Amino acid dipepetide frequency for Pararhizobium sp. BGMRC6574

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.552AlaAla: 15.552 ± 0.164	1.186AlaCys: 1.186 ± 0.036	7.305AlaAsp: 7.305 ± 0.085	7.989AlaGlu: 7.989 ± 0.091	4.888AlaPhe: 4.888 ± 0.079	11.258AlaGly: 11.258 ± 0.114	2.42AlaHis: 2.42 ± 0.048	6.817AlaIle: 6.817 ± 0.076	4.011AlaLys: 4.011 ± 0.077	12.83AlaLeu: 12.83 ± 0.119	3.72AlaMet: 3.72 ± 0.07	3.081AlaAsn: 3.081 ± 0.06	4.973AlaPro: 4.973 ± 0.07	3.074AlaGln: 3.074 ± 0.055	9.127AlaArg: 9.127 ± 0.111	6.755AlaSer: 6.755 ± 0.093	5.981AlaThr: 5.981 ± 0.065	8.659AlaVal: 8.659 ± 0.087	1.452AlaTrp: 1.452 ± 0.042	2.6AlaTyr: 2.6 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.977CysAla: 0.977 ± 0.035	0.101CysCys: 0.101 ± 0.01	0.543CysAsp: 0.543 ± 0.022	0.511CysGlu: 0.511 ± 0.025	0.318CysPhe: 0.318 ± 0.015	0.946CysGly: 0.946 ± 0.029	0.249CysHis: 0.249 ± 0.016	0.375CysIle: 0.375 ± 0.02	0.167CysLys: 0.167 ± 0.012	0.814CysLeu: 0.814 ± 0.029	0.167CysMet: 0.167 ± 0.014	0.186CysAsn: 0.186 ± 0.013	0.416CysPro: 0.416 ± 0.02	0.205CysGln: 0.205 ± 0.014	0.679CysArg: 0.679 ± 0.027	0.444CysSer: 0.444 ± 0.021	0.42CysThr: 0.42 ± 0.018	0.641CysVal: 0.641 ± 0.023	0.122CysTrp: 0.122 ± 0.009	0.2CysTyr: 0.2 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.641AspAla: 7.641 ± 0.095	0.462AspCys: 0.462 ± 0.021	3.821AspAsp: 3.821 ± 0.075	4.157AspGlu: 4.157 ± 0.068	2.255AspPhe: 2.255 ± 0.045	5.632AspGly: 5.632 ± 0.084	1.463AspHis: 1.463 ± 0.038	2.897AspIle: 2.897 ± 0.054	1.611AspLys: 1.611 ± 0.047	6.176AspLeu: 6.176 ± 0.072	1.415AspMet: 1.415 ± 0.04	1.328AspAsn: 1.328 ± 0.034	3.635AspPro: 3.635 ± 0.054	1.552AspGln: 1.552 ± 0.039	4.889AspArg: 4.889 ± 0.076	2.035AspSer: 2.035 ± 0.047	3.139AspThr: 3.139 ± 0.057	4.356AspVal: 4.356 ± 0.063	0.96AspTrp: 0.96 ± 0.029	1.522AspTyr: 1.522 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	8.393GluAla: 8.393 ± 0.099	0.461GluCys: 0.461 ± 0.019	3.149GluAsp: 3.149 ± 0.063	3.783GluGlu: 3.783 ± 0.065	1.581GluPhe: 1.581 ± 0.039	4.858GluGly: 4.858 ± 0.069	1.349GluHis: 1.349 ± 0.034	3.488GluIle: 3.488 ± 0.062	2.51GluLys: 2.51 ± 0.061	4.784GluLeu: 4.784 ± 0.065	1.575GluMet: 1.575 ± 0.042	1.85GluAsn: 1.85 ± 0.043	3.16GluPro: 3.16 ± 0.061	1.724GluGln: 1.724 ± 0.042	6.469GluArg: 6.469 ± 0.097	2.55GluSer: 2.55 ± 0.053	4.368GluThr: 4.368 ± 0.068	3.448GluVal: 3.448 ± 0.065	0.716GluTrp: 0.716 ± 0.026	0.916GluTyr: 0.916 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.877PheAla: 4.877 ± 0.075	0.395PheCys: 0.395 ± 0.02	2.892PheAsp: 2.892 ± 0.048	2.29PheGlu: 2.29 ± 0.041	1.604PhePhe: 1.604 ± 0.048	3.551PheGly: 3.551 ± 0.053	0.774PheHis: 0.774 ± 0.027	1.535PheIle: 1.535 ± 0.038	0.905PheLys: 0.905 ± 0.031	3.383PheLeu: 3.383 ± 0.062	0.871PheMet: 0.871 ± 0.032	0.931PheAsn: 0.931 ± 0.032	1.612PhePro: 1.612 ± 0.044	0.911PheGln: 0.911 ± 0.028	2.337PheArg: 2.337 ± 0.044	2.36PheSer: 2.36 ± 0.05	2.026PheThr: 2.026 ± 0.043	3.268PheVal: 3.268 ± 0.069	0.55PheTrp: 0.55 ± 0.025	0.921PheTyr: 0.921 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	8.955GlyAla: 8.955 ± 0.083	0.871GlyCys: 0.871 ± 0.028	4.806GlyAsp: 4.806 ± 0.07	5.737GlyGlu: 5.737 ± 0.081	3.651GlyPhe: 3.651 ± 0.052	7.19GlyGly: 7.19 ± 0.103	1.955GlyHis: 1.955 ± 0.042	4.576GlyIle: 4.576 ± 0.07	3.249GlyLys: 3.249 ± 0.068	8.358GlyLeu: 8.358 ± 0.093	2.453GlyMet: 2.453 ± 0.048	2.317GlyAsn: 2.317 ± 0.052	3.418GlyPro: 3.418 ± 0.057	2.549GlyGln: 2.549 ± 0.058	6.659GlyArg: 6.659 ± 0.075	4.982GlySer: 4.982 ± 0.079	5.058GlyThr: 5.058 ± 0.064	5.904GlyVal: 5.904 ± 0.082	1.236GlyTrp: 1.236 ± 0.037	2.314GlyTyr: 2.314 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.611HisAla: 2.611 ± 0.049	0.218HisCys: 0.218 ± 0.015	1.441HisAsp: 1.441 ± 0.036	1.269HisGlu: 1.269 ± 0.03	0.882HisPhe: 0.882 ± 0.03	2.015HisGly: 2.015 ± 0.044	0.586HisHis: 0.586 ± 0.03	0.902HisIle: 0.902 ± 0.026	0.396HisLys: 0.396 ± 0.02	2.101HisLeu: 2.101 ± 0.042	0.489HisMet: 0.489 ± 0.019	0.409HisAsn: 0.409 ± 0.017	1.296HisPro: 1.296 ± 0.034	0.503HisGln: 0.503 ± 0.021	1.649HisArg: 1.649 ± 0.04	0.99HisSer: 0.99 ± 0.027	0.976HisThr: 0.976 ± 0.03	1.662HisVal: 1.662 ± 0.039	0.295HisTrp: 0.295 ± 0.017	0.57HisTyr: 0.57 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.414IleAla: 7.414 ± 0.094	0.46IleCys: 0.46 ± 0.02	3.798IleAsp: 3.798 ± 0.056	3.662IleGlu: 3.662 ± 0.058	1.778IlePhe: 1.778 ± 0.041	4.898IleGly: 4.898 ± 0.072	0.943IleHis: 0.943 ± 0.03	1.844IleIle: 1.844 ± 0.051	1.123IleLys: 1.123 ± 0.037	4.225IleLeu: 4.225 ± 0.07	1.0IleMet: 1.0 ± 0.032	1.152IleAsn: 1.152 ± 0.036	2.135IlePro: 2.135 ± 0.041	1.038IleGln: 1.038 ± 0.031	3.188IleArg: 3.188 ± 0.05	2.482IleSer: 2.482 ± 0.05	2.375IleThr: 2.375 ± 0.044	4.89IleVal: 4.89 ± 0.074	0.528IleTrp: 0.528 ± 0.024	1.07IleTyr: 1.07 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.128LysAla: 4.128 ± 0.079	0.147LysCys: 0.147 ± 0.011	1.811LysAsp: 1.811 ± 0.049	1.591LysGlu: 1.591 ± 0.046	0.727LysPhe: 0.727 ± 0.031	2.593LysGly: 2.593 ± 0.055	0.598LysHis: 0.598 ± 0.025	1.525LysIle: 1.525 ± 0.042	1.433LysLys: 1.433 ± 0.054	2.966LysLeu: 2.966 ± 0.064	0.719LysMet: 0.719 ± 0.03	0.949LysAsn: 0.949 ± 0.032	2.019LysPro: 2.019 ± 0.053	0.981LysGln: 0.981 ± 0.035	2.598LysArg: 2.598 ± 0.047	1.822LysSer: 1.822 ± 0.048	2.009LysThr: 2.009 ± 0.046	2.164LysVal: 2.164 ± 0.05	0.305LysTrp: 0.305 ± 0.016	0.567LysTyr: 0.567 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	13.309LeuAla: 13.309 ± 0.144	0.834LeuCys: 0.834 ± 0.027	6.303LeuAsp: 6.303 ± 0.085	5.347LeuGlu: 5.347 ± 0.077	3.623LeuPhe: 3.623 ± 0.065	7.827LeuGly: 7.827 ± 0.098	1.783LeuHis: 1.783 ± 0.041	4.16LeuIle: 4.16 ± 0.065	3.365LeuLys: 3.365 ± 0.058	8.168LeuLeu: 8.168 ± 0.131	2.215LeuMet: 2.215 ± 0.047	2.206LeuAsn: 2.206 ± 0.051	5.02LeuPro: 5.02 ± 0.062	2.331LeuGln: 2.331 ± 0.05	6.341LeuArg: 6.341 ± 0.076	6.492LeuSer: 6.492 ± 0.09	5.198LeuThr: 5.198 ± 0.07	8.146LeuVal: 8.146 ± 0.115	0.945LeuTrp: 0.945 ± 0.032	2.048LeuTyr: 2.048 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.277MetAla: 3.277 ± 0.057	0.174MetCys: 0.174 ± 0.013	1.269MetAsp: 1.269 ± 0.033	1.242MetGlu: 1.242 ± 0.034	0.639MetPhe: 0.639 ± 0.022	1.743MetGly: 1.743 ± 0.041	0.481MetHis: 0.481 ± 0.022	1.389MetIle: 1.389 ± 0.034	1.096MetLys: 1.096 ± 0.031	2.466MetLeu: 2.466 ± 0.049	0.698MetMet: 0.698 ± 0.026	0.864MetAsn: 0.864 ± 0.026	1.577MetPro: 1.577 ± 0.036	0.834MetGln: 0.834 ± 0.027	2.185MetArg: 2.185 ± 0.042	1.542MetSer: 1.542 ± 0.034	1.796MetThr: 1.796 ± 0.039	1.806MetVal: 1.806 ± 0.039	0.183MetTrp: 0.183 ± 0.013	0.289MetTyr: 0.289 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.493AsnAla: 3.493 ± 0.061	0.198AsnCys: 0.198 ± 0.014	1.562AsnAsp: 1.562 ± 0.039	1.339AsnGlu: 1.339 ± 0.039	0.941AsnPhe: 0.941 ± 0.025	2.623AsnGly: 2.623 ± 0.063	0.564AsnHis: 0.564 ± 0.022	1.19AsnIle: 1.19 ± 0.038	0.558AsnLys: 0.558 ± 0.024	2.301AsnLeu: 2.301 ± 0.047	0.578AsnMet: 0.578 ± 0.025	0.584AsnAsn: 0.584 ± 0.024	1.64AsnPro: 1.64 ± 0.039	0.689AsnGln: 0.689 ± 0.031	1.894AsnArg: 1.894 ± 0.038	1.088AsnSer: 1.088 ± 0.035	1.259AsnThr: 1.259 ± 0.036	2.024AsnVal: 2.024 ± 0.041	0.397AsnTrp: 0.397 ± 0.018	0.678AsnTyr: 0.678 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.812ProAla: 5.812 ± 0.078	0.347ProCys: 0.347 ± 0.018	3.586ProAsp: 3.586 ± 0.061	3.745ProGlu: 3.745 ± 0.06	2.092ProPhe: 2.092 ± 0.046	4.248ProGly: 4.248 ± 0.054	1.062ProHis: 1.062 ± 0.032	2.4ProIle: 2.4 ± 0.043	1.691ProLys: 1.691 ± 0.048	4.433ProLeu: 4.433 ± 0.062	1.141ProMet: 1.141 ± 0.034	1.314ProAsn: 1.314 ± 0.037	2.226ProPro: 2.226 ± 0.054	1.436ProGln: 1.436 ± 0.038	2.827ProArg: 2.827 ± 0.053	2.973ProSer: 2.973 ± 0.052	2.389ProThr: 2.389 ± 0.047	4.088ProVal: 4.088 ± 0.058	0.6ProTrp: 0.6 ± 0.023	1.16ProTyr: 1.16 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.566GlnAla: 3.566 ± 0.064	0.186GlnCys: 0.186 ± 0.013	1.309GlnAsp: 1.309 ± 0.039	1.328GlnGlu: 1.328 ± 0.039	0.946GlnPhe: 0.946 ± 0.03	1.982GlnGly: 1.982 ± 0.046	0.541GlnHis: 0.541 ± 0.022	1.617GlnIle: 1.617 ± 0.037	1.011GlnLys: 1.011 ± 0.033	2.323GlnLeu: 2.323 ± 0.045	0.807GlnMet: 0.807 ± 0.026	0.87GlnAsn: 0.87 ± 0.036	1.475GlnPro: 1.475 ± 0.035	0.991GlnGln: 0.991 ± 0.044	2.188GlnArg: 2.188 ± 0.047	1.673GlnSer: 1.673 ± 0.037	1.648GlnThr: 1.648 ± 0.038	1.84GlnVal: 1.84 ± 0.043	0.322GlnTrp: 0.322 ± 0.015	0.527GlnTyr: 0.527 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.193ArgAla: 8.193 ± 0.103	0.556ArgCys: 0.556 ± 0.026	4.335ArgAsp: 4.335 ± 0.069	4.881ArgGlu: 4.881 ± 0.077	3.249ArgPhe: 3.249 ± 0.058	5.138ArgGly: 5.138 ± 0.07	1.871ArgHis: 1.871 ± 0.046	4.265ArgIle: 4.265 ± 0.069	2.419ArgLys: 2.419 ± 0.046	7.908ArgLeu: 7.908 ± 0.089	2.215ArgMet: 2.215 ± 0.045	1.842ArgAsn: 1.842 ± 0.043	3.656ArgPro: 3.656 ± 0.056	2.466ArgGln: 2.466 ± 0.05	6.616ArgArg: 6.616 ± 0.101	4.331ArgSer: 4.331 ± 0.066	4.079ArgThr: 4.079 ± 0.065	4.916ArgVal: 4.916 ± 0.073	0.929ArgTrp: 0.929 ± 0.03	1.785ArgTyr: 1.785 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.444SerAla: 6.444 ± 0.075	0.383SerCys: 0.383 ± 0.018	3.303SerAsp: 3.303 ± 0.064	3.156SerGlu: 3.156 ± 0.051	2.265SerPhe: 2.265 ± 0.054	5.733SerGly: 5.733 ± 0.09	1.063SerHis: 1.063 ± 0.029	2.825SerIle: 2.825 ± 0.056	1.556SerLys: 1.556 ± 0.047	5.244SerLeu: 5.244 ± 0.073	1.388SerMet: 1.388 ± 0.039	1.438SerAsn: 1.438 ± 0.04	2.625SerPro: 2.625 ± 0.048	1.514SerGln: 1.514 ± 0.041	3.917SerArg: 3.917 ± 0.063	3.159SerSer: 3.159 ± 0.073	2.802SerThr: 2.802 ± 0.056	4.188SerVal: 4.188 ± 0.062	0.708SerTrp: 0.708 ± 0.025	1.253SerTyr: 1.253 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.166ThrAla: 6.166 ± 0.074	0.443ThrCys: 0.443 ± 0.021	3.006ThrAsp: 3.006 ± 0.057	2.543ThrGlu: 2.543 ± 0.048	2.115ThrPhe: 2.115 ± 0.037	5.457ThrGly: 5.457 ± 0.067	1.152ThrHis: 1.152 ± 0.029	3.231ThrIle: 3.231 ± 0.055	1.52ThrLys: 1.52 ± 0.039	5.932ThrLeu: 5.932 ± 0.08	1.437ThrMet: 1.437 ± 0.035	1.373ThrAsn: 1.373 ± 0.036	3.102ThrPro: 3.102 ± 0.05	1.354ThrGln: 1.354 ± 0.033	3.695ThrArg: 3.695 ± 0.057	2.845ThrSer: 2.845 ± 0.046	2.929ThrThr: 2.929 ± 0.048	4.644ThrVal: 4.644 ± 0.065	0.624ThrTrp: 0.624 ± 0.022	1.189ThrTyr: 1.189 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	9.096ValAla: 9.096 ± 0.098	0.695ValCys: 0.695 ± 0.026	4.589ValAsp: 4.589 ± 0.075	4.787ValGlu: 4.787 ± 0.065	3.045ValPhe: 3.045 ± 0.053	5.667ValGly: 5.667 ± 0.071	1.53ValHis: 1.53 ± 0.039	3.553ValIle: 3.553 ± 0.068	2.082ValLys: 2.082 ± 0.056	7.507ValLeu: 7.507 ± 0.095	1.892ValMet: 1.892 ± 0.037	1.914ValAsn: 1.914 ± 0.038	3.9ValPro: 3.9 ± 0.055	1.798ValGln: 1.798 ± 0.042	5.443ValArg: 5.443 ± 0.078	4.563ValSer: 4.563 ± 0.064	4.472ValThr: 4.472 ± 0.067	6.383ValVal: 6.383 ± 0.088	0.878ValTrp: 0.878 ± 0.031	1.578ValTyr: 1.578 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.057TrpAla: 1.057 ± 0.032	0.125TrpCys: 0.125 ± 0.011	0.579TrpAsp: 0.579 ± 0.022	0.498TrpGlu: 0.498 ± 0.019	0.483TrpPhe: 0.483 ± 0.02	0.765TrpGly: 0.765 ± 0.031	0.361TrpHis: 0.361 ± 0.018	0.623TrpIle: 0.623 ± 0.026	0.441TrpLys: 0.441 ± 0.021	1.564TrpLeu: 1.564 ± 0.045	0.326TrpMet: 0.326 ± 0.016	0.447TrpAsn: 0.447 ± 0.021	0.654TrpPro: 0.654 ± 0.027	0.565TrpGln: 0.565 ± 0.026	1.095TrpArg: 1.095 ± 0.032	0.788TrpSer: 0.788 ± 0.023	0.725TrpThr: 0.725 ± 0.028	0.683TrpVal: 0.683 ± 0.025	0.223TrpTrp: 0.223 ± 0.014	0.291TrpTyr: 0.291 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.715TyrAla: 2.715 ± 0.055	0.239TyrCys: 0.239 ± 0.015	1.536TyrAsp: 1.536 ± 0.037	1.277TyrGlu: 1.277 ± 0.035	0.913TyrPhe: 0.913 ± 0.029	2.117TyrGly: 2.117 ± 0.048	0.515TyrHis: 0.515 ± 0.021	0.792TyrIle: 0.792 ± 0.026	0.509TyrLys: 0.509 ± 0.023	2.177TyrLeu: 2.177 ± 0.046	0.443TyrMet: 0.443 ± 0.019	0.547TyrAsn: 0.547 ± 0.021	1.032TyrPro: 1.032 ± 0.027	0.631TyrGln: 0.631 ± 0.024	1.852TyrArg: 1.852 ± 0.038	1.091TyrSer: 1.091 ± 0.032	1.106TyrThr: 1.106 ± 0.032	1.666TyrVal: 1.666 ± 0.035	0.32TyrTrp: 0.32 ± 0.016	0.581TyrTyr: 0.581 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3546 proteins (1155526 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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