 ± 0.028	2.154AsnTyr: 2.154 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	2.864ProAla: 2.864 ± 0.071	0.473ProCys: 0.473 ± 0.03	2.651ProAsp: 2.651 ± 0.062	2.98ProGlu: 2.98 ± 0.065	1.683ProPhe: 1.683 ± 0.049	2.581ProGly: 2.581 ± 0.059	0.685ProHis: 0.685 ± 0.03	2.015ProIle: 2.015 ± 0.063	1.831ProLys: 1.831 ± 0.048	3.023ProLeu: 3.023 ± 0.053	1.008ProMet: 1.008 ± 0.036	1.42ProAsn: 1.42 ± 0.042	0.781ProPro: 0.781 ± 0.039	1.345ProGln: 1.345 ± 0.048	1.287ProArg: 1.287 ± 0.042	2.092ProSer: 2.092 ± 0.052	2.02ProThr: 2.02 ± 0.058	3.045ProVal: 3.045 ± 0.065	0.44ProTrp: 0.44 ± 0.027	1.734ProTyr: 1.734 ± 0.057	0.0ProXaa: 0.0 ± 0.0
Gln	2.553GlnAla: 2.553 ± 0.06	0.352GlnCys: 0.352 ± 0.026	1.558GlnAsp: 1.558 ± 0.043	1.682GlnGlu: 1.682 ± 0.056	1.198GlnPhe: 1.198 ± 0.044	1.854GlnGly: 1.854 ± 0.05	0.542GlnHis: 0.542 ± 0.026	2.047GlnIle: 2.047 ± 0.056	1.933GlnLys: 1.933 ± 0.055	2.908GlnLeu: 2.908 ± 0.069	1.021GlnMet: 1.021 ± 0.034	1.411GlnAsn: 1.411 ± 0.045	1.144GlnPro: 1.144 ± 0.043	1.219GlnGln: 1.219 ± 0.044	1.64GlnArg: 1.64 ± 0.047	1.497GlnSer: 1.497 ± 0.04	1.842GlnThr: 1.842 ± 0.051	1.834GlnVal: 1.834 ± 0.051	0.422GlnTrp: 0.422 ± 0.025	1.317GlnTyr: 1.317 ± 0.048	0.0GlnXaa: 0.0 ± 0.0
Arg	3.088ArgAla: 3.088 ± 0.069	0.58ArgCys: 0.58 ± 0.029	2.359ArgAsp: 2.359 ± 0.053	2.818ArgGlu: 2.818 ± 0.07	2.214ArgPhe: 2.214 ± 0.063	2.803ArgGly: 2.803 ± 0.07	1.137ArgHis: 1.137 ± 0.043	3.627ArgIle: 3.627 ± 0.07	3.491ArgLys: 3.491 ± 0.075	4.911ArgLeu: 4.911 ± 0.082	1.816ArgMet: 1.816 ± 0.048	2.561ArgAsn: 2.561 ± 0.06	1.793ArgPro: 1.793 ± 0.061	2.044ArgGln: 2.044 ± 0.057	3.045ArgArg: 3.045 ± 0.08	2.416ArgSer: 2.416 ± 0.059	2.498ArgThr: 2.498 ± 0.061	2.683ArgVal: 2.683 ± 0.055	0.64ArgTrp: 0.64 ± 0.03	2.244ArgTyr: 2.244 ± 0.058	0.0ArgXaa: 0.0 ± 0.0
Ser	4.557SerAla: 4.557 ± 0.081	0.891SerCys: 0.891 ± 0.04	3.478SerAsp: 3.478 ± 0.067	3.245SerGlu: 3.245 ± 0.068	2.888SerPhe: 2.888 ± 0.062	4.736SerGly: 4.736 ± 0.088	1.169SerHis: 1.169 ± 0.039	4.053SerIle: 4.053 ± 0.07	3.275SerLys: 3.275 ± 0.074	5.749SerLeu: 5.749 ± 0.094	1.69SerMet: 1.69 ± 0.047	2.498SerAsn: 2.498 ± 0.069	2.199SerPro: 2.199 ± 0.051	1.786SerGln: 1.786 ± 0.056	2.795SerArg: 2.795 ± 0.062	3.583SerSer: 3.583 ± 0.086	3.16SerThr: 3.16 ± 0.071	4.399SerVal: 4.399 ± 0.088	0.698SerTrp: 0.698 ± 0.029	2.619SerTyr: 2.619 ± 0.071	0.0SerXaa: 0.0 ± 0.0
Thr	4.768ThrAla: 4.768 ± 0.082	0.698ThrCys: 0.698 ± 0.03	3.704ThrAsp: 3.704 ± 0.08	3.033ThrGlu: 3.033 ± 0.071	2.712ThrPhe: 2.712 ± 0.067	4.627ThrGly: 4.627 ± 0.1	0.982ThrHis: 0.982 ± 0.035	3.929ThrIle: 3.929 ± 0.083	2.773ThrLys: 2.773 ± 0.06	5.427ThrLeu: 5.427 ± 0.092	1.367ThrMet: 1.367 ± 0.044	2.352ThrAsn: 2.352 ± 0.064	2.551ThrPro: 2.551 ± 0.057	1.547ThrGln: 1.547 ± 0.049	2.24ThrArg: 2.24 ± 0.054	3.397ThrSer: 3.397 ± 0.076	3.168ThrThr: 3.168 ± 0.079	4.529ThrVal: 4.529 ± 0.091	0.678ThrTrp: 0.678 ± 0.032	2.411ThrTyr: 2.411 ± 0.066	0.0ThrXaa: 0.0 ± 0.0
Val	5.239ValAla: 5.239 ± 0.097	1.158ValCys: 1.158 ± 0.038	4.286ValAsp: 4.286 ± 0.083	4.219ValGlu: 4.219 ± 0.077	3.01ValPhe: 3.01 ± 0.075	4.451ValGly: 4.451 ± 0.087	1.05ValHis: 1.05 ± 0.042	4.46ValIle: 4.46 ± 0.096	4.643ValLys: 4.643 ± 0.089	5.855ValLeu: 5.855 ± 0.09	1.985ValMet: 1.985 ± 0.061	3.665ValAsn: 3.665 ± 0.069	2.716ValPro: 2.716 ± 0.064	1.735ValGln: 1.735 ± 0.045	3.433ValArg: 3.433 ± 0.075	4.779ValSer: 4.779 ± 0.094	4.115ValThr: 4.115 ± 0.088	5.277ValVal: 5.277 ± 0.096	0.793ValTrp: 0.793 ± 0.032	2.872ValTyr: 2.872 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.748TrpAla: 0.748 ± 0.031	0.173TrpCys: 0.173 ± 0.015	0.67TrpAsp: 0.67 ± 0.028	0.575TrpGlu: 0.575 ± 0.029	0.516TrpPhe: 0.516 ± 0.028	0.834TrpGly: 0.834 ± 0.036	0.305TrpHis: 0.305 ± 0.021	0.713TrpIle: 0.713 ± 0.034	0.693TrpLys: 0.693 ± 0.034	1.177TrpLeu: 1.177 ± 0.041	0.386TrpMet: 0.386 ± 0.027	0.737TrpAsn: 0.737 ± 0.033	0.308TrpPro: 0.308 ± 0.024	0.487TrpGln: 0.487 ± 0.025	0.612TrpArg: 0.612 ± 0.031	0.657TrpSer: 0.657 ± 0.03	0.668TrpThr: 0.668 ± 0.031	0.645TrpVal: 0.645 ± 0.027	0.182TrpTrp: 0.182 ± 0.017	0.504TrpTyr: 0.504 ± 0.029	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.138TyrAla: 3.138 ± 0.066	0.591TyrCys: 0.591 ± 0.025	2.969TyrAsp: 2.969 ± 0.068	2.335TyrGlu: 2.335 ± 0.056	1.945TyrPhe: 1.945 ± 0.052	3.273TyrGly: 3.273 ± 0.078	0.729TyrHis: 0.729 ± 0.029	2.842TyrIle: 2.842 ± 0.063	2.643TyrLys: 2.643 ± 0.063	3.441TyrLeu: 3.441 ± 0.067	1.291TyrMet: 1.291 ± 0.043	2.384TyrAsn: 2.384 ± 0.066	1.67TyrPro: 1.67 ± 0.047	1.135TyrGln: 1.135 ± 0.042	2.067TyrArg: 2.067 ± 0.053	2.708TyrSer: 2.708 ± 0.069	2.5TyrThr: 2.5 ± 0.06	2.924TyrVal: 2.924 ± 0.054	0.521TyrTrp: 0.521 ± 0.027	2.073TyrTyr: 2.073 ± 0.062	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.012XaaXaa: 0.012 ± 0.006

Statistics based on 2263 proteins (756260 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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